|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
51-476 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 530.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd13132 10 APLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVGVYLQRALVI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13132 90 LLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVALLLNILLN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTF 290
Cdd:cd13132 170 YLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLEWWAFEILVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 291 LAG-LVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAALKDVV 369
Cdd:cd13132 250 LAGlLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVW 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 370 AYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGIIGLWAG 449
Cdd:cd13132 330 AYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLGLGLKGLWIG 409
|
410 420
....*....|....*....|....*..
gi 300793956 450 LIVCVFFQALSYLIYILRTNWNRVAEQ 476
Cdd:cd13132 410 LIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
51-467 |
3.06e-72 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 237.78 E-value: 3.06e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd13131 10 LPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13131 89 ALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKGI--HIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWT 284
Cdd:cd13131 169 YVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGLPIGLTIFFEVSL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 285 FEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAA 364
Cdd:cd13131 249 FAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALLLLL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 365 LKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGII 444
Cdd:cd13131 329 FPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLLAFTTGLGAF 408
|
410 420
....*....|....*....|...
gi 300793956 445 GLWAGLIVCVFFQALSYLIYILR 467
Cdd:cd13131 409 GVWIGLIIGLALAAILLLWRFRR 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
52-464 |
6.44e-71 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 233.88 E-value: 6.44e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:COG0534 16 PIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAI-FLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:COG0534 95 LLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTF 290
Cdd:COG0534 175 PLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 291 LAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAALKDVVA 370
Cdd:COG0534 255 LVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPII 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 371 YVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVsLMFAAKLGIIGLWAGL 450
Cdd:COG0534 335 GLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY-LLAFLGLGLTGVWLAL 413
|
410
....*....|....
gi 300793956 451 IVCVFFQALSYLIY 464
Cdd:COG0534 414 PIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
52-391 |
3.37e-60 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 203.25 E-value: 3.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAvSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAIFLNTERLLLFLRQ-DPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL--DLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIG 288
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 289 TFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAALKDV 368
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 300793956 369 VAYVFTNDKDIISLVSQVMPIFA 391
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
52-470 |
1.78e-54 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 190.42 E-value: 1.78e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:cd13137 9 PVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFP-CWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13137 88 LLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFFlSALLFLYVWWKG-IHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTF 285
Cdd:cd13137 168 YVLIFGLwgfpGLGVAGAALATVISRVV-GALLLLFLLLRGrLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 286 EIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAAL 365
Cdd:cd13137 247 LVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 366 KDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGIIG 445
Cdd:cd13137 327 APPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLGLTG 406
|
410 420
....*....|....*....|....*
gi 300793956 446 LWAGLIVCVFFQALSYLIYILRTNW 470
Cdd:cd13137 407 IWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
51-466 |
2.91e-54 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 189.46 E-value: 2.91e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNvTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFL-NTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGM 209
Cdd:cd12082 81 AILLGLLLAALLLfFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 210 NAFLLY---ALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFE 286
Cdd:cd12082 161 DPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 287 IGTFLAGLVNVTE-LGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAAL 365
Cdd:cd12082 241 IIVAIVAAFGGAAaLAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 366 KDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVsLMFAAKLGIIG 445
Cdd:cd12082 321 PEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAY-VLAYLGLGLYG 399
|
410 420
....*....|....*....|.
gi 300793956 446 LWAGLIVCVFFQALSYLIYIL 466
Cdd:cd12082 400 IWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-470 |
5.55e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 189.28 E-value: 5.55e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAvSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:cd13133 13 PLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYFS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAI-FLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13133 92 LLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVLD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLY----ALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIH--IHTWGGWtRECFQEWSSYTRLAIPSMFMVCIEWWT 284
Cdd:cd13133 172 YALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrFGLRRAW-RFDRELLRRILRLGLPSGLQFFLDVGA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 285 FEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAA 364
Cdd:cd13133 251 FTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILFLL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 365 LKDVVAYVFTNDKD---IISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVsLMFAAKL 441
Cdd:cd13133 331 FPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAY-LLVVLGA 409
|
410 420
....*....|....*....|....*....
gi 300793956 442 GIIGLWAGLIVCVFFQALSYLIYILRTNW 470
Cdd:cd13133 410 GLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
52-481 |
1.70e-42 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 158.44 E-value: 1.70e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVnVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:PRK01766 20 PILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERIAHQVRQGLWLA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAIFLNTERLLL-FLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:PRK01766 99 LFLSVLIMLVLYNAVPPILnMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLGLLINIPLN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKG--IHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWT 284
Cdd:PRK01766 179 YIFIYGKfgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARrfRDFRLFKGLYKPDWAVIKRLLKLGLPIGLAIFFEVSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 285 FEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLcTGVC-ALLVGILLA 363
Cdd:PRK01766 259 FAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA-VGLGmALLTAIFLV 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 364 ALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGI 443
Cdd:PRK01766 338 LFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGP 417
|
410 420 430
....*....|....*....|....*....|....*...
gi 300793956 444 IGLWAGLIVCVFFQALSYLIYILRTnWNRVAEQAQVRA 481
Cdd:PRK01766 418 FGFWIGLIIGLTAAAILLLLRLRKL-QRQPSAIILQRA 454
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
52-471 |
3.76e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 145.68 E-value: 3.76e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGH-LGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVG-VILQRGIL 129
Cdd:cd13138 11 PLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAKkAVGTLLVL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 130 ILLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQG-IIMPQVIVGIAAnVVNVG 208
Cdd:cd13138 90 FLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGdSKTPLYFVIIAC-VLNII 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 209 MNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHtwggWTRECF----QEWSSYTRLAIPSMFMVCIewwt 284
Cdd:cd13138 169 LDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFK----LSLKDFrfdkEILKEILKIGLPSALQQSL---- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 285 FEIG-TFLAGLVN---VTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGI 360
Cdd:cd13138 241 VSISfLIINSIVNsygVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 361 LLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAK 440
Cdd:cd13138 321 LVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTG 400
|
410 420 430
....*....|....*....|....*....|.
gi 300793956 441 LGIIGLWAGLIVCVFFQALSYLIYILRTNWN 471
Cdd:cd13138 401 LGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-470 |
7.98e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 142.26 E-value: 7.98e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVtGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI- 130
Cdd:cd13134 11 PIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFn 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13134 90 LLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFfLSALLFLYVWWKGIHIHTW-GGWTRECFQEWSSYTRLAIPS--------MFM 277
Cdd:cd13134 170 YLLIFGWfglpKLGVAGVAISTVISRA-VGLVLLFILLFRKLKIRFRlKDLRPFPKKLLKKILKIGLPSageelsynLSQ 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 278 VCIewwtfeigTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALL 357
Cdd:cd13134 249 TVI--------TAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 358 VGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMF 437
Cdd:cd13134 321 VALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGI 400
|
410 420 430
....*....|....*....|....*....|...
gi 300793956 438 AAKLGIIGLWAGLIVCVFFQALSYLIYILRTNW 470
Cdd:cd13134 401 VLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKW 433
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
51-467 |
9.26e-36 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 138.85 E-value: 9.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGK-VELDAVTLAVSVVNVtgISVGTG-LASACDTLMSQSFGGKNLKRVGVILQRGI 128
Cdd:cd13136 10 LPAILSNITVPLLGLVDTAVVGHLGSaAYLGAVALGTTIFNT--LFWLFGfLRMGTTGLVAQALGAGDREEAIALLVRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 129 LI-----LLLCCFPCWAIFLnterLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAAN 203
Cdd:cd13136 88 LLalaigLLLILLQSPLLAL----ALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 204 VVNVGMNAFLLYALDLGVVGSAWANTTSQFfLSALLFLYVWWKGIHIHTWGGWTR-ECFQEWSSYTRLAIPSMFMVCIEW 282
Cdd:cd13136 164 VVNIVLDPLFVFGLGWGVAGAALATVIAQY-LGALLGLWLLRRRVRLLGKSLSRRlPSKAALKRLFKLNRDIFIRTLALL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 283 WTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILL 362
Cdd:cd13136 243 AAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLF 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 363 AALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGkqKIGAVLNAIGYYGFGFpIGVSLMFAAKLG 442
Cdd:cd13136 323 FLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGAT--DTRYLRNSMLVSLAVF-LPLLFLLVPLWG 399
|
410 420
....*....|....*....|....*
gi 300793956 443 IIGLWAGLIVCVFFQALSYLIYILR 467
Cdd:cd13136 400 NHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-472 |
3.27e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 126.15 E-value: 3.27e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVnVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:cd13142 19 PIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAI--FLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQG-IIMPQVIVGIAAnVVNVG 208
Cdd:cd13142 98 IILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGdTKTPMKIMFGSV-LLNVI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 209 MNAFLLYAL----DLGVVGSAWANTTSQFfLSALLFLYVWWKG---IHIHTwggwtRECFQEWSSYT---RLAIPSMFMV 278
Cdd:cd13142 177 LDPLLIFGIgpfpGLGVAGAALATVISRG-IAAVIGLYLLFKGrvgLKISL-----RDLKPDWEWLKkifRIGLPSSIEQ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 279 CIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLV 358
Cdd:cd13142 251 SARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 359 GILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFA 438
Cdd:cd13142 331 GVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYV 410
|
410 420 430
....*....|....*....|....*....|....
gi 300793956 439 AKLGIIGLWAGLIVCVFFQALSYLIYILRTNWNR 472
Cdd:cd13142 411 LGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
52-447 |
5.39e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 119.54 E-value: 5.39e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHL-GKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGI-L 129
Cdd:cd13143 12 PAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLL-MALGLMIGVGGASLISRRLGAGDREKANRIFSTALlL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 130 ILLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGM 209
Cdd:cd13143 91 SLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 210 NAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCiewwTFEIGT 289
Cdd:cd13143 171 DPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQL----SSSVVT 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 290 F-----LAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAA 364
Cdd:cd13143 247 IvlnltLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 365 LKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGyyGFGFPIGVSLMFAAKLGII 444
Cdd:cd13143 327 FPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLR--QGLFLIPLLLILPRLFGLD 404
|
...
gi 300793956 445 GLW 447
Cdd:cd13143 405 GIW 407
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
52-210 |
1.90e-25 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 102.64 E-value: 1.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFP-CWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:pfam01554 80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-467 |
2.21e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 102.99 E-value: 2.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAV---------TLAVSVVNVTGISVGTglasacdtlmSQSFGGKNLKRVGV 122
Cdd:cd13140 13 PIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVKV----------SQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 123 ILQRGILILLLCCFpCWAIFLNT--ERLLLFLR-QDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVG 199
Cdd:cd13140 83 YARNALQLNLLLGI-LYGLLLLLfaKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIIN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 200 IAANVVNVGMNAFLLYALD----LGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSM 275
Cdd:cd13140 162 AIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 276 FMVCIewWTFeIGTFLAGLVNV---TELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTG 352
Cdd:cd13140 242 LQSIL--FAL-ISMILARIIASfgpVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIAS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 353 VCALLVGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVlNAIGYYGFGFPIG 432
Cdd:cd13140 319 AIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAI-ISIVFNGLRIPLA 397
|
410 420 430
....*....|....*....|....*....|....*.
gi 300793956 433 VSLMFAAkLGIIGLWAGL-IVCVFFQALSYLIYILR 467
Cdd:cd13140 398 LLLSPTG-LGLNGIWWAIsISSILKGIILTIWFLLY 432
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-447 |
6.26e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 101.54 E-value: 6.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGI-LI 130
Cdd:cd13144 16 PAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLlLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13144 95 LLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCiewwtfe 286
Cdd:cd13144 175 PILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGLPSIIMQA------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 287 IGTFLAGLVN-------VTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVG 359
Cdd:cd13144 248 ISSVMVFGLNkilagfgPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 360 ILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPigVSLMFAA 439
Cdd:cd13144 328 LLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLP--LAWLLAK 405
|
....*...
gi 300793956 440 KLGIIGLW 447
Cdd:cd13144 406 MFGLNGVW 413
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
273-432 |
1.33e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 94.55 E-value: 1.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 273 PSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTG 352
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 353 VCALLVGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGyYGFGFPIG 432
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
51-450 |
9.29e-20 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 92.12 E-value: 9.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVgTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:PRK00187 17 GPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFC-VGVIAAVGTLVAIRHGAGDIEGATRLAQAGLWL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:PRK00187 96 AWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVANLLLN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKGiHIHTWG---GWTRECFQEWSSYTRLAIPSMFMVCIEWW 283
Cdd:PRK00187 176 YALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHP-AYAAYPlrkGLSRPSRAALRELWRLGLPIGGTYAVEVG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 284 TFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLA 363
Cdd:PRK00187 255 LFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFW 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 364 ALKDVVAYVFTNDKD-----IISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFA 438
Cdd:PRK00187 335 LLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFT 414
|
410
....*....|..
gi 300793956 439 AKLGIIGLWAGL 450
Cdd:PRK00187 415 LGWGAVGVWWGL 426
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-460 |
2.08e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 72.43 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVE--LDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGIL 129
Cdd:cd13146 16 PILIGQLFQLLYNITDTIWISMIDPSDpaLVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 130 ILLLCCFPCWAI-FLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVG 208
Cdd:cd13146 96 LALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 209 MNAFLLYALDLGVVGSAWANTTSQfFLSALLFLYVWWKG-----IHIHTWGGwtreCFQEWSSYTRLAIPSMFMVCIEWW 283
Cdd:cd13146 176 LDPILIFVFDMGVKGAALATVLAQ-AISLLYLLYVFLIGksnvtIHIKLSNI----SSSVIVEILRVGLPQMLLQLISSI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 284 TFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLA 363
Cdd:cd13146 251 SFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 364 ALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGI 443
Cdd:cd13146 331 LVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGI 410
|
410
....*....|....*..
gi 300793956 444 IGLWAGLIVCVFFQALS 460
Cdd:cd13146 411 TGVYFGIVSANFFTALL 427
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-473 |
2.77e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 71.87 E-value: 2.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:cd13139 22 PMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAI-FLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13139 101 VALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYAL----DLGVVGSAWAnTTSQFFLSALLFLYVWWKGIHIHTWGgwtRECFQ-EWS---SYTRLAIPSM--FMVCI 280
Cdd:cd13139 181 PLFIFGLgpipAMGVTGAAIA-TTIGRSIGVLYQLYHLFKGKGRIQIR---RRHLKlDWAiikKIIKIAVGGIlqFLIAS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 281 EWWTFeigtfLAGLVnvTELGAQAVI-YELA----SVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCA 355
Cdd:cd13139 257 SSWIF-----LVRII--AEFGSTALAgYTIAiriiMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 356 LLVGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSL 435
Cdd:cd13139 330 GIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLL 409
|
410 420 430
....*....|....*....|....*....|....*...
gi 300793956 436 MFAAKLGIIGLWAGLIVCVFFQALSYLIYILRTNWNRV 473
Cdd:cd13139 410 ARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKTV 447
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-452 |
5.78e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 67.70 E-value: 5.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTgLASACDTLMSQSFGGKNLKRVGVILQRGIL-- 129
Cdd:cd13135 9 PLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGS-ISIGFTILGSQSVGAKDIKRINDYAISSIVyn 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 130 -ILLLCCFPCWaiFLNTERLLLFLRQDPEVARLAQVYVMICIPALP-AAFLFQLQTrYLQSQGIIMPQVIVGIAANVVNV 207
Cdd:cd13135 88 sIIGVILFLLW--LFGARIIFVLFGVDGQILGYSINYVRIFSIYLLlLGILFTFSS-ILQGIGETKPIMYGGIIKNLLNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 208 GMNAFLLYAL----DLGVVGSAWANTTSQFflSALLFLYVWWKGIHIHTWGGWTRECFQE-WSSY---TRLAIPSMFMVc 279
Cdd:cd13135 165 ILDYVLIFGNfgfpRLGIIGAAIATTIANV--LNLIILVYLCRKIKKLTFKLSNTKVLKAnIRPYkftIKLGLPLGGEE- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 280 IEWWTFEIG--TFLAGLvNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALL 357
Cdd:cd13135 242 FLWNIGNLAviRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 358 VGILLAALKDVVAYVFTNDKDIISLvSQVMPIFAPFHLFDALAGT-CGGVLRGTGKQKIGAVLNAIGYYgfgfpIGVSLM 436
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINY-SIPYLIFIIIILFFKSINIvYGFAIRAIGDTKWMLYTQIIGTI-----IVVSVA 394
|
410 420
....*....|....*....|
gi 300793956 437 ----FAAKLGIIGLWAGLIV 452
Cdd:cd13135 395 llliFVFKLGLAGVYITLFI 414
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
51-452 |
3.96e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 62.17 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd13147 16 IPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 210
Cdd:cd13147 95 GLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNIILD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 211 AFLLYALDLGVVGSAWANTTSQFFlSALLFLYvwWKGIHIHTWGGWTRECFQEWSSYT----RLAIPSMF-MVCIEWWTF 285
Cdd:cd13147 175 PIFIYTLGLGIAGAAWATVISMLI-SSLVLLY--WFFVKKDTYVSLSLKNFKFDKKIVkdilKVGIPASLeQLIMSVLMI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 286 EIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAAL 365
Cdd:cd13147 252 ILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIF 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 366 KDVVAYVFTNDKDIISLVS------QVMPIFAPFHLFDALAgtcGGVLRGTGKQKIGAVLNAIgyYGFGFPIGVSLMFAA 439
Cdd:cd13147 332 APQIAYLFTYSEESAHLAPeivaflRIMCLFLPFVPFGMMS---SSMFQGIGKGLTSLIITIL--RELIFQVLFAYLFAI 406
|
410
....*....|....*
gi 300793956 440 --KLGIIGLWAGLIV 452
Cdd:cd13147 407 vlGLGLFGVWWGIVL 421
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
51-452 |
7.54e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 61.17 E-value: 7.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 51 GPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGiSVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd13149 16 LPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKRLATDSLIL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLLF-LRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGM 209
Cdd:cd13149 95 SLLLSVIVSLLGLFTIPPLFSlLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVIL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 210 NAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTF 285
Cdd:cd13149 175 DPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIGIPAALSNILTPLSA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 286 EIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNAD---QARCSCTTVLLCTGVCALLVGILL 362
Cdd:cd13149 255 AFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYErvqEGLKISLKFSLIYGAILGIVLALF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 363 AalkDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYygFGFPIGVSLMFAAKLG 442
Cdd:cd13149 335 A---GWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRV--FLLYIPLAYVGSHLLG 409
|
410
....*....|
gi 300793956 443 IIGLWAGLIV 452
Cdd:cd13149 410 FAGVFIGALA 419
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
53-462 |
2.78e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 59.64 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 53 VFLAQLMIF--LISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILI 130
Cdd:cd13141 18 LPIAIGMIIqtLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 131 LLLCCFPCWAIFLNTERLLL-FLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGM 209
Cdd:cd13141 97 AAVLGLVVLVLGYLFGRLYLeTLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLNIIL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 210 NAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWK----GIHIHTWggwtRECFQEWSSYTRLAIPS------- 274
Cdd:cd13141 177 APILITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLekylRLDLALW----RPDLPTWKRLLKIGLPSggefllt 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 275 -MFMVCIEWWTFEIGT-----FLAG--LVNVTELGAQAVIYELASVAymvpfgfgvaasvrvGNALGAGNADQARCSCTT 346
Cdd:cd13141 253 fVYMAVIYWALRPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAIA---------------GQNFGAGNYDRVRETFRI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 347 VLLCTgvCALLVGILLAAL--KDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGY 424
Cdd:cd13141 318 TAILT--TALMLVLTLLCQlvPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRL 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 300793956 425 YGFGFPIgVSLMFAAKLGIIGLWAGLIVCVFFQA-LSYL 462
Cdd:cd13141 396 LTFALPV-IWLSAQPDFRIEQIWYLSVATTILQAaLSLL 433
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
53-462 |
2.98e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 59.19 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 53 VFLAQLMIFLISIVSSIFCGH-LGKVELDAVTLAVSVVNVTGISVGTGLASAcdtlMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:COG2244 11 LLLGQLLGALLGFLLLPLLARlLGPEEYGLFALALSIVALLSVLADLGLSTA----LVRFIAEYREEELRRLLSTALLLR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWAIFLNTERLLLFLRQDPEVARlaqvYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNA 211
Cdd:COG2244 87 LLLSLLLALLLLLLAPFIAALLGEPELAL----LLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 212 FLLYaLDLGVVGSAWANTTSQFFLSALLFLYVWwkgihIHTWggwtrecfqewssytrlaipsmfmvciewwtfeigtFL 291
Cdd:COG2244 163 LLAL-LGLGLWGLVLKYSLPLLLSGLLGLLLTN-----LDRL------------------------------------LL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 292 AGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAALKDVVAY 371
Cdd:COG2244 201 GALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 372 VFTNDKDIISlvSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIgyyGFGFPIGVSLMFAAKLGIIGLWAGLI 451
Cdd:COG2244 281 LLFGPEYAEA--APVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI---GAVLNLVLNLLLIPRYGLVGAAIATL 355
|
410
....*....|.
gi 300793956 452 VCVFFQALSYL 462
Cdd:COG2244 356 LSYLVLLLLLL 366
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
59-467 |
8.62e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 51.44 E-value: 8.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 59 MIF--LISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLC-C 135
Cdd:cd13145 22 FFFntMFNVVDTFFAGKISTEALAALSLSFPIFFII-IAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILaI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 136 FPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLY 215
Cdd:cd13145 101 LLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 216 A----LDLGVVGSAWANTTSQFflsaLLFLYVWWKGIHIHTWGGWTRECF----QEWSSYTRLAIPSMF-MVCIEWWTFE 286
Cdd:cd13145 181 GgggiPAMGVSGIALATIISQF----IGMFYLLYKVRKSGIISGCRLRDFiprlDVYKEILKQGFPASLnMMTIGLGIFV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 287 IgTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARcscTTVLLCtgvcaLLVGILLAALK 366
Cdd:cd13145 257 I-TYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVR---ETYKKA-----LKYGFVIMVVA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 367 DVVAY--------VFTNDKDIISLVSQVMPIfapfhlfDALAGTCGGVLrgtgkQKIGAVLNAIGYYGFGFPIGVS---- 434
Cdd:cd13145 328 TVFLLffaeplmsLFTNDPAVIAIGAGYLRI-------DALIFYAYVVL-----FISVSVLQGLKRPIFALWIGLYrqlv 395
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 300793956 435 --------LMFAAKLGIIGLWAGLIVCVFFQALSYLIYILR 467
Cdd:cd13145 396 gpalvfwlLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
52-450 |
3.94e-06 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 49.35 E-value: 3.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSvVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 131
Cdd:PRK10189 37 PIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADS-FNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIM 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 132 LLCCFPCWA-IFLNTERLLLFL--RQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVG 208
Cdd:PRK10189 116 TLFAVLLAVlIHFFGEQIIDLVagDATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGMNILNII 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 209 MNAFLLYAL----DLGVVGSAWANTTSQfFLSALLFLYVWWKGIHihtwgGWTRECFQewSSYTRLAIPSMFMV------ 278
Cdd:PRK10189 196 ISSILIYGLfswqGLGFVGAGLGLTISR-YIGAVAIIWVLMIGFN-----PALRISLK--SYFKPLNFAIIWEVmgigip 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 279 -CIEWWTFEIGT-----FLAGLvnVTELGAQAVI-YELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTV--LL 349
Cdd:PRK10189 268 aSIESVLFNGGKlltqmFVAGM--GTSVIAGNFIaFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRHVfwLS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 350 CTGVCALlvGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYG--- 426
Cdd:PRK10189 346 TLGLTAI--AWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMWGcrv 423
|
410 420
....*....|....*....|....*
gi 300793956 427 -FGFPIGVSLMFaaklGIIGLWAGL 450
Cdd:PRK10189 424 vAGYILGIMLGF----GVVGVWMGM 444
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
96-316 |
3.98e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 49.38 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 96 VGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPC--WAIFLNTERL-LLFLRQ--DPEVARLAQVYVMICI 170
Cdd:COG0728 274 FGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAavGLIVLAEPIVrLLFERGafTAEDTALTALALAAYA 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 171 PALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALdlGVVGSAWANTTSqFFLSALLFLYVWWKGIHI 250
Cdd:COG0728 354 LGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLS-ALVNALLLLVLLRRRLGG 430
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300793956 251 HTWGGWtrecfqeWSSYTRLAIPSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMV 316
Cdd:COG0728 431 LPLRGI-------LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
289-470 |
1.51e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 44.24 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 289 TFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAALKDV 368
Cdd:cd12082 19 TFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 369 VAYVFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYY--GFGFPIGVSLMFAAKLGIIGL 446
Cdd:cd12082 99 ILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLlnILLDPLLIFGLGPPELGIAGA 178
|
170 180
....*....|....*....|....
gi 300793956 447 WAGLIVCVFFQALSYLIYILRTNW 470
Cdd:cd12082 179 ALATVISYVIGALLLLIYLRKGKK 202
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
161-445 |
9.14e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 41.76 E-value: 9.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 161 LAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMnAFLLYALDLGVVGSAWANTTSQFFLSALLF 240
Cdd:cd13128 107 ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLIL-ALILVLLGGGLIGFALAYLIASVLSAILLL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 241 LYVWWKGIHIHTWggwtRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTFLAG-LVNVTELGAQAVIYELASVAYMVPFG 319
Cdd:cd13128 186 YIYRKKILLPKFF----SFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGyFLGDAAVGIYNAAYRIAELLLFIPSA 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 320 FGVAASVRVGNALgAGNADQARCSCTTVLLCTGVCALLVGILLAALKDVVAYVFTNDKdiISLVSQVMPIFAPFHLFDAL 399
Cdd:cd13128 262 ISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFL 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 300793956 400 AGTCGGVLRGTGKQKIGAVLNAIgyyGFGFPIGVSLMFAAKLGIIG 445
Cdd:cd13128 339 NGIFGSILQAIGKQKLTLKILLI---GALLNVILNLLLIPKYGIIG 381
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-400 |
1.07e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 41.87 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 52 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVV----NVTGISVGTGLASAcdtlMSQSFGGKNLKRVGVILQRG 127
Cdd:cd13148 20 PNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLmltqMMSNGAMGGGVSSA----IARALGAGDRERAEALVWHA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 128 ILI-LLLCCFPCWAIFLNTERLLLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVN 206
Cdd:cd13148 96 LVIaLAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAVVQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 207 VGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKGIHIH---TWGGWTRECFQEWSSYTRLAIPSMFMVC 279
Cdd:cd13148 176 IPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRlrlRALRLERRLFRDILRVGLLAALSPLQTN 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 280 IewwTFEIGTFLAGLVNVTELGAqaviYELAS-VAY-MVP--FGFGVAASVRVGNALGAGNADQARCSCTTVLLCTGVCA 355
Cdd:cd13148 256 L---TVLLLTGLVGRFGTAALAG----YGIGSrLEFlLIPlvFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVLA 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 300793956 356 LLVGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAPFHLFDALA 400
Cdd:cd13148 329 GAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLG 373
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
149-373 |
2.53e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.51 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 149 LLFLRQDPEVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALDLGVVGSAWAN 228
Cdd:cd13123 102 LLAPGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGV 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 229 TTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSsytRLAIPSMFMVCIEWWTFEIGTFLAGLVNVtelGAQAVIYe 308
Cdd:cd13123 182 LLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVL---KLMLPALLGVSVSQINLLVDTILASFLPE---GSISALY- 254
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300793956 309 LASVAYMVPFG-FGVAASV----RVGNALGAGNADQARCSCTTVLLCTGVCALLVGILLAAL-KDVVAYVF 373
Cdd:cd13123 255 YADRLYQLPLGiFGVAIATallpRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLaEPIVRLLF 325
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
269-467 |
5.29e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 39.50 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 269 RLAIPS--------MFMVciewwtfeIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQA 340
Cdd:cd13145 13 KLAIPAsvgfffntMFNV--------VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793956 341 RcscttvllCTGVCALLVGILLAALKDVVAYVFTN--------DKDIISLVSQVM-PIFA--PFHLfdaLAGTCGGVLRG 409
Cdd:cd13145 85 R--------RYAAQGLSFGIILAILLTVIGLFAAPplfrllgaEGDYLDLALEYMdVIFAgsIFFL---LNFGLNGILNA 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300793956 410 TGKQK-------IGAVLNAIGYYGFGFPIGVSLmfaaKLGIIGLwAGLIVCVFFQALSYLIYILR 467
Cdd:cd13145 154 QGDTKsyrnfliIGFFLNIILDPLFIFGGGGIP----AMGVSGI-ALATIISQFIGMFYLLYKVR 213
|
|
| |
