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Conserved domains on  [gi|300794570|ref|NP_001178624|]
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zinc finger protein 516 isoform 1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10443076)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 780-1040 2.40e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  780 GSIAPP--WTQPSGHKSICSnLAFLARSGRTGPPPAlggkdcqPLLLARFTRTQVPGGVPGSKGSSSPLGVTTKAASIPK 857
Cdd:PHA03247 2675 QASSPPqrPRRRAARPTVGS-LTSLADPPPPPPTPE-------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  858 NKESPSG-----------GPCAPWAP-GPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTP 925
Cdd:PHA03247 2747 GPATPGGparparppttaGPPAPAPPaAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  926 SVITRVGAQPSANSKPVEKL-------GVPAVGTGF-------TPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPL-PP 990
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPppslplgGSVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDqPE 2906

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 300794570  991 REAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQ 1040
Cdd:PHA03247 2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 1.04e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.04e-06
                           10        20
                   ....*....|....*....|....*.
gi 300794570    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 3.08e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.08e-04
                           10        20
                   ....*....|....*....|...
gi 300794570    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1086-1108 3.43e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.43e-04
                           10        20
                   ....*....|....*....|...
gi 300794570  1086 FVCVECGKSFHQPSQLRAHLRAH 1108
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 6.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.13e-03
                           10        20
                   ....*....|....*....|...
gi 300794570   236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 780-1040 2.40e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  780 GSIAPP--WTQPSGHKSICSnLAFLARSGRTGPPPAlggkdcqPLLLARFTRTQVPGGVPGSKGSSSPLGVTTKAASIPK 857
Cdd:PHA03247 2675 QASSPPqrPRRRAARPTVGS-LTSLADPPPPPPTPE-------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  858 NKESPSG-----------GPCAPWAP-GPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTP 925
Cdd:PHA03247 2747 GPATPGGparparppttaGPPAPAPPaAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  926 SVITRVGAQPSANSKPVEKL-------GVPAVGTGF-------TPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPL-PP 990
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPppslplgGSVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDqPE 2906

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 300794570  991 REAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQ 1040
Cdd:PHA03247 2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 1.04e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.04e-06
                           10        20
                   ....*....|....*....|....*.
gi 300794570    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 3.08e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.08e-04
                           10        20
                   ....*....|....*....|...
gi 300794570    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1086-1108 3.43e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.43e-04
                           10        20
                   ....*....|....*....|...
gi 300794570  1086 FVCVECGKSFHQPSQLRAHLRAH 1108
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 807-998 1.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   807 RTGPPPAlggkdCQPlllARFTRTQVPGGVPGSKGSSSPLGVTtKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAghgq 886
Cdd:pfam03154  177 QSGAASP-----PSP---PPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP---- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   887 DPPSAAVQGPLPKPKQEASSRLAPSPGSGGlsrsatPTPSVITRVGAQPSANSKPVEKLGVP---AVGTGFTPPnkhsAP 963
Cdd:pfam03154  244 SPHPPLQPMTQPPPPSQVSPQPLPQPSLHG------QMPPMPHSLQTGPSHMQHPVPPQPFPltpQSSQSQVPP----GP 313

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 300794570   964 DSLKAKFSPQPQGQPPSKGEGGSPLPPREAPVKPA 998
Cdd:pfam03154  314 SPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 6.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.13e-03
                           10        20
                   ....*....|....*....|...
gi 300794570   236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 780-1040 2.40e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  780 GSIAPP--WTQPSGHKSICSnLAFLARSGRTGPPPAlggkdcqPLLLARFTRTQVPGGVPGSKGSSSPLGVTTKAASIPK 857
Cdd:PHA03247 2675 QASSPPqrPRRRAARPTVGS-LTSLADPPPPPPTPE-------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  858 NKESPSG-----------GPCAPWAP-GPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTP 925
Cdd:PHA03247 2747 GPATPGGparparppttaGPPAPAPPaAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  926 SVITRVGAQPSANSKPVEKL-------GVPAVGTGF-------TPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPL-PP 990
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPppslplgGSVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDqPE 2906

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 300794570  991 REAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQ 1040
Cdd:PHA03247 2907 RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 1.04e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.04e-06
                           10        20
                   ....*....|....*....|....*.
gi 300794570    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 784-1036 1.89e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  784 PPWTQPSGHKSICSNLAFLARSGRTGPPPALGGKDCQP----LLLARFTRTQVPGGVPGSKGSSSPLGVTTKAASIPKNK 859
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  860 ESPSGGPcAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGL-SRSATPTPSVITRVGAQPSAN 938
Cdd:PHA03247 2706 PTPEPAP-HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTtAGPPAPAPPAAPAAGPPRRLT 2784

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  939 SKPVEKLGvPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPSkgeGGSPLPPREAPVKPAQE----LRTLATCAA-GPRG 1013
Cdd:PHA03247 2785 RPAVASLS-ESRESLPSPWDPADPPAAVLAPAAALPPAASPA---GPLPPPTSAQPTAPPPPpgppPPSLPLGGSvAPGG 2860

                         250       260
                  ....*....|....*....|...
gi 300794570 1014 DAALQAPPGAPPTLHSIQQEPAA 1036
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPV 2883
PHA03247 PHA03247
large tegument protein UL36; Provisional
 807-1025 4.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 4.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  807 RTGPPPALGGKDCQPLLLARFTRTQVPggvpgsKGSSSPlgvttkaaSIPKNKESPSGGPCAPWAPGPDGYRQTRAGHGQ 886
Cdd:PHA03247 2566 RSVPPPRPAPRPSEPAVTSRARRPDAP------PQSARP--------RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  887 DPPSAAVQGPLPKPKQEASS-RLAPSPGSGGLSRSATpTPSVITRVGAQPSANSKPVEKLGVPAVGTGFTPPNKHSAPDS 965
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERpRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  966 LKAKFSPQ-PQGQPPSKGEGGSPLPPR--------EAPVKPAQELRTLATCA-AGPRGDAALQAPPGAPP 1025
Cdd:PHA03247 2711 APHALVSAtPLPPGPAAARQASPALPAapappavpAGPATPGGPARPARPPTtAGPPAPAPPAAPAAGPP 2780
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 832-1041 1.85e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  832 VPGGVPGSKGSSSPLGVTTKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPS 911
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  912 PGSGGLSRSATPTPSVITRVGAQPSANSKPVEKLGVPAVGTgfTPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPLPPr 991
Cdd:PRK07764  667 DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAA--TPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP- 743

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 300794570  992 eAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQE 1041
Cdd:PRK07764  744 -EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
861-1037 2.95e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  861 SPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPkqeASSRLAPSPGSGGLSRSATPTPSVITRVGAQPSANSK 940
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGA---AGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDA 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  941 PVEKLGVPAvgtgftPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPLPP--REAPVKPA--------QELRTLATCAAG 1010
Cdd:PRK07003  443 ADGDAPVPA------KANARASADSRCDERDAQPPADSGSASAPASDAPPdaAFEPAPRAaapsaatpAAVPDARAPAAA 516

                         170       180
                  ....*....|....*....|....*..
gi 300794570 1011 PRGDAalqAPPGAPPTLHSIQQEPAAA 1037
Cdd:PRK07003  517 SREDA---PAAAAPPAPEARPPTPAAA 540
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 833-1019 5.22e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  833 PGGVPGSKGSSSPLGVTTKAASIPKNKESPSGGPCA-PWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPS 911
Cdd:PRK07764  629 PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDgGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAAT 708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  912 PGSGGLSRSATPTPSVitrvgAQPSANSKPVEKLGVPAvgtgftPPNKHSAPDSLKAKFSPQPQGQPPskGEGGSPLPPR 991
Cdd:PRK07764  709 PPAGQADDPAAQPPQA-----AQGASAPSPAADDPVPL------PPEPDDPPDPAGAPAQPPPPPAPA--PAAAPAAAPP 775

                         170       180       190
                  ....*....|....*....|....*....|
gi 300794570  992 EAPVKPAQELRTLATCAAGP--RGDAALQA 1019
Cdd:PRK07764  776 PSPPSEEEEMAEDDAPSMDDedRRDAEEVA 805
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
799-1027 5.71e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 5.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  799 LAFL--ARSGRTGPPPALGGKDCQPLLLARFTRTQVPggvPGSKGSSSPLGVTTKAASIPKNKESPSGGPCAPWAPGPDG 876
Cdd:PRK12323  361 LAFRpgQSGGGAGPATAAAAPVAQPAPAAAAPAAAAP---APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  877 YRQTRAGHGQDPPSAAvqgPLPKPkqeASSRLAPSPGSGGLSRSATPTPSVitrvgAQPSANSKPVEKlgvpavgtgfTP 956
Cdd:PRK12323  438 QASARGPGGAPAPAPA---PAAAP---AAAARPAAAGPRPVAAAAAAAPAR-----AAPAAAPAPADD----------DP 496

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300794570  957 PNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPLPPREAPVKPAQELRTLATCAAGPRGDAALQ-APPGAPPTL 1027
Cdd:PRK12323  497 PPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEpVVAPRPPRA 568
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
62-84 6.90e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.61  E-value: 6.90e-05
                           10        20
                   ....*....|....*....|...
gi 300794570    62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
838-1107 2.39e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  838 GSKGSSSPlgvtTKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGL 917
Cdd:PRK12323  367 QSGGGAGP----ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  918 SRSATPTPSviTRVGAQPSANSKPVEKLGVPAVGTGFTPPnkhsAPDSLKAKFSPQPQGQPPSKgeggsplpprEAPVK- 996
Cdd:PRK12323  443 GPGGAPAPA--PAPAAAPAAAARPAAAGPRPVAAAAAAAP----ARAAPAAAPAPADDDPPPWE----------ELPPEf 506

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  997 ----PAQELRTLATCAAGPRGDAALQAPPGAPPTLhsiQQEPAAAEGQEKRLDILSIFKYIPKDFA------TLYQGWGV 1066
Cdd:PRK12323  507 aspaPAQPDAAPAGWVAESIPDPATADPDDAFETL---APAPAAAPAPRAAAATEPVVAPRPPRASasglpdMFDGDWPA 583

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 300794570 1067 SSPGPEHRGTPRTQARQGDFVCVEcGKSFHqpsqLRAHLRA 1107
Cdd:PRK12323  584 LAARLPVRGLAQQLARQSELAGVE-GDTVR----LRVPVPA 619
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 3.08e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.08e-04
                           10        20
                   ....*....|....*....|...
gi 300794570    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 846-1041 3.16e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  846 LGVTTKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPlPKPKQEASSRLAPSPGSGGLSRSATPTP 925
Cdd:PRK07764  582 WQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGA-AAAPAEASAAPAPGVAAPEHHPKHVAVP 660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  926 SVITRVGAQPSANSKPVEKLGVPAVGTGFTPPNKHSAPDSLKAK--------FSPQPQGQPPSKGEGGSPLPPREAPVKP 997
Cdd:PRK07764  661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPApaatppagQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 300794570  998 AQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQE 1041
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEE 784
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1086-1108 3.43e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.43e-04
                           10        20
                   ....*....|....*....|...
gi 300794570  1086 FVCVECGKSFHQPSQLRAHLRAH 1108
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03378 PHA03378
EBNA-3B; Provisional
 862-1040 8.31e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 8.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  862 PSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPkQEASSRLAPSPGSGGLSRSATPTPSVITRVGAQPSANSKP 941
Cdd:PHA03378  669 IGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPP-AAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPP 747

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  942 VEKLGVPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPSKGE---GGSPLPPREAPVKPAQELRTLATCAAGPRGDAALQ 1018
Cdd:PHA03378  748 AAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRprgAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQ 827

                         170       180
                  ....*....|....*....|..
gi 300794570 1019 APPGAPPTLHSIQQEPAAAEGQ 1040
Cdd:PHA03378  828 LLTGGVKRGRPSLKKPAALERQ 849
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 62-84 1.07e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.07e-03
                           10        20
                   ....*....|....*....|...
gi 300794570    62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 807-998 1.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   807 RTGPPPAlggkdCQPlllARFTRTQVPGGVPGSKGSSSPLGVTtKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAghgq 886
Cdd:pfam03154  177 QSGAASP-----PSP---PPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP---- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   887 DPPSAAVQGPLPKPKQEASSRLAPSPGSGGlsrsatPTPSVITRVGAQPSANSKPVEKLGVP---AVGTGFTPPnkhsAP 963
Cdd:pfam03154  244 SPHPPLQPMTQPPPPSQVSPQPLPQPSLHG------QMPPMPHSLQTGPSHMQHPVPPQPFPltpQSSQSQVPP----GP 313

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 300794570   964 DSLKAKFSPQPQGQPPSKGEGGSPLPPREAPVKPA 998
Cdd:pfam03154  314 SPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 780-1048 1.78e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  780 GSIAPPWTQPSGHKSICSNLAFLARSGRTGPPPALGGKDcqplllaRFTRTQVPGGVPGSKGSSSPLGVTTKAasiPKNK 859
Cdd:PHA03307  190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA-------ADDAGASSSDSSSSESSGCGWGPENEC---PLPR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  860 ESPSGGPCAPWAPGPDGYRQTRAGHGqdPPSAAVQGPLPkpkqeassrlAPSPGSGGLSRSATPTPSVITRVGAQPSANS 939
Cdd:PHA03307  260 PAPITLPTRIWEASGWNGPSSRPGPA--SSSSSPRERSP----------SPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  940 KPVEKlGVPAVGTGFTPPNKHSAPDSLKAKfSPQPQGQPPSKGEGGSPLPPREAPVKPAQELRTLATCAAGP--RGDAAL 1017
Cdd:PHA03307  328 STSSS-SESSRGAAVSPGPSPSRSPSPSRP-PPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRarRRDATG 405

                         250       260       270
                  ....*....|....*....|....*....|.
gi 300794570 1018 QAPPGAPPTLHSIQQEPAAAEGQEKRLDILS 1048
Cdd:PHA03307  406 RFPAGRPRPSPLDAGAASGAFYARYPLLTPS 436
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 808-1037 1.99e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   808 TGPPPALGGKDCQPLLLARFTRTQVPGGVPGSKgssSPLGVTTKAASIPKNKESPSGGPCAPwAPGPDGYRQTRAGHGQD 887
Cdd:pfam03154  214 TSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPPPSQVSPQPLPQPSLH-GQMPPMPHSLQTGPSHM 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   888 PPSAAVQgPLPKPKQEASSRLAPSPGSG----GLSRSATPTPSVITRVGAQPSANSKPVEKLGVPAVGTGFTPPNKHsAP 963
Cdd:pfam03154  290 QHPVPPQ-PFPLTPQSSQSQVPPGPSPAapgqSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQ-LP 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   964 DSLKAKFSPQPQGQPPSKGEGGSPLPPreaPVKPAQELRTLATCAAGP------RGDAALQAPPGAPPTLHSIQQEPAAA 1037
Cdd:pfam03154  368 NPQSHKHPPHLSGPSPFQMNSNLPPPP---ALKPLSSLSTHHPPSAHPpplqlmPQSQQLPPPPAQPPVLTQSQSLPPPA 444
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 873-1146 2.04e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  873 GPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTPSVITRVGAQPSANSKPVEklgvpavGT 952
Cdd:PHA03307   38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTP-------PG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  953 GFTPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPLPPREAPVKPAQELRTLATCAAGPRGDAALQA-------PPGAPP 1025
Cdd:PHA03307  111 PSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSspeetarAPSSPP 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570 1026 TLHSIQQEPAAAEGQEKRLDIlSIFKYIPKDFATLYQGWGVSSPGPEHRGTPRTQARQGDFVCVECGKSFHQPSQLRAHL 1105
Cdd:PHA03307  191 AEPPPSTPPAAASPRPPRRSS-PISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRI 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 300794570 1106 RAHTVvfecDSPRGSEVHTASTDTPKQGRDHTAPGTVPAGP 1146
Cdd:PHA03307  270 WEASG----WNGPSSRPGPASSSSSPRERSPSPSPSSPGSG 306
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
884-1000 2.71e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.68  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  884 HGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTPSVITRVGAQPSANSKPVEKLGVPavgtgftPPNkhSAP 963
Cdd:PRK14971  374 GPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVN-------PPS--TAP 444

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 300794570  964 DSLKAKFSPQPQGQPPSKgeGGSPLPPREAPVKPAQE 1000
Cdd:PRK14971  445 QAVRPAQFKEEKKIPVSK--VSSLGPSTLRPIQEKAE 479
PHA03378 PHA03378
EBNA-3B; Provisional
 849-1031 3.01e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  849 TTKAASIPKNKESPSGGPCAPWAPGPdgYRQTRAGHGQDPPSAAVQGPLPkPKQEASSRLAPSPGSGGLSRSATPTPSVI 928
Cdd:PHA03378  678 PTGANTMLPIQWAPGTMQPPPRAPTP--MRPPAAPPGRAQRPAAATGRAR-PPAAAPGRARPPAAAPGRARPPAAAPGRA 754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  929 TRVGAQPSANSKPVEKLGVPavgTGFTPPNKHSAPDSlKAKFSPQPQgQPPSKGEGGSPLPPREAPVKPA---QELRTLA 1005
Cdd:PHA03378  755 RPPAAAPGRARPPAAAPGAP---TPQPPPQAPPAPQQ-RPRGAPTPQ-PPPQAGPTSMQLMPRAAPGQQGptkQILRQLL 829

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 300794570 1006 TC-------------------AAGPR-------GDAALQAPPGAPPTLHSIQ 1031
Cdd:PHA03378  830 TGgvkrgrpslkkpaalerqaAAGPTpspgsgtSDKIVQAPVFYPPVLQPIQ 881
PHA03247 PHA03247
large tegument protein UL36; Provisional
 781-1025 3.17e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  781 SIAPPWTQPSGHKSICSNLAFLARSGRTGPPPALGGKDCQPLLLARFTRTQVPGGVPGSkGSSSPLGVTTKAASIPKNKE 860
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG-PLPPPTSAQPTAPPPPPGPP 2846

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  861 SPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGP---LPKPKQEASSRLAPSPgSGGLSRSATPTPSVITRVGAQPSA 937
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrLARPAVSRSTESFALP-PDQPERPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  938 NSKPVEKLGVPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPSKGEGG-------SPLPPREAPVKPAQELRTLATCAAG 1010
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfrvpQPAPSREAPASSTPPLTGHSLSRVS 3005

                         250
                  ....*....|....*.
gi 300794570 1011 PRGDA-ALQAPPGAPP 1025
Cdd:PHA03247 3006 SWASSlALHEETDPPP 3021
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 6.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.13e-03
                           10        20
                   ....*....|....*....|...
gi 300794570   236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 920-1037 6.65e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  920 SATPTPSVITrvgAQPSANSKPVeKLGVPAVGTGFTPPNKHSAPDSlkakfSPQPQGQPPSKgeggSPLPPREAPVKPAQ 999
Cdd:PRK14950  359 LLVPVPAPQP---AKPTAAAPSP-VRPTPAPSTRPKAAAAANIPPK-----EPVRETATPPP----VPPRPVAPPVPHTP 425

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 300794570 1000 ELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAA 1037
Cdd:PRK14950  426 ESAPKLTRAAIPVDEKPKYTPPAPPKEEEKALIADGDV 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 809-1047 7.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  809 GPPPALGGKDCQPLLLARFTRTQVPGGVPG--SKGSSSPLGVTTKAAsipknKESPSGGPCAPWAPGPDGYRQTRAGHGQ 886
Cdd:PHA03247  256 APPPVVGEGADRAPETARGATGPPPPPEAAapNGAAAPPDGVWGAAL-----AGAPLALPAPPDPPPPAPAGDAEEEDDE 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  887 DPpSAAVQGPLPKPKQEASSrlapspgsgGLSRSATPT---PSVITRVGA-QPSANSKPVEKLGVPAVGTGFTPPNKHSA 962
Cdd:PHA03247  331 DG-AMEVVSPLPRPRQHYPL---------GFPKRRRPTwtpPSSLEDLSAgRHHPKRASLPTRKRRSARHAATPFARGPG 400

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  963 PDSLKAKFSPQPqGQPPSKGEGGSPLPPREAPVKPAQelrtlatCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQEK 1042
Cdd:PHA03247  401 GDDQTRPAAPVP-ASVPTPAPTPVPASAPPPPATPLP-------SAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRK 472


                  ....*
gi 300794570 1043 RLDIL 1047
Cdd:PHA03247  473 ALDAL 477
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 34-56 7.52e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 7.52e-03
                           10        20
                   ....*....|....*....|...
gi 300794570    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 856-1034 8.05e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 8.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   856 PKNKESPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQG--PLPKPKQEASSRLAPSP---GSGGLSRSATPTPSVITR 930
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGspATSQPPNQTQSTAAPHTliqQTPTLHPQRLPSPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570   931 VGAQPSANSKPVEKLGVPAVGTGFTPPNKHS---APDSLKAKFSPQPQGQPPSKGEGGSPLPPR-EAPVKPAQELRTLAT 1006
Cdd:pfam03154  251 PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSpAAPGQSQQRIHTPPS 330

                          170       180
                   ....*....|....*....|....*....
gi 300794570  1007 CAAGPRGDAALQAP-PGAPPTLHSIQQEP 1034
Cdd:pfam03154  331 QSQLQSQQPPREQPlPPAPLSMPHIKPPP 359
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 901-1037 9.51e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.55  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794570  901 KQEASSRLAPSPGSGGLSRSATPTPSVIT--RVGAQPSANSKPVEKLGVPAVGTGFTPPNKHSAPdsLKAKFSPQPQGQP 978
Cdd:PTZ00436  200 KQKAAAKKAAAPSGKKSAKAAAPAKAAAApaKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPP--AKAAAPPAKAAAP 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300794570  979 PSKGEGG---SPLPPREAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAA 1037
Cdd:PTZ00436  278 PAKAAAPpakAAAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAA 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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