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Conserved domains on  [gi|1937918922|ref|NP_446203|]
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whey acidic protein precursor [Rattus norvegicus]

Protein Classification

WAP domain-containing protein( domain architecture ID 10077516)

WAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 56-127 3.34e-13

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


:

Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 60.16  E-value: 3.34e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937918922  56 QNDMCCPSSCGRPcktpvnieVQKAGRCPWNPIQMiaagPCPKDNPCSIDSDCSGTMKCCNNGCIMSCMDPE 127
Cdd:cd00199     1 GNNMTKPGSCPRP--------VEKPGRCPMVNPPS----LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 56-127 3.34e-13

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 60.16  E-value: 3.34e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937918922  56 QNDMCCPSSCGRPcktpvnieVQKAGRCPWNPIQMiaagPCPKDNPCSIDSDCSGTMKCCNNGCIMSCMDPE 127
Cdd:cd00199     1 GNNMTKPGSCPRP--------VEKPGRCPMVNPPS----LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
79-127 3.44e-10

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.99  E-value: 3.44e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1937918922   79 KAGRCPWNPIqmIAAGPCPKDNPCSIDSDCSGTMKCCNNGCIMSCMDPE 127
Cdd:smart00217   1 KPGSCPWPTI--ASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 79-126 7.49e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 37.79  E-value: 7.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1937918922  79 KAGRCPWNPIQmiaaGPCPkdNPCSIDSDCSGTMKCCNNGCIMSCMDP 126
Cdd:pfam00095   1 KPGCCPRLGAR----GCCR--SCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 56-127 3.34e-13

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 60.16  E-value: 3.34e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937918922  56 QNDMCCPSSCGRPcktpvnieVQKAGRCPWNPIQMiaagPCPKDNPCSIDSDCSGTMKCCNNGCIMSCMDPE 127
Cdd:cd00199     1 GNNMTKPGSCPRP--------VEKPGRCPMVNPPS----LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
79-127 3.44e-10

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.99  E-value: 3.44e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1937918922   79 KAGRCPWNPIqmIAAGPCPKDNPCSIDSDCSGTMKCCNNGCIMSCMDPE 127
Cdd:smart00217   1 KPGSCPWPTI--ASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 79-126 7.49e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 37.79  E-value: 7.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1937918922  79 KAGRCPWNPIQmiaaGPCPkdNPCSIDSDCSGTMKCCNNGCIMSCMDP 126
Cdd:pfam00095   1 KPGCCPRLGAR----GCCR--SCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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