NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1983575919|ref|NP_001258092|]
View 

folliculin-interacting protein 1 [Rattus norvegicus]

Protein Classification

folliculin-interacting protein( domain architecture ID 10630352)

folliculin-interacting protein is a binding partner of the GTPase-activating protein FLCN, and is involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 316-548 6.86e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


:

Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 6.86e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  316 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadAGQRSLAYNRIVD 395
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA---------SGRKQSFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  396 ALTEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNQLCHRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVMP 472
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575919  473 NGQP-PIKIFLEKHSSQSVGMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDLVQRLLYFLTYFIRCSEL 548
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 975-1161 4.84e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


:

Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 4.84e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  975 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERLRQCLASDLSHAVQHPVLDEPIAEAVCIIADM 1053
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919 1054 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLAEYLRGQMRVHV 1132
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1983575919 1133 KELGVVLGIESSDLPLLAAVASTHSPYVA 1161
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.29e-37

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


:

Pssm-ID: 464228  Cd Length: 125  Bit Score: 135.86  E-value: 4.29e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919   41 QIRLIVYQD-CERRGRNVLFDSSVKRKNEDTSVSKLCNDAQVKVFGKCCQLKPGGDSSSSLDSSIT-----LSSDGKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSqgsrpLVSQTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1983575919  115 PKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 316-548 6.86e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 6.86e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  316 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadAGQRSLAYNRIVD 395
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA---------SGRKQSFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  396 ALTEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNQLCHRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVMP 472
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575919  473 NGQP-PIKIFLEKHSSQSVGMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDLVQRLLYFLTYFIRCSEL 548
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 975-1161 4.84e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 4.84e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  975 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERLRQCLASDLSHAVQHPVLDEPIAEAVCIIADM 1053
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919 1054 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLAEYLRGQMRVHV 1132
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1983575919 1133 KELGVVLGIESSDLPLLAAVASTHSPYVA 1161
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.29e-37

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 135.86  E-value: 4.29e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919   41 QIRLIVYQD-CERRGRNVLFDSSVKRKNEDTSVSKLCNDAQVKVFGKCCQLKPGGDSSSSLDSSIT-----LSSDGKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSqgsrpLVSQTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1983575919  115 PKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 316-548 6.86e-105

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 329.23  E-value: 6.86e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  316 ESCGPNPGIVRKKKIAIGVIFSLSkdEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAmkmsrrsadAGQRSLAYNRIVD 395
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLS--ESSESEFEQFLFEHFPLLESHMSRLRVAIENA---------SGRKQSFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  396 ALTEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNQLCHRFMKEFTFLMENASKNQ---FLPALITAVLTNHLAWVPTVMP 472
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575919  473 NGQP-PIKIFLEKHSSQSVGMLAKTHPYNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDLVQRLLYFLTYFIRCSEL 548
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 975-1161 4.84e-98

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 309.19  E-value: 4.84e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919  975 IPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGS-DERLRQCLASDLSHAVQHPVLDEPIAEAVCIIADM 1053
Cdd:pfam14638    1 LPLPKSKSISNSEDMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919 1054 DKWTVQVASSQRRVTDN-KLGKEVLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLAEYLRGQMRVHV 1132
Cdd:pfam14638   81 DKWTVQVLSSQTSDLKNnGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 1983575919 1133 KELGVVLGIESSDLPLLAAVASTHSPYVA 1161
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 41-159 4.29e-37

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 135.86  E-value: 4.29e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575919   41 QIRLIVYQD-CERRGRNVLFDSSVKRKNEDTSVSKLCNDAQVKVFGKCCQLKPGGDSSSSLDSSIT-----LSSDGKDQC 114
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHAVAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSqgsrpLVSQTSETD 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1983575919  115 PKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLML 159
Cdd:pfam14636   81 PQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH