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Conserved domains on  [gi|13786136|ref|NP_112607|]
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platelet-derived growth factor C precursor [Rattus norvegicus]

Protein Classification

CUB domain-containing protein( domain architecture ID 10035934)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 1.58e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 100.52  E-value: 1.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 326
Cdd:cd00135   1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                        90
                ....*....|....
gi 13786136 327 VALEHHEECDCVCR 340
Cdd:cd00135  73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 2.66e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 98.25  E-value: 2.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136  49 VVTISGNGSIHSPKFPHTYPRNTVLVWRLVaVDENVRIQLTFDErFGLEDPEDdlCKYDFVEVEE--PSDGSVLGRWCGS 126
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIE-APPGYRIRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 13786136 127 gTVPGKQTSKGNHIRIRFVSDEYFPSePGFCIHYSI 162
Cdd:cd00041  80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 1.58e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 100.52  E-value: 1.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 326
Cdd:cd00135   1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                        90
                ....*....|....
gi 13786136 327 VALEHHEECDCVCR 340
Cdd:cd00135  73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 2.66e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 98.25  E-value: 2.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136  49 VVTISGNGSIHSPKFPHTYPRNTVLVWRLVaVDENVRIQLTFDErFGLEDPEDdlCKYDFVEVEE--PSDGSVLGRWCGS 126
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIE-APPGYRIRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 13786136 127 gTVPGKQTSKGNHIRIRFVSDEYFPSePGFCIHYSI 162
Cdd:cd00041  80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 56-160 1.50e-22

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 90.53  E-value: 1.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136     56 GSIHSPKFPHTYPRNTVLVWRLVAvDENVRIQLTFDErFGLEDpeDDLCKYDFVEVEE--PSDGSVLGRWCGSGTVPGKQ 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRA-PPGYRIELQFTD-FDLES--SDNCEYDYVEIYDgpSASSPLLGRFCGSEAPPPVI 76

                           90       100
                   ....*....|....*....|....*..
gi 13786136    134 TSKGNHIRIRFVSDEYFPSEpGFCIHY 160
Cdd:smart00042  77 SSSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
55-148 1.13e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 85.81  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136    55 NGSIHSPKFPHTYPRNTVLVWRLVAvDENVRIQLTFDErFGLEDpeDDLCKYDFVEV--EEPSDGSVLGRWCGSGtVPGK 132
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRA-PPGFRVKLTFQD-FELED--HDECGYDYVEIrdGPSASSPLLGRFCGSG-IPED 83

                          90
                  ....*....|....*.
gi 13786136   133 QTSKGNHIRIRFVSDE 148
Cdd:pfam00431  84 IVSSSNQMTIKFVSDA 99
PDGF pfam00341
PDGF/VEGF domain;
250-337 4.03e-14

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 66.93  E-value: 4.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136   250 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVKGlhKSLTDVA 328
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 13786136   329 LEHHEECDC 337
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 250-337 1.32e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 54.35  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136    250 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPkigvkGLHKSLTDVA 328
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 13786136    329 LEHHEECDC 337
Cdd:smart00141  73 FEEHTKCEC 81
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 1.58e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 100.52  E-value: 1.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 326
Cdd:cd00135   1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                        90
                ....*....|....
gi 13786136 327 VALEHHEECDCVCR 340
Cdd:cd00135  73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 2.66e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 98.25  E-value: 2.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136  49 VVTISGNGSIHSPKFPHTYPRNTVLVWRLVaVDENVRIQLTFDErFGLEDPEDdlCKYDFVEVEE--PSDGSVLGRWCGS 126
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIE-APPGYRIRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 13786136 127 gTVPGKQTSKGNHIRIRFVSDEYFPSePGFCIHYSI 162
Cdd:cd00041  80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 56-160 1.50e-22

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 90.53  E-value: 1.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136     56 GSIHSPKFPHTYPRNTVLVWRLVAvDENVRIQLTFDErFGLEDpeDDLCKYDFVEVEE--PSDGSVLGRWCGSGTVPGKQ 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRA-PPGYRIELQFTD-FDLES--SDNCEYDYVEIYDgpSASSPLLGRFCGSEAPPPVI 76

                           90       100
                   ....*....|....*....|....*..
gi 13786136    134 TSKGNHIRIRFVSDEYFPSEpGFCIHY 160
Cdd:smart00042  77 SSSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
55-148 1.13e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 85.81  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136    55 NGSIHSPKFPHTYPRNTVLVWRLVAvDENVRIQLTFDErFGLEDpeDDLCKYDFVEV--EEPSDGSVLGRWCGSGtVPGK 132
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRA-PPGFRVKLTFQD-FELED--HDECGYDYVEIrdGPSASSPLLGRFCGSG-IPED 83

                          90
                  ....*....|....*.
gi 13786136   133 QTSKGNHIRIRFVSDE 148
Cdd:pfam00431  84 IVSSSNQMTIKFVSDA 99
PDGF pfam00341
PDGF/VEGF domain;
250-337 4.03e-14

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 66.93  E-value: 4.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136   250 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVKGlhKSLTDVA 328
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 13786136   329 LEHHEECDC 337
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 250-337 1.32e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 54.35  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786136    250 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPkigvkGLHKSLTDVA 328
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 13786136    329 LEHHEECDC 337
Cdd:smart00141  73 FEEHTKCEC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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