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Conserved domains on  [gi|281371412|ref|NP_001163807|]
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latent-transforming growth factor beta-binding protein 4 precursor [Rattus norvegicus]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 5.18e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.18e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281371412   418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
885-921 2.03e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.03e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    885 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 921
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1367-1409 2.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1367 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1409
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1200-1242 5.03e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1200 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1242
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1056-1097 1.15e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 281371412   1056 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1097
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-962 7.51e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.51e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    927 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 962
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 842-874 1.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  842 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 874
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 3.15e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.15e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 281371412    357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 4.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 281371412  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 9.64e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 9.64e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 3.05e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 3.11e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.11e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 281371412    595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1581-1615 6.49e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.49e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412   1581 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1615
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 9.44e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 9.44e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412    718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
968-1006 1.84e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 281371412    968 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1006
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1332 2.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 281371412 1303 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1332
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 7.84e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 7.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1098-1126 9.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 35.29  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 281371412  1098 DVNECETLQGVC-GSALCENVEGSFLCVCP 1126
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 5.18e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.18e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281371412   418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
885-921 2.03e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.03e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    885 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 921
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1367-1409 2.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1367 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1409
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1200-1242 5.03e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1200 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1242
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1056-1097 1.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 281371412   1056 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1097
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 885-917 2.91e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.91e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  885 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 917
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-962 7.51e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.51e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    927 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 962
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1056-1091 7.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 7.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281371412 1056 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1091
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 842-874 1.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  842 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 874
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
842-874 2.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.69e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 281371412    842 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 874
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 3.15e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.15e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 281371412    357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 4.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 281371412  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-958 6.93e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.93e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  927 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 958
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 9.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 9.64e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-716 1.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 281371412    679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 716
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 1.24e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281371412  357 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 391
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 3.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 3.11e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.11e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 281371412    595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1581-1615 6.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.49e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412   1581 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1615
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
927-956 8.37e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 8.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   927 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 956
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 760-792 8.50e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 8.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281371412  760 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 792
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 9.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 9.44e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412    718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 637-678 9.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 281371412  637 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 678
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1066-1096 1.02e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 281371412  1066 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1096
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 718-752 1.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 281371412  718 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 752
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
760-790 1.54e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   760 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 790
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
968-1006 1.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 281371412    968 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1006
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1332 2.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 281371412 1303 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1332
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1581-1619 2.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281371412 1581 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1619
Cdd:cd00054     1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1303-1332 2.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.24e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 281371412   1303 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1332
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
357-386 2.28e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   357 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 386
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1581-1614 4.82e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 281371412  1581 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1614
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
637-667 5.11e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.11e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   637 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 667
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
679-709 6.16e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   679 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 709
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 595-627 7.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281371412  595 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 627
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 7.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 7.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1098-1126 9.23e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 281371412  1098 DVNECETLQGVC-GSALCENVEGSFLCVCP 1126
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 5.18e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.18e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281371412   418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
885-921 2.03e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.03e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    885 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 921
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1367-1409 2.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1367 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1409
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1200-1242 5.03e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281371412  1200 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1242
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1056-1097 1.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 281371412   1056 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1097
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 885-917 2.91e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.91e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  885 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 917
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-962 7.51e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.51e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    927 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 962
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1056-1091 7.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 7.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281371412 1056 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1091
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 842-874 1.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  842 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 874
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
842-874 2.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.69e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 281371412    842 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 874
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 3.15e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.15e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 281371412    357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 4.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 281371412  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-958 6.93e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.93e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281371412  927 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 958
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 9.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 9.64e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-716 1.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 281371412    679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 716
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 1.24e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281371412  357 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 391
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 3.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371412    637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 3.11e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.11e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 281371412    595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1581-1615 6.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.49e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412   1581 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1615
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
927-956 8.37e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 8.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   927 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 956
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 760-792 8.50e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 8.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281371412  760 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 792
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 9.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 9.44e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 281371412    718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 637-678 9.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 281371412  637 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 678
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1066-1096 1.02e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 281371412  1066 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1096
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 718-752 1.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 281371412  718 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 752
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
760-790 1.54e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   760 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 790
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
360-392 1.69e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.69e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 281371412    360 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 392
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
968-1006 1.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 281371412    968 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1006
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1332 2.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 281371412 1303 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1332
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1581-1619 2.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281371412 1581 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1619
Cdd:cd00054     1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1303-1332 2.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.24e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 281371412   1303 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1332
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
357-386 2.28e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   357 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 386
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1581-1614 4.82e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 281371412  1581 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1614
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
637-667 5.11e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.11e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   637 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 667
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
679-709 6.16e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281371412   679 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 709
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 595-627 7.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281371412  595 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 627
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 7.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 7.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371412    802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1098-1126 9.23e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 281371412  1098 DVNECETLQGVC-GSALCENVEGSFLCVCP 1126
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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