|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
974-1280 |
4.77e-168 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 505.58 E-value: 4.77e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 974 AIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGqg 1053
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1054 NTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDA 1133
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1134 DPVVSKALGCLEASWETIeqgrngSFVYTKALMAYAFTLAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSEHYLY 1213
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2075919621 1214 TPQASSVEVEMSAYVVLARLTAHpapsPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKY 1280
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
754-844 |
3.04e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 3.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 754 TWVWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 833
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 2075919621 834 LPTSLPMTVQL 844
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1356 |
4.55e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 149.85 E-value: 4.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 129 VFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKELfPL-AYIEDPkMNRIMQWQDVKT-ENGLKQLSFSLSAEPIQGPYKIV 206
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 207 V-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKP-----VLGRVKVRLCH---------- 270
Cdd:COG2373 449 LyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPaaglkVEGEVTLRPARtafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 271 -GNPSFSSETKSAcKEENSKLDNNGCSTQEVNITEFQLKENYLKVRqafhVNATVTEEGtgsefggyGRiEVERTRNkFL 349
Cdd:COG2373 529 fGDPDEEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG--------GR-PVTRSAT-VP 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 350 FLKADshFRHGI------------PFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSISGYSL 417
Cdd:COG2373 594 VHPAD--FYVGIrlplfdgdpegaPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRYESQEKEEPVAEG 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 418 NIKVyhkeenlcihsscTAERHAeahhtayavyslskSYIYLDTEAGVlpcnqiHTVQAhfilKGQVLGVLPQIVFHylv 497
Cdd:COG2373 672 TLTT-------------GADGPA--------------SLSLTPVEWGR------YRLEV----KDPDGGLATSVRFY--- 711
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 498 mAQGSilqtgnhthqvesgvlqGNFALEIPVEFSMVP---------MAKMLIYTilP-DGEVIadsvkFQVEkclRNKVH 567
Cdd:COG2373 712 -AGGN-----------------ASWGAERPDRLELSLdkesykpgeTAKLLIQS--PfAGRAL-----VTVE---RDGVL 763
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 568 LSFSpsQSLPASQTHMRVTASPQSLCGLRAvdqSVLLLRPeaelspsliydlpGMQDSNFIPRSHH-----PFEDEDDCL 642
Cdd:COG2373 764 ETQW--VDVKGGGTTVEIPVTEDWAPNAYV---SATLVRP-------------GDSTANDMPARAYgvaplPVDPPARRL 825
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 643 --------MYQPRDTEELTYSVPYGREKDVYR--YVRDMGLTAFTNLKIKHP-TYCYDD-----EIFEIFEPTVELNTSP 706
Cdd:COG2373 826 kveltapeKLRPGETLTVTVKVKGAAGKAAEVtlAAVDEGILNLTGYKTPDPlDFFYGKralgvETRDLYGRLIGAFGGA 905
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 707 MwEKIEIMALIANENPLPKEPPRKDPprkdpepKDTVVetirnYFPetwvwdLVTVNSSGVTEVEMTVPDTITEWKAGAL 786
Cdd:COG2373 906 A-GALRSGGDGALGRGGNPKPPRKRF-------KPVAL-----FSG------PVKTDADGKATVSFDLPDFNGTLRVMAV 966
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 787 CLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMTVQLEASPDFTavPVGNDQDSYCLGA 866
Cdd:COG2373 967 AWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAA 1042
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 867 NGRHTSSWLVTPKSLGNVNFSVSVEAQqspepcgsevatvpetGRKDTVIKVLIVEPEGIKKEHTFSSLLcasDAELSET 946
Cdd:COG2373 1043 GGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVTRATSGVL---APGESWT 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 947 LSLLLPPRVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKyLNETQQLTENIKSKALGYLRA 1026
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQA 1182
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1027 GYQRELNYKHKDGSYSAFGdhnGQGQGNTWLTAFVLKSFAQARAF-IFIDESHITDAFTWLSKQQKDSGcfrssgslfnn 1105
Cdd:COG2373 1183 AIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW----------- 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1106 AMKGGVDDEITLSAYITMALLESSLPDadpvvskaLGCLEASWETIEQGRNGsfvYTKALMAYAFTLAGNQEKRNEILKS 1185
Cdd:COG2373 1249 EIEYDDAYRLAVRAYALYVLARAGKAD--------LGDLRYLYDRRKDALSP---LAKAQLAAALALLGDKARAEELLAA 1317
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1186 LdkeaikednsihWERPQKPMKSEHYLYTPQaSSVEvemSAYVVLARLTAHPAPSPEDLALstgtIKWLTKQQNShGGFS 1265
Cdd:COG2373 1318 A------------LARLRETGARDYWYGDYG-SPLR---DQALALALLAELGPDAPLAPKL----ARWLAKALKS-GRWL 1376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1266 STQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsfsQKFQVDKSNRLLLQQVSLPDI-PGNYTIRVSGEGCVYAQTTL 1344
Cdd:COG2373 1377 STQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTL 1451
|
1290
....*....|..
gi 2075919621 1345 RYNLPLEKQQPA 1356
Cdd:COG2373 1452 SGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1390-1480 |
2.78e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.83 E-value: 2.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1390 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1468
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2075919621 1469 YETDEVAFAEYS 1480
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
974-1280 |
4.77e-168 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 505.58 E-value: 4.77e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 974 AIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGqg 1053
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1054 NTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDA 1133
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1134 DPVVSKALGCLEASWETIeqgrngSFVYTKALMAYAFTLAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSEHYLY 1213
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2075919621 1214 TPQASSVEVEMSAYVVLARLTAHpapsPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKY 1280
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
964-1280 |
4.57e-161 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 487.96 E-value: 4.57e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 964 FSVMGDILSSAIK----NTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDG 1039
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1040 SYSAFgdhnGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSA 1119
Cdd:pfam07678 81 SYSAF----GHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1120 YITMALLES-----SLPDADPVVSKALGCLEAswetiEQGRNGSFVYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKED 1194
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1195 NSIHWERPQKPMKSEHYLYTPQASSVEVEMSAYVVLARLtahpapSPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVAL 1274
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 2075919621 1275 DALSKY 1280
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
754-844 |
3.04e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 3.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 754 TWVWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 833
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 2075919621 834 LPTSLPMTVQL 844
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1356 |
4.55e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 149.85 E-value: 4.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 129 VFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKELfPL-AYIEDPkMNRIMQWQDVKT-ENGLKQLSFSLSAEPIQGPYKIV 206
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 207 V-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKP-----VLGRVKVRLCH---------- 270
Cdd:COG2373 449 LyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPaaglkVEGEVTLRPARtafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 271 -GNPSFSSETKSAcKEENSKLDNNGCSTQEVNITEFQLKENYLKVRqafhVNATVTEEGtgsefggyGRiEVERTRNkFL 349
Cdd:COG2373 529 fGDPDEEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG--------GR-PVTRSAT-VP 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 350 FLKADshFRHGI------------PFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSISGYSL 417
Cdd:COG2373 594 VHPAD--FYVGIrlplfdgdpegaPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRYESQEKEEPVAEG 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 418 NIKVyhkeenlcihsscTAERHAeahhtayavyslskSYIYLDTEAGVlpcnqiHTVQAhfilKGQVLGVLPQIVFHylv 497
Cdd:COG2373 672 TLTT-------------GADGPA--------------SLSLTPVEWGR------YRLEV----KDPDGGLATSVRFY--- 711
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 498 mAQGSilqtgnhthqvesgvlqGNFALEIPVEFSMVP---------MAKMLIYTilP-DGEVIadsvkFQVEkclRNKVH 567
Cdd:COG2373 712 -AGGN-----------------ASWGAERPDRLELSLdkesykpgeTAKLLIQS--PfAGRAL-----VTVE---RDGVL 763
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 568 LSFSpsQSLPASQTHMRVTASPQSLCGLRAvdqSVLLLRPeaelspsliydlpGMQDSNFIPRSHH-----PFEDEDDCL 642
Cdd:COG2373 764 ETQW--VDVKGGGTTVEIPVTEDWAPNAYV---SATLVRP-------------GDSTANDMPARAYgvaplPVDPPARRL 825
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 643 --------MYQPRDTEELTYSVPYGREKDVYR--YVRDMGLTAFTNLKIKHP-TYCYDD-----EIFEIFEPTVELNTSP 706
Cdd:COG2373 826 kveltapeKLRPGETLTVTVKVKGAAGKAAEVtlAAVDEGILNLTGYKTPDPlDFFYGKralgvETRDLYGRLIGAFGGA 905
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 707 MwEKIEIMALIANENPLPKEPPRKDPprkdpepKDTVVetirnYFPetwvwdLVTVNSSGVTEVEMTVPDTITEWKAGAL 786
Cdd:COG2373 906 A-GALRSGGDGALGRGGNPKPPRKRF-------KPVAL-----FSG------PVKTDADGKATVSFDLPDFNGTLRVMAV 966
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 787 CLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMTVQLEASPDFTavPVGNDQDSYCLGA 866
Cdd:COG2373 967 AWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAA 1042
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 867 NGRHTSSWLVTPKSLGNVNFSVSVEAQqspepcgsevatvpetGRKDTVIKVLIVEPEGIKKEHTFSSLLcasDAELSET 946
Cdd:COG2373 1043 GGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVTRATSGVL---APGESWT 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 947 LSLLLPPRVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKyLNETQQLTENIKSKALGYLRA 1026
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQA 1182
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1027 GYQRELNYKHKDGSYSAFGdhnGQGQGNTWLTAFVLKSFAQARAF-IFIDESHITDAFTWLSKQQKDSGcfrssgslfnn 1105
Cdd:COG2373 1183 AIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW----------- 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1106 AMKGGVDDEITLSAYITMALLESSLPDadpvvskaLGCLEASWETIEQGRNGsfvYTKALMAYAFTLAGNQEKRNEILKS 1185
Cdd:COG2373 1249 EIEYDDAYRLAVRAYALYVLARAGKAD--------LGDLRYLYDRRKDALSP---LAKAQLAAALALLGDKARAEELLAA 1317
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1186 LdkeaikednsihWERPQKPMKSEHYLYTPQaSSVEvemSAYVVLARLTAHPAPSPEDLALstgtIKWLTKQQNShGGFS 1265
Cdd:COG2373 1318 A------------LARLRETGARDYWYGDYG-SPLR---DQALALALLAELGPDAPLAPKL----ARWLAKALKS-GRWL 1376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1266 STQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsfsQKFQVDKSNRLLLQQVSLPDI-PGNYTIRVSGEGCVYAQTTL 1344
Cdd:COG2373 1377 STQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTL 1451
|
1290
....*....|..
gi 2075919621 1345 RYNLPLEKQQPA 1356
Cdd:COG2373 1452 SGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1390-1480 |
2.78e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.83 E-value: 2.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1390 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1468
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2075919621 1469 YETDEVAFAEYS 1480
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
348-443 |
7.17e-32 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 120.05 E-value: 7.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 348 FLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSiSGYSLNIKVYHKEEN 427
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 2075919621 428 LCIHSSCTAERHAEAH 443
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
974-1280 |
4.77e-168 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 505.58 E-value: 4.77e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 974 AIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGqg 1053
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1054 NTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDA 1133
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1134 DPVVSKALGCLEASWETIeqgrngSFVYTKALMAYAFTLAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSEHYLY 1213
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2075919621 1214 TPQASSVEVEMSAYVVLARLTAHpapsPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKY 1280
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
964-1280 |
4.57e-161 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 487.96 E-value: 4.57e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 964 FSVMGDILSSAIK----NTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDG 1039
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1040 SYSAFgdhnGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSA 1119
Cdd:pfam07678 81 SYSAF----GHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1120 YITMALLES-----SLPDADPVVSKALGCLEAswetiEQGRNGSFVYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKED 1194
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1195 NSIHWERPQKPMKSEHYLYTPQASSVEVEMSAYVVLARLtahpapSPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVAL 1274
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 2075919621 1275 DALSKY 1280
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
974-1280 |
2.26e-115 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 364.02 E-value: 2.26e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 974 AIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGdhnGQGQG 1053
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1054 NTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDa 1133
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1134 DPVVSKALGCLEASWETIEQgrngsfVYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKEDNSIHWerpqkpmksEHYLY 1213
Cdd:cd02891 157 DASIEKALAYLETQLDGLLD------PYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW---------SLSWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2075919621 1214 TPQASSVEVEMSAYVVLARLtahpapSPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKY 1280
Cdd:cd02891 222 GDYGSSLRVEATAYALLALL------KLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
975-1280 |
1.40e-79 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 264.52 E-value: 1.40e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 975 IKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQ---LTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGDhngqG 1051
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKN----R 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1052 QGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGV---DDEITLSAYITMALLES 1128
Cdd:cd02896 78 PSSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1129 ------SLPDADPVVSKALGCLEASWETIEQgrngsfVYTKALMAYAFTLAGNQEKRNEiLKSLDKEAIKEDNSIHWERP 1202
Cdd:cd02896 158 rsicppEVQNLDQSIRKAISYLENQLPNLQR------PYALAITAYALALADSPLSHAA-NRKLLSLAKRDGNGWYWWTI 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2075919621 1203 QKPmksehYLYTPQASSVEVEMSAYVVLARLtahpapSPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKY 1280
Cdd:cd02896 231 DSP-----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
974-1280 |
1.20e-67 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 230.52 E-value: 1.20e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 974 AIKNTQNLIQMPYG--------CGEQNMVLFAPNIYVLKYLNETqqlteNIKSKALGYLRAGYQRELNYKHKDGSYSAFG 1045
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAAT-----GIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1046 dhnGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMkgGVDDEITLSAYITMAL 1125
Cdd:cd00688 76 ---GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1126 LESSLPDADPVVSKALGCLEASWETIEQGRNG--SFVYTKALMAYAFTLAG--NQEKRNEILKSLDKEAIKEDNSIHWER 1201
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCQNYDGGFGPGgeSHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1202 pqkpmksehyLYTPQASSVEVEMSAYVVLARLtahpapSPEDLALSTGTIKWLTKQQNSHGGFSS-------TQDTVVAL 1274
Cdd:cd00688 231 ----------RTNKLSDSCYTEWAAYALLALG------KLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFAL 294
|
....*.
gi 2075919621 1275 DALSKY 1280
Cdd:cd00688 295 LALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
754-844 |
3.04e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 3.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 754 TWVWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 833
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 2075919621 834 LPTSLPMTVQL 844
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1356 |
4.55e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 149.85 E-value: 4.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 129 VFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKELfPL-AYIEDPkMNRIMQWQDVKT-ENGLKQLSFSLSAEPIQGPYKIV 206
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 207 V-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKP-----VLGRVKVRLCH---------- 270
Cdd:COG2373 449 LyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPaaglkVEGEVTLRPARtafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 271 -GNPSFSSETKSAcKEENSKLDNNGCSTQEVNITEFQLKENYLKVRqafhVNATVTEEGtgsefggyGRiEVERTRNkFL 349
Cdd:COG2373 529 fGDPDEEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG--------GR-PVTRSAT-VP 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 350 FLKADshFRHGI------------PFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSISGYSL 417
Cdd:COG2373 594 VHPAD--FYVGIrlplfdgdpegaPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRYESQEKEEPVAEG 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 418 NIKVyhkeenlcihsscTAERHAeahhtayavyslskSYIYLDTEAGVlpcnqiHTVQAhfilKGQVLGVLPQIVFHylv 497
Cdd:COG2373 672 TLTT-------------GADGPA--------------SLSLTPVEWGR------YRLEV----KDPDGGLATSVRFY--- 711
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 498 mAQGSilqtgnhthqvesgvlqGNFALEIPVEFSMVP---------MAKMLIYTilP-DGEVIadsvkFQVEkclRNKVH 567
Cdd:COG2373 712 -AGGN-----------------ASWGAERPDRLELSLdkesykpgeTAKLLIQS--PfAGRAL-----VTVE---RDGVL 763
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 568 LSFSpsQSLPASQTHMRVTASPQSLCGLRAvdqSVLLLRPeaelspsliydlpGMQDSNFIPRSHH-----PFEDEDDCL 642
Cdd:COG2373 764 ETQW--VDVKGGGTTVEIPVTEDWAPNAYV---SATLVRP-------------GDSTANDMPARAYgvaplPVDPPARRL 825
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 643 --------MYQPRDTEELTYSVPYGREKDVYR--YVRDMGLTAFTNLKIKHP-TYCYDD-----EIFEIFEPTVELNTSP 706
Cdd:COG2373 826 kveltapeKLRPGETLTVTVKVKGAAGKAAEVtlAAVDEGILNLTGYKTPDPlDFFYGKralgvETRDLYGRLIGAFGGA 905
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 707 MwEKIEIMALIANENPLPKEPPRKDPprkdpepKDTVVetirnYFPetwvwdLVTVNSSGVTEVEMTVPDTITEWKAGAL 786
Cdd:COG2373 906 A-GALRSGGDGALGRGGNPKPPRKRF-------KPVAL-----FSG------PVKTDADGKATVSFDLPDFNGTLRVMAV 966
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 787 CLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMTVQLEASPDFTavPVGNDQDSYCLGA 866
Cdd:COG2373 967 AWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAA 1042
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 867 NGRHTSSWLVTPKSLGNVNFSVSVEAQqspepcgsevatvpetGRKDTVIKVLIVEPEGIKKEHTFSSLLcasDAELSET 946
Cdd:COG2373 1043 GGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVTRATSGVL---APGESWT 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 947 LSLLLPPRVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKyLNETQQLTENIKSKALGYLRA 1026
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQA 1182
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1027 GYQRELNYKHKDGSYSAFGdhnGQGQGNTWLTAFVLKSFAQARAF-IFIDESHITDAFTWLSKQQKDSGcfrssgslfnn 1105
Cdd:COG2373 1183 AIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW----------- 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1106 AMKGGVDDEITLSAYITMALLESSLPDadpvvskaLGCLEASWETIEQGRNGsfvYTKALMAYAFTLAGNQEKRNEILKS 1185
Cdd:COG2373 1249 EIEYDDAYRLAVRAYALYVLARAGKAD--------LGDLRYLYDRRKDALSP---LAKAQLAAALALLGDKARAEELLAA 1317
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1186 LdkeaikednsihWERPQKPMKSEHYLYTPQaSSVEvemSAYVVLARLTAHPAPSPEDLALstgtIKWLTKQQNShGGFS 1265
Cdd:COG2373 1318 A------------LARLRETGARDYWYGDYG-SPLR---DQALALALLAELGPDAPLAPKL----ARWLAKALKS-GRWL 1376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1266 STQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsfsQKFQVDKSNRLLLQQVSLPDI-PGNYTIRVSGEGCVYAQTTL 1344
Cdd:COG2373 1377 STQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTL 1451
|
1290
....*....|..
gi 2075919621 1345 RYNLPLEKQQPA 1356
Cdd:COG2373 1452 SGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1390-1480 |
2.78e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.83 E-value: 2.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 1390 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1468
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2075919621 1469 YETDEVAFAEYS 1480
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
348-443 |
7.17e-32 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 120.05 E-value: 7.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 348 FLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSiSGYSLNIKVYHKEEN 427
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 2075919621 428 LCIHSSCTAERHAEAH 443
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
457-605 |
2.96e-31 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 119.76 E-value: 2.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 457 IYLDTEAGVLPCNQIHTVQAHFILKGQVlgvlPQIVFHYLVMAQGSILQTGNHTHQVEsgvlqgnfaLEIPVEFSMVPMA 536
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTV----ERDGFTYLVLSKGQIVVVGRGGVTTS---------FSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2075919621 537 KMLIYTI---LPDGEVIADSVKFQVEKCLRNKVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLL 605
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
223-309 |
4.29e-24 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 97.34 E-value: 4.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 223 EFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVLGRVKVRLCHgnpsfSSETKSACKEENSK-LDNNGCSTQEVN 301
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCL-----KDDSKRKCFESFSKeLDKDGCGSASLS 75
|
....*...
gi 2075919621 302 ITEFQLKE 309
Cdd:pfam17791 76 TEEFQLTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
129-221 |
1.44e-19 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 85.06 E-value: 1.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2075919621 129 VFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKELFPLAYIEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVVL 208
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 2075919621 209 K-QSGVKEEHSFTV 221
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| |
