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Conserved domains on  [gi|148540125|ref|NP_987089|]
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dentin matrix acidic phosphoprotein 1 isoform 2 precursor [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 12073942)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Arabidopsis thaliana methyltransferase PMT25

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DMP1 pfam07263
Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix ...
1-489 2.95e-111

Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.


:

Pssm-ID: 462128 [Multi-domain]  Cd Length: 519  Bit Score: 339.21  E-value: 2.95e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    1 MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPM---------------ANSDHTDSSESGEELGSDRS 65
Cdd:pfam07263   1 MKTSILLMFLWGLSCALPVARYQNTESESSEEWKGHLAQSPTPPLssesseeskvsseeqANEDPSDSTESEEDLGSDDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   66 QY--RPAGGLSKSAGMDADKEEDEDDSG-DDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQ-ENSAQDT 141
Cdd:pfam07263  81 QYvyRPAGGLSRSGGKEGDDKDDDEDDSgDDTFGDEDNGPGPEERQEGGNSRLGSDEDSADTTQSREDSASQgEDSAQDT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  142 PSDSKDH-HSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEE 220
Cdd:pfam07263 161 TSESRDLdNEDEVSSRPESGDSTQDSESEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPDSIRSERGNSRMSSASVKSKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  221 SKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRE-TQSDSTEDF--------RSKEESRSETQEDT 291
Cdd:pfam07263 241 SKGDSEQASTQDSGDSQSVEYPSRKFFRKSRISEEDDRGELDDSNTMEeVKSDSTESTsskeaglsQSREDSKSESQEDS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  292 AETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQ-TGDQRDSESSEEDRLNTFSSSESQSTE 370
Cdd:pfam07263 321 EESQSQEDSQNSQDPSSESSQEADLPSQESSSESQEEVVSESRGDNPDNTSSsEEDQEDSDSSEEDSLSTFSSSESESRE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  371 EQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSS 450
Cdd:pfam07263 401 EQADSESNESLRSSEESPESSEDENSSSQEGLQSHSASTESQSEESQSEQDSQSEEDDESDSQDSSRSKEDSNSTESTSS 480
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 148540125  451 SEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY 489
Cdd:pfam07263 481 SEEDGQSKNMEIESRKLTVDAYHNKPIGDQDDNDCQDGY 519
 
Name Accession Description Interval E-value
DMP1 pfam07263
Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix ...
1-489 2.95e-111

Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.


Pssm-ID: 462128 [Multi-domain]  Cd Length: 519  Bit Score: 339.21  E-value: 2.95e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    1 MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPM---------------ANSDHTDSSESGEELGSDRS 65
Cdd:pfam07263   1 MKTSILLMFLWGLSCALPVARYQNTESESSEEWKGHLAQSPTPPLssesseeskvsseeqANEDPSDSTESEEDLGSDDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   66 QY--RPAGGLSKSAGMDADKEEDEDDSG-DDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQ-ENSAQDT 141
Cdd:pfam07263  81 QYvyRPAGGLSRSGGKEGDDKDDDEDDSgDDTFGDEDNGPGPEERQEGGNSRLGSDEDSADTTQSREDSASQgEDSAQDT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  142 PSDSKDH-HSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEE 220
Cdd:pfam07263 161 TSESRDLdNEDEVSSRPESGDSTQDSESEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPDSIRSERGNSRMSSASVKSKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  221 SKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRE-TQSDSTEDF--------RSKEESRSETQEDT 291
Cdd:pfam07263 241 SKGDSEQASTQDSGDSQSVEYPSRKFFRKSRISEEDDRGELDDSNTMEeVKSDSTESTsskeaglsQSREDSKSESQEDS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  292 AETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQ-TGDQRDSESSEEDRLNTFSSSESQSTE 370
Cdd:pfam07263 321 EESQSQEDSQNSQDPSSESSQEADLPSQESSSESQEEVVSESRGDNPDNTSSsEEDQEDSDSSEEDSLSTFSSSESESRE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  371 EQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSS 450
Cdd:pfam07263 401 EQADSESNESLRSSEESPESSEDENSSSQEGLQSHSASTESQSEESQSEQDSQSEEDDESDSQDSSRSKEDSNSTESTSS 480
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 148540125  451 SEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY 489
Cdd:pfam07263 481 SEEDGQSKNMEIESRKLTVDAYHNKPIGDQDDNDCQDGY 519
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
99-305 1.45e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 54.23  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    99 DNGPGPEERQWGGPSRLDsDEDSADTTQSSEDSTSQENSAQ-DTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGS 177
Cdd:TIGR00927  643 ERTGEEGERPTEAEGENG-EESGGEAEQEGETETKGENESEgEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGET 721
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   178 EGE--------SSHGDGSEFDDEG---MQSDDPGSTRSDRGHTRMsSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKS 246
Cdd:TIGR00927  722 EAEgtedegeiETGEEGEEVEDEGegeAEGKHEVETEGDRKETEH-EGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGK 800
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148540125   247 FRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRSETQEDTAETQSQEDSPEGQD 305
Cdd:TIGR00927  801 VEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSD 859
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
97-408 2.45e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.21  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  97 DEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGG 176
Cdd:NF033609 560 DSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASD 639
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 177 SEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEED 256
Cdd:NF033609 640 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 719
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 257 DRGELADSNSRETQSDSTEDFRSKEESRSETQEDtaeTQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGD 336
Cdd:NF033609 720 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 796
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148540125 337 NPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSAS 408
Cdd:NF033609 797 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGS 868
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
11-336 1.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   11 WGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGS----DRSQYRPAGGLSKSAGMDADKEED 86
Cdd:PHA03307   68 PTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPtpppASPPPSPAPDLSEMLRPVGSPGPP 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   87 EDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDS 166
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  167 EseeyRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDdsqdvefssrkS 246
Cdd:PHA03307  228 A----ADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP-----------R 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  247 FRRSRVSEEDDRGELADSNSR--ETQSDSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSE 324
Cdd:PHA03307  293 ERSPSPSPSSPGSGPAPSSPRasSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372
                         330
                  ....*....|..
gi 148540125  325 SQEGVASESRGD 336
Cdd:PHA03307  373 RAPSSPAASAGR 384
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
43-352 1.02e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 41.82  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  43 PPMANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSA 122
Cdd:NF033609 556 PIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSD 635
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 123 DTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGST 202
Cdd:NF033609 636 SASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 715
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 203 RSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEE 282
Cdd:NF033609 716 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148540125 283 SRSETQEDT-AETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSES 352
Cdd:NF033609 796 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
46-342 2.77e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  46 ANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQwGGPSRLDSDEDSADTT 125
Cdd:NF033609 576 SDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS-DSDSDSDSDSDSDSDS 654
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 126 QSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSD 205
Cdd:NF033609 655 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 734
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 206 RGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRS 285
Cdd:NF033609 735 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 814
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148540125 286 ETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTS 342
Cdd:NF033609 815 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNN 871
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
152-464 4.08e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.89  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 152 EADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQ 231
Cdd:NF033609 553 EIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS 632
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 232 DSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRSETQEDTaETQSQEDSPEGQDPSSESS 311
Cdd:NF033609 633 DSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 711
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 312 EEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESA 391
Cdd:NF033609 712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148540125 392 QDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADN 464
Cdd:NF033609 792 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDS 864
 
Name Accession Description Interval E-value
DMP1 pfam07263
Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix ...
1-489 2.95e-111

Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.


Pssm-ID: 462128 [Multi-domain]  Cd Length: 519  Bit Score: 339.21  E-value: 2.95e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    1 MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPM---------------ANSDHTDSSESGEELGSDRS 65
Cdd:pfam07263   1 MKTSILLMFLWGLSCALPVARYQNTESESSEEWKGHLAQSPTPPLssesseeskvsseeqANEDPSDSTESEEDLGSDDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   66 QY--RPAGGLSKSAGMDADKEEDEDDSG-DDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQ-ENSAQDT 141
Cdd:pfam07263  81 QYvyRPAGGLSRSGGKEGDDKDDDEDDSgDDTFGDEDNGPGPEERQEGGNSRLGSDEDSADTTQSREDSASQgEDSAQDT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  142 PSDSKDH-HSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEE 220
Cdd:pfam07263 161 TSESRDLdNEDEVSSRPESGDSTQDSESEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPDSIRSERGNSRMSSASVKSKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  221 SKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRE-TQSDSTEDF--------RSKEESRSETQEDT 291
Cdd:pfam07263 241 SKGDSEQASTQDSGDSQSVEYPSRKFFRKSRISEEDDRGELDDSNTMEeVKSDSTESTsskeaglsQSREDSKSESQEDS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  292 AETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQ-TGDQRDSESSEEDRLNTFSSSESQSTE 370
Cdd:pfam07263 321 EESQSQEDSQNSQDPSSESSQEADLPSQESSSESQEEVVSESRGDNPDNTSSsEEDQEDSDSSEEDSLSTFSSSESESRE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  371 EQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSS 450
Cdd:pfam07263 401 EQADSESNESLRSSEESPESSEDENSSSQEGLQSHSASTESQSEESQSEQDSQSEEDDESDSQDSSRSKEDSNSTESTSS 480
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 148540125  451 SEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY 489
Cdd:pfam07263 481 SEEDGQSKNMEIESRKLTVDAYHNKPIGDQDDNDCQDGY 519
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
99-305 1.45e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 54.23  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    99 DNGPGPEERQWGGPSRLDsDEDSADTTQSSEDSTSQENSAQ-DTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGS 177
Cdd:TIGR00927  643 ERTGEEGERPTEAEGENG-EESGGEAEQEGETETKGENESEgEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGET 721
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   178 EGE--------SSHGDGSEFDDEG---MQSDDPGSTRSDRGHTRMsSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKS 246
Cdd:TIGR00927  722 EAEgtedegeiETGEEGEEVEDEGegeAEGKHEVETEGDRKETEH-EGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGK 800
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148540125   247 FRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRSETQEDTAETQSQEDSPEGQD 305
Cdd:TIGR00927  801 VEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSD 859
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
97-408 2.45e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.21  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  97 DEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGG 176
Cdd:NF033609 560 DSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASD 639
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 177 SEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEED 256
Cdd:NF033609 640 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 719
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 257 DRGELADSNSRETQSDSTEDFRSKEESRSETQEDtaeTQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGD 336
Cdd:NF033609 720 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 796
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148540125 337 NPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSAS 408
Cdd:NF033609 797 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGS 868
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
11-336 1.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   11 WGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGS----DRSQYRPAGGLSKSAGMDADKEED 86
Cdd:PHA03307   68 PTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPtpppASPPPSPAPDLSEMLRPVGSPGPP 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   87 EDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDS 166
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  167 EseeyRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDdsqdvefssrkS 246
Cdd:PHA03307  228 A----ADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP-----------R 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  247 FRRSRVSEEDDRGELADSNSR--ETQSDSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSE 324
Cdd:PHA03307  293 ERSPSPSPSSPGSGPAPSSPRasSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372
                         330
                  ....*....|..
gi 148540125  325 SQEGVASESRGD 336
Cdd:PHA03307  373 RAPSSPAASAGR 384
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
26-302 1.54e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.60  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125    26 ESESSEERTGNLAQSPPPPMAnsdhtdssESGEELGSDRSQyrpaGGLSKSAGMDADKEEDEDDSGDDtfgDEDNGPGPE 105
Cdd:TIGR00927  637 EAEHTGERTGEEGERPTEAEG--------ENGEESGGEAEQ----EGETETKGENESEGEIPAERKGE---QEGEGEIEA 701
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   106 ERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRpEAGDSTQDSESEEYRVGGGSEGESSHGD 185
Cdd:TIGR00927  702 KEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGK-HEVETEGDRKETEHEGETEAEGKEDEDE 780
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   186 GSefddegMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGEL-ADS 264
Cdd:TIGR00927  781 GE------IQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKgVDG 854
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 148540125   265 NSRETQSDSTEDFRSKEESRSETQEDTAETQSQEDSPE 302
Cdd:TIGR00927  855 GGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEENEE 892
PRK12678 PRK12678
transcription termination factor Rho; Provisional
20-239 2.08e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 43.74  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  20 ARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGSDRSQYRPagglsKSAGMDADKEEDEDDSGDDTFGDED 99
Cdd:PRK12678  85 AAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERG-----EAARRGAARKAGEGGEQPATEARAD 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 100 NGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEaDSRPEAGDSTQDSESEEYRVGGGSEG 179
Cdd:PRK12678 160 AAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQG-DRREERGRRDGGDRRGRRRRRDRRDA 238
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 180 ESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRmSSAGIRSEESKGDHEPTSTQDsDDSQDV 239
Cdd:PRK12678 239 RGDDNREDRGDRDGDDGEGRGGRRGRRFRDR-DRRGRRGGDGGNEREPELRED-DVLVPV 296
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
127-420 8.87e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 8.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   127 SSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDR 206
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGET 710
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   207 GHTRMSSAGIRSEESKGDHEPTSTQdsddsqdvefssrksfRRSRVSEEDDRGELADSNSRETQSDSTE-DFRSKEESRS 285
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETG----------------EEGEEVEDEGEGEAEGKHEVETEGDRKEtEHEGETEAEG 774
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125   286 ETQEDTAETQSQEDSPEGQDPSSESSEEAGEpsqesssesQEGVASESRGDNPDNTSQTGDQRDSESSEEDrLNTFSSSE 365
Cdd:TIGR00927  775 KEDEDEGEIQAGEDGEMKGDEGAEGKVEHEG---------ETEAGEKDEHEGQSETQADDTEVKDETGEQE-LNAENQGE 844
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148540125   366 SQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEglqsqsaSRESRSQESQSEQ 420
Cdd:TIGR00927  845 AKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEE-------EEEEEEEEEENEE 892
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
43-352 1.02e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 41.82  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  43 PPMANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSA 122
Cdd:NF033609 556 PIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSD 635
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 123 DTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGST 202
Cdd:NF033609 636 SASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 715
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 203 RSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEE 282
Cdd:NF033609 716 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148540125 283 SRSETQEDT-AETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSES 352
Cdd:NF033609 796 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
46-342 2.77e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  46 ANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQwGGPSRLDSDEDSADTT 125
Cdd:NF033609 576 SDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS-DSDSDSDSDSDSDSDS 654
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 126 QSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSD 205
Cdd:NF033609 655 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 734
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 206 RGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRS 285
Cdd:NF033609 735 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 814
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148540125 286 ETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTS 342
Cdd:NF033609 815 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNN 871
PHA02664 PHA02664
hypothetical protein; Provisional
97-180 3.24e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 39.98  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125  97 DEDNGPGPEERQwGGPS---RLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRV 173
Cdd:PHA02664 430 EAEAHDEFDQDP-GAPAhadRADSDEDDMDEQESGDERADGEDDSDSSYSYSTTSSEDESDSADDSWGDESDSGIEHDDG 508

                 ....*..
gi 148540125 174 GGGSEGE 180
Cdd:PHA02664 509 GVGQAIE 515
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
152-464 4.08e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.89  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 152 EADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQ 231
Cdd:NF033609 553 EIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS 632
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 232 DSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSDSTEDFRSKEESRSETQEDTaETQSQEDSPEGQDPSSESS 311
Cdd:NF033609 633 DSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 711
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148540125 312 EEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESA 391
Cdd:NF033609 712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148540125 392 QDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADN 464
Cdd:NF033609 792 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDS 864
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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