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Conserved domains on  [gi|13928836|ref|NP_113800|]
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apelin preproprotein [Rattus norvegicus]

Protein Classification

Apelin domain-containing protein( domain architecture ID 10634032)

Apelin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Apelin pfam15360
APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility ...
 23-77 5.29e-19

APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.


:

Pssm-ID: 464670  Cd Length: 55  Bit Score: 72.53  E-value: 5.29e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13928836   23 VPLMLPPDGKGLEEGNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF 77
Cdd:pfam15360  1 GPLASTEDGKGLEEGNVRTLVQPRPVRNGPGQRQAGWRKFRRQRPRLSHKGPMPF 55
 
Name Accession Description Interval E-value
Apelin pfam15360
APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility ...
 23-77 5.29e-19

APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.


Pssm-ID: 464670  Cd Length: 55  Bit Score: 72.53  E-value: 5.29e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13928836   23 VPLMLPPDGKGLEEGNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF 77
Cdd:pfam15360  1 GPLASTEDGKGLEEGNVRTLVQPRPVRNGPGQRQAGWRKFRRQRPRLSHKGPMPF 55
 
Name Accession Description Interval E-value
Apelin pfam15360
APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility ...
 23-77 5.29e-19

APJ endogenous ligand; Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.


Pssm-ID: 464670  Cd Length: 55  Bit Score: 72.53  E-value: 5.29e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13928836   23 VPLMLPPDGKGLEEGNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF 77
Cdd:pfam15360  1 GPLASTEDGKGLEEGNVRTLVQPRPVRNGPGQRQAGWRKFRRQRPRLSHKGPMPF 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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