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Conserved domains on  [gi|41054894|ref|NP_955784|]
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desmoglein-4 precursor [Rattus norvegicus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182337)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.84e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 2.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  161 VYTANIEENSDANALVVKLSATDADEDNhlNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 41054894  241 drDGATDGLSSECDCRIKILDVNDN 265
Cdd:cd11304   76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 2.43e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYSILSGNDGNWFEIqtDPKTneGILKLVKMLDYEQEPNIYLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 41054894  352 RNQAEFHHSVasqfqmhSTPVRIQVINV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.38e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894   62 EDNSKRNPIARIR---SDCEVSQRITYRISGAGIDrppyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 41054894  139 RPLELRVKVMDVNDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-492 2.75e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  401 DSLMNYVLGTYTAIDMDTGSPAtNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRT 478
Cdd:cd11304    9 NAPPGTVVLTVSATDPDSGENG-EVTYSIvSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATDGGGpPLS 83

                         90
                 ....*....|....
gi 41054894  479 ATGTICIEVPDAND 492
Cdd:cd11304   84 STATVTITVLDVND 97
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 790-846 6.48e-09

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 52.92  E-value: 6.48e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41054894    790 ADEDEGRPANDCLLIYDHEGTGSPVGSIGC-CSWIVD-DLDESYMETLDPKFRTLAEIC 846
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.84e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 2.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  161 VYTANIEENSDANALVVKLSATDADEDNhlNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 41054894  241 drDGATDGLSSECDCRIKILDVNDN 265
Cdd:cd11304   76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 1.03e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 1.03e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    162 YTANIEENSDANALVVKLSATDADEDnhLNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 41054894    242 RDGatDGLSSECDCRIKIL 260
Cdd:pfam00028   76 SGG--PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-267 1.84e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.84e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     180 SATDADEDNhlNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGSDRDGatDGLSSECDCRIKI 259
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGG--PPLSSTATVTITV 73


                    ....*...
gi 41054894     260 LDVNDNFP 267
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 2.43e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYSILSGNDGNWFEIqtDPKTneGILKLVKMLDYEQEPNIYLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 41054894  352 RNQAEFHHSVasqfqmhSTPVRIQVINV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-377 3.24e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 3.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    274 YSASIEENCLS-SELIRLQAIDLDEegTDNWLAQYSILSGNDGNWFEIQTDPktneGILKLVKMLDYEQEPNIYLSIGVR 352
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....*
gi 41054894    353 NqaefhHSVASQFQmhSTPVRIQVI 377
Cdd:pfam00028   75 D-----SGGPPLSS--TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.38e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894   62 EDNSKRNPIARIR---SDCEVSQRITYRISGAGIDrppyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 41054894  139 RPLELRVKVMDVNDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 1.71e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.71e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894      75 SDCEVSQRITYRISGAGIDrppyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNP 154
Cdd:smart00112    5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 41054894     155 P 155
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
54-147 2.25e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 2.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     54 FAAACREGE-DNSKRNPIARIRSDCEVSQRITYRISGAGidrpPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNS 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 41054894    133 RGEDLERPLELRVKV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-492 2.75e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  401 DSLMNYVLGTYTAIDMDTGSPAtNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRT 478
Cdd:cd11304    9 NAPPGTVVLTVSATDPDSGENG-EVTYSIvSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATDGGGpPLS 83

                         90
                 ....*....|....
gi 41054894  479 ATGTICIEVPDAND 492
Cdd:cd11304   84 STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 4.93e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 4.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     291 QAIDLDEEgtDNWLAQYSILSGNDGNWFEIqtDPKTneGILKLVKMLDYEQEPNIYLSIGVRNQAEFHHSVasqfqmhST 370
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                    ....*....
gi 41054894     371 PVRIQVINV 379
Cdd:smart00112   68 TVTITVLDV 76
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 790-846 6.48e-09

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 52.92  E-value: 6.48e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41054894    790 ADEDEGRPANDCLLIYDHEGTGSPVGSIGC-CSWIVD-DLDESYMETLDPKFRTLAEIC 846
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-495 4.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 4.96e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     412 TAIDMDTGSPAtNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRTATGTICIEVPD 489
Cdd:smart00112    1 SATDADSGENG-KVTYSIlSGNDDGLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGpPLSSTATVTITVLD 75


                    ....*.
gi 41054894     490 ANDYCP 495
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
401-487 1.82e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    401 DSLMNYVLGTYTAIDMDTGsPATNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRT 478
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG-PNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLD----RESIGEYELTVEATDSGGpPLS 82


                   ....*....
gi 41054894    479 ATGTICIEV 487
Cdd:pfam00028   83 STATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-265 2.84e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 2.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  161 VYTANIEENSDANALVVKLSATDADEDNhlNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGS 240
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 41054894  241 drDGATDGLSSECDCRIKILDVNDN 265
Cdd:cd11304   76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 1.03e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 1.03e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    162 YTANIEENSDANALVVKLSATDADEDnhLNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 41054894    242 RDGatDGLSSECDCRIKIL 260
Cdd:pfam00028   76 SGG--PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-267 1.84e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.84e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     180 SATDADEDNhlNSKIAYKIISQEPAGapMFMVNRYTGEVRTMSNfLDREQHSMYNLLVRGSDRDGatDGLSSECDCRIKI 259
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGG--PPLSSTATVTITV 73


                    ....*...
gi 41054894     260 LDVNDNFP 267
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 2.43e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  273 SYSASIEENC-LSSELIRLQAIDLDEEgtDNWLAQYSILSGNDGNWFEIqtDPKTneGILKLVKMLDYEQEPNIYLSIGV 351
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 41054894  352 RNQAEFHHSVasqfqmhSTPVRIQVINV 379
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-377 3.24e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 3.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    274 YSASIEENCLS-SELIRLQAIDLDEegTDNWLAQYSILSGNDGNWFEIQTDPktneGILKLVKMLDYEQEPNIYLSIGVR 352
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....*
gi 41054894    353 NqaefhHSVASQFQmhSTPVRIQVI 377
Cdd:pfam00028   75 D-----SGGPPLSS--TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.38e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894   62 EDNSKRNPIARIR---SDCEVSQRITYRISGAGIDrppyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 41054894  139 RPLELRVKVMDVNDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 1.71e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.71e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894      75 SDCEVSQRITYRISGAGIDrppyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNP 154
Cdd:smart00112    5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 41054894     155 P 155
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
54-147 2.25e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 2.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     54 FAAACREGE-DNSKRNPIARIRSDCEVSQRITYRISGAGidrpPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNS 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 41054894    133 RGEDLERPLELRVKV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-492 2.75e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894  401 DSLMNYVLGTYTAIDMDTGSPAtNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRT 478
Cdd:cd11304    9 NAPPGTVVLTVSATDPDSGENG-EVTYSIvSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATDGGGpPLS 83

                         90
                 ....*....|....
gi 41054894  479 ATGTICIEVPDAND 492
Cdd:cd11304   84 STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 4.93e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 4.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     291 QAIDLDEEgtDNWLAQYSILSGNDGNWFEIqtDPKTneGILKLVKMLDYEQEPNIYLSIGVRNQAEFHHSVasqfqmhST 370
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                    ....*....
gi 41054894     371 PVRIQVINV 379
Cdd:smart00112   68 TVTITVLDV 76
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 790-846 6.48e-09

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 52.92  E-value: 6.48e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41054894    790 ADEDEGRPANDCLLIYDHEGTGSPVGSIGC-CSWIVD-DLDESYMETLDPKFRTLAEIC 846
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSlESSTSDsDQDYDYLSDWGPRFKKLAELY 59
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 57-153 4.38e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.96  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894   57 ACREGEDNSKRnpIARIRSDCEVSQRITYRISGAGIDRPPyGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGED 136
Cdd:cd00031    5 SAVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                         90
                 ....*....|....*..
gi 41054894  137 LERPLELRVKVMDVNDN 153
Cdd:cd00031   82 PQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-495 4.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 4.96e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894     412 TAIDMDTGSPAtNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRTATGTICIEVPD 489
Cdd:smart00112    1 SATDADSGENG-KVTYSIlSGNDDGLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGpPLSSTATVTITVLD 75


                    ....*.
gi 41054894     490 ANDYCP 495
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
401-487 1.82e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054894    401 DSLMNYVLGTYTAIDMDTGsPATNVRYVI-GHDAGSWLKVDSRTGEIQFSREFDtkskYITDGMYAAEILAIDDGS-GRT 478
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG-PNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLD----RESIGEYELTVEATDSGGpPLS 82


                   ....*....
gi 41054894    479 ATGTICIEV 487
Cdd:pfam00028   83 STATVTITV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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