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Conserved domains on  [gi|281604174|ref|NP_001163905|]
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transforming growth factor beta activator LRRC32 precursor [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-278 1.66e-27

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 281604174 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 281604174 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-278 1.66e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 281604174 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 4.02e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  51 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 130
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 131 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 210
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 211 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 289
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281604174 290 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 344
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 281604174 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-437 2.43e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  43 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 96
Cdd:PLN00113 251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  97 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 176
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 177 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 253
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 254 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 330
Cdd:PLN00113 485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 331 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 410
Cdd:PLN00113 539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                        410       420
                 ....*....|....*....|....*..
gi 281604174 411 AsLQRLNLQGNqVSPCGGQAEPGPPGC 437
Cdd:PLN00113 595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-575 1.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 123 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 199
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 272
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 273 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:PLN00113 243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 351 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 405
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 406 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 485
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 486 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 564
Cdd:PLN00113 439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                        490
                 ....*....|.
gi 281604174 565 RRLYLQGNPLS 575
Cdd:PLN00113 502 MQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-424 7.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 7.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 199 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 277
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 278 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 354
Cdd:cd21340   58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281604174 355 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 424
Cdd:cd21340  108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
150-210 5.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.28e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281604174  150 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
316-376 6.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281604174  316 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-278 1.66e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 281604174 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 4.02e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  51 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 130
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 131 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 210
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 211 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 289
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 281604174 290 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 344
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 281604174 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-422 1.93e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  39 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRlaagmalns 118
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 119 gGLGRLPLVVSLDLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIeDGAFEALP 198
Cdd:COG4886  108 -ELSNLTNLESLDLSGNQL--TDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 199 QLTHLNLSRNSLTCISD--FSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPDLAMFPRLIYLNVSN 275
Cdd:COG4886  183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 276 NLIqlpTGLPQDSEdlhapsegwsasllsnpsrnasihpLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSF 355
Cdd:COG4886  260 NQL---TDLPPLAN-------------------------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281604174 356 EARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ 422
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-410 5.66e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 5.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  38 GLSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALN 117
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 118 SGGLGRLPLVVSLDLSGNslhgslveRLLGEAPRLRTLSLAENSLTRLARHtFWGMPAMEQLDLHSNVLMDIEDgAFEAL 197
Cdd:COG4886   89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 198 PQLTHLNLSRNSLTCISDF--SLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNV 273
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDL---PEPLGNLtNLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 274 SNNLIqlpTGLPqdsedlhapsegwsasllsnpsrnaSIHPLSQLLNLDLSYNEIELVPagFLEHLTSLRFLNLSRNCLR 353
Cdd:COG4886  236 SNNQL---TDLP-------------------------ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281604174 354 SFEARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGL 410
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-575 9.87e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 9.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 295 SEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHN 374
Cdd:COG4886   27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 375 vlealeLGTKVLGSLKTLLLQDNTLRELPPyTFAGLASLQRLNLQGNQVSPCGgqaepgppgcVDFSGIPTLHFLNMAGN 454
Cdd:COG4886  107 ------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP----------EPLGNLTNLKSLDLSNN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 455 SMETLRAGSFLHTPLTELDLSANPgLDVATGALVGLEaSLEVLELQGNGLVVLRVDLPCFRRLKRLNLAENRLSHLPAWT 534
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 281604174 535 RAVSLEVLDLRNNSFSLLPGNamGGLeTSLRRLYLQGNPLS 575
Cdd:COG4886  248 NLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-437 2.43e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  43 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 96
Cdd:PLN00113 251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  97 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 176
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 177 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 253
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 254 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 330
Cdd:PLN00113 485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 331 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 410
Cdd:PLN00113 539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                        410       420
                 ....*....|....*....|....*..
gi 281604174 411 AsLQRLNLQGNqVSPCGGQAEPGPPGC 437
Cdd:PLN00113 595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-552 8.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 8.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 268 LIYLNVSNNLIQLPTGLPQDSEDLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNL 347
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 348 SRNclrsfeaRRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPyTFAGLASLQRLNLQGNQVSPCG 427
Cdd:COG4886  104 SGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 428 gqaepgppgcVDFSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPgLDVATGALVGLEaSLEVLELQGNGLVVL 507
Cdd:COG4886  176 ----------EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEPLANLT-NLETLDLSNNQLTDL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 281604174 508 RvDLPCFRRLKRLNLAENRLSHLPAWTRAVSLEVLDLRNNSFSLL 552
Cdd:COG4886  244 P-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-421 5.05e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.57  E-value: 5.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  43 QVPSVLSL--DIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALNSGG 120
Cdd:PLN00113 203 QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 121 LGRLplvVSLDLSGNSLHGSLVErLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQL 200
Cdd:PLN00113 283 LQKL---ISLDLSDNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 201 THLNLSRNSLT-------CISDfslqQLQVLDLSCNSIETfQTAPESQAQFQLAWLDLRENKLL-HFP-DLAMFPRLIYL 271
Cdd:PLN00113 359 TVLDLSTNNLTgeipeglCSSG----NLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPsEFTKLPLVYFL 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 272 NVSNNLIQLptglpqdsedlHAPSEGWSASLLS--NPSRNASIHPL------SQLLNLDLSYNEI-ELVPAGFLEhLTSL 342
Cdd:PLN00113 434 DISNNNLQG-----------RINSRKWDMPSLQmlSLARNKFFGGLpdsfgsKRLENLDLSRNQFsGAVPRKLGS-LSEL 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 343 RFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEA-LELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGN 421
Cdd:PLN00113 502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-211 1.42e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  52 IQALYLSGNRLQSIlvSPLSFYTALRHLDLSDNEISFLQPgvFQALPYLEHLNLAHNRLAagmalNSGGLGRLPLVVSLD 131
Cdd:cd21340   26 LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-----VVEGLENLTNLEELH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 132 LS------GNSLHgSLVERLLGEAPRLRTLSLAENSLTRLArhTFWGMPAMEQLDLHSNVLMDIED--GAFEALPQLTHL 203
Cdd:cd21340   97 IEnqrlppGEKLT-FDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLREL 173


                 ....*...
gi 281604174 204 NLSRNSLT 211
Cdd:cd21340  174 DLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-575 1.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 123 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 199
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 272
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 273 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:PLN00113 243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 351 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 405
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 406 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 485
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 486 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 564
Cdd:PLN00113 439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                        490
                 ....*....|.
gi 281604174 565 RRLYLQGNPLS 575
Cdd:PLN00113 502 MQLKLSENKLS 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-477 4.92e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  39 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSfytaLRHLDLSDNEISFLQPGVFqaLPYLEHLNLAHNRLAAGMALNS 118
Cdd:PLN00113  87 SAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSS----LRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 119 GGLGRLPLvvsLDLSGNSLHGSlVERLLGEAPRLRTLSLAENSLTRLARHTF-------W-----------------GMP 174
Cdd:PLN00113 161 GSFSSLKV---LDLGGNVLVGK-IPNSLTNLTSLEFLTLASNQLVGQIPRELgqmkslkWiylgynnlsgeipyeigGLT 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 175 AMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCI---SDFSLQQLQVLDLSCNSIETfqTAPESQAQFQ-LAWLD 250
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPippSIFSLQKLISLDLSDNSLSG--EIPELVIQLQnLEILH 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 251 LRENKLL-HFPD-LAMFPRLIYLNV-SNNLI-QLPTGLPQDSE----DLHAPS------EGWSAS-------LLSNpSRN 309
Cdd:PLN00113 315 LFSNNFTgKIPVaLTSLPRLQVLQLwSNKFSgEIPKNLGKHNNltvlDLSTNNltgeipEGLCSSgnlfkliLFSN-SLE 393

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 310 ASIHP----LSQLLNLDLSYNEI--ELvPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEALELGT 383
Cdd:PLN00113 394 GEIPKslgaCRSLRRVRLQDNSFsgEL-PSEFTK-LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 384 KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQVSpcggqaepgppGCV--DFSGIPTLHFLNMAGNSMETLRA 461
Cdd:PLN00113 472 FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS-----------GEIpdELSSCKKLVSLDLSHNQLSGQIP 540

                        490
                 ....*....|....*..
gi 281604174 462 GSFLHTP-LTELDLSAN 477
Cdd:PLN00113 541 ASFSEMPvLSQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-379 3.24e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 127 VVSLDLSGNSLHgSLVERLLGEaprLRTLSLAENSLTRLARhtfwGMP-AMEQLDLHSNVLMDIEdgafEALPQ-LTHLN 204
Cdd:PRK15370 201 ITTLILDNNELK-SLPENLQGN---IKTLYANSNQLTSIPA----TLPdTIQEMELSINRITELP----ERLPSaLQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 205 LSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPEsqaqfqlawldlrenkllHFPDlamfpRLIYLNV-SNNLIQLPTG 283
Cdd:PRK15370 269 LFHNKISCLPENLPEELRYLSVYDNSIRTL---PA------------------HLPS-----GITHLNVqSNSLTALPET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 284 LPQDSEDLHAPSEgwsaSLLSNPsrnASIHPlsQLLNLDLSYNEIELVPAGFLEHLTSlrfLNLSRNCLRSFEArragSL 363
Cdd:PRK15370 323 LPPGLKTLEAGEN----ALTSLP---ASLPP--ELQVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPE----NL 386

                        250
                 ....*....|....*..
gi 281604174 364 P-CLVLLDLSHNVLEAL 379
Cdd:PRK15370 387 PaALQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-424 7.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 7.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 199 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 277
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 278 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 354
Cdd:cd21340   58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281604174 355 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 424
Cdd:cd21340  108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
150-210 5.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.28e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281604174  150 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 41-211 1.14e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.96  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  41 LLQVPSVLSLDIQALYLsGNRLQSILVSPLSFYTALRHLDLSDNEISflQPGV---FQALPY---LEHLNLAHNRL-AAG 113
Cdd:COG5238  204 LTQNTTVTTLWLKRNPI-GDEGAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIgAEG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 114 MALNSGGLGRLPLVVSLDLSGNSLHG----SLVERLLGEAPrLRTLSLAENSLT-----RLARHtFWGMPAMEQLDLHSN 184
Cdd:COG5238  281 AIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQGNKT-LHTLNLAYNGIGaqgaiALAKA-LQENTTLHSLDLSDN 358

                        170       180       190
                 ....*....|....*....|....*....|.
gi 281604174 185 VLMDIEDGAF----EALPQLTHLNLSRNSLT 211
Cdd:COG5238  359 QIGDEGAIALakylEGNTTLRELNLGKNNIG 389
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
201-515 4.21e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 201 THLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESqAQFQLAWLDLRENKLLHFPdlAMFPRLI-YLNVS-NNLI 278
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLILDNNELKSL---PEN-LQGNIKTLYANSNQLTSIP--ATLPDTIqEMELSiNRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 279 QLPTGLPqdsedlhapsegwsasllsnpsrnasihplSQLLNLDLSYNEIELVPAGFLEhltSLRFLNLSRNCLRSFEAR 358
Cdd:PRK15370 255 ELPERLP------------------------------SALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAH 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 359 ragsLPC-LVLLDLSHNVLEALElGTKVLGsLKTLLLQDNTLRELPpytfAGLA-SLQRLNLQGNQVSPCggqAEPGPPg 436
Cdd:PRK15370 302 ----LPSgITHLNVQSNSLTALP-ETLPPG-LKTLEAGENALTSLP----ASLPpELQVLDVSKNQITVL---PETLPP- 367

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281604174 437 cvdfsgiptlhflnmagnsmetlragsflhtPLTELDLSANPGLDVATGalvgLEASLEVLELQGNGLVVLRVDLPCFR 515
Cdd:PRK15370 368 -------------------------------TITTLDVSRNALTNLPEN----LPAALQIMQASRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 179-374 4.97e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 179 LDLHSNVLMDIEDgaFEALPQLTHLNLSRNSLTCISDF-SLQQLQVLDLSCNSI---ETFQTAPEsqaqfqlawldLREn 254
Cdd:cd21340   29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRIsvvEGLENLTN-----------LEE- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 255 kllhfpdlamfprliyLNVSNNliQLPTGLpqdsedlhapsegwsaSLLSNPsrnASIHPLSQ-LLNLDLSYNEIE-LVP 332
Cdd:cd21340   95 ----------------LHIENQ--RLPPGE----------------KLTFDP---RSLAALSNsLRVLNISGNNIDsLEP 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 281604174 333 agfLEHLTSLRFLNLSRNCLRSFE--ARRAGSLPCLVLLDLSHN 374
Cdd:cd21340  138 ---LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-244 1.68e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.78  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  40 SLLQVPSVLSLDIQALYLSGNRLQSIlvsPLSFYTALRHLDLSDNEISFLQpgvfQALPY-LEHLNLAHNRLAA------ 112
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISClpenlp 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 113 ----GMALNSGGLGRLPL-----VVSLDLSGNSLhGSLVERLlgeAPRLRTLSLAENSLTRLARHTfwgMPAMEQLDLHS 183
Cdd:PRK15370 283 eelrYLSVYDNSIRTLPAhlpsgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSK 355

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281604174 184 NVLMDIEdgafEALP-QLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESQAQF 244
Cdd:PRK15370 356 NQITVLP----ETLPpTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL---PESLPHF 410
LRR_8 pfam13855
Leucine rich repeat;
55-110 4.72e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 281604174   55 LYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRL 110
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
76-137 1.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281604174   76 LRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmALNSGGLGRLPLVVSLDLSGNSL 137
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
316-376 6.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281604174  316 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 388-553 1.98e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 388 SLKTLLLQDNTLRELPPYTFagLASLQRLNLQGNQVSPCGGqaepgppgcvdFSGIPTLHFLNMAGNSMETLragSFLH- 466
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV---EGLEn 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 467 -TPLTELDLSAN---PG--LDVATGALVGLEASLEVLELQGNGLVVLRvDLPCFRRLKRLNLAENRLSHLPAWTRAVS-- 538
Cdd:cd21340   89 lTNLEELHIENQrlpPGekLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                        170
                 ....*....|....*..
gi 281604174 539 --LEVLDLRNNSFSLLP 553
Cdd:cd21340  168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
515-574 3.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281604174  515 RRLKRLNLAENRLSHLP--AWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPL 574
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
366-423 4.17e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 281604174  366 LVLLDLSHNVLEALELGT-KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQV 423
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
179-231 4.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 281604174  179 LDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSI 231
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 362-578 1.56e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 362 SLPCLVLLDLSHNVL--EALELGTKVL---GSLKTLLLQDNTLRELPPYT------FAGLASLQRLNLQGNQVSPcggqa 430
Cdd:cd00116   21 KLLCLQVLRLEGNTLgeEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGP----- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 431 ePGPPGCVDFSGIPTLHFLNMAGNSMET----LRAGSFLHTP--LTELDLSAN----PGLDVATGALVGLeASLEVLELQ 500
Cdd:cd00116   96 -DGCGVLESLLRSSSLQELKLNNNGLGDrglrLLAKGLKDLPpaLEKLVLGRNrlegASCEALAKALRAN-RDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 501 GN-----GLVVLRVDLPCFRRLKRLNLAENRLSH---------LPAWTravSLEVLDLRNNSFSLLP----GNAMGGLET 562
Cdd:cd00116  174 NNgigdaGIRALAEGLKANCNLEVLDLNNNGLTDegasalaetLASLK---SLEVLNLGDNNLTDAGaaalASALLSPNI 250

                        250
                 ....*....|....*.
gi 281604174 563 SLRRLYLQGNPLSCCG 578
Cdd:cd00116  251 SLLTLSLSCNDITDDG 266
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 311-478 1.78e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 311 SIHPLSQLLNLDLSY---NEIELVPAgfLEHLTSLRFLNLSRNCLRSFEarRAGSLPCLVLLDLSHN---VLEALELgtk 384
Cdd:cd21340   16 KIDNLSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNrisVVEGLEN--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 385 vLGSLKTLLLQDNTLRELPPYTF-----AGLA-SLQRLNLQGNQVSpcggqaEPGPpgcvdFSGIPTLHFLNMAGN---S 455
Cdd:cd21340   89 -LTNLEELHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNID------SLEP-----LAPLRNLEQLDASNNqisD 156

                        170       180
                 ....*....|....*....|....
gi 281604174 456 METLrAGSFLHTP-LTELDLSANP 478
Cdd:cd21340  157 LEEL-LDLLSSWPsLRELDLTGNP 179
PLN03150 PLN03150
hypothetical protein; Provisional
 510-575 2.99e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 2.99e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281604174 510 DLPCFRRLKRLNLAENRL-SHLPAWTRAV-SLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPLS 575
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIrGNIPPSLGSItSLEVLDLSYNSFNGSIPESLGQL-TSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 91-163 7.30e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 7.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281604174  91 PGVFQALPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERlLGEAPRLRTLSLAENSLT 163
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPS---LGSITSLEVLDLSYNSFNGSIPES-LGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 336-424 6.30e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 336 LEHLTSLrflNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGLASLQR 415
Cdd:PLN03150 441 LRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLGQLTSLRI 494


                 ....*....
gi 281604174 416 LNLQGNQVS 424
Cdd:PLN03150 495 LNLNGNSLS 503
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 101-350 7.02e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 7.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 101 EHLNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGSLVERL---LGEAPRLRTLSLAENSLT-----RLARHtFWG 172
Cdd:COG5238  156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGdegaeILAEA-LKG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 173 MPAMEQLDLHSNvlmDIEDGAFEAL-------PQLTHLNLSRNSLTCISDFSL-------QQLQVLDLSCNSIetfqTAP 238
Cdd:COG5238  235 NKSLTTLDLSNN---QIGDEGVIALaealknnTTVETLYLSGNQIGAEGAIALakalqgnTTLTSLDLSVNRI----GDE 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 239 ESQAQFQLawldLRENKLLHFPDLAmfprliYLNVSNnliqlptglpqdsedlhapsEGWSAsLLSNPSRNASIHplsql 318
Cdd:COG5238  308 GAIALAEG----LQGNKTLHTLNLA------YNGIGA--------------------QGAIA-LAKALQENTTLH----- 351

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 281604174 319 lNLDLSYNEIE----LVPAGFLEHLTSLRFLNLSRN 350
Cdd:COG5238  352 -SLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKN 386
PLN03150 PLN03150
hypothetical protein; Provisional
 52-141 3.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  52 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMalnSGGLGRLPLVVSLD 131
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI---PESLGQLTSLRILN 496

                         90
                 ....*....|
gi 281604174 132 LSGNSLHGSL 141
Cdd:PLN03150 497 LNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
98-186 3.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174   98 PYLEHLNLAHNRLaagmalnsgglgrlplvvsldlsgNSLHGSLVERLlgeaPRLRTLSLAENSLTRLARHTFWGMPAME 177
Cdd:pfam13855   1 PNLRSLDLSNNRL------------------------TSLDDGAFKGL----SNLKVLDLSNNLLTTLSPGAFSGLPSLR 52


                  ....*....
gi 281604174  178 QLDLHSNVL 186
Cdd:pfam13855  53 YLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
198-256 3.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281604174  198 PQLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSIETFqtapeSQAQFQ----LAWLDLRENKL 256
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-350 4.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281604174  315 LSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 52-140 4.38e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  52 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmalnsgglGRLPLVvsld 131
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS----------GRVPAA---- 509


                 ....*....
gi 281604174 132 LSGNSLHGS 140
Cdd:PLN03150 510 LGGRLLHRA 518
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 216-471 5.64e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 216 FSLQQLQVLDLSCNSIETF---QTAPESQAQFQLAWLDLRENKLLHFPD--------LAMFPRLIYLNVSNN-------- 276
Cdd:cd00116   20 PKLLCLQVLRLEGNTLGEEaakALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNalgpdgcg 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 277 -LIQLPTGLPQDSEDLHAPSEGWSA------SLLSNPSRnasihplsqLLNLDLSYNEIELVP----AGFLEHLTSLRFL 345
Cdd:cd00116  100 vLESLLRSSSLQELKLNNNGLGDRGlrllakGLKDLPPA---------LEKLVLGRNRLEGAScealAKALRANRDLKEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 346 NLSRNCLRSFEARRAG----SLPCLVLLDLSHNVLE-----ALELGTKVLGSLKTLLLQDNTLRELPPYTFA-----GLA 411
Cdd:cd00116  171 NLANNGIGDAGIRALAeglkANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAALAsallsPNI 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174 412 SLQRLNLQGNQVSPCGGQAEPGPpgCVDFsgiPTLHFLNMAGNsmETLRAGSFLHTPLTE 471
Cdd:cd00116  251 SLLTLSLSCNDITDDGAKDLAEV--LAEK---ESLLELDLRGN--KFGEEGAQLLAESLL 303
LRR_8 pfam13855
Leucine rich repeat;
388-454 6.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281604174  388 SLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ---VSPcggqaepgppgcVDFSGIPTLHFLNMAGN 454
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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