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Conserved domains on  [gi|2173616055|ref|NP_001386261|]
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kelch-like protein 30 [Rattus norvegicus]

Protein Classification

kelch-like protein 30( domain architecture ID 13605388)

kelch-like protein 30 (KLHL30) is a BTB-Kelch family protein

Gene Symbol:  KLHL30
Gene Ontology:  GO:0005515
PubMed:  23676014|17120193|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1-137 2.25e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18259:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 137  Bit Score: 269.39  E-value: 2.25e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   1 MVRNVDDLDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVE 80
Cdd:cd18259     1 MVRNIDDLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055  81 PAAVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18259    81 PAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 128-231 2.80e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


:

Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 192.66  E-value: 2.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 128 QQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHD 207
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90       100
                  ....*....|....*....|....
gi 2173616055 208 PQDRAAYLPELLNLVHLDALPRPC 231
Cdd:cd18469    81 PQARAAHLPELLSLVHLSLLTDQY 104
PHA03098 super family cl33709
kelch-like protein; Provisional
 29-494 8.71e-37

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 143.75  E-value: 8.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  29 LPKLADVTLLV--GDQELPCHRSLLALNSPYFHAMFAGDFAESfsaRVELR-DVEpaAVGQLVDFVYTGRLTITQSNVEA 105
Cdd:PHA03098    6 LQKFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNiDYD--SFNEVIKYIYTGKINITSNNVKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 106 LTRSASRLHFPTVQKVCGRYLQQQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLAS 185
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 186 DLLQVQPEQSRLEALLRWVRHDPQDRAAYLPELLNLVHLDALPRPCVQQLLA-----TEPLIQESEAC------------ 248
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRwklriKKKKIVFNKRCikiiyskkynln 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 249 -----QEALSQGHSAEPPGLPQKMQ-----------------------------EVLVVVGGRaleedeEGGEEPSPhtg 294
Cdd:PHA03098  241 kilprSSTFGSIIYIHITMSIFTYNyitnysplseintiidihyvycfgsvvlnNVIYFIGGM------NKNNLSVN--- 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 295 NFAFYNTKARQWMALPDFpDYHKWGFSLATLNSDVYVTGGSRGtkTDTWSTTQAWCFplKEAVWKPVAPMLKARTNHAST 374
Cdd:PHA03098  312 SVVSYDTKTKSWNKVPEL-IYPRKNPGVTVFNNRIYVIGGIYN--SISLNTVESWKP--GESKWREEPPLIFPRYNPCVV 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 375 ALNGEIYAIGG-----TALDAveVERYDPYTDSWAPVRPALKYVSNFSAASCQGRLYLVG-----SSACKYNMlaLQCYS 444
Cdd:PHA03098  387 NVNNLIYVIGGiskndELLKT--VECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGgisyiDNIKVYNI--VESYN 462

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 445 PVTDVWSVIASPFLPKYLSSprCAALNGALYLIGDNTKKVY-----VYDPGANLW 494
Cdd:PHA03098  463 PVTNKWTELSSLNFPRINAS--LCIFNNKIYVVGGDKYEYYineieVYDDKTNTW 515
 
Name Accession Description Interval E-value
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-137 2.25e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 269.39  E-value: 2.25e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   1 MVRNVDDLDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVE 80
Cdd:cd18259     1 MVRNIDDLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055  81 PAAVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18259    81 PAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 128-231 2.80e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 192.66  E-value: 2.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 128 QQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHD 207
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90       100
                  ....*....|....*....|....
gi 2173616055 208 PQDRAAYLPELLNLVHLDALPRPC 231
Cdd:cd18469    81 PQARAAHLPELLSLVHLSLLTDQY 104
PHA03098 PHA03098
kelch-like protein; Provisional
 29-494 8.71e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 143.75  E-value: 8.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  29 LPKLADVTLLV--GDQELPCHRSLLALNSPYFHAMFAGDFAESfsaRVELR-DVEpaAVGQLVDFVYTGRLTITQSNVEA 105
Cdd:PHA03098    6 LQKFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNiDYD--SFNEVIKYIYTGKINITSNNVKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 106 LTRSASRLHFPTVQKVCGRYLQQQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLAS 185
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 186 DLLQVQPEQSRLEALLRWVRHDPQDRAAYLPELLNLVHLDALPRPCVQQLLA-----TEPLIQESEAC------------ 248
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRwklriKKKKIVFNKRCikiiyskkynln 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 249 -----QEALSQGHSAEPPGLPQKMQ-----------------------------EVLVVVGGRaleedeEGGEEPSPhtg 294
Cdd:PHA03098  241 kilprSSTFGSIIYIHITMSIFTYNyitnysplseintiidihyvycfgsvvlnNVIYFIGGM------NKNNLSVN--- 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 295 NFAFYNTKARQWMALPDFpDYHKWGFSLATLNSDVYVTGGSRGtkTDTWSTTQAWCFplKEAVWKPVAPMLKARTNHAST 374
Cdd:PHA03098  312 SVVSYDTKTKSWNKVPEL-IYPRKNPGVTVFNNRIYVIGGIYN--SISLNTVESWKP--GESKWREEPPLIFPRYNPCVV 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 375 ALNGEIYAIGG-----TALDAveVERYDPYTDSWAPVRPALKYVSNFSAASCQGRLYLVG-----SSACKYNMlaLQCYS 444
Cdd:PHA03098  387 NVNNLIYVIGGiskndELLKT--VECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGgisyiDNIKVYNI--VESYN 462

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 445 PVTDVWSVIASPFLPKYLSSprCAALNGALYLIGDNTKKVY-----VYDPGANLW 494
Cdd:PHA03098  463 PVTNKWTELSSLNFPRINAS--LCIFNNKIYVVGGDKYEYYineieVYDDKTNTW 515
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
261-538 8.26e-33

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.19  E-value: 8.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 261 PGLPQKMQE-VLVVVGGRALEEDEEGGEEPSphtgNFAF-YNTKARQWMALPDFPDYHKWGFSLATLNSDVYVTGGSRGT 338
Cdd:COG3055     7 PDLPTPRSEaAAALLDGKVYVAGGLSGGSAS----NSFEvYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 339 KTDTWSTTQAWCFPLKEAVWKPVAPMLKARTNHASTALNGEIYAIGGTALDAV--EVERYDPYTDSWAPVRPALKYVSNF 416
Cdd:COG3055    83 NPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNvaWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 417 SAA-SCQGRLYLVGSSAckynmlalqcYSPVTDVWSVIASpfLPKYLSSPRCAALNGALYLIG---DNTKKVYVYDPGAN 492
Cdd:COG3055   163 AAAvLPDGKILVIGGRN----------GSGFSNTWTTLAP--LPTARAGHAAAVLGGKILVFGgesGFSDEVEAYDPATN 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2173616055 493 LWQKVQS-QHSLHENGAlVPLGDLLYVTGGRWQGMDGDYHV-EMEAYD 538
Cdd:COG3055   231 TWTALGElPTPRHGHAA-VLTDGKVYVIGGETKPGVRTPLVtSAEVYD 277
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-130 1.02e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 115.43  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  23 LQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLtITQSN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 2173616055 103 VEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 135-229 1.46e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 109.35  E-value: 1.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  135 CLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRAAY 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*
gi 2173616055  215 LPELLNLVHLDALPR 229
Cdd:smart00875  81 LPELLEHVRLPLLSP 95
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 135-237 3.80e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 105.32  E-value: 3.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 135 CLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRAAY 214
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 2173616055 215 LPELLNLVHLDALPRPCVQQLLA 237
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-130 5.15e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 104.70  E-value: 5.15e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRL 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 2173616055  114 HFPTVQKVCGRYLQQQL 130
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 367-408 6.43e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.07  E-value: 6.43e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2173616055 367 ARTNHASTALNGEIYAIGG----TALDavEVERYDPYTDSWAPVRP 408
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLN--SVEVYDPETNTWSKLPS 44
Kelch smart00612
Kelch domain;
329-378 1.35e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.35e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2173616055  329 VYVTGGSRGTKtdtwSTTQAWCFPLKEAVWKPVAPMLKARTNHASTALNG 378
Cdd:smart00612   2 IYVVGGFDGGQ----RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-137 2.25e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 269.39  E-value: 2.25e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   1 MVRNVDDLDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVE 80
Cdd:cd18259     1 MVRNIDDLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055  81 PAAVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18259    81 PAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 128-231 2.80e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 192.66  E-value: 2.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 128 QQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHD 207
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90       100
                  ....*....|....*....|....
gi 2173616055 208 PQDRAAYLPELLNLVHLDALPRPC 231
Cdd:cd18469    81 PQARAAHLPELLSLVHLSLLTDQY 104
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-135 2.36e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 158.78  E-value: 2.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18250     2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18250    82 TGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-137 3.28e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 136.85  E-value: 3.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18237     4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18237    84 RISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-137 1.07e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 135.50  E-value: 1.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  18 DMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLT 97
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  98 ITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
PHA03098 PHA03098
kelch-like protein; Provisional
 29-494 8.71e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 143.75  E-value: 8.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  29 LPKLADVTLLV--GDQELPCHRSLLALNSPYFHAMFAGDFAESfsaRVELR-DVEpaAVGQLVDFVYTGRLTITQSNVEA 105
Cdd:PHA03098    6 LQKFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNiDYD--SFNEVIKYIYTGKINITSNNVKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 106 LTRSASRLHFPTVQKVCGRYLQQQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLAS 185
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 186 DLLQVQPEQSRLEALLRWVRHDPQDRAAYLPELLNLVHLDALPRPCVQQLLA-----TEPLIQESEAC------------ 248
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRwklriKKKKIVFNKRCikiiyskkynln 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 249 -----QEALSQGHSAEPPGLPQKMQ-----------------------------EVLVVVGGRaleedeEGGEEPSPhtg 294
Cdd:PHA03098  241 kilprSSTFGSIIYIHITMSIFTYNyitnysplseintiidihyvycfgsvvlnNVIYFIGGM------NKNNLSVN--- 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 295 NFAFYNTKARQWMALPDFpDYHKWGFSLATLNSDVYVTGGSRGtkTDTWSTTQAWCFplKEAVWKPVAPMLKARTNHAST 374
Cdd:PHA03098  312 SVVSYDTKTKSWNKVPEL-IYPRKNPGVTVFNNRIYVIGGIYN--SISLNTVESWKP--GESKWREEPPLIFPRYNPCVV 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 375 ALNGEIYAIGG-----TALDAveVERYDPYTDSWAPVRPALKYVSNFSAASCQGRLYLVG-----SSACKYNMlaLQCYS 444
Cdd:PHA03098  387 NVNNLIYVIGGiskndELLKT--VECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGgisyiDNIKVYNI--VESYN 462

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 445 PVTDVWSVIASPFLPKYLSSprCAALNGALYLIGDNTKKVY-----VYDPGANLW 494
Cdd:PHA03098  463 PVTNKWTELSSLNFPRINAS--LCIFNNKIYVVGGDKYEYYineieVYDDKTNTW 515
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-132 2.57e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 128.70  E-value: 2.57e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18235     2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDA 132
Cdd:cd18235    82 TAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-138 6.58e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 127.98  E-value: 6.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  18 DMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLT 97
Cdd:cd18268     9 ELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEIL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  98 ITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18268    89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
261-538 8.26e-33

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.19  E-value: 8.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 261 PGLPQKMQE-VLVVVGGRALEEDEEGGEEPSphtgNFAF-YNTKARQWMALPDFPDYHKWGFSLATLNSDVYVTGGSRGT 338
Cdd:COG3055     7 PDLPTPRSEaAAALLDGKVYVAGGLSGGSAS----NSFEvYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 339 KTDTWSTTQAWCFPLKEAVWKPVAPMLKARTNHASTALNGEIYAIGGTALDAV--EVERYDPYTDSWAPVRPALKYVSNF 416
Cdd:COG3055    83 NPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNvaWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 417 SAA-SCQGRLYLVGSSAckynmlalqcYSPVTDVWSVIASpfLPKYLSSPRCAALNGALYLIG---DNTKKVYVYDPGAN 492
Cdd:COG3055   163 AAAvLPDGKILVIGGRN----------GSGFSNTWTTLAP--LPTARAGHAAAVLGGKILVFGgesGFSDEVEAYDPATN 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2173616055 493 LWQKVQS-QHSLHENGAlVPLGDLLYVTGGRWQGMDGDYHV-EMEAYD 538
Cdd:COG3055   231 TWTALGElPTPRHGHAA-VLTDGKVYVIGGETKPGVRTPLVtSAEVYD 277
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-137 3.76e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 120.25  E-value: 3.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18249    86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-137 1.12e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 119.11  E-value: 1.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18265     4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18265    84 GGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-137 1.48e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 118.66  E-value: 1.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18256    83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-129 1.73e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 118.15  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  11 HLPSHAQDMLEGLqrlRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDF 90
Cdd:cd18247     1 DLPSSGFPVMEEI---RRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINF 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQ 129
Cdd:cd18247    78 AYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
305-562 3.63e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 122.57  E-value: 3.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 305 QWMALPDFPDYHKwGFSLATLNSDVYVTGGSRGTKTdtwsTTQAWCFPLKEAVWKPVAPMLKARTNHASTAL-NGEIYAI 383
Cdd:COG3055     2 TWSSLPDLPTPRS-EAAAALLDGKVYVAGGLSGGSA----SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 384 GGTALDAV------EVERYDPYTDSWAPVRPALKYVSNFSAASCQGRLYLVGSSACKYNMLALQCYSPVTDVWSVIASpf 457
Cdd:COG3055    77 GGFTGANPsstplnDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 458 LPKYLSSPRCAAL-NGALYLI-GDNtkkvyvYDPGANLWQKVQSQHSLHENGALVPLGDLLYVTGGRWQgmdgdYHVEME 535
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIgGRN------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG-----FSDEVE 223

                         250       260
                  ....*....|....*....|....*..
gi 2173616055 536 AYDTVRDAWARHGSLPRLWLYHGASTI 562
Cdd:COG3055   224 AYDPATNTWTALGELPTPRHGHAAVLT 250
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-130 1.02e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 115.43  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  23 LQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLtITQSN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 2173616055 103 VEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-135 3.08e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 114.85  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18242    83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 1.27e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 113.77  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLV--------GDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAV 84
Cdd:cd18273     7 AAHARALLAQLKSFYDARLLTDVTIEVngpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESM 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2173616055  85 GQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18273    87 ALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-135 2.10e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 112.62  E-value: 2.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18253    81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 135-229 1.46e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 109.35  E-value: 1.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  135 CLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRAAY 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*
gi 2173616055  215 LPELLNLVHLDALPR 229
Cdd:smart00875  81 LPELLEHVRLPLLSP 95
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-113 1.71e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 108.41  E-value: 1.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSAS 111
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                  ..
gi 2173616055 112 RL 113
Cdd:cd18186    81 KL 82
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-132 1.82e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 109.55  E-value: 1.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDA 132
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 4.02e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 108.89  E-value: 4.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-138 1.84e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 107.49  E-value: 1.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  21 EGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQ 100
Cdd:cd18269    16 DGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLND 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055 101 SNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18269    96 QNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-138 3.10e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 107.38  E-value: 3.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  10 FHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRD-VEPAAVGQLV 88
Cdd:cd18267    18 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLL 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2173616055  89 DFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18267    98 DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 135-237 3.80e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 105.32  E-value: 3.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 135 CLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRAAY 214
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 2173616055 215 LPELLNLVHLDALPRPCVQQLLA 237
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-130 3.85e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 105.96  E-value: 3.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18339     2 PAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIY 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18339    82 TAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-137 4.43e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 106.25  E-value: 4.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  11 HLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRD-VEPAAVGQLVD 89
Cdd:cd18254     1 HKPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2173616055  90 FVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18254    81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-136 4.93e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 105.14  E-value: 4.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSAS 111
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                          90       100
                  ....*....|....*....|....*
gi 2173616055 112 RLHFPTVQKVCGRYLQQQLDATNCL 136
Cdd:cd18234    81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-130 5.15e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 104.70  E-value: 5.15e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRL 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 2173616055  114 HFPTVQKVCGRYLQQQL 130
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-138 6.96e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 105.69  E-value: 6.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  21 EGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQ 100
Cdd:cd18340    16 DGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITE 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055 101 SNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18340    96 QNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-130 1.43e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 104.38  E-value: 1.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18338     2 PRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVY 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18338    82 TAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 6.75e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 99.88  E-value: 6.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18276     4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSS 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18276    84 DLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-137 2.26e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 98.36  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQEL-PCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18252     2 SSHPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18252    82 YTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 130-250 2.50e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 98.62  E-value: 2.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055 210 DRAAYLPELLNLVHLDALPRPCVQQLLATEPLIQESEACQE 250
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRD 121
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-135 2.68e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 97.85  E-value: 2.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18255    81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 3.03e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 98.37  E-value: 3.03e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18271     6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18271    86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-138 3.18e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 98.38  E-value: 3.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  21 EGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQ 100
Cdd:cd18341    16 DGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLND 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055 101 SNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18341    96 GNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 1.61e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 96.21  E-value: 1.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVG-DQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18274     3 PLHACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18274    83 YTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-131 1.63e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 95.91  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVG----DQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQL 87
Cdd:cd18248     1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLD 131
Cdd:cd18248    81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 4.24e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 94.73  E-value: 4.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18336     1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18336    81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 129-228 7.99e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 93.16  E-value: 7.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18444     1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                          90       100
                  ....*....|....*....|
gi 2173616055 209 QDRAAYLPELLNLVHLDALP 228
Cdd:cd18444    81 PERKKHLAKLLALIRLPLLT 100
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-137 1.23e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 93.76  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  22 GLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQS 101
Cdd:cd18236    14 GLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQ 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2173616055 102 NVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18236    94 NVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 3.76e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 92.79  E-value: 3.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18246    22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTA 101

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLD 131
Cdd:cd18246   102 EIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 4.31e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 92.37  E-value: 4.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18270     9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCL 136
Cdd:cd18270    89 NLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-138 7.03e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 91.66  E-value: 7.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  10 FHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVD 89
Cdd:cd18337     1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2173616055  90 FVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18337    81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 130-243 2.55e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 89.21  E-value: 2.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2173616055 210 DRAAYLPELLNLVHLDALPRPCVQQLLATEPLIQ 243
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 3.67e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 89.33  E-value: 3.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18335    82 CLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 129-219 4.66e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 87.73  E-value: 4.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18458     1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                          90
                  ....*....|.
gi 2173616055 209 QDRAAYLPELL 219
Cdd:cd18458    81 ENRRQYLEALL 91
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-135 2.93e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 87.16  E-value: 2.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18264    10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYT 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18264    90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 130-252 5.78e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 85.89  E-value: 5.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055 210 DRAAYLPELLNLVHLDALPRPCVQQLLATEPLIQESEACQEAL 252
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 123
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 9.60e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 84.98  E-value: 9.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18287     5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTG 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2173616055  95 RLTIT---QSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18287    85 RLTLTdlkEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-126 1.44e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 84.60  E-value: 1.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18326     5 FPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18326    85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 130-230 1.48e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 83.90  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQ---QGLLGVAAKawaFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRH 206
Cdd:cd18457     1 LHPNNCLGIRQFAETmmcSSLVDAANK---YIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKY 77

                          90       100
                  ....*....|....*....|....
gi 2173616055 207 DPQDRAAYLPELLNLVHLdALPRP 230
Cdd:cd18457    78 DRENREEYLPELLSKVRL-PLLRP 100
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 131-224 2.54e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 83.23  E-value: 2.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 131 DATNCLGICEFGE--QQGLLGVAAKAWAFlrENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18468     1 TPSNCLGIWALAEalQCTELHNMAKAYAL--QNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDP 78

                          90
                  ....*....|....*.
gi 2173616055 209 QDRAAYLPELLNLVHL 224
Cdd:cd18468    79 KNRKQHIAELLAVVRL 94
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 130-252 3.12e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 83.93  E-value: 3.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055 210 DRAAYLPELLNLVHLDALPRPCVQQLLATEPLIQESEACQEAL 252
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYL 123
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-127 3.26e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 83.38  E-value: 3.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18198     6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAY 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18198    86 TATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 132-219 4.19e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 82.36  E-value: 4.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 132 ATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDR 211
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                  ....*...
gi 2173616055 212 AAYLPELL 219
Cdd:cd18455    82 KVHLKDLM 89
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-130 5.99e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 82.95  E-value: 5.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18194     4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMY 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18194    84 EGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-135 6.93e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 82.76  E-value: 6.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  26 LRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEA 105
Cdd:cd18240    11 LRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEE 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 2173616055 106 LTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18240    91 LLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-211 2.34e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 79.67  E-value: 2.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                  ..
gi 2173616055 210 DR 211
Cdd:cd18480    81 AR 82
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 129-237 3.77e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 79.96  E-value: 3.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....*....
gi 2173616055 209 QDRAAYLPELLNLVHLDALPrpcvQQLLA 237
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLP----PQLLA 105
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-141 5.87e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 80.32  E-value: 5.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGL--QRLRSLpkLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18266     8 HSNLVLQGLneQRQRGL--FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLY 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGICEF 141
Cdd:cd18266    86 SSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQEL 134
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 130-237 9.01e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 78.91  E-value: 9.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|....*...
gi 2173616055 210 DRAAYLPELLNLVHLDALPrpcvQQLLA 237
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLP----PQLLA 105
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-122 2.19e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 78.38  E-value: 2.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18328     5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18328    85 YTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 130-227 2.22e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 77.68  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*...
gi 2173616055 210 DRAAYLPELLNLVHLDAL 227
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLL 98
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 129-227 2.57e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 77.80  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90
                  ....*....|....*....
gi 2173616055 209 QDRAAYLPELLNLVHLDAL 227
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLL 99
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 129-224 2.69e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*.
gi 2173616055 209 QDRAAYLPELLNLVHL 224
Cdd:cd18448    81 QHRKRHLDDLLSQVRL 96
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-224 2.73e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 77.46  E-value: 2.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90
                  ....*....|....*
gi 2173616055 210 DRAAYLPELLNLVHL 224
Cdd:cd18485    81 SRVQHLVELLKQVRL 95
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-135 3.50e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 77.92  E-value: 3.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  10 FHLPSHAQDMLEGLQRLRSLPKLADVTLLVGD--QELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQL 87
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18239    81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-127 4.61e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 77.58  E-value: 4.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARV-------ELRDVEPAAVG 85
Cdd:cd18327     6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  86 QLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18327    86 ALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 129-206 7.20e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 75.51  E-value: 7.20e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRH 206
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-122 9.31e-17

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 75.84  E-value: 9.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  33 ADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASR 112
Cdd:cd18314     7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASK 86

                          90
                  ....*....|
gi 2173616055 113 LHFPTVQKVC 122
Cdd:cd18314    87 YQVPDLEKLC 96
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-136 2.00e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 76.16  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18261    10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCL 136
Cdd:cd18261    90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-134 3.03e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 75.16  E-value: 3.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVG----DQELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18281    22 LSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                          90       100
                  ....*....|....*....|....*..
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18281   101 YTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-135 3.35e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 75.28  E-value: 3.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  24 QRLRSLpkLADVTLLVGD---QELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRD------VEPAAVGQLVDFVYTG 94
Cdd:cd18241    17 QRKQGL--FCDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTG 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18241    95 RIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 129-224 4.10e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 74.00  E-value: 4.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQ---QGLLGVAAKawaFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVR 205
Cdd:cd18459     1 QLDPSNCLGIRAFADThacRELLRIADK---FTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVK 77

                          90
                  ....*....|....*....
gi 2173616055 206 HDPQDRAAYLPELLNLVHL 224
Cdd:cd18459    78 YNIQERRPHLPQVLQHVRL 96
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-134 5.65e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 74.47  E-value: 5.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18251     5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18251    85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-129 6.00e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 74.46  E-value: 6.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSA-RVELRDVEPAAVGQLVDFV 91
Cdd:cd18956     4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTvRLNGDIVTAPAFGRLLDFM 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQ 129
Cdd:cd18956    84 YEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-127 9.14e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 74.09  E-value: 9.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHaMFagdfaesFSARVELRD--------VEPAAV 84
Cdd:cd18323     4 PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MF-------YKEQLDKRDlvcinneiVTAPAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2173616055  85 GQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18323    76 SLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQ 118
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-219 9.27e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 72.97  E-value: 9.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|
gi 2173616055 210 DRAAYLPELL 219
Cdd:cd18483    81 KREMHLPEIF 90
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 133-228 1.36e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 72.31  E-value: 1.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 133 TNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRA 212
Cdd:cd18515     3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                          90
                  ....*....|....*.
gi 2173616055 213 AYLPELLNLVHLDALP 228
Cdd:cd18515    83 CYLSELLQTVRLALLP 98
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-137 1.63e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 73.08  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  17 QDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSAR---VELRDVEPAAVGQLVDFVYT 93
Cdd:cd18258     2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLG 137
Cdd:cd18258    82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 2.58e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 72.20  E-value: 2.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTS 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18332    82 RLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 3.57e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 72.15  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAesfSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPS---LQRVELNDISPLGLATVITYAYTG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCL 136
Cdd:cd18260    78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 130-224 3.64e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 71.37  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*
gi 2173616055 210 DRAAYLPELLNLVHL 224
Cdd:cd18460    81 HRQHFWPELLQHVRL 95
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 4.00e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 71.83  E-value: 4.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTS 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRY 125
Cdd:cd18215    82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-127 5.82e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 71.22  E-value: 5.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  19 MLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFS--ARVELRDVEPAAVGQLVDFVYTGRL 96
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGstYKIELEGISVEVMEEILDYIYTGQI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  97 TITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-134 1.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 70.80  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  31 KLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSA 110
Cdd:cd18343    20 RFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAA 99

                          90       100
                  ....*....|....*....|....
gi 2173616055 111 SRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18343   100 DKYALERLKVMCEEALCNNLSVEN 123
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 130-225 1.51e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 69.76  E-value: 1.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90
                  ....*....|....*.
gi 2173616055 210 DRAAYLPELLNLVHLD 225
Cdd:cd18462    81 KRIECAYDLLSSIKLD 96
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 130-228 3.13e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 68.72  E-value: 3.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 2173616055 210 DRAAYLPELLNLVHLDALP 228
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 133-228 4.90e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 67.91  E-value: 4.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 133 TNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRA 212
Cdd:cd18464     3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                          90
                  ....*....|....*.
gi 2173616055 213 AYLPELLNLVHLDALP 228
Cdd:cd18464    83 EVLPELLRSVRLALLP 98
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-126 5.22e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 68.43  E-value: 5.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  16 AQDMLeglqRLRSLPKLADVTLLVGD--QELPCHRSLLALNSPYFHAMFAGDFA-ESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18294     2 AADMK----SLINNPEFSDVKFLVGPerQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIY 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18294    78 TNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 130-208 5.75e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 67.25  E-value: 5.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQE-DEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 16-94 8.39e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 68.05  E-value: 8.39e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2173616055  16 AQDMLEGLQRlrslPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18286     5 GKDLLQLFLN----GEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGG 79
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 9.27e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 67.96  E-value: 9.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18331     7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTS 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18331    87 RLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-130 1.17e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 67.42  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGD----QELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18282     7 MADVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFYGGLAEN-KNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATL 85

                          90       100
                  ....*....|....*....|...
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18282    86 YAAKKYLVPHLARACVQFLETSL 108
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 131-207 1.25e-13

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 66.28  E-value: 1.25e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055 131 DATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHD 207
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 129-222 1.28e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 67.00  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 129 QLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....
gi 2173616055 209 QDRAAYLPELLNLV 222
Cdd:cd18447    81 PNRQPYMVDILAKV 94
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 133-228 1.49e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 66.70  E-value: 1.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 133 TNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRA 212
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*.
gi 2173616055 213 AYLPELLNLVHLDALP 228
Cdd:cd18516    84 KALPVLLESIRFRLMP 99
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-95 1.97e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 67.17  E-value: 1.97e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055  31 KLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGR 95
Cdd:cd18279    17 RFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 81
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-113 2.64e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 65.38  E-value: 2.64e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2173616055  35 VTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRL 113
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-131 3.83e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 66.16  E-value: 3.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  29 LPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSAR-----VELRDVEPAAVGQLVDFVYTGRLTITQSNV 103
Cdd:cd18296    14 ELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENA 93

                          90       100
                  ....*....|....*....|....*...
gi 2173616055 104 EALTRSASRLHFPTVQKVCGRYLQQQLD 131
Cdd:cd18296    94 YDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-122 4.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 65.93  E-value: 4.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAmfagdFAESFSARVELRD---VEPAAVGQLVDFV 91
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGA-----QYKDTEDNIVFLDqsqVSADGFQKLLEFI 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18217    76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 4.19e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 65.55  E-value: 4.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGdfaeSFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGD----GTSGSVVLPESFAEVFGLLLDFFYTG 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRY 125
Cdd:cd18232    77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-130 5.70e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 65.39  E-value: 5.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVG----DQELPCHRSLLALNSPYFHAMFAGDFAESFSaRVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18349     8 MADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATL 86

                          90       100
                  ....*....|....*....|...
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18349    87 YAAKKYIVPALAKACVNFLETSL 109
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 130-204 5.90e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 64.33  E-value: 5.90e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWV 204
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-130 6.41e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 65.83  E-value: 6.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18325     3 FPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFM 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVC-GRYLQQQL 130
Cdd:cd18325    83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVCkGKLKDKEL 122
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-129 6.93e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 66.21  E-value: 6.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18324     3 FPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFM 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQ 129
Cdd:cd18324    83 YEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-114 9.83e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 63.72  E-value: 9.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFaGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSAS 111
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                  ...
gi 2173616055 112 RLH 114
Cdd:cd18315    80 LLQ 82
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 130-228 1.06e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 64.09  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*....
gi 2173616055 210 DRAAYLPELLNLVHLDALP 228
Cdd:cd18477    81 NRQKALPTVFESIRFRLLP 99
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 1.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 64.88  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSAR-------VELRDVEPAAVGQ 86
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcvLDLHHVTVTGFAP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2173616055  87 LVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18228    81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-135 1.34e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 65.36  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   7 DLDFHLPS-HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVG 85
Cdd:cd18244     4 DVEVYNSSiHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFS 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2173616055  86 QLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18244    84 HVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 1.43e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 64.99  E-value: 1.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  10 FHLPSHAQDMLEGL-QRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSAR-VELRDVEPAAVGQL 87
Cdd:cd18207     4 YQVSQHSADMLHNLnQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGDI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18207    84 LDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-134 1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 64.71  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGD----QELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18347    22 LSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                          90       100
                  ....*....|....*....|....*..
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18347   101 YTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-134 1.66e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 64.69  E-value: 1.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGD----------QELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTGRLTITQS 101
Cdd:cd18346    22 LSDVRFVVGKgrprgpgpgaQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 100

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2173616055 102 NVEALTRSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18346   101 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-95 1.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 64.48  E-value: 1.73e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055  31 KLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGR 95
Cdd:cd18345    17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-130 2.41e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 63.41  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSN-VEALTR 108
Cdd:cd18300     7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIV 86

                          90       100
                  ....*....|....*....|..
gi 2173616055 109 SASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18300    87 LANRLCLPRLVALCEQYIVKEL 108
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 130-224 2.61e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 63.22  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSrLEALLRWVRHDPQ 209
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQV-FETLMVWIRHDPK 79

                          90
                  ....*....|....*
gi 2173616055 210 DRAAYLPELLNLVHL 224
Cdd:cd18476    80 ARKGYIHDLFKKVRL 94
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 3.32e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 64.15  E-value: 3.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKL-ADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18272    13 SHSSRVAQSIMDLCLEDGLfADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIY 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18272    93 HGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-134 3.38e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 63.58  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  31 KLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSA 110
Cdd:cd18342    21 RFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAA 100

                          90       100
                  ....*....|....*....|....
gi 2173616055 111 SRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18342   101 DKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 4.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 63.16  E-value: 4.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAG----DFAESFSARVELRDVEPaavgqLVDF 90
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGqadaELNITLPEEVTVKGFEP-----LIQF 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18277    85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 130-228 4.12e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 62.48  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*....
gi 2173616055 210 DRAAYLPELLNLVHLDALP 228
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLMP 99
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 130-227 6.30e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 62.49  E-value: 6.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90
                  ....*....|....*...
gi 2173616055 210 DRAAYLPELLNLVHLDAL 227
Cdd:cd18446    81 ERLPLLPRVLENVRLPLL 98
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 130-208 6.67e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 61.37  E-value: 6.67e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 131-185 1.04e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 59.98  E-value: 1.04e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 131 DATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLAS 185
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-101 2.35e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 61.58  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFsarvEL-RDVEPAAVGQ 86
Cdd:cd18289     5 LHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAF----ELpATVPPACFQQ 80

                          90
                  ....*....|....*
gi 2173616055  87 LVDFVYTGRLTITQS 101
Cdd:cd18289    81 ILSFCYTGKLTMAAS 95
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-128 2.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 61.14  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVelrdVEPAAVGQLVDFV 91
Cdd:cd18334     1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDM----VNPTVFRQILDFI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  92 YTGRLTIT----QSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18334    77 YTGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-134 2.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 61.60  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   1 MVRNVDDLDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDfaesfsaRVELRDVE 80
Cdd:cd18243     1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCS 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2173616055  81 PAAVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18243    74 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-126 3.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 59.79  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFA----GDFAESFSARVELRDVEPaavgqLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18955     1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVC 75

                          90
                  ....*....|....*....
gi 2173616055 108 RSASRLHFPTVQKVCGRYL 126
Cdd:cd18955    76 RCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-122 4.82e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 59.94  E-value: 4.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   9 DFhlPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFagdfaesfsarVELRDV------EPA 82
Cdd:cd18206     1 DF--PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF-----------VDQKDVvhldisNAA 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  83 AVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18206    68 GLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 130-229 5.69e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 59.63  E-value: 5.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90       100
                  ....*....|....*....|
gi 2173616055 210 DRAAYLPELLNLVHLDALPR 229
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLSR 100
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-134 9.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 59.65  E-value: 9.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVG----DQELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALT 107
Cdd:cd18348    21 MADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATL 99

                          90       100
                  ....*....|....*....|....*..
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18348   100 YAAKKYIVPHLARACVNFLETSLSAKN 126
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-126 9.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 59.68  E-value: 9.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRD--VEPAAVGQLVD 89
Cdd:cd18196     1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALID 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2173616055  90 FVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-125 9.92e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 59.22  E-value: 9.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  16 AQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGD-FAESFSARVELR-DVEPAAV-GQLVDFVY 92
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELVeDPECAAVfEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRY 125
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-119 1.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 59.52  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGL--QRLRSLpkLADVTLLVGDQELPCHRSLLALNSPYFH------------AMFAGDFAESFSARV-ELRDV 79
Cdd:cd18195     1 HAGALLLQLneQRLRGL--FCDVTLIAGDTKFRAHRSVLAASSPYFRellssplplgaaAVAAAPGATQSPERVlELPGV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  80 EPAAVGQLVDFVYTGRLTITQSN-VEALTRSASRLHFPTVQ 119
Cdd:cd18195    79 KAGVFSDVLNFIYSSRVALPGSAaAKELGAAGKRLGIPFLQ 119
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-125 1.43e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 58.28  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDF---AESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSA 110
Cdd:cd18307     3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDmkaTDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGA 82

                          90
                  ....*....|....*
gi 2173616055 111 SRLHFPTVQKVCGRY 125
Cdd:cd18307    83 KYFNIPRLKDHCVDF 97
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 130-206 1.47e-10

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 57.36  E-value: 1.47e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRH 206
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-134 1.96e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 58.81  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEA--LT 107
Cdd:cd18344    21 SLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHLHSHSMAcdVL 100

                          90       100
                  ....*....|....*....|....*..
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18344   101 AAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-225 2.18e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 57.76  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*.
gi 2173616055 210 DRAAYLPELLNLVHLD 225
Cdd:cd18479    81 SRSQYLSSVLSQIRID 96
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-136 2.63e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 57.90  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRL 113
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                          90       100
                  ....*....|....*....|...
gi 2173616055 114 HFPTVQKVCGRYLQQQLDATNCL 136
Cdd:cd18263    95 QISGALALCLDFLQREISPARCL 117
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-106 3.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 57.58  E-value: 3.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSArVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIYSS 79

                          90
                  ....*....|..
gi 2173616055  95 RLTITQSNVEAL 106
Cdd:cd18209    80 SLFVEKSSLAAV 91
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 34-112 5.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 55.98  E-value: 5.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRD--VEPAAVGQLVDFVYTGRLTIT-QSNVEALTRSA 110
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRLDLFsVENVHEVLELA 80


                  ..
gi 2173616055 111 SR 112
Cdd:cd18190    81 SK 82
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 130-217 6.29e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 56.12  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*...
gi 2173616055 210 DRAAYLPE 217
Cdd:cd18451    81 ERERYFEE 88
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-128 7.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 56.41  E-value: 7.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  16 AQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAEsfsarVELRDVEPA-AVGQLVDFVYTG 94
Cdd:cd18229     2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSE-----IEVPPVVPAqTVRQLVEFMYSG 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18229    77 SLVVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 8.51e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 56.88  E-value: 8.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAG----DFAESFSARVELRDVEPaavgqLVDF 90
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGqtenDLVVSLPEEVTARGFGP-----LLQF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18278    89 AYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-122 1.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 56.01  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFA-ESFSARVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAvSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                          90       100
                  ....*....|....*....|....*....
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18202    82 SELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 1.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 55.99  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  11 HLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMF---AGDFAESFSARVelrdVEPAAVGQL 87
Cdd:cd18224     5 HSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFlstELDVARTYVVDF----ITPANFEKV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18224    81 LSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-125 1.65e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 55.96  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  11 HLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFA--GDFAESFSArveLRDVEPAAVGQLV 88
Cdd:cd18212     2 HSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAdeGEVGQSIYM---LEGMVAETFGALL 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2173616055  89 DFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRY 125
Cdd:cd18212    79 EFIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-96 1.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.80  E-value: 1.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2173616055  33 ADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRL 96
Cdd:cd18280    15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL 78
PHA02790 PHA02790
Kelch-like protein; Provisional
 49-486 2.16e-09

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 60.06  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  49 SLLALNSPYFHAMFAGDFAESFS--ARVELrDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:PHA02790   38 TILKKLSPYFRTHLRQKYTKNKDpvTRVCL-DLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 127 QQQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQE--DEFLQLprdRLATCLASDLLQVQPEQSRLEALLRWV 204
Cdd:PHA02790  117 LRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYL---SMKLILESDELNVPDEDYVVDFVIKWY 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 205 RHDPQD------------RAAYL-PELLN----------LVHLDALPR-----PCVQQLLATEPLIQESEACQEAlsqgh 256
Cdd:PHA02790  194 MKRRNRlgnlllliknviRSNYLsPRGINnvkwildctkIFHCDKQPRksykyPFIEYPMNMDQIIDIFHMCTST----- 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 257 saeppglpqKMQEVLVVVGGraleedeegGEEPSPHTGNFAFyNTKARQWMALP--DFPDYHKWGfslATLNSDVYVTGG 334
Cdd:PHA02790  269 ---------HVGEVVYLIGG---------WMNNEIHNNAIAV-NYISNNWIPIPpmNSPRLYASG---VPANNKLYVVGG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 335 -SRGTKTDTWSTtqawcfplKEAVWKPVAPMLKARTNHASTALNGEIYAIGGTALDAVEVERYDPYTDSWApVRPALKYV 413
Cdd:PHA02790  327 lPNPTSVERWFH--------GDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDTTTEYLLPNHDQWQ-FGPSTYYP 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2173616055 414 SNFSAASCQG-RLYLVGSSAckynmlalQCYSPVTDVWSVIASPFLPKylSSPRCAALNGALYLIGDNTKKVYV 486
Cdd:PHA02790  398 HYKSCALVFGrRLFLVGRNA--------EFYCESSNTWTLIDDPIYPR--DNPELIIVDNKLLLIGGFYRGSYI 461
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-123 2.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 55.18  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  19 MLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGD-FAESFSARVELRDVEPAAVGQLVDFVYTGRLT 97
Cdd:cd18293     2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEpPPAGQKVVLELQGLKAHTLLKLVDFLYTSELE 81

                          90       100
                  ....*....|....*....|....*.
gi 2173616055  98 ITQSNVEALTRSASRLHFPTVQKVCG 123
Cdd:cd18293    82 VSSEEAQDVLAAARRLQISELESLCL 107
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 2.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 55.63  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQ----ELPCHRSLLALNSPYFHAMFAGD-FAESFSARVELRDVEPAAVGQLV 88
Cdd:cd18211     7 SAPSNLLNEMHKLRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2173616055  89 DFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18211    87 EFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-121 3.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 55.04  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGL--QRLRSLpkLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGdfaeSFSARVEL-RDVEPAAV 84
Cdd:cd18290     3 LQMEIPNFGNSILECLneQRLQGL--YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2173616055  85 GQLVDFVYTGRLTITQSNVEALTRSASrlhFPTVQKV 121
Cdd:cd18290    77 QQILSFCYTGRLSMNVGDQFLLMYTAG---FLQIQEI 110
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-128 3.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 54.86  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFH-AMFAGDfaesfSARVELRDV-EPAAVGQLVDFVY 92
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLND-----TNCLVLPSViEAAAFENLLQLIY 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18200    76 SGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 3.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 54.51  E-value: 3.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSA-RVELRDVepAAVGQLVDFVYT 93
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVfHLDIKNV--GGIGQILDFMYT 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18233    79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 130-206 3.71e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 54.24  E-value: 3.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2173616055 130 LDATNCLGICEFGEQ-QGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVqPEQSRLEALLRWVRH 206
Cdd:cd18489     1 LSLDTLVGILRWSSQpHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEH 77
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-105 7.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 53.85  E-value: 7.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAgDFAEsfSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ-DFTQ--EPLVEIEGVSNMAFRHLIEFTYTA 77

                          90
                  ....*....|.
gi 2173616055  95 RLTItQSNVEA 105
Cdd:cd18221    78 KLMV-QGEEEA 87
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-133 7.67e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.79  E-value: 7.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  21 EGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQ 100
Cdd:cd18295     8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHV 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2173616055 101 SNVEALTRSAsrlhfptvqKVCG-RYLQQQLDAT 133
Cdd:cd18295    88 DDVEDCKRLA---------KQCRlEELIEELEAK 112
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 134-220 8.36e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 53.34  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 134 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDpQDRAA 213
Cdd:cd18470     5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83


                  ....*..
gi 2173616055 214 YLPELLN 220
Cdd:cd18470    84 YAADLLS 90
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-130 8.83e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 53.64  E-value: 8.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRS 109
Cdd:cd18352    11 ATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRA 90

                          90       100
                  ....*....|....*....|.
gi 2173616055 110 ASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18352    91 ADQYLLEGLKRLCEYTIAQDL 111
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 130-228 1.44e-08

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 52.48  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQ 209
Cdd:cd18466     1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                          90
                  ....*....|....*....
gi 2173616055 210 DRAAYLPELLNLVHLDALP 228
Cdd:cd18466    81 KRKKHVVEVLEPVRFPLLP 99
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-138 2.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 52.10  E-value: 2.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFaesfsarVELRDVEPAAVGQLVDFVYTGRLTITQSNVEALTRSASRL 113
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|....*
gi 2173616055 114 HFPTVQKVCGRYLQQQLDATNCLGI 138
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 2.60e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 52.34  E-value: 2.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVelrDVEPAAVGQL 87
Cdd:cd18220     1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISV---IKNPNVFEQL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18220    78 LSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-122 2.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 52.23  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  24 QRLRSlPKLADVTLLVGDQE--LPCHRSLLALNSPYFHAMFAGDfaeSFSARVE--LRDVEPAAVGQLVDFVYTGRLTIT 99
Cdd:cd18231     7 QRLFQ-PDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQN---KQLQRVElsLEALTSQGLQQILNFIYTSKLLVN 82

                          90       100
                  ....*....|....*....|...
gi 2173616055 100 QSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18231    83 SCNVQDVLNAAAVLQMNDIAASC 105
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-134 3.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 51.89  E-value: 3.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVePAAVGQLV-DFVYTGR---LTITQSNVEA 105
Cdd:cd18297    10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDI-RYDIFQLMmQYLYTGGvesLDVAQDDALE 88

                          90       100
                  ....*....|....*....|....*....
gi 2173616055 106 LTRSASRLHFPTVQKVCGRYLQQQLDATN 134
Cdd:cd18297    89 LLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 3.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 51.99  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  11 HLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAEsfsarVELRDV-EPAAVGQLVD 89
Cdd:cd18208     4 NLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSVvSVQSVQKLID 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2173616055  90 FVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18208    79 FMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-122 3.28e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 52.13  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDV-EPAAVGQLVDFVY 92
Cdd:cd18329     3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVY 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 2173616055  93 TGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18329    83 SGKLSLTSQNVIEVMSAASYLQMTDVISVC 112
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-128 3.69e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 51.83  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVelrdVEPAAVGQLVDFV 91
Cdd:cd18333     1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEM----VSPGIFRLILDYI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  92 YTGRLT----ITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18333    77 YTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-131 8.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 51.21  E-value: 8.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPA-AVGQLVDF 90
Cdd:cd18230     1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAqGFKAIIDF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLD 131
Cdd:cd18230    81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 9.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 50.81  E-value: 9.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVeLRDvePAAVGQL 87
Cdd:cd18222     1 IQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISV-IKN--PTVFEQL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18222    78 LSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-128 9.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 50.61  E-value: 9.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVelrdVEPAAVGQLVDFVY 92
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDM----VSPTVFQQILDFIY 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2173616055  93 TGRL---TITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18216    77 TGKLldsLFEEPNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 1.82e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 49.73  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAM---FAGDFAESFSARVELrdVEPAAVGQLVDFV 91
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLlshYIQDTGRPSTASFDV--FSSDAFSIILDFV 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18199    79 YSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 134-208 3.04e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 48.57  E-value: 3.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055 134 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 130-222 4.25e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 48.27  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEA-VAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDP 208
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                          90
                  ....*....|....
gi 2173616055 209 QDRAAYLPELLNLV 222
Cdd:cd18482    81 KERAASAAEVLKCV 94
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 4.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 48.78  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSArveLRDVEPAAVGQLVDFVYTG 94
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCL---GEGISPSTFKQLLDFVYGE 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18218    78 SVEVQPGELRPLLEAARALEVESLEEACWRAL 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 367-408 6.43e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.07  E-value: 6.43e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2173616055 367 ARTNHASTALNGEIYAIGG----TALDavEVERYDPYTDSWAPVRP 408
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLN--SVEVYDPETNTWSKLPS 44
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-122 8.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 47.90  E-value: 8.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVelrdVEPAAVGQLVDFV 91
Cdd:cd18225     3 LPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFALLLEMV 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18225    79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSC 109
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 135-212 8.41e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 47.60  E-value: 8.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2173616055 135 CLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDLLQVQPEQSRLEALLRWVRHDPQDRA 212
Cdd:cd18465     6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRA 83
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-130 9.35e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 48.04  E-value: 9.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTITQS-NVEALTRSA 110
Cdd:cd18358    20 FSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADlDPLELIALA 99

                          90       100
                  ....*....|....*....|
gi 2173616055 111 SRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18358   100 NRFCLPHLVALTEQHAVQEL 119
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-83 1.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 47.11  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2173616055  33 ADVTLLVGDQE-LPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAA 83
Cdd:cd18191     2 HDLRFLLDGGTqLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGA 53
PRK14131 PRK14131
N-acetylneuraminate epimerase;
308-429 2.02e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.40  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 308 ALPDFPDYHKWGFSlATLNSDVYVTGGSRGTKtdtWST--TQAwcfplKEAVWKPVAPMLKARTNHA-STALNGEIYAIG 384
Cdd:PRK14131   21 QLPDLPVPFKNGTG-AIDNNTVYVGLGSAGTS---WYKldLNA-----PSKGWTKIAAFPGGPREQAvAAFIDGKLYVFG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2173616055 385 G----------TALDavEVERYDPYTDSWA--PVRPALKYVSNFSAASCQGRLYLVG 429
Cdd:PRK14131   92 GigktnsegspQVFD--DVYKYDPKTNSWQklDTRSPVGLAGHVAVSLHNGKAYITG 146
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-122 2.60e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 46.59  E-value: 2.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  28 SLPKLADVTLLVGD-QELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQ-LVDFVYTGR-LTITQS-NV 103
Cdd:cd18302     1 KHSDLYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSWIEA-SSCSALTMPIPSDILEiILDYLYTDEaSAVKESqNV 79

                          90       100
                  ....*....|....*....|..
gi 2173616055 104 EALTR---SASRLHFPTVQKVC 122
Cdd:cd18302    80 EFLCNvlvIADQLLITRLKEIC 101
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-127 2.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 46.47  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYfhamFAGDFAESFSARVELRDV-EPAAVGQLVDF 90
Cdd:cd18227     5 FPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDVmNPRVFENILLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQ 127
Cdd:cd18227    81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-98 4.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 45.99  E-value: 4.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFagdFAESFSARVELRDVEPAAVGQLVDFVY 92
Cdd:cd18210     2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQV---LLKNMSSISLPGVMDPGAFESVLASAY 78


                  ....*.
gi 2173616055  93 TGRLTI 98
Cdd:cd18210    79 TGKLTM 84
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 15-118 4.65e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 45.28  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSpyfhAMFAGDFAESFSARVELR-DVEPAAVGQLVDFVYT 93
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVS----SLFRERLLGSNGPLPPLSlEVTPVGWEAVLTFAYT 76

                          90       100
                  ....*....|....*....|....*
gi 2173616055  94 GRLTITQSNVEALTRSASRLHFPTV 118
Cdd:cd18262    77 GVLGRNPATVGDILVAAEALGAPRV 101
PHA02713 PHA02713
hypothetical protein; Provisional
 8-518 5.66e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 49.24  E-value: 5.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGD-QELPCHRSLLALNSPYFHAMFAGDF-AESFSARVELRDVEPAAVG 85
Cdd:PHA02713    1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  86 QLVDFVYTGRltITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAV 165
Cdd:PHA02713   81 NIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 166 AQEDEF----LQLPRDRLATclaSDLLQVQPEQSRLEALLRWVRHD--PQDRAAYLPELLNLVHLDALPRpcvqQLLATE 239
Cdd:PHA02713  159 ITTDAFkktvFEILFDIIST---NDNVYLYREGYKVTILLKWLEYNyiTEEQLLCILSCIDIQNLDKKSR----LLLYSN 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 240 PLIQESEACQEAL---SQGHSAEPpglpqkMQEVLVVvggraleedeeggeepspHTGNFAF-------YNTKARQWMAL 309
Cdd:PHA02713  232 KTINMYPSCIQFLldnKQNRNIIP------RQLCLVC------------------HDTKYNVcnpcilvYNINTMEYSVI 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 310 PDFPDyHKWGFSLATLNSDVYVTGgsrGTKTDTWSTTQAWCFPLKEAVWKPVAPMLKARTNHASTALNGEIYAIGGTALD 389
Cdd:PHA02713  288 STIPN-HIINYASAIVDNEIIIAG---GYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGT 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 390 AVE--VERYDPYTDSWAPVRPALKYVSNFSAASCQGRLYLVGSSACKYNmlalqcYSPVTDVWSViaspflpkylssprc 467
Cdd:PHA02713  364 NVErtIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID------YTSVHHMNSI--------------- 422

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2173616055 468 aalngALYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDLLYV 518
Cdd:PHA02713  423 -----DMEEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYV 468
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-126 7.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 45.30  E-value: 7.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  24 QRLRSLpkLADVTLLVGDQELPCHRSLLALNSPYFHAM---FAGDFAESFSARVELrdVEPAAVGQLVDFVYTGRLTITQ 100
Cdd:cd18330    12 QRKRDF--FCDCSIIVEGRIFKAHRNILFANSGYFRALlihYIQDSGRHSTASLDI--VTSEAFSIILDFLYSGKLDLCS 87

                          90       100
                  ....*....|....*....|....*.
gi 2173616055 101 SNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18330    88 ENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-96 7.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 45.59  E-value: 7.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHamfaGDFAESFSARVELRDVEPAAVG-Q 86
Cdd:cd18214     1 LHFRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLR----DQFLLNDSREVQISILQNSEVGrQ 76

                          90
                  ....*....|
gi 2173616055  87 LVDFVYTGRL 96
Cdd:cd18214    77 LLLSCYTGVL 86
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-121 9.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.78  E-value: 9.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSS 80

                          90       100
                  ....*....|....*....|....*...
gi 2173616055  95 RLTITQSN-VEALTRSASRLHFPTVQKV 121
Cdd:cd18223    81 KVVVKRQEtVTDLVAAGKKLGITFLENL 108
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-120 1.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 44.98  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  12 LPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAEsfSARVELRDVEPAAVGQLVDFV 91
Cdd:cd18193     1 LANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSE--CVRLKPTDIQPDIFSYLLHLM 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 2173616055  92 YTGRLTITQSNVEALTRSASRLH-FPTVQK 120
Cdd:cd18193    79 YTGKMAPQLIDPVRLEQGIKFLHaYPLIQE 108
Kelch smart00612
Kelch domain;
329-378 1.35e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.35e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2173616055  329 VYVTGGSRGTKtdtwSTTQAWCFPLKEAVWKPVAPMLKARTNHASTALNG 378
Cdd:smart00612   2 IYVVGGFDGGQ----RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-94 1.47e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 43.82  E-value: 1.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2173616055  34 DVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSA----RVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTD 84
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 149-207 2.33e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 43.73  E-value: 2.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 149 GVAAKAWAFLRENFEAVAQEDEFLQ-LPRDRLATCLASDLLQVQPEQSRLEALLRWVRHD 207
Cdd:cd18454    22 GVREKLDSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHD 81
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-131 3.82e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 43.41  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAV---GQLVDF 90
Cdd:cd18201     3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKES-CDQTTVTHLDVVAVqgfSVILDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQQLD 131
Cdd:cd18201    82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 17-98 3.85e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 43.53  E-value: 3.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  17 QDMLEGLQRLRslPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPA--AVGQLVDFVYTG 94
Cdd:cd18309     7 QDMEAFLESVG--GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSrqAFDSLLRYIYYG 84


                  ....
gi 2173616055  95 RLTI 98
Cdd:cd18309    85 DVTM 88
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-95 3.88e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 43.34  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  14 SHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFsaRVELRDVEPAAVGQLVDFVYT 93
Cdd:cd18213     3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECI--KIQPTDIQPDIFSYLLHIMYT 80


                  ..
gi 2173616055  94 GR 95
Cdd:cd18213    81 GK 82
Kelch smart00612
Kelch domain;
380-423 3.90e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 3.90e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2173616055  380 IYAIGG----TALDAVEVerYDPYTDSWAPVrPALKYV-SNFSAASCQG 423
Cdd:smart00612   2 IYVVGGfdggQRLKSVEV--YDPETNKWTPL-PSMPTPrSGHGVAVING 47
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-128 4.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 43.33  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFsaRVELRDvEPAAVGQL 87
Cdd:cd18203     1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSEL--QVSLMH-SSRVVADL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2173616055  88 VDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVCGRYLQQ 128
Cdd:cd18203    78 LLSCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 4.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 42.71  E-value: 4.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDfaesfSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTA 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18205    76 TLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-116 4.62e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 43.07  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  32 LADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTiTQSNVEA--LTRS 109
Cdd:cd18359    20 FSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFS-SSPDLDDmkLIIL 98


                  ....*..
gi 2173616055 110 ASRLHFP 116
Cdd:cd18359    99 ANRLCLP 105
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 130-224 7.66e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 41.84  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 130 LDATNCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAQEDEFLQLPRDRLATCLASDllqVQPEQSRLEAL----LRWVR 205
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESN---QELESINERKLcqlvLEWVQ 77

                          90
                  ....*....|....*....
gi 2173616055 206 HDPQDRAAYLPELLNLVHL 224
Cdd:cd18502    78 RSIEEGGLDLDDLTEKVHM 96
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-113 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 41.73  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  13 PSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDfaESFSARVELRD--VEPAAVGQLVDF 90
Cdd:cd18192     2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINH--QHTTAQLNLSNmkISAECFDLILQF 79

                          90       100
                  ....*....|....*....|...
gi 2173616055  91 VYTGRLTITQSNVEALTRSASRL 113
Cdd:cd18192    80 MYLGKIMTAPSDFEQLKVAMNYL 102
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-135 1.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 41.54  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAEsfsarVELRDVEPAAVGQLVDFVYTGRLTITQSNVEA--LT 107
Cdd:cd18303    16 ELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNE-----LDLSDISYEVVLALLRWLYTDELDLTLDDEFLleLM 90

                          90       100
                  ....*....|....*....|....*...
gi 2173616055 108 RSASRLHFPTVQKVCGRYLQQQLDATNC 135
Cdd:cd18303    91 KAAKRFQLTDLVERCERALMSSVNVDNC 118
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-126 1.56e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 41.04  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  21 EGLQRLRSLPKLADVTLLVGDQE-LPCHRSLLALNSPYFhamfagdfAESFSARVELR---DVEPAAVGQLVDFVYTGRL 96
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVF--------ADLFLMMTVVTldsDITPEAFRRVLEFLYTGVL 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 2173616055  97 TITQSNVEALTRSASRLHFPTVQKVCGRYL 126
Cdd:cd18299    73 DENEDDLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-96 1.67e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 41.91  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2173616055  32 LADVTLLVGD-QELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQ--------LVDFVYTGRL 96
Cdd:cd18310    18 YSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIvgydafmlVLSYLYSGRL 91
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-123 1.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 41.11  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  34 DVTLLVGDQELPCHRSLLAlNSPYFHAMFAGDFAESFSARVELRDVEP--------AAVGQLvdfvYTGRLTITQSNVEA 105
Cdd:cd18305    17 DITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDnitvealnVVFGSL----YRDEIEIKPSRVVS 91

                          90
                  ....*....|....*...
gi 2173616055 106 LTRSASRLHFPTVQKVCG 123
Cdd:cd18305    92 ILAAATLLQLDGLIQQCS 109
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-113 3.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.55  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  25 RLRsLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDfaeSFSARVELRDVEPAAVGQLVDFVYTGRLTITQSNVE 104
Cdd:cd18226    16 RQK-QSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKN---PNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIP 91


                  ....*....
gi 2173616055 105 ALTRSASRL 113
Cdd:cd18226    92 LVLEAAKFL 100
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-124 4.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 40.41  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESfSARVELRDVEPAAVGQLVDFVYTG 94
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRSDIFEEVLNYMYTA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 2173616055  95 RLTITQSNVEALTRSASRLHFPTVQKVCGR 124
Cdd:cd18204    80 KISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-113 5.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 39.81  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  15 HAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMF--AGDFaesfsarVELRDVEPAAVGQLVDFVY 92
Cdd:cd18219     4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFsvAGQV-------VELNFIRADIFAEILNYIY 76

                          90       100
                  ....*....|....*....|..
gi 2173616055  93 TGRLTITQSN-VEALTRSASRL 113
Cdd:cd18219    77 SSKIVRVRSDlLEELIKSGQLL 98
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-130 5.55e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 39.83  E-value: 5.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  23 LQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRL---TIT 99
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCcpaSIL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2173616055 100 QSnvEALTRSASRLHFPTVQKVCGRYLQQQL 130
Cdd:cd18360    81 QA--MALLICAEMYQVSRLQHICELYIITQL 109
PRK14131 PRK14131
N-acetylneuraminate epimerase;
450-521 9.99e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055 450 WSVIAS-PFLPKylSSPRCAALNGALYLIGDNTKK-----------VYVYDPGANLWQKV--QSQHSLHENGALVPLGDL 515
Cdd:PRK14131   64 WTKIAAfPGGPR--EQAVAAFIDGKLYVFGGIGKTnsegspqvfddVYKYDPKTNSWQKLdtRSPVGLAGHVAVSLHNGK 141


                  ....*.
gi 2173616055 516 LYVTGG 521
Cdd:PRK14131  142 AYITGG 147
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 23-113 3.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 37.56  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055  23 LQRLRSLPK---LADVTL-LVGDQELPCHRSLLALNSPYFhAMFAGDFAESFSARVELRDVEPAAVGQLVDFVYTGRLTI 98
Cdd:cd18311     2 LQRLQNLFNkteYCDLTLqFRDNEQLKVHRLVLSACTDYF-NVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEF 80

                          90
                  ....*....|....*
gi 2173616055  99 TQSNVEALTRSASRL 113
Cdd:cd18311    81 EEKSYGKLLRTAKEL 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 319-364 4.52e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 4.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2173616055 319 GFSLATLNSDVYVTGGSRGTKtdtwSTTQAWCFPLKEAVWKPVAPM 364
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQ----SLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-122 7.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 36.77  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616055   8 LDFHLPSHAQDMLEGLQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAgdFAESFSARVELrdVEPAAVG-Q 86
Cdd:cd18197     1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITI--LQSAEVGrK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2173616055  87 LVDFVYTGRLTITQSNVEALTRSASRLHFPTVQKVC 122
Cdd:cd18197    77 LLLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKC 112
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-68 7.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 36.46  E-value: 7.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2173616055  30 PKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFAE 68
Cdd:cd18298    10 PRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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