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Conserved domains on  [gi|219282679|ref|NP_001136434|]
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zinc finger protein 458 isoform 1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 219282679     5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 219282679 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 219282679 575 HK 576
Cdd:COG5189  417 HR 418
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ..
gi 219282679 660 KK 661
Cdd:COG5189  418 RK 419
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100
                 ....*....|....*....|.
gi 219282679 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNN 121
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 219282679     5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 7.14e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.14e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 219282679    5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 2.29e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.29e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 219282679   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 219282679 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 219282679 575 HK 576
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ..
gi 219282679 660 KK 661
Cdd:COG5189  418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 219282679  347 RLSRHKKIHTGEKPYKCEVCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100
                 ....*....|....*....|.
gi 219282679 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNN 121
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 219282679     5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 7.14e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.14e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 219282679    5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 2.29e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.29e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 219282679   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 219282679 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-607 1.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 247 KPYKCEVCDRAFHDPSKLSQHKIIHTGEKPYKCDV--CGKAFHYPSILSKHKIIHTEENL----------------CKCD 308
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 309 ICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTGEKPYKC--------EVCGKAFHYLSILSKHK 380
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 381 IVHTEENPYKCEVCGKAFDYPSRLSNHKKIHTEEkPYKCEVCGNAFCFSSSLRKH-KIIHTGEKPYKCEVCGKAFGSPSR 459
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 460 LSKHKKIHTEEK------PYKCEVCGKAFHFPSLLSVHKR--IHTGE--KPYKC--EICGKAFYCASTLSVHKRIHTGEN 527
Cdd:COG5048  271 QSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 528 NYKC--EVCGKAF-----HCPSTLSVHRRIHTQEKPYKCEV--CGQAFHVSSKLSYHKRIHTAEKP--YKCEICGKAFYY 596
Cdd:COG5048  351 PAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410
                 ....*....|.
gi 219282679 597 PSRLSKHKIVH 607
Cdd:COG5048  431 HYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
306-735 5.41e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 5.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 306 KCDICGKAFHYPLLLSQHKIVHTGEKPYKCED--CGKAFYYPSRLSRHKKIHTGEKPYKCEVCGKAFHYLSILSKHKIVH 383
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 384 TEEN-PYKCEVCGKAFDYPSRLSNHKKIHTEEKPYKCEVCGNAFC-FSSSLRKHKIIHTGEKpykcevCGKAFGSPSRLS 461
Cdd:COG5048  115 SNSNdNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSL------SKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 462 KHKKIHTEEKPYKCEVCGKAFHFPSLLSVHKRIHTgEKPYKCEICGKAFYCASTLSVHKRIHTGENNYKCEVCGKAFHCP 541
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 542 STLSVHRRIHT-------QEKPYKCEVCGQAFHVSSKLSYHKR--IHTAE--KPYKC--EICGKAFYYPSRLSKHKIVHM 608
Cdd:COG5048  268 ASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 609 GEKRYHgqacgkaLDYPSRHSKHKKLNPGEKPhkceicgkAFHFPSLLSIHKKIHTGEKTCKCEVCGKDfhYPSRLSNHK 688
Cdd:COG5048  348 SISPAK-------EKLLNSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRD--SNLSLHIIT 410

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 219282679 689 KIHTEGKAYKCDICDKTFNYKSLLSKHKIGHTVENTYHSEVCGKAFG 735
Cdd:COG5048  411 HLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-577 2.25e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 162 QKPHESENYSKDFHYPSLLSQNKVVHTGEKSYQCED--HGKTFHYPSTFSKHKKIHTGEKPHKCevCGKAFDYPSRLSNH 239
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 240 KRIHTGEKPYKCEVCD-RAFHDPSKLSQHKIIHTGEKPYKC---DVCGKAFHYPSILSKHKIIHTEENlckcdiCGKAFH 315
Cdd:COG5048  109 SLSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNplpGNNSSSVNTPQSNSLHPPLPANSL------SKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 316 YPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTgEKPYKCEVCGKAFHYLSILSKH-KIVHTEENPYKCEVC 394
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 395 GKAFDYPSR-LSNHKKIHTEE-----KPYKCEVCGNAFCFSSSLRKHK--IIHTGE--KPYKC--EVCGKAFGSPSRLSK 462
Cdd:COG5048  262 RSSLPTASSqSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 463 HKKIHTEEKPYKC--EVCGKAFHFPS-----LLSVHKRIHTGEKPYKCE--ICGKAFYCASTLSVHKRIHTGEN--NYKC 531
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpyNCKN 421

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 219282679 532 EVCGKAFHCPSTLSVHRRIHTQEKPYKCEVCGqAFHVSSKLSYHKR 577
Cdd:COG5048  422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 219282679 575 HK 576
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 385-465 3.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 385 EENPYKCEV--CGKAFDYPSRLSNHKKiHTEEKPYKCEvcgnafcfSSSLRKHKIIHTGEKPYKCEVCGKAFGSPSRLSK 462
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 219282679 463 HKK 465
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 399-482 3.24e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 399 DYPSRLSNHKkihtEEKPYKCEV--CGNAFCFSSSLRKHKIiHTGEKPykcevcgKAFGSPSRlSKHKKIHTEEKPYKCE 476
Cdd:COG5189  336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSP-EKMNIFSAKDKPYRCE 402


                 ....*.
gi 219282679 477 VCGKAF 482
Cdd:COG5189  403 VCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-717 9.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 9.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 219 KPHKCEVCGKAFDYPSRLSNHKRIHTGEKPYKCEV--CDRAFHDPSKLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHK 296
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 297 IIHTEENL-CKCDICGKAFHYPLllSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTGEKPykcEVCGKAFHYLSI 375
Cdd:COG5048  112 SSSSNSNDnNLLSSHSLPPSSRD--PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 376 LSKHKIVHTEENPYKCEVCGKAFDYPSRLSNHKKIHTEEkPYKCEVCGNAFCFSSSLRKH-KIIHTGEKPYKCEVCGKAF 454
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 455 GSPSRLSKHkkihteekpykcevcgkafHFPSLLSVHKRIHTgekPYKCEICGKAFYCASTLSVHKR--IHTGENNykce 532
Cdd:COG5048  266 PTASSQSSS-------------------PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGESL---- 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 533 vcgKAFHCPSTLsvhrrihtqekpykcevCGQAFHVSSKLSYHKRIHTAEKPYKCeicgkafyyPSRLSKHKIVHMGEKR 612
Cdd:COG5048  320 ---KPFSCPYSL-----------------CGKLFSRNDALKRHILLHTSISPAKE---------KLLNSSSKFSPLLNNE 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 613 YHGQACgkalDYPSRHSKHKKLNPgekPHKCEICGKAFHFPSLLSIHKKIHTGEKtCKCEVCGKDFHYPSRLSNHKKIHT 692
Cdd:COG5048  371 PPQSLQ----QYKDLKNDKKSETL---SNSCIRNFKRDSNLSLHIITHLSFRPYN-CKNPPCSKSFNRHYNLIPHKKIHT 442

                        490       500
                 ....*....|....*....|....*
gi 219282679 693 EGKAYKCDICdKTFNYKSLLSKHKI 717
Cdd:COG5048  443 NHAPLLCSIL-KSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ..
gi 219282679 660 KK 661
Cdd:COG5189  418 RK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-409 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 329 GEKPYKCE--DCGKAFYYPSRLSRHKKihTGEkpykcevCGKAFHYLSILSKHKIVHTEENPYKCEVCGKAFDYPSRLSN 406
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 219282679 407 HKK 409
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 219282679  347 RLSRHKKIHTGEKPYKCEVCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-286 1.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219282679 231 DYPSRLSNHKrihtGEKPYKCEV--CDRAFHDPSKLSQHK-------------------IIHTGEKPYKCDVCGKAF 286
Cdd:COG5189  336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-454 2.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....
gi 219282679  431 SLRKHKIIHTGEKPYKCEVCGKAF 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100
                 ....*....|....*....|.
gi 219282679 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNN 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
488-512 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|....*
gi 219282679  488 LSVHKRIHTGEKPYKCEICGKAFYC 512
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-286 6.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.12e-03
                          10        20
                  ....*....|....*....|...
gi 219282679  264 LSQHKIIHTGEKPYKCDVCGKAF 286
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 622-720 6.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219282679 622 LDYPSRHSKHKklnpGEKPHKCEI--CGKAFHFPSLLSIHKKI-HTGEKTCKcevcgkdfhYPSRLSnHKKIHTEGKAYK 698
Cdd:COG5189  335 IDTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE---------NPSPEK-MNIFSAKDKPYR 400

                         90       100
                 ....*....|....*....|...
gi 219282679 699 CDICDKtfNYKSLLS-KHKIGHT 720
Cdd:COG5189  401 CEVCDK--RYKNLNGlKYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-232 8.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|...
gi 219282679  210 KHKKIHTGEKPHKCEVCGKAFDY 232
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 554-594 8.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219282679 554 EKPYKCEV--CGQAFHVSSKLSYHKR-------------------IHTAEKPYKCEICGKAF 594
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-258 8.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.89e-03
                          10        20
                  ....*....|....*....|....
gi 219282679  235 RLSNHKRIHTGEKPYKCEVCDRAF 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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