NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19173806|ref|NP_596919|]
View 

histidine-rich glycoprotein precursor [Rattus norvegicus]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
PubMed:  1855589|9007972|3555466|14587292
SCOP:  4001013

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 19-120 3.58e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 48.58  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806     19 LSPTNCDAS--KPLAEKVLDLINKGRRSGYTFQLLRVSDAHlDRVETATIYYLVLDVVESDCWVLSTKAQDeCLPamrtS 96
Cdd:smart00043   6 PSDVPPNDPevQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVDLEN-CPF----L 79

                           90       100
                   ....*....|....*....|....*.
gi 19173806     97 EVVIGQC--KVIATRYSNESQDLSVN 120
Cdd:smart00043  80 DQGEKFCtaKVWEKPWENKIKLVEFK 105
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-220 8.44e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 42.03  E-value: 8.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806    142 LVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERViRMRGGERTSYFIEFSVR--NCS-TQHFPRHPPVF----G 214
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSA-KSQVVAGTNYYLKVEVGetNCKkLSVDLENCPFLdqgeK 84


                   ....*.
gi 19173806    215 LCRVVL 220
Cdd:smart00043  85 FCTAKV 90
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 19-120 3.58e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.58  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806     19 LSPTNCDAS--KPLAEKVLDLINKGRRSGYTFQLLRVSDAHlDRVETATIYYLVLDVVESDCWVLSTKAQDeCLPamrtS 96
Cdd:smart00043   6 PSDVPPNDPevQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVDLEN-CPF----L 79

                           90       100
                   ....*....|....*....|....*.
gi 19173806     97 EVVIGQC--KVIATRYSNESQDLSVN 120
Cdd:smart00043  80 DQGEKFCtaKVWEKPWENKIKLVEFK 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 15-120 1.63e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.70  E-value: 1.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806  15 CSHALSPTNCDAsKPLAEKVLDLINKGRRSGYtFQLLRVSDAHLDRVETaTIYYLVLDVVESDCwvlsTKAQDECLPAMR 94
Cdd:cd00042   2 GPSDIPANDPEV-QELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAG-TNYYITVEAGDTNC----KKSSVPLDCPDC 74

                        90       100       110
                ....*....|....*....|....*....|
gi 19173806  95 --TSEVVIGQCKVIATR--YSNESQDLSVN 120
Cdd:cd00042  75 klLEEGKKKFCTAKVWEkpWENFKELLSFK 104
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-220 8.44e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 42.03  E-value: 8.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806    142 LVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERViRMRGGERTSYFIEFSVR--NCS-TQHFPRHPPVF----G 214
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSA-KSQVVAGTNYYLKVEVGetNCKkLSVDLENCPFLdqgeK 84


                   ....*.
gi 19173806    215 LCRVVL 220
Cdd:smart00043  85 FCTAKV 90
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 19-120 3.58e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.58  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806     19 LSPTNCDAS--KPLAEKVLDLINKGRRSGYTFQLLRVSDAHlDRVETATIYYLVLDVVESDCWVLSTKAQDeCLPamrtS 96
Cdd:smart00043   6 PSDVPPNDPevQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVDLEN-CPF----L 79

                           90       100
                   ....*....|....*....|....*.
gi 19173806     97 EVVIGQC--KVIATRYSNESQDLSVN 120
Cdd:smart00043  80 DQGEKFCtaKVWEKPWENKIKLVEFK 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 15-120 1.63e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.70  E-value: 1.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806  15 CSHALSPTNCDAsKPLAEKVLDLINKGRRSGYtFQLLRVSDAHLDRVETaTIYYLVLDVVESDCwvlsTKAQDECLPAMR 94
Cdd:cd00042   2 GPSDIPANDPEV-QELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAG-TNYYITVEAGDTNC----KKSSVPLDCPDC 74

                        90       100       110
                ....*....|....*....|....*....|
gi 19173806  95 --TSEVVIGQCKVIATR--YSNESQDLSVN 120
Cdd:cd00042  75 klLEEGKKKFCTAKVWEkpWENFKELLSFK 104
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-220 8.44e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 42.03  E-value: 8.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173806    142 LVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERViRMRGGERTSYFIEFSVR--NCS-TQHFPRHPPVF----G 214
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSA-KSQVVAGTNYYLKVEVGetNCKkLSVDLENCPFLdqgeK 84


                   ....*.
gi 19173806    215 LCRVVL 220
Cdd:smart00043  85 FCTAKV 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH