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Conserved domains on  [gi|300794036|ref|NP_001178597|]
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transmembrane protein 185B [Rattus norvegicus]

Protein Classification

TMEM185 family RING finger protein( domain architecture ID 10563171)

TMEM185 family protein with a RING finger domain similar to Arabidopsis thaliana transmembrane Fragile-X-F-associated protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 31-253 2.78e-53

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


:

Pssm-ID: 402059  Cd Length: 245  Bit Score: 175.72  E-value: 2.78e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036   31 RLDGIIQWSYWAVFAPIWLWKLLVIVGASVGAGVWARNPRYRTEGEACVEFKAMLIAvgihLLLLMFEILVCDRVERGT- 109
Cdd:pfam10269   2 KLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTYv 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  110 -----HFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILC-------------SVNILQFI----FIALRLDRIIH-- 165
Cdd:pfam10269  78 glsgaLDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  166 --WPWLVVFVPLWILMSFLClvvlyyIVWSLLFLRSLDVVAEQRRTHVTMAISWITIVVPLLTFEVLLVHRLDGHNT--- 240
Cdd:pfam10269 158 gwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNISSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAava 231

                         250
                  ....*....|....
gi 300794036  241 -FSYISIFTPLWLS 253
Cdd:pfam10269 232 dIPIAVVFAPLFLL 245
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 31-253 2.78e-53

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 175.72  E-value: 2.78e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036   31 RLDGIIQWSYWAVFAPIWLWKLLVIVGASVGAGVWARNPRYRTEGEACVEFKAMLIAvgihLLLLMFEILVCDRVERGT- 109
Cdd:pfam10269   2 KLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTYv 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  110 -----HFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILC-------------SVNILQFI----FIALRLDRIIH-- 165
Cdd:pfam10269  78 glsgaLDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  166 --WPWLVVFVPLWILMSFLClvvlyyIVWSLLFLRSLDVVAEQRRTHVTMAISWITIVVPLLTFEVLLVHRLDGHNT--- 240
Cdd:pfam10269 158 gwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNISSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAava 231

                         250
                  ....*....|....
gi 300794036  241 -FSYISIFTPLWLS 253
Cdd:pfam10269 232 dIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 154-258 5.48e-06

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 45.37  E-value: 5.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036 154 IFIALRLDRIIHWPWLVVFVPLwilmsFLCLVVLYYIVwSLLFLRSLdvVAEQRRTHVTMAISWITIVVPLLTFEVLLVH 233
Cdd:cd22816   29 VLLALKLEGHLSASWWTVFSPL-----FAADGLSAYFC-VIVFVRLY--QEGEKRLAVLRLFWSLTVLSLIFVFEMLLCQ 100

                         90       100
                 ....*....|....*....|....*
gi 300794036 234 RLDGHNTFSYISIFTPLWLSLLTLM 258
Cdd:cd22816  101 KLEGQNELWYSLVFSPLFILLQLLM 125
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 31-253 2.78e-53

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 175.72  E-value: 2.78e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036   31 RLDGIIQWSYWAVFAPIWLWKLLVIVGASVGAGVWARNPRYRTEGEACVEFKAMLIAvgihLLLLMFEILVCDRVERGT- 109
Cdd:pfam10269   2 KLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTYv 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  110 -----HFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILC-------------SVNILQFI----FIALRLDRIIH-- 165
Cdd:pfam10269  78 glsgaLDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036  166 --WPWLVVFVPLWILMSFLClvvlyyIVWSLLFLRSLDVVAEQRRTHVTMAISWITIVVPLLTFEVLLVHRLDGHNT--- 240
Cdd:pfam10269 158 gwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNISSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAava 231

                         250
                  ....*....|....
gi 300794036  241 -FSYISIFTPLWLS 253
Cdd:pfam10269 232 dIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 154-258 5.48e-06

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 45.37  E-value: 5.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794036 154 IFIALRLDRIIHWPWLVVFVPLwilmsFLCLVVLYYIVwSLLFLRSLdvVAEQRRTHVTMAISWITIVVPLLTFEVLLVH 233
Cdd:cd22816   29 VLLALKLEGHLSASWWTVFSPL-----FAADGLSAYFC-VIVFVRLY--QEGEKRLAVLRLFWSLTVLSLIFVFEMLLCQ 100

                         90       100
                 ....*....|....*....|....*
gi 300794036 234 RLDGHNTFSYISIFTPLWLSLLTLM 258
Cdd:cd22816  101 KLEGQNELWYSLVFSPLFILLQLLM 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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