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Conserved domains on  [gi|564326918|ref|XP_006228632|]
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latent-transforming growth factor beta-binding protein 4 isoform X2 [Rattus norvegicus]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 11256465)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.82e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 4.82e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564326918   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-854 2.13e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.13e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    818 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 854
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1300-1342 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1300 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1342
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1133-1175 4.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1133 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1175
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
989-1030 1.24e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564326918    989 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1030
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-895 8.10e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.10e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    860 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 895
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 775-807 1.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.71e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  775 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 807
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.46e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.46e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564326918    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 612-649 4.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564326918  612 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 649
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
693-734 1.06e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    693 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 734
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-611 3.32e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    570 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 611
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-564 3.35e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.35e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 564326918    528 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 564
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1514-1548 6.87e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.87e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918   1514 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1548
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-685 1.03e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918    651 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 685
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
901-939 1.99e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564326918    901 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 939
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1236-1265 2.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.16e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 564326918 1236 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1265
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
735-770 8.63e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.63e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    735 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 770
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.82e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 4.82e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564326918   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-854 2.13e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.13e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    818 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 854
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1300-1342 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1300 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1342
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1133-1175 4.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1133 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1175
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
989-1030 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564326918    989 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1030
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-850 3.08e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.08e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  818 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 850
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 989-1024 8.05e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 8.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564326918  989 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1024
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-895 8.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.10e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    860 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 895
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 775-807 1.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.71e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  775 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 807
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
775-807 2.79e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.79e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564326918    775 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 807
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.46e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.46e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564326918    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 612-649 4.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564326918  612 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 649
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 860-891 7.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.41e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  860 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 891
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
693-734 1.06e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    693 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 734
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
612-649 1.14e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 564326918    612 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 649
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 1.35e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564326918  290 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 324
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-611 3.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    570 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 611
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-564 3.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.35e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 564326918    528 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 564
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1514-1548 6.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.87e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918   1514 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1548
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 693-725 9.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564326918  693 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 725
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
860-889 9.68e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.68e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   860 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 889
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-611 9.83e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 9.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564326918  570 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 611
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-685 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918    651 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 685
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 999-1029 1.13e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.13e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 564326918   999 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1029
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 651-685 1.35e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564326918  651 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 685
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
693-723 1.75e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   693 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 723
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
901-939 1.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564326918    901 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 939
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1236-1265 2.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.16e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 564326918 1236 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1265
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1514-1552 2.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564326918 1514 DINECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1552
Cdd:cd00054     1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1236-1265 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 564326918   1236 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1265
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
290-319 2.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   290 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 319
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1514-1547 5.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.36e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 564326918  1514 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1547
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
570-600 5.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   570 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 600
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
612-642 6.85e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.85e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   612 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 642
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 528-560 7.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564326918  528 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 560
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
735-770 8.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.63e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    735 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 770
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.82e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 4.82e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564326918   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-854 2.13e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.13e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    818 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 854
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1300-1342 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1300 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1342
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1133-1175 4.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564326918  1133 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1175
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
989-1030 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564326918    989 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1030
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-850 3.08e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.08e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  818 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 850
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 989-1024 8.05e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 8.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564326918  989 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1024
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-895 8.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.10e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    860 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 895
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 775-807 1.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.71e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  775 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 807
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
775-807 2.79e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.79e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564326918    775 DVDECNSGTPCGLHGQCTNAQGSFHCSCSTGYR 807
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.46e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.46e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564326918    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 612-649 4.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564326918  612 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 649
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 860-891 7.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.41e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564326918  860 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 891
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
693-734 1.06e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    693 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 734
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
612-649 1.14e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 564326918    612 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 649
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 1.35e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564326918  290 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 324
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-611 3.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564326918    570 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 611
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-564 3.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.35e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 564326918    528 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 564
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1514-1548 6.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.87e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918   1514 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1548
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 693-725 9.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564326918  693 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 725
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
860-889 9.68e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.68e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   860 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 889
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-611 9.83e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 9.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564326918  570 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 611
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-685 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564326918    651 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 685
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 999-1029 1.13e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.13e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 564326918   999 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1029
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 651-685 1.35e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564326918  651 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 685
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
693-723 1.75e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   693 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 723
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
293-325 1.77e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.77e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564326918    293 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 325
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
901-939 1.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564326918    901 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 939
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1236-1265 2.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.16e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 564326918 1236 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1265
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1514-1552 2.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564326918 1514 DINECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1552
Cdd:cd00054     1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1236-1265 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 564326918   1236 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1265
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
290-319 2.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   290 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 319
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1514-1547 5.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.36e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 564326918  1514 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1547
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
570-600 5.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   570 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 600
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
612-642 6.85e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 6.85e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564326918   612 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 642
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 528-560 7.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564326918  528 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 560
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
735-770 8.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.63e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564326918    735 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 770
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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