BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQLIYSGSLH 109
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 47087101 110 LPLDALPAHLLVASGLQMWQVVDRCSEILRE 140
Cdd:cd18200  81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQLIYSGSLH 109
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 47087101 110 LPLDALPAHLLVASGLQMWQVVDRCSEILRE 140
Cdd:cd18200  81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101     49 DVSLLVQGRELRAHKAVLAAASPYFHdKLLLGDAPRLTLPNV----IEADAFEGLLQLIYSGSLHLPLDALPAHLLVASG 124
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFK-ALFSSDFKESDKSEIylddVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 47087101    125 LQMWQVVDRCSEILRELE 142
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

zinc finger;

                           10        20
                   ....*....|....*....|.
gi 47087101    405 CGICNKRFKLKHHLTEHMKTH 425
Cdd:smart00355   3 CPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQLIYSGSLH 109
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 47087101 110 LPLDALPAHLLVASGLQMWQVVDRCSEILRE 140
Cdd:cd18200  81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  24 HIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQLI 103
Cdd:cd18227   2 RVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSC 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47087101 104 YSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEILR 139
Cdd:cd18227  82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  23 IHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQL 102
Cdd:cd18220   1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47087101 103 IYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEILREL 141
Cdd:cd18220  81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESI 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  31 SSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDApRLTLPNVIEADAFEGLLQLIYSGSLHL 110
Cdd:cd18229   2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHS-EIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                        90       100
                ....*....|....*....|....*...
gi 47087101 111 PLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18229  81 AQSEALQILTAASILQIKTVIDECTQII 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  21 QTIHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLL 100
Cdd:cd18290   1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQIL 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47087101 101 QLIYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSE 136
Cdd:cd18290  81 SFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  23 IHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQL 102
Cdd:cd18214   1 LHFRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSREVQISILQNSEVGRQLLLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47087101 103 IYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18214  81 CYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  21 QTIHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLL 100
Cdd:cd18289   3 QMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQIL 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47087101 101 QLIYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18289  83 SFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  23 IHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhDKLL----LGDAPRLTLPNVIEADAFEG 98
Cdd:cd18198   1 IGIPFPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYF-KKLFtsgaVVDQQNVYEIDFVSPEALTA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47087101  99 LLQLIYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18198  80 LLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  25 IDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTlPNVIEADAFEGLL 100
Cdd:cd18324   1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHlfykDQLDKRDIVHLN-SDIVTAPAFALLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47087101 101 QLIYSGSLH---LPLDALpahLLVASGLQMWQVVDRCSEILRELET 143
Cdd:cd18324  80 EFMYEGKLQfkdLPIEDV---LAAASYLHMYDIVKVCKKKLKEKAT 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  23 IHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLG---DAPRLTLPNVIEADAFEGL 99
Cdd:cd18326   1 IGIPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGavvDQQNVYEIDFVSAEALTAL 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47087101 100 LQLIYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18326  81 LDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  26 DFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhdKLLLGDAPRLTLPNVIEADAFEGLLQLIYS 105
Cdd:cd18206   1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYF--RMLFVDQKDVVHLDISNAAGLGQVLEFMYT 78

                        90       100       110
                ....*....|....*....|....*....|
gi 47087101 106 GSLHLPLDALPAHLLVASGLQMWQVVDRCS 135
Cdd:cd18206  79 AKLSLSPENVDDVLAVATFLQMQDIVTACH 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  25 IDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTlPNVIEADAFEGLL 100
Cdd:cd18194   1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHlfyrDRLDKRDLVRLN-SDIVTAPAFGLLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47087101 101 QLIYSGSLHlpLDALPAH--LLVASGLQMWQVVDRCSEILRELET 143
Cdd:cd18194  80 DFMYEGRLA--LRDLPVEdvLAAASYLHMYDIVKVCKGRLQEKAL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  23 IHIDFPHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPNVIEADAFEGLLQL 102
Cdd:cd18197   1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47087101 103 IYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18197  81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHdKLLLGDAPR----LTLPNVIEADAFEGLLQLIYS 105
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFY-SIFTDQLKNnvsvINLDPEIEPEGFRILLDFMYT 80

                        90       100
                ....*....|....*....|....*....
gi 47087101 106 GSLHLPLDALPAHLLVASGLQMWQVVDRC 134
Cdd:cd18215  81 SRLNLREGNIMAVMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTL-PNVIEADAFEGLLQLIYSGSL 108
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLdQSQVSADGFQKLLEFIYTGNL 80

                        90       100
                ....*....|....*....|....*....
gi 47087101 109 HLPLDALPAHLLVASGLQMWQVVDRCSEI 137
Cdd:cd18217  81 NLDSWNVAEIHQAASYLGMEEVVAKCKIK 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  29 HHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDklLLGDAPRLTLPNVIEADAFEGLLQLIYSGSL 108
Cdd:cd18219   3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQ--LFSVAGQVVELNFIRADIFAEILNYIYSSKI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHdKLLLGDAPR---LTLPNVIEADAFEGLLQLIYSG 106
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFL-QALVGQTENdlvVSLPEEVTARGFGPLLQFAYTA 92

                        90       100       110
                ....*....|....*....|....*....|..
gi 47087101 107 SLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18278  93 KLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  47 FCDVSLLVQGRELRAHKAVLAAASPYFhdKLLLGDA-----PRLTLPNViEADAFEGLLQLIYSGSLHLPLDALPAHLLV 121
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYF--AALLKETppdehPVIILPDV-PYSELKALLDFIYTGEVNVSQEQLESLLKL 77

                ....*....
gi 47087101 122 AsglQMWQV 130
Cdd:cd18315  78 A---ELLQI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLL-LGDAP-RLTLPNVIEADAFEGLLQLIYSGS 107
Cdd:cd18277  10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgQADAElNITLPEEVTVKGFEPLIQFAYTAK 89

                        90       100       110
                ....*....|....*....|....*....|.
gi 47087101 108 LHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18277  90 LILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  28 PHHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHdKLLLGD-----APRLTLPNViEADAFEGLLQL 102
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFH-AMFTGDlsesrANRVTLQDV-DGKALLLLIDY 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47087101 103 IYSGSLHLPLDALPAHLLVASGLQMWQVVDRCSEIL 138
Cdd:cd18235  80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhdKLLL-------GDAPRLTLpNVIEADAFEGLLQL 102
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYF--RMLLshyiqdtGRPSTASF-DVFSSDAFSIILDF 77

                        90       100       110
                ....*....|....*....|....*....|..
gi 47087101 103 IYSGSLHLPLDALPAHLLVASGLQMWQVVDRC 134
Cdd:cd18199  78 VYSGKLSLTSQNVIEVMSAASYLQMTDVINVC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhDKLLLGDAPRLTLPNV----IEADAFEGLLQLIYS 105
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYF-CAMFTSEMSEKGKSEVelqgLTASTMEILLDFVYT 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47087101 106 GSLHLPL----DALPAhllvASGLQMWQVVDRCSEIL 138
Cdd:cd18242  83 ETVHVTVenvqELLPA----ACLLQLKGVKQACCEFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTLPNViEADAFEGLLQLIYS 105
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHlmftSNMTESKSSEVELKDA-EPDIIELLVEFAYT 82

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47087101 106 GSLHLPLDALPAHLLVASGLQMWQVVDRCSEILRE 140
Cdd:cd18237  83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47087101  34 LLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYF------HDKLLLGDAPRLTLpNVIEADAFEGLLQLIYSGS 107
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFraklnyNPPKDDGSTYKIEL-EGISVEVMEEILDYIYTGQ 79