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Conserved domains on  [gi|41281609|ref|NP_446392|]
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protocadherin alpha 12 precursor [Rattus norvegicus]

Protein Classification

protocadherin( domain architecture ID 11175747)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 1.86e-69

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 226.83  E-value: 1.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 41281609   879 PGPGELPDKFIIPGSPAIISIRQESANNQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 3.33e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 125.72  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    30 QLHYSIPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECNIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 41281609   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-345 5.98e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 5.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 246 EYKVRVMENAAKETLVIKLNATDLDEGVNGQLVYSLMSikPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 41281609 326 APPMVGHCVVFVEILDTNDN 345
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-450 7.44e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 7.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 353 SLSLPVREDAQPNTVIALISISDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSP 432
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 41281609 433 SLCATASVSVEVADVNDN 450
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-560 2.41e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 2.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 460 TVFVKENNPPGAHIFTVSAEDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAQDA 539
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 41281609 540 GVPALGSNVTLQVFVLDENDN 560
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 3.85e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 3.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 137 EQRLLIYESKQPDSRFPLEGASDADIGENAVLVYRLSQN---EYFSLESSTNSkqikrpsLILKKTLDREKTRELNLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSIDPSTGE-------ITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 41281609 214 ATDGGKPELTGTVQLWVHVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-669 5.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 5.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 580 VPRSVGSGHVVTKVRAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDHGEPALT 659
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 41281609 660 ATATVLVSLV 669
Cdd:cd11304  84 STATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 1.86e-69

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 226.83  E-value: 1.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 41281609   879 PGPGELPDKFIIPGSPAIISIRQESANNQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 3.33e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 125.72  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    30 QLHYSIPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECNIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 41281609   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-345 5.98e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 5.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 246 EYKVRVMENAAKETLVIKLNATDLDEGVNGQLVYSLMSikPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 41281609 326 APPMVGHCVVFVEILDTNDN 345
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-450 7.44e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 7.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 353 SLSLPVREDAQPNTVIALISISDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSP 432
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 41281609 433 SLCATASVSVEVADVNDN 450
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-560 2.41e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 2.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 460 TVFVKENNPPGAHIFTVSAEDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAQDA 539
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 41281609 540 GVPALGSNVTLQVFVLDENDN 560
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-347 2.74e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 2.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    265 NATDLDEGVNGQLVYSLMSikPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKGAPPMVGHCVVFVEILDTND 344
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 41281609    345 NSP 347
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 3.85e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 3.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 137 EQRLLIYESKQPDSRFPLEGASDADIGENAVLVYRLSQN---EYFSLESSTNSkqikrpsLILKKTLDREKTRELNLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSIDPSTGE-------ITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 41281609 214 ATDGGKPELTGTVQLWVHVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-340 4.43e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 4.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   247 YKVRVMENAAKETLVIKLNATDLDEGVNGQLVYSLmsIKPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKGA 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 41281609   327 PPMVGHCVVFVEIL 340
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 374-452 3.52e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.52e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281609    374 SDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSPSLCATASVSVEVADVNDNAP 452
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 3.59e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    157 ASDADIGENAVLVYRLSQNE---YFSLESSTNSkqikrpsLILKKTLDREKTRELNLLLTATDGGKPELTGTVQLWVHVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSIDPETGE-------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 41281609    234 DVNDNDP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-669 5.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 5.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 580 VPRSVGSGHVVTKVRAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDHGEPALT 659
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 41281609 660 ATATVLVSLV 669
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 477-562 1.49e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.49e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    477 SAEDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSAQDAGVPALGSNVTLQVFVLD 556
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 41281609    557 ENDNAP 562
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 594-675 5.10e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    594 RAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDHGEPALTATATVLVSLV-ENS 672
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVND 78


                   ...
gi 41281609    673 QAP 675
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
460-555 2.54e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   460 TVFVKENNPPGAHIFTVSAEDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSAQDA 539
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 41281609   540 GVPALGSNVTLQVFVL 555
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-668 4.78e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   574 GTVSELVPRsvgsGHVVTKVRAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDH 653
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 41281609   654 GEPALTATATVLVSL 668
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
358-444 8.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 8.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   358 VREDAQPNTVIALISISDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSPSLCAT 437
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 41281609   438 ASVSVEV 444
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 1.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   142 IYESKQPDSRFPLEGASDADIGENAVLVYRLSQNEY---FSLESSTNSkqikrpsLILKKTLDREKTRELNLLLTATDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 41281609   219 KPELTGTVQLWVHVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 3.30e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 3.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609  32 HYSIPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREELcgrsaeCNIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 41281609 111 -DRPLQVF----HVEVEVRDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 1.42e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.42e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281609     64 FRVASKDRGDLLEVNLQNGILFVNSRIDREELCgrsaecNIHLEVIV----DRPLQVF-HVEVEVRDINDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 1.86e-69

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 226.83  E-value: 1.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 41281609   879 PGPGELPDKFIIPGSPAIISIRQESANNQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 3.33e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 125.72  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    30 QLHYSIPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECNIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 41281609   110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-345 5.98e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 5.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 246 EYKVRVMENAAKETLVIKLNATDLDEGVNGQLVYSLMSikPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 41281609 326 APPMVGHCVVFVEILDTNDN 345
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-450 7.44e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 7.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 353 SLSLPVREDAQPNTVIALISISDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSP 432
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 41281609 433 SLCATASVSVEVADVNDN 450
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-560 2.41e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 2.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 460 TVFVKENNPPGAHIFTVSAEDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAQDA 539
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 41281609 540 GVPALGSNVTLQVFVLDENDN 560
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-347 2.74e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 2.74e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    265 NATDLDEGVNGQLVYSLMSikPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKGAPPMVGHCVVFVEILDTND 344
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 41281609    345 NSP 347
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 3.85e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 3.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 137 EQRLLIYESKQPDSRFPLEGASDADIGENAVLVYRLSQN---EYFSLESSTNSkqikrpsLILKKTLDREKTRELNLLLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSIDPSTGE-------ITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 41281609 214 ATDGGKPELTGTVQLWVHVLDVNDN 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-340 4.43e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 4.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   247 YKVRVMENAAKETLVIKLNATDLDEGVNGQLVYSLmsIKPTGRHLFTLDENSGELRVNGTLDYEENKSYEIEVLATDKGA 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 41281609   327 PPMVGHCVVFVEIL 340
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 374-452 3.52e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.52e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281609    374 SDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSPSLCATASVSVEVADVNDNAP 452
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 3.59e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 3.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    157 ASDADIGENAVLVYRLSQNE---YFSLESSTNSkqikrpsLILKKTLDREKTRELNLLLTATDGGKPELTGTVQLWVHVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSIDPETGE-------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 41281609    234 DVNDNDP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-669 5.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 5.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609 580 VPRSVGSGHVVTKVRAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDHGEPALT 659
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIV--SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 41281609 660 ATATVLVSLV 669
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 477-562 1.49e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.49e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    477 SAEDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSAQDAGVPALGSNVTLQVFVLD 556
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 41281609    557 ENDNAP 562
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 594-675 5.10e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    594 RAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDHGEPALTATATVLVSLV-ENS 672
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVND 78


                   ...
gi 41281609    673 QAP 675
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
460-555 2.54e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   460 TVFVKENNPPGAHIFTVSAEDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSAQDA 539
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 41281609   540 GVPALGSNVTLQVFVL 555
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-668 4.78e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   574 GTVSELVPRsvgsGHVVTKVRAVDADSGYNAWLSYELQlgTGGVRSPFRVGLYTGEISTTRALDEVDAPRQTLLVLVKDH 653
Cdd:pfam00028   3 ASVPENAPV----GTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 41281609   654 GEPALTATATVLVSL 668
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
358-444 8.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 8.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   358 VREDAQPNTVIALISISDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRETVSTYDLVVTARDGGSPSLCAT 437
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 41281609   438 ASVSVEV 444
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 1.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609   142 IYESKQPDSRFPLEGASDADIGENAVLVYRLSQNEY---FSLESSTNSkqikrpsLILKKTLDREKTRELNLLLTATDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 41281609   219 KPELTGTVQLWVHVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 3.30e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 3.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609  32 HYSIPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREELcgrsaeCNIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 41281609 111 -DRPLQVF----HVEVEVRDINDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 1.42e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.42e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281609     64 FRVASKDRGDLLEVNLQNGILFVNSRIDREELCgrsaecNIHLEVIV----DRPLQVF-HVEVEVRDINDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 1.82e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609  33 YSIPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGdLLEVNLQNGILFVNSRIDREELcgrsaeCNIHLEVIVDR 112
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEALPS-WLHWEPHSGILEGLEKLDREDK------GVHYISVSAAS 76

                        90       100
                ....*....|....*....|..
gi 41281609 113 -----PLQVFHVEVEVRDINDN 129
Cdd:cd00031  77 lganvPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
32-133 6.57e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281609    32 HYSIPEEAKHGTFVGRI-AQDLGLELTELVprLFRVASKDRGDLLEVNLQNGILFVNSRIDREElcgrsaecnihleviv 110
Cdd:pfam00028   2 SASVPENAPVGTEVLTVtATDPDLGPNGRI--FYSILGGGPGGNFRIDPDTGDISTTKPLDRES---------------- 63

                          90       100
                  ....*....|....*....|...
gi 41281609   111 drpLQVFHVEVEVRDiNDNPPMF 133
Cdd:pfam00028  64 ---IGEYELTVEATD-SGGPPLS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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