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Conserved domains on  [gi|21728410|ref|NP_663712|]
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leucine-rich repeat-containing protein 3 precursor [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-147 3.79e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  49 HCSSRGLQEIPRDIPANTVL--LKLDANRISRVPNgAFQHLPQLRELDLSHNAIEAIgPAAFSGLAgGLRLLDLSHNRIR 126
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLT-NLEELDLSGNQLT 218

                        90       100
                ....*....|....*....|...
gi 21728410 127 RIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 219 DLP-EPLANLTNleTLDLSNNQL 240
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-63 1.15e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.38  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21728410    33 CPQSCQCPDhagaVAVHCSSRGLQEIPRDIP 63
Cdd:pfam01462   2 CPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-147 3.79e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  49 HCSSRGLQEIPRDIPANTVL--LKLDANRISRVPNgAFQHLPQLRELDLSHNAIEAIgPAAFSGLAgGLRLLDLSHNRIR 126
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLT-NLEELDLSGNQLT 218

                        90       100
                ....*....|....*....|...
gi 21728410 127 RIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 219 DLP-EPLANLTNleTLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
69-125 5.49e-17

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 5.49e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21728410    69 LKLDANRISRVPNGAFQHLPQLRELDLSHNAIEAIGPAAFSGLAgGLRLLDLSHNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-162 5.70e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 5.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  69 LKLDANRISRVPNgaFQHLPQLRELDLSHNAIE-----AIGPAAFSGLAGGLRLLDLSHNRIRRIpkDALGKLSA--KIR 141
Cdd:cd21340  73 LYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNleQLD 148

                        90       100
                ....*....|....*....|....*..
gi 21728410 142 LSHNPLHCECALQEA------LWELKL 162
Cdd:cd21340 149 ASNNQISDLEELLDLlsswpsLRELDL 175
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-129 7.13e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 7.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410   42 HAGAVAVHCSSRGLQEIPRDIPANTVLLKLDANRISRVPngafQHLPQ-LRELDLSHNAIEAIgPaafSGLAGGLRLLDL 120
Cdd:PRK15370 219 QGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCL-P---ENLPEELRYLSV 290


                 ....*....
gi 21728410  121 SHNRIRRIP 129
Cdd:PRK15370 291 YDNSIRTLP 299
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-68 4.36e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 4.36e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21728410     33 CPQSCQCPDhagaVAVHCSSRGLQEIPRDIPANTVL 68
Cdd:smart00013   2 CPAPCNCSG----TAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-63 1.15e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.38  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21728410    33 CPQSCQCPDhagaVAVHCSSRGLQEIPRDIP 63
Cdd:pfam01462   2 CPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-147 3.79e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  49 HCSSRGLQEIPRDIPANTVL--LKLDANRISRVPNgAFQHLPQLRELDLSHNAIEAIgPAAFSGLAgGLRLLDLSHNRIR 126
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLT-NLEELDLSGNQLT 218

                        90       100
                ....*....|....*....|...
gi 21728410 127 RIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 219 DLP-EPLANLTNleTLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
69-125 5.49e-17

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 5.49e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21728410    69 LKLDANRISRVPNGAFQHLPQLRELDLSHNAIEAIGPAAFSGLAgGLRLLDLSHNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
88-147 1.23e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.23e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21728410    88 PQLRELDLSHNAIEAIGPAAFSGLAgGLRLLDLSHNRIRRIPKDALGKLSA--KIRLSHNPL 147
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSlrYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-147 2.15e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  55 LQEIPRDIPANTVL--LKLDANRISRVPNgAFQHLPQLRELDLSHNAIEAIgpAAFSGLAGgLRLLDLSHNRIRRIPKDA 132
Cdd:COG4886 194 ITDLPEPLGNLTNLeeLDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTN-LEELDLSNNQLTDLPPLA 269

                        90
                ....*....|....*.
gi 21728410 133 -LGKLSaKIRLSHNPL 147
Cdd:COG4886 270 nLTNLK-TLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-147 2.68e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.68e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21728410  81 NGAFQHLPQLRELDLSHNAIEAIgPAAFSGLAgGLRLLDLSHNRIRRIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDL-PEELANLT-NLKELDLSNNQLTDLP-EPLGNLTNlkSLDLSNNQL 171
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-162 5.70e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 5.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  69 LKLDANRISRVPNgaFQHLPQLRELDLSHNAIE-----AIGPAAFSGLAGGLRLLDLSHNRIRRIpkDALGKLSA--KIR 141
Cdd:cd21340  73 LYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNleQLD 148

                        90       100
                ....*....|....*....|....*..
gi 21728410 142 LSHNPLHCECALQEA------LWELKL 162
Cdd:cd21340 149 ASNNQISDLEELLDLlsswpsLRELDL 175
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-129 7.13e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 7.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410   42 HAGAVAVHCSSRGLQEIPRDIPANTVLLKLDANRISRVPngafQHLPQ-LRELDLSHNAIEAIgPaafSGLAGGLRLLDL 120
Cdd:PRK15370 219 QGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCL-P---ENLPEELRYLSV 290


                 ....*....
gi 21728410  121 SHNRIRRIP 129
Cdd:PRK15370 291 YDNSIRTLP 299
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-68 4.36e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 4.36e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21728410     33 CPQSCQCPDhagaVAVHCSSRGLQEIPRDIPANTVL 68
Cdd:smart00013   2 CPAPCNCSG----TAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-171 8.31e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 8.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  48 VHCSSRGLQEIPRDIPA-NTVLLKLDANRISRVPNgaFQHLPQLRELDLSHNAIEAIGPaaFSGLAGgLRLLDLSHNRIR 126
Cdd:cd21340   7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVN-LKKLYLGGNRIS 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 21728410 127 RIpkDALGKLSAkirLSHnpLHCEC-ALQEALwELKLDPDSVDEIA 171
Cdd:cd21340  82 VV--EGLENLTN---LEE--LHIENqRLPPGE-KLTFDPRSLAALS 119
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-147 3.37e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410   40 PDH--AGAVAVHCSSRGLQEIPRDIPANTVLLKLDANRISRVPNG---AFQHL---------------PQLRELDLSHNA 99
Cdd:PRK15370 299 PAHlpSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASlppELQVLdvsknqitvlpetlpPTITTLDVSRNA 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 21728410  100 IEAIgPaafSGLAGGLRLLDLSHNRIRRIPKD-----ALGKLSAKIRLSHNPL 147
Cdd:PRK15370 379 LTNL-P---ENLPAALQIMQASRNNLVRLPESlphfrGEGPQPTRIIVEYNPF 427
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-161 8.83e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 8.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  58 IPRDIPANTVLLKLDANRISRVPNGAFQHLPQLRELDLSHNaieaigpAAFSGLAgGLRLLDLSHNRIRRIPkDALGKLS 137
Cdd:COG4886  66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLT-NLESLDLSGNQLTDLP-EELANLT 136

                        90       100
                ....*....|....*....|....*.
gi 21728410 138 A--KIRLSHNPLHcecALQEALWELK 161
Cdd:COG4886 137 NlkELDLSNNQLT---DLPEPLGNLT 159
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-63 1.15e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.38  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21728410    33 CPQSCQCPDhagaVAVHCSSRGLQEIPRDIP 63
Cdd:pfam01462   2 CPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
87-110 2.74e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.33  E-value: 2.74e-04
                           10        20
                   ....*....|....*....|....
gi 21728410     87 LPQLRELDLSHNAIEAIGPAAFSG 110
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
87-110 2.74e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 37.33  E-value: 2.74e-04
                           10        20
                   ....*....|....*....|....
gi 21728410     87 LPQLRELDLSHNAIEAIGPAAFSG 110
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-148 3.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410   69 LKLDANRIS-RVPNGaFQHLPQLREL------------------------DLSHNAIEAIGPAAFSGLAgGLRLLDLSHN 123
Cdd:PLN00113 480 LDLSRNQFSgAVPRK-LGSLSELMQLklsenklsgeipdelssckklvslDLSHNQLSGQIPASFSEMP-VLSQLDLSQN 557

                         90       100
                 ....*....|....*....|....*...
gi 21728410  124 RIR-RIPKDaLGKLSA--KIRLSHNPLH 148
Cdd:PLN00113 558 QLSgEIPKN-LGNVESlvQVNISHNHLH 584
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-129 6.24e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 6.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 21728410    88 PQLRELDLSHNAIEAIGPaaFSGLAgGLRLLDLSHN-RIRRIP 129
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLP-NLETLDLSGNnKITDLS 40
PLN03150 PLN03150
hypothetical protein; Provisional
 83-145 1.03e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 1.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21728410   83 AFQHLpqlRELDLSHNAIEAIGPAAFsGLAGGLRLLDLSHNRIRRIPKDALGKLSAKIRLSHN 145
Cdd:PLN03150 440 KLRHL---QSINLSGNSIRGNIPPSL-GSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 53-125 4.46e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 4.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21728410  53 RGLQEIPRDIPANTVL--LKLDANRI----SRVPNGAFQHLPQLRELDLSHNAIEAIGPAAFS----GLAGGLRLLDLSH 122
Cdd:cd00116 180 AGIRALAEGLKANCNLevLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAALAsallSPNISLLTLSLSC 259


                ...
gi 21728410 123 NRI 125
Cdd:cd00116 260 NDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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