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Conserved domains on  [gi|197381061|ref|NP_001128028|]
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U5 small nuclear ribonucleoprotein 40 kDa protein [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 1.14e-81

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.45  E-value: 1.14e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 197381061 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 1.14e-81

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.45  E-value: 1.14e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 197381061 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-352 2.86e-78

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 241.86  E-value: 2.86e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 143 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 219
Cdd:cd00200   84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 220 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 299
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 197381061 300 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 123-313 1.16e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 123 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 202
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 203 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 278
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 197381061 279 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 313
Cdd:PLN00181 705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 2.58e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.58e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 197381061    59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWS 95
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
59-95 1.88e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.88e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 197381061   59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWS 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 1.14e-81

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.45  E-value: 1.14e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 197381061 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-352 2.86e-78

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 241.86  E-value: 2.86e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 143 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 219
Cdd:cd00200   84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 220 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 299
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 197381061 300 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
19-353 1.44e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 1.44e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  19 RPRHELLLGAAGSGPGAGQQQATPGALLQTGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYG 98
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  99 DcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVK 178
Cdd:COG2319  110 G-LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 179 LWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 257
Cdd:COG2319  188 LWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 258 NTVRVWDVRPfapkERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 337
Cdd:COG2319  268 GTVRLWDLAT----GELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                        330
                 ....*....|....*.
gi 197381061 338 PDEPIILSASSDKRLY 353
Cdd:COG2319  340 PDGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
63-317 3.47e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.09  E-value: 3.47e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSET 141
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 142 GERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKV 220
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 221 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSK 300
Cdd:COG2319  315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA----TGELLRTLTG--H--TGAVTSVAFSPDGRT 386

                        250
                 ....*....|....*..
gi 197381061 301 IAAGSADRFVYVWDTTS 317
Cdd:COG2319  387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-353 8.13e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.58  E-value: 8.13e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 102 NYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCtGSDDGTVKLWD 181
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 182 IRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 260
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 261 RVWDVRPFapkeRCVKIFQGnvHnfEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 340
Cdd:cd00200  160 KLWDLRTG----KCVATLTG--H--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        250
                 ....*....|...
gi 197381061 341 PIILSASSDKRLY 353
Cdd:cd00200  232 YLLASGSEDGTIR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-314 4.56e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 4.56e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYGDCDNYaTLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 143 ERVKRLKGHTSFVNSCyPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 221
Cdd:cd00200  126 KCLTTLRGHTDWVNSV-AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 222 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSKI 301
Cdd:cd00200  205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSG--H--TNSVTSLAWSPDGKRL 276

                        250
                 ....*....|...
gi 197381061 302 AAGSADRFVYVWD 314
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
121-352 1.18e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 1.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 121 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAV 200
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 201 TFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQG 280
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197381061 281 NvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319  161 H----SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-264 1.28e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 1.28e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  59 PIMLLSGHEGEVYCCKFHPngstlasagfdrlillwsvygdcdnyatlkghsgavmelhyntDGSMLFSASTDKTVAVWD 138
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSP-------------------------------------------DGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 139 SETGERVKRLKGHTSFVNSCYPARRGPQLvCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 217
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGT 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 197381061 218 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 123-313 1.16e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 123 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 202
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 203 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 278
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 197381061 279 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 313
Cdd:PLN00181 705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 54-230 4.91e-18

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 84.94  E-value: 4.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  54 SSLQAPIMLLSGHEGEVYCCKFHPNG-STLASAGFDRLILLWSV-YGDCDNyaTLKGHSGAVMELHYNTDGSMLFSASTD 131
Cdd:PTZ00421 112 QNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVeRGKAVE--VIKCHSDQITSLEWNLDGSLLCTTSKD 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 132 KTVAVWDSETGERVKRLKGHTSF-VNSCYPARRGPQLV---CTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF----N 203
Cdd:PTZ00421 190 KKLNIIDPRDGTIVSSVEAHASAkSQRCLWAKRKDLIItlgCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIpffdE 269

                        170       180
                 ....*....|....*....|....*..
gi 197381061 204 DTSDQIISGGIDNDIKVWDLRQNKLTY 230
Cdd:PTZ00421 270 DTNLLYIGSKGEGNIRCFELMNERLTF 296
WD40 COG2319
WD40 repeat [General function prediction only];
58-141 9.44e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 9.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYGDCDnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 137
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                 ....
gi 197381061 138 DSET 141
Cdd:COG2319  400 DLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 106-315 1.41e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.14  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 106 LKGHSGAVMELHYNT-DGSMLFSASTDKTVAVWD-------SETGERVKRLKGHtsfvnscyparrgpqlvctgsddgtv 177
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGH-------------------------- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 178 klwdiRKKAAIQTFQ-NTYQVLAvtfndtsdqiiSGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 256
Cdd:PTZ00421 125 -----TKKVGIVSFHpSAMNVLA-----------SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSK 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 197381061 257 DNTVRVWDVRpfapkeRCVKIFQGNVHNFEKNlLRCSWSPDGSKI----AAGSADRFVYVWDT 315
Cdd:PTZ00421 189 DKKLNIIDPR------DGTIVSSVEAHASAKS-QRCLWAKRKDLIitlgCSKSQQRQIMLWDT 244
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 208-357 1.90e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 1.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 208 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN-TVRVWDVrpfapkERCVKIfqGNVHNfe 286
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSI------NQGVSI--GTIKT-- 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197381061 287 KNLLRCSWSPD--GSKIAAGSADRFVYVWDTTSRRI-LYKLPGHAGSINEVAFhPDEPIILSASSDKRLYMGEI 357
Cdd:PLN00181 617 KANICCVQFPSesGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 2.58e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.58e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 197381061    59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWS 95
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
59-95 1.88e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.88e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 197381061   59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWS 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
77-265 2.08e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061  77 PNGSTLASAGFDRLILLWSVYGDCDNYATLKGHSGAVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVKRLKGHTSFV 155
Cdd:COG3391   34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDLATGKVVATIPVGGGPR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 156 NSCYpARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDND-----IKVWDLRQNKLTY 230
Cdd:COG3391  114 GLAV-DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVA 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 197381061 231 TMRGhADSVTGLSLSSEGSYLL--------SNAMDNTVRVWDV 265
Cdd:COG3391  193 TIPV-GGGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
WD40 pfam00400
WD domain, G-beta repeat;
226-264 2.76e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197381061  226 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-264 3.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.21e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197381061   225 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 7.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.31e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 197381061   104 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 138
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-181 1.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 197381061   141 TGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWD 181
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLA-SGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-138 1.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 197381061  104 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 138
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
142-181 1.52e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 197381061  142 GERVKRLKGHTSFVNSCYPARRGpQLVCTGSDDGTVKLWD 181
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 209-284 2.18e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 2.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 197381061  209 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 284
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEFPR 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 317-354 3.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 197381061   317 SRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYM 354
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-349 5.16e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197381061 210 ISGGIDNDIKVWDLRQNKLTYTMRgHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERcvkIFQGN-VHNFEk 287
Cdd:COG3391   84 VANSGSGRVSVIDLATGKVVATIP-VGGGPRGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVAT---IPVGAgPHGIA- 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 197381061 288 nllrcsWSPDGSKIAAGSAD-----RFVYVWDTTSRRILYKLPGhAGSINEVAFHPDEPIILSASSD 349
Cdd:COG3391  159 ------VDPDGKRLYVANSGsntvsVIVSVIDTATGKVVATIPV-GGGPVGVAVSPDGRRLYVANRG 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-314 7.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 197381061   273 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 314
Cdd:smart00320   3 ELLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
318-354 1.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 197381061  318 RRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYM 354
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 pfam00400
WD domain, G-beta repeat;
273-314 4.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 197381061  273 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 314
Cdd:pfam00400   2 KLLKTLEGH----TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-222 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 197381061   188 IQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWD 222
Cdd:smart00320   5 LKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-222 9.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 197381061  197 VLAVTFNDTSDQIISGGIDNDIKVWD 222
Cdd:pfam00400  14 VTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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