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Conserved domains on  [gi|1937880448|ref|NP_647555|]
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proton-coupled amino acid transporter 2 [Rattus norvegicus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
50-461 1.31e-60

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 204.08  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448  50 KGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQ--RFCHRLNKPFMDYGDTVMH 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 128 GlasspntwlqshahWGRHVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSttischknetvvlTPTIDSRLYMLAFL 207
Cdd:pfam01490  81 P--------------KGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFG 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 208 PVLGLLVFIRNLRVLTIFSLLANVSMLVSLVIIAQYIIQGIP-DPSQLPLVASW-----KTYPLFFGTAIFSFESIGVVL 281
Cdd:pfam01490 134 LIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 282 PLENKMKDARRFPT---ILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPN-CWLYQSVKLLYVVGILCTYALQFY 357
Cdd:pfam01490 214 PIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 358 VPAEII--------IPLAVSQVSKRWALPVDLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTY 429
Cdd:pfam01490 294 PIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLK 373
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1937880448 430 ----YGEGMSPLTITKDALISILGFMGFVVGTYQAL 461
Cdd:pfam01490 374 ktkkKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
50-461 1.31e-60

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 204.08  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448  50 KGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQ--RFCHRLNKPFMDYGDTVMH 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 128 GlasspntwlqshahWGRHVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSttischknetvvlTPTIDSRLYMLAFL 207
Cdd:pfam01490  81 P--------------KGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFG 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 208 PVLGLLVFIRNLRVLTIFSLLANVSMLVSLVIIAQYIIQGIP-DPSQLPLVASW-----KTYPLFFGTAIFSFESIGVVL 281
Cdd:pfam01490 134 LIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 282 PLENKMKDARRFPT---ILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPN-CWLYQSVKLLYVVGILCTYALQFY 357
Cdd:pfam01490 214 PIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 358 VPAEII--------IPLAVSQVSKRWALPVDLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTY 429
Cdd:pfam01490 294 PIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLK 373
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1937880448 430 ----YGEGMSPLTITKDALISILGFMGFVVGTYQAL 461
Cdd:pfam01490 374 ktkkKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
66-329 1.10e-04

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 44.47  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448  66 MGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRfchrlnkpfmdygdTVMHGLASSPNTWLqshAHWGR 145
Cdd:PTZ00206   74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADK--------------TNIRTYEGVARVLL---GPWGS 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 146 HVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTptidsRLYMLAFLPVLGLLVFIRNLRVLTIF 225
Cdd:PTZ00206  137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLT-----SLMWLCFMLPLVIPRHIDSLRYVSTI 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 226 SLLANVSMLVslVIIAQYIIQGIP-----------DPSQLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKD--ARR 292
Cdd:PTZ00206  212 AVSFMVYLVI--VIVVHSCMNGLPeniknvsvgkdDNAEIILFNSGNRAIEGLGVFIFAYVFQITAYEVYMDMTNrsVGK 289
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1937880448 293 FPTILSLGMSIITTLYIAIGALGYLRFGDDIKASITL 329
Cdd:PTZ00206  290 FVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL 326
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
50-461 1.31e-60

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 204.08  E-value: 1.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448  50 KGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQ--RFCHRLNKPFMDYGDTVMH 127
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 128 GlasspntwlqshahWGRHVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSttischknetvvlTPTIDSRLYMLAFL 207
Cdd:pfam01490  81 P--------------KGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFG 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 208 PVLGLLVFIRNLRVLTIFSLLANVSMLVSLVIIAQYIIQGIP-DPSQLPLVASW-----KTYPLFFGTAIFSFESIGVVL 281
Cdd:pfam01490 134 LIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 282 PLENKMKDARRFPT---ILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPN-CWLYQSVKLLYVVGILCTYALQFY 357
Cdd:pfam01490 214 PIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 358 VPAEII--------IPLAVSQVSKRWALPVDLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTY 429
Cdd:pfam01490 294 PIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLK 373
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1937880448 430 ----YGEGMSPLTITKDALISILGFMGFVVGTYQAL 461
Cdd:pfam01490 374 ktkkKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
66-329 1.10e-04

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 44.47  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448  66 MGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRfchrlnkpfmdygdTVMHGLASSPNTWLqshAHWGR 145
Cdd:PTZ00206   74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADK--------------TNIRTYEGVARVLL---GPWGS 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 146 HVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTptidsRLYMLAFLPVLGLLVFIRNLRVLTIF 225
Cdd:PTZ00206  137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLT-----SLMWLCFMLPLVIPRHIDSLRYVSTI 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937880448 226 SLLANVSMLVslVIIAQYIIQGIP-----------DPSQLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKD--ARR 292
Cdd:PTZ00206  212 AVSFMVYLVI--VIVVHSCMNGLPeniknvsvgkdDNAEIILFNSGNRAIEGLGVFIFAYVFQITAYEVYMDMTNrsVGK 289
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1937880448 293 FPTILSLGMSIITTLYIAIGALGYLRFGDDIKASITL 329
Cdd:PTZ00206  290 FVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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