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Conserved domains on  [gi|309951088|ref|NP_742016|]
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interferon gamma inducible protein 47 [Rattus norvegicus]

Protein Classification

p47_IIGP_like domain-containing protein( domain architecture ID 12060281)

p47_IIGP_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 40-413 0e+00

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


:

Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 572.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088   40 SPETLSAIHYALQEGRLSDVMNQIQEAISAAENAVLEVAVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPY 119
Cdd:pfam05049   1 SPEVITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  120 QHPKYPNVIFWDLPGTGTPNFHTDTYLDRVGFANYDFFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTKVDSDLYSEER 199
Cdd:pfam05049  81 SHPHFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNEQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  200 TRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIFLISNFDLDAFDFPKLEETLLKELPGHKRHMFALLLPNISDASIELK 279
Cdd:pfam05049 161 GKPQTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  280 KHFLQEKICLEALKSGAMSFIPFMPFISGFDLPQQEQCLKDYRSYFGLDDKSIEEIAERLETPLEDIKGQLKCLDFWSFV 359
Cdd:pfam05049 241 RQSLKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKSPAFFKLT 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 309951088  360 KDDSIIARARSAGEAFCSVKGGLGSSVVQALKVYYMRTQFLNVVVEDAKHLLRK 413
Cdd:pfam05049 321 KDDSILARLTRYINAFCRVLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRK 374
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 40-413 0e+00

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 572.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088   40 SPETLSAIHYALQEGRLSDVMNQIQEAISAAENAVLEVAVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPY 119
Cdd:pfam05049   1 SPEVITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  120 QHPKYPNVIFWDLPGTGTPNFHTDTYLDRVGFANYDFFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTKVDSDLYSEER 199
Cdd:pfam05049  81 SHPHFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNEQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  200 TRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIFLISNFDLDAFDFPKLEETLLKELPGHKRHMFALLLPNISDASIELK 279
Cdd:pfam05049 161 GKPQTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  280 KHFLQEKICLEALKSGAMSFIPFMPFISGFDLPQQEQCLKDYRSYFGLDDKSIEEIAERLETPLEDIKGQLKCLDFWSFV 359
Cdd:pfam05049 241 RQSLKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKSPAFFKLT 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 309951088  360 KDDSIIARARSAGEAFCSVKGGLGSSVVQALKVYYMRTQFLNVVVEDAKHLLRK 413
Cdd:pfam05049 321 KDDSILARLTRYINAFCRVLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRK 374
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 74-270 3.77e-129

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 370.12  E-value: 3.77e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  74 VLEVAVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPYQHPKYPNVIFWDLPGTGTPNFHTDTYLDRVGFAN 153
Cdd:cd04104    1 PLNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 154 YDFFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTKVDSDLYSEERTRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIF 233
Cdd:cd04104   81 YDFFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKPRSFNKEQVLQQIRDNCLENLQEAGVSEPPVF 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 309951088 234 LISNFDLDAFDFPKLEETLLKELPGHKRHMFALLLPN 270
Cdd:cd04104  161 LVSNFDPSDYDFPKLRDTLLKDLPAHKRHNFLLSLPN 197
YeeP COG3596
Predicted GTPase [General function prediction only];
41-265 7.73e-13

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 69.02  E-value: 7.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  41 PETLSAIHYALQEGRlsdvmNQIQEAI--SAAENAVLEVAVIGESGTGKSSFINALRGlgheeAESADVGTVE-TTMYKT 117
Cdd:COG3596    9 TERLEALKRLPQVLR-----ELLAEALerLLVELPPPVIALVGKTGAGKSSLINALFG-----AEVAEVGVGRpCTREIQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 118 PY--QHPKYPNVIFWDLPGTGTPNFHTDT---YLDRVGFANYDFFIIISSSRFSVNDALLAQKIKD--AGKKFYFVRTKV 190
Cdd:COG3596   79 RYrlESDGLPGLVLLDTPGLGEVNERDREyreLRELLPEADLILWVVKADDRALATDEEFLQALRAqyPDPPVLVVLTQV 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 309951088 191 DsDLY-SEERTRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIFLIS-NFDLDAFDFPKLEETLLKELPGHKRHMFA 265
Cdd:COG3596  159 D-RLEpEREWDPPYNWPSPPKEQNIRRALEAIAEQLGVPIDRVIPVSaAEDRTGYGLEELVDALAEALPEAKRSRLA 234
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 71-94 9.64e-03

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 37.07  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|....
gi 309951088   71 ENAVLEVAVIGESGTGKSSFINAL 94
Cdd:TIGR03598  15 PDDGPEIAFAGRSNVGKSSLINAL 38
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 40-413 0e+00

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 572.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088   40 SPETLSAIHYALQEGRLSDVMNQIQEAISAAENAVLEVAVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPY 119
Cdd:pfam05049   1 SPEVITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  120 QHPKYPNVIFWDLPGTGTPNFHTDTYLDRVGFANYDFFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTKVDSDLYSEER 199
Cdd:pfam05049  81 SHPHFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSNEQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  200 TRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIFLISNFDLDAFDFPKLEETLLKELPGHKRHMFALLLPNISDASIELK 279
Cdd:pfam05049 161 GKPQTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  280 KHFLQEKICLEALKSGAMSFIPFMPFISGFDLPQQEQCLKDYRSYFGLDDKSIEEIAERLETPLEDIKGQLKCLDFWSFV 359
Cdd:pfam05049 241 RQSLKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKSPAFFKLT 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 309951088  360 KDDSIIARARSAGEAFCSVKGGLGSSVVQALKVYYMRTQFLNVVVEDAKHLLRK 413
Cdd:pfam05049 321 KDDSILARLTRYINAFCRVLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRK 374
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 74-270 3.77e-129

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 370.12  E-value: 3.77e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  74 VLEVAVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPYQHPKYPNVIFWDLPGTGTPNFHTDTYLDRVGFAN 153
Cdd:cd04104    1 PLNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 154 YDFFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTKVDSDLYSEERTRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIF 233
Cdd:cd04104   81 YDFFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKPRSFNKEQVLQQIRDNCLENLQEAGVSEPPVF 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 309951088 234 LISNFDLDAFDFPKLEETLLKELPGHKRHMFALLLPN 270
Cdd:cd04104  161 LVSNFDPSDYDFPKLRDTLLKDLPAHKRHNFLLSLPN 197
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 78-236 4.44e-14

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 69.41  E-value: 4.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  78 AVIGESGTGKSSFINALRGLGHEEAESADVGTVETTMYKTPYQHPKYPnVIFWDLPGTGTPNFHTDTYLDRVGFANYDFF 157
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDPDVYVKELDKGKVK-LVLVDTPGLDEFGGLGREELARLLLRGADLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 158 III--SSSRFSVNDA--LLAQKIKDAGKKFYFVRTKVdsDLYSEERTRPRTFRKEQVLQRIRDYC-LSNLTDIGVSEPRI 232
Cdd:cd00882   80 LLVvdSTDRESEEDAklLILRRLRKEGIPIILVGNKI--DLLEEREVEELLRLEELAKILGVPVFeVSAKTGEGVDELFE 157


                 ....
gi 309951088 233 FLIS 236
Cdd:cd00882  158 KLIE 161
YeeP COG3596
Predicted GTPase [General function prediction only];
41-265 7.73e-13

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 69.02  E-value: 7.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  41 PETLSAIHYALQEGRlsdvmNQIQEAI--SAAENAVLEVAVIGESGTGKSSFINALRGlgheeAESADVGTVE-TTMYKT 117
Cdd:COG3596    9 TERLEALKRLPQVLR-----ELLAEALerLLVELPPPVIALVGKTGAGKSSLINALFG-----AEVAEVGVGRpCTREIQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 118 PY--QHPKYPNVIFWDLPGTGTPNFHTDT---YLDRVGFANYDFFIIISSSRFSVNDALLAQKIKD--AGKKFYFVRTKV 190
Cdd:COG3596   79 RYrlESDGLPGLVLLDTPGLGEVNERDREyreLRELLPEADLILWVVKADDRALATDEEFLQALRAqyPDPPVLVVLTQV 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 309951088 191 DsDLY-SEERTRPRTFRKEQVLQRIRDYCLSNLTDIGVSEPRIFLIS-NFDLDAFDFPKLEETLLKELPGHKRHMFA 265
Cdd:COG3596  159 D-RLEpEREWDPPYNWPSPPKEQNIRRALEAIAEQLGVPIDRVIPVSaAEDRTGYGLEELVDALAEALPEAKRSRLA 234
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
 77-267 5.45e-08

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 52.55  E-value: 5.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  77 VAVIGESGTGKSSFINALrgLGheeAESADVGTVETTMYKTpyqHPKY---PNVIFWDLPGTG-TPNFHTDT---YLDRV 149
Cdd:cd09912    3 LAVVGEFSAGKSTLLNAL--LG---EEVLPTGVTPTTAVIT---VLRYgllKGVVLVDTPGLNsTIEHHTEItesFLPRA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 150 gfanyDFFIIISSSR--FSVNDALLAQKIKDA-GKKFYFVRTKVDSdLYSEERtrprtfrkEQVLQRIRDycLSNLTDIG 226
Cdd:cd09912   75 -----DAVIFVLSADqpLTESEREFLKEILKWsGKKIFFVLNKIDL-LSEEEL--------EEVLEYSRE--ELGVLELG 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 309951088 227 VSEPRIFLIS----NFDLDAFDFPKLEETLLKELpghKRHMFALL 267
Cdd:cd09912  139 GGEPRIFPVSakeaLEARLQGDEELLEQSGFEEL---EEHLEEFL 180
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 76-189 5.80e-06

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 44.92  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088   76 EVAVIGESGTGKSSFINALRGlghEEAESADV-G-TVETTMYKTpyqHPKYPNVIFWDLPGTgTPNFHTDTYLDRVGFAN 153
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTG---AKAIVSDYpGtTRDPNEGRL---ELKGKQIILVDTPGL-IEGASEGEGLGRAFLAI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 309951088  154 YD----FFIIISSSRFSVNDALLAQKIKDAGKKFYFVRTK 189
Cdd:pfam01926  74 IEadliLFVVDSEEGITPLDEELLELLRENKKPIILVLNK 113
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
77-229 1.67e-05

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 44.97  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  77 VAVIGESGTGKSSFINALRGlghEEAESADV-GTVETTMYKTPYQHPKY-PNVIFWDLPGT----GTPNFHTDTYLDRVG 150
Cdd:COG1100    6 IVVVGTGGVGKTSLVNRLVG---DIFSLEKYlSTNGVTIDKKELKLDGLdVDLVIWDTPGQdefrETRQFYARQLTGASL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 151 FAnydffIIISSSRFSVNDAL--LAQKIKDAGKK--FYFVRTKvdSDLYSEERTRPrtfrKEQVLQRIRD------YCLS 220
Cdd:COG1100   83 YL-----FVVDGTREETLQSLyeLLESLRRLGKKspIILVLNK--IDLYDEEEIED----EERLKEALSEdnivevVATS 151


                 ....*....
gi 309951088 221 NLTDIGVSE 229
Cdd:COG1100  152 AKTGEGVEE 160
CrfC COG0699
Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, ...
 56-121 1.31e-03

Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair];


Pssm-ID: 440463 [Multi-domain]  Cd Length: 582  Bit Score: 41.16  E-value: 1.31e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 309951088  56 LSDVMNQIQEAISAAENAVLEVAVIGESGTGKSSFINALRGlgheeAESADVGTVETTMYKTPYQH 121
Cdd:COG0699   14 RADLRRRLDQARLDLADPSLRIVMAGTTSQGKSQLVNALLG-----RRLLPSGAGETTGVPTEIKH 74
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 66-107 3.00e-03

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 38.92  E-value: 3.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 309951088  66 AISAAENAVLE----------VAVIGESGTGKSSFINALrgLGHEEAESADV 107
Cdd:cd01854   67 AVSAKTGEGLDelrellkgktSVLVGQSGVGKSTLLNAL--LPELVLATGEI 116
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
66-107 7.22e-03

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 38.17  E-value: 7.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 309951088  66 AISAAENAVLE----------VAVIGESGTGKSSFINALrgLGHEEAESADV 107
Cdd:COG1162  148 AVSAKTGEGLDelrellkgktSVLVGQSGVGKSTLINAL--LPDADLATGEI 197
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 76-229 7.97e-03

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 37.10  E-value: 7.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088  76 EVAVIGESGTGKSSFINALRGLGHEeaesADVGtvettmyKTP--YQHPKY----PNVIFWDLPGTGtpnFH-------- 141
Cdd:cd01876    1 EVAFAGRSNVGKSSLINALTNRKKL----ARTS-------KTPgrTQLINFfnvgDKFRLVDLPGYG---YAkvskevre 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951088 142 -----TDTYLDR----VGfanydFFIIISSSR-FSVNDALLAQKIKDAGKKFYFVRTKVD----SDLYSEERTRPRTFRK 207
Cdd:cd01876   67 kwgklIEEYLENrenlKG-----VVLLIDARHgPTPIDLEMLEFLEELGIPFLIVLTKADklkkSELAKVLKKIKEELNL 141

                        170       180
                 ....*....|....*....|..
gi 309951088 208 EQVLQRIrdYCLSNLTDIGVSE 229
Cdd:cd01876  142 FNILPPV--ILFSSKKGTGIDE 161
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 71-94 9.64e-03

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 37.07  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|....
gi 309951088   71 ENAVLEVAVIGESGTGKSSFINAL 94
Cdd:TIGR03598  15 PDDGPEIAFAGRSNVGKSSLINAL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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