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Conserved domains on  [gi|26051250|ref|NP_742086|]
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TNFSF12-TNFSF13 protein [Homo sapiens]

Protein Classification

TNF domain-containing protein( domain architecture ID 10212252)

TNF domain-containing protein similar to Homo sapiens lymphotoxin-alpha, which acts as cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 197-328 3.07e-27

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


:

Pssm-ID: 238108  Cd Length: 137  Bit Score: 103.96  E-value: 3.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250 197 VLHLVPINATSKDdsdvTEVMWQPALRRG---RGLQAQGYGVRIQDAGVYLLYSQVLFQD---VTFTMGQVVSREGQGRQ 270
Cdd:cd00184   2 AAHLIGTNSSSGG----TGLSWESDDGRAflsGGLELQNGELVVPQDGLYYIYSQVYFRGqccSTLSVSHVLQLRTDSYP 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26051250 271 E--TLFRCIRSMPSHP-DRAYNSCYSAGVFHLHQGDILSVIIPRaRAKLNLSPHGTFLGFV 328
Cdd:cd00184  78 EpiLLLKGIRSVCSSVsEGWYNSVYLGGLFQLRAGDRLSVNVSA-PALLDLSQGTTFFGAF 137
TNF super family cl00147
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 131-166 7.32e-08

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


The actual alignment was detected with superfamily member smart00207:

Pssm-ID: 444713  Cd Length: 125  Bit Score: 50.42  E-value: 7.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 26051250    131 SGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQ 166
Cdd:smart00207   1 LSWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQ 36
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 197-328 3.07e-27

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 103.96  E-value: 3.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250 197 VLHLVPINATSKDdsdvTEVMWQPALRRG---RGLQAQGYGVRIQDAGVYLLYSQVLFQD---VTFTMGQVVSREGQGRQ 270
Cdd:cd00184   2 AAHLIGTNSSSGG----TGLSWESDDGRAflsGGLELQNGELVVPQDGLYYIYSQVYFRGqccSTLSVSHVLQLRTDSYP 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26051250 271 E--TLFRCIRSMPSHP-DRAYNSCYSAGVFHLHQGDILSVIIPRaRAKLNLSPHGTFLGFV 328
Cdd:cd00184  78 EpiLLLKGIRSVCSSVsEGWYNSVYLGGLFQLRAGDRLSVNVSA-PALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
236-330 1.89e-10

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 57.71  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250   236 RIQDAGVYLLYSQVLFQDVTFTMGQV-----VSREG--QGRQETLFRCIRSMPS--HPDRAYNSCYSAGVFHLHQGDILS 306
Cdd:pfam00229  24 VVPQAGLYYVYSQVYFRGEGCPSGSVplthyLYKFSssYPGPVLLLKGAESPCSseNPEYWYQSIYLGGLFELRAGDRLS 103

                          90       100
                  ....*....|....*....|....*
gi 26051250   307 VIIPrARAKLNLSPHG-TFLGFVKL 330
Cdd:pfam00229 104 VNVS-NPSLVDLSAPGkTYFGAFLL 127
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 131-166 7.32e-08

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 50.42  E-value: 7.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 26051250    131 SGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQ 166
Cdd:smart00207   1 LSWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQ 36
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 226-307 1.93e-03

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 37.71  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250    226 RGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQET--------LFRCIRSMPSHPDRAYNSCYSAGVF 297
Cdd:smart00207  14 SGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVELSLSLHLRKPsyplplllLEAARSSCWSASSAWKDSVYLGGLF 93

                           90
                   ....*....|
gi 26051250    298 HLHQGDILSV 307
Cdd:smart00207  94 PLTAGDRLSV 103
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 197-328 3.07e-27

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 103.96  E-value: 3.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250 197 VLHLVPINATSKDdsdvTEVMWQPALRRG---RGLQAQGYGVRIQDAGVYLLYSQVLFQD---VTFTMGQVVSREGQGRQ 270
Cdd:cd00184   2 AAHLIGTNSSSGG----TGLSWESDDGRAflsGGLELQNGELVVPQDGLYYIYSQVYFRGqccSTLSVSHVLQLRTDSYP 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26051250 271 E--TLFRCIRSMPSHP-DRAYNSCYSAGVFHLHQGDILSVIIPRaRAKLNLSPHGTFLGFV 328
Cdd:cd00184  78 EpiLLLKGIRSVCSSVsEGWYNSVYLGGLFQLRAGDRLSVNVSA-PALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
236-330 1.89e-10

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 57.71  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250   236 RIQDAGVYLLYSQVLFQDVTFTMGQV-----VSREG--QGRQETLFRCIRSMPS--HPDRAYNSCYSAGVFHLHQGDILS 306
Cdd:pfam00229  24 VVPQAGLYYVYSQVYFRGEGCPSGSVplthyLYKFSssYPGPVLLLKGAESPCSseNPEYWYQSIYLGGLFELRAGDRLS 103

                          90       100
                  ....*....|....*....|....*
gi 26051250   307 VIIPrARAKLNLSPHG-TFLGFVKL 330
Cdd:pfam00229 104 VNVS-NPSLVDLSAPGkTYFGAFLL 127
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 131-166 7.32e-08

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 50.42  E-value: 7.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 26051250    131 SGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQ 166
Cdd:smart00207   1 LSWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQ 36
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 226-307 1.93e-03

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 37.71  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26051250    226 RGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQET--------LFRCIRSMPSHPDRAYNSCYSAGVF 297
Cdd:smart00207  14 SGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVELSLSLHLRKPsyplplllLEAARSSCWSASSAWKDSVYLGGLF 93

                           90
                   ....*....|
gi 26051250    298 HLHQGDILSV 307
Cdd:smart00207  94 PLTAGDRLSV 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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