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Conserved domains on  [gi|564325800|ref|XP_006228150|]
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zinc finger protein 260-like [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 2.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 2.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564325800   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFYVG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-634 3.89e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 209 KIYKCRECDKHFTQKRNLIIHQRCHGGKKPYKCS--ECEKCFIQVGDLRRHQRIHTGEKPYKCSecDKCFSYKSSLRSHQ 286
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 287 IIHTGEKPykcNECDKCFTHKGSLSIHQRIHTGEKpYKCHECDKCFTQKGSLITHQRIHTgekpykcsecdkgftlkCSL 366
Cdd:COG5048  110 LSSSSSNS---NDNNLLSSHSLPPSSRDPQLPDLL-SISNLRNNPLPGNNSSSVNTPQSN-----------------SLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 367 IIHQIIHTGKKAYKCSecdkcftlkcDLSIHQRIHTGEKLYRCNECDKCFTKKYRLRSHQTIHTGEKPYKCSECdkSFTL 446
Cdd:COG5048  169 PPLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 447 KCHLRIHQRIHTGEKPYKCSECDKYFTQKGGLSTHQKIH---------AGEKPYRCSKCDKCYTRKSHLSVHQR--IHIG 515
Cdd:COG5048  237 PKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 516 E--KPYKCNE--CDKCFTDKYCLKTHQRIHSGNKPYKCSEC----DKSFALKARLKSHQIIHTGEKPYK-----CSKCGK 582
Cdd:COG5048  317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKksetlSNSCIR 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564325800 583 YFTQKGSLSIHQRIHTGEKP--YKCSECDKCFTRKSSLNVHQRIHTGEKPYKCC 634
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 2.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 2.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564325800   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFYVG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-55 1.84e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.84e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564325800    13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFYVGNH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.76e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.76e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564325800  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLF 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-634 3.89e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 209 KIYKCRECDKHFTQKRNLIIHQRCHGGKKPYKCS--ECEKCFIQVGDLRRHQRIHTGEKPYKCSecDKCFSYKSSLRSHQ 286
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 287 IIHTGEKPykcNECDKCFTHKGSLSIHQRIHTGEKpYKCHECDKCFTQKGSLITHQRIHTgekpykcsecdkgftlkCSL 366
Cdd:COG5048  110 LSSSSSNS---NDNNLLSSHSLPPSSRDPQLPDLL-SISNLRNNPLPGNNSSSVNTPQSN-----------------SLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 367 IIHQIIHTGKKAYKCSecdkcftlkcDLSIHQRIHTGEKLYRCNECDKCFTKKYRLRSHQTIHTGEKPYKCSECdkSFTL 446
Cdd:COG5048  169 PPLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 447 KCHLRIHQRIHTGEKPYKCSECDKYFTQKGGLSTHQKIH---------AGEKPYRCSKCDKCYTRKSHLSVHQR--IHIG 515
Cdd:COG5048  237 PKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 516 E--KPYKCNE--CDKCFTDKYCLKTHQRIHSGNKPYKCSEC----DKSFALKARLKSHQIIHTGEKPYK-----CSKCGK 582
Cdd:COG5048  317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKksetlSNSCIR 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564325800 583 YFTQKGSLSIHQRIHTGEKP--YKCSECDKCFTRKSSLNVHQRIHTGEKPYKCC 634
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 564325800  253 DLRRHQRIHTGEKPYKCSECDKCFSY 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 2.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 2.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564325800   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFYVG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-55 1.84e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.84e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564325800    13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFYVGNH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.76e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.76e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564325800  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLF 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-634 3.89e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 209 KIYKCRECDKHFTQKRNLIIHQRCHGGKKPYKCS--ECEKCFIQVGDLRRHQRIHTGEKPYKCSecDKCFSYKSSLRSHQ 286
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 287 IIHTGEKPykcNECDKCFTHKGSLSIHQRIHTGEKpYKCHECDKCFTQKGSLITHQRIHTgekpykcsecdkgftlkCSL 366
Cdd:COG5048  110 LSSSSSNS---NDNNLLSSHSLPPSSRDPQLPDLL-SISNLRNNPLPGNNSSSVNTPQSN-----------------SLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 367 IIHQIIHTGKKAYKCSecdkcftlkcDLSIHQRIHTGEKLYRCNECDKCFTKKYRLRSHQTIHTGEKPYKCSECdkSFTL 446
Cdd:COG5048  169 PPLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 447 KCHLRIHQRIHTGEKPYKCSECDKYFTQKGGLSTHQKIH---------AGEKPYRCSKCDKCYTRKSHLSVHQR--IHIG 515
Cdd:COG5048  237 PKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 516 E--KPYKCNE--CDKCFTDKYCLKTHQRIHSGNKPYKCSEC----DKSFALKARLKSHQIIHTGEKPYK-----CSKCGK 582
Cdd:COG5048  317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKksetlSNSCIR 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564325800 583 YFTQKGSLSIHQRIHTGEKP--YKCSECDKCFTRKSSLNVHQRIHTGEKPYKCC 634
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-654 5.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 265 KPYKCSECDKCFSYKSSLRSHQIIHTGEKPYKCN--ECDKCFTHKGSLSIHQRIHTGEKPYKCheCDKCFTQKGSLITHQ 342
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 343 RIHTGEKPYKCSECDKgfTLKCSLIIHQIIHTGkkaYKCSECDKCFTLKCDLSIHQRIHTGEKLYRC--NECDKCFTKKY 420
Cdd:COG5048  110 LSSSSSNSNDNNLLSS--HSLPPSSRDPQLPDL---LSISNLRNNPLPGNNSSSVNTPQSNSLHPPLpaNSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 421 RLRSHQTIHTGEKPYKCSECDKSFTLKCHLRIHQRIHTGEKPYKCSE----CDKYFTQKGGLSTHQKIHAGEKP--YRCS 494
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnsqlSPKSLLSQSPSSLSSSDSSSSASesPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 495 KCDKCYTRKSHLSVHQRIHIG-EKPYKCNECDKCFTDKYCLKTHQR--IHSG--NKPYKCSE--CDKSFALKARLKSHQI 567
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 568 IHTGEKPYKC--SKCGKYFTQK------GSLSIHQRIHTGEKPYKC-SECDKCFTRKSSLNVHQRIHTGEKP--YKCCEC 636
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410
                 ....*....|....*...
gi 564325800 637 EKCFSHKGDFRKHQRIHI 654
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-659 5.35e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 321 KPYKCHECDKCFTQKGSLITHQRIHTGEKPYKCS--ECDKGFTLKCSLIIHQIIHTGKKAYKCS-ECDKCFTLKCDLSIH 397
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 398 QRIHTGEKLYRCNECDKCFTKKYRLRSHQTIHTGEKPYKCSECDKSFT-LKCHLRIHQRIHTGEKPYKCSECDKYFTQKG 476
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 477 GLSTHQKIhagekpYRCSKCDKCYTRKSHLSVHQRIHIgEKPYKCNECDKCFTDKYCLKTHQRIHSGNKPYKCSECDKSF 556
Cdd:COG5048  192 VSTSIPSS------SENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 557 ALKARLKSHQIIHTGE-------KPYKCSKCGKYFTQKGSLSIHQR--IHTGE--KPYKCSE--CDKCFTRKSSLNVHQR 623
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 564325800 624 IHTGEKPYKCCECEKCFSHKGDF--RKHQRIHIGKKPN 659
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKFSPLLnnEPPQSLQQYKDLK 382
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 514-593 1.40e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 514 IGEKPYKCN--ECDKCFTDKYCLKTHqRIHSGNKPYKCSECDKsfalkarlKSHQIIHTGEKPYKCSKCGKYFTQKGSLS 591
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ..
gi 564325800 592 IH 593
Cdd:COG5189  416 YH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-542 2.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 459 GEKPYKCS--ECDKYFTQKGGLSTHQKI-HAGEKPYRCSKCDKcytrkshlsvHQRIHIGEKPYKCNECDKCFTDKYCLK 535
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 564325800 536 THqRIHS 542
Cdd:COG5189  416 YH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 431-509 2.53e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 431 GEKPYKCS--ECDKSFTLKCHLRIHqRIHtgekpykcSECDKYFTQKGGLSTHQKIHAGEKPYRCSKCDKCYTRKSHLSV 508
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 564325800 509 H 509
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 564325800  253 DLRRHQRIHTGEKPYKCSECDKCFSY 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-474 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 564325800  449 HLRIHQRIHTGEKPYKCSECDKYFTQ 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 3.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 564325800  281 SLRSHQIIHTGEKPYKCNECDKCFTH 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 291-358 3.56e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564325800 291 GEKPYKCN--ECDKCFTHKGSLSIHqRIHTgekpykchECDKCFTQKGSLITHQRIHTGEKPYKCSECDK 358
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
544-606 4.07e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564325800 544 NKPYKCSECDKSFALKARLKSHQIIHTGEKPYKCSK--CGKYFTQKGSLSIHQRIHTGEKPYKCS 606
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-445 4.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.64e-03
                          10        20
                  ....*....|....*....|....*
gi 564325800  421 RLRSHQTIHTGEKPYKCSECDKSFT 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 564325800  309 SLSIHQRIHTGEKPYKCHECDKCFTQ 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-614 5.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 564325800  589 SLSIHQRIHTGEKPYKCSECDKCFTR 614
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-586 9.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 564325800  561 RLKSHQIIHTGEKPYKCSKCGKYFTQ 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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