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Conserved domains on  [gi|564325521|ref|XP_006228034|]
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endoplasmic reticulum membrane-associated RNA degradation protein isoform X1 [Rattus norvegicus]

Protein Classification

endoplasmic reticulum membrane-associated RNA degradation protein( domain architecture ID 10621442)

endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD) is a DUF4209 domain-containing protein that may play a role in neuronal migration during embryonic development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-205 1.48e-25

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 100.43  E-value: 1.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  133 LERALGDVFLLIG-------NECPFLLRDLLASAELAHVFGHAVMDVLKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80
DUF4209 super family cl16470
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 298-388 8.14e-04

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


The actual alignment was detected with superfamily member pfam13910:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 38.80  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  298 LEAGLRRVFATVNKcpdrLLTAESTILYTTFDEILAkhmsDGSINQLpcfLGEPAMDFLWDFLNYQEGPRIRDRLSHGEI 377
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|.
gi 564325521  378 NIREFPKAAAS 388
Cdd:pfam13910  70 SPSEFNPSYAS 80
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-205 1.48e-25

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 100.43  E-value: 1.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  133 LERALGDVFLLIG-------NECPFLLRDLLASAELAHVFGHAVMDVLKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 298-388 8.14e-04

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 38.80  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  298 LEAGLRRVFATVNKcpdrLLTAESTILYTTFDEILAkhmsDGSINQLpcfLGEPAMDFLWDFLNYQEGPRIRDRLSHGEI 377
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|.
gi 564325521  378 NIREFPKAAAS 388
Cdd:pfam13910  70 SPSEFNPSYAS 80
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-205 1.48e-25

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 100.43  E-value: 1.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  133 LERALGDVFLLIG-------NECPFLLRDLLASAELAHVFGHAVMDVLKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 298-388 8.14e-04

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 38.80  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325521  298 LEAGLRRVFATVNKcpdrLLTAESTILYTTFDEILAkhmsDGSINQLpcfLGEPAMDFLWDFLNYQEGPRIRDRLSHGEI 377
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|.
gi 564325521  378 NIREFPKAAAS 388
Cdd:pfam13910  70 SPSEFNPSYAS 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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