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Conserved domains on  [gi|564327707|ref|XP_006228966|]
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G1/S-specific cyclin-E1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 104-240 1.85e-94

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20579:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 137  Bit Score: 279.46  E-value: 1.85e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 104 SPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQN 183
Cdd:cd20579    1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564327707 184 IIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20579   81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 244-357 3.65e-74

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410284  Cd Length: 114  Bit Score: 226.97  E-value: 3.65e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 244 PLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWC 323
Cdd:cd20581    1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564327707 324 DIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMED 357
Cdd:cd20581   81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 104-240 1.85e-94

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 279.46  E-value: 1.85e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 104 SPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQN 183
Cdd:cd20579    1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564327707 184 IIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20579   81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 244-357 3.65e-74

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 226.97  E-value: 3.65e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 244 PLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWC 323
Cdd:cd20581    1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564327707 324 DIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMED 357
Cdd:cd20581   81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 116-243 4.32e-53

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 173.09  E-value: 4.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707  116 EVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGIS 195
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFL-SKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 564327707  196 ALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLS 243
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
115-243 8.53e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 108.32  E-value: 8.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGI 194
Cdd:COG5024  182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFL-SSRVVSLEKYQLVGI 260

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564327707 195 SALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLS 243
Cdd:COG5024  261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 151-236 9.69e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 83.03  E-value: 9.69e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707   151 DWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDgaCSGDEILTM 230
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 564327707   231 ELMMMK 236
Cdd:smart00385  78 ERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 246-365 1.51e-12

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 63.80  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707  246 TIVSWLNVYVQVAYVNDTGEVL-MPQYpqqvfvqiaeLLDLCVLDVGCLEFPYGVLAASALYHFSSL-------ELMQKV 317
Cdd:pfam02984   2 TPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKTlnspewtETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 564327707  318 SGYQWCDIEKCVKWMVPFamVIREMGSSKLKHFRGVPMEDSHNIQTHT 365
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLEL--LLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 104-240 1.85e-94

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 279.46  E-value: 1.85e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 104 SPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQN 183
Cdd:cd20579    1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564327707 184 IIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20579   81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 110-240 1.34e-89

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 266.87  E-value: 1.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 110 NWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQNIIKTLL 189
Cdd:cd20519    1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564327707 190 QLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20519   81 QLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 104-240 1.41e-77

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 236.28  E-value: 1.41e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 104 SPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQN 183
Cdd:cd20580    1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564327707 184 IIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20580   81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 244-357 3.65e-74

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 226.97  E-value: 3.65e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 244 PLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWC 323
Cdd:cd20581    1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564327707 324 DIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMED 357
Cdd:cd20581   81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 116-243 4.32e-53

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 173.09  E-value: 4.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707  116 EVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGIS 195
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFL-SKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 564327707  196 ALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLS 243
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 115-239 4.16e-43

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 147.29  E-value: 4.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRI---MLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQL 191
Cdd:cd20507    3 EYVKDIykyLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYL-SKKQVPRKKLQL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564327707 192 IGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALK 239
Cdd:cd20507   82 VGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 244-341 9.43e-41

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 140.11  E-value: 9.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 244 PLTIVSWLNVYVQVAYVNDT-----GEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSL-ELMQKV 317
Cdd:cd20520    1 PPTPNSWLNLYLQLAQLNPPpkendSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLVSPDdEAIEQV 80

                         90       100
                 ....*....|....*....|....
gi 564327707 318 SGYQWCDIEKCVKWMVPFAMVIRE 341
Cdd:cd20520   81 TGYSWEQLAPCVEWMTPFAEVLEE 104
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 244-341 4.31e-39

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 135.67  E-value: 4.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 244 PLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWC 323
Cdd:cd20582    1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80

                         90
                 ....*....|....*...
gi 564327707 324 DIEKCVKWMVPFAMVIRE 341
Cdd:cd20582   81 CISECVNWMVPFVRTVRE 98
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 115-239 8.44e-38

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 133.14  E-value: 8.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGI 194
Cdd:cd20504    4 DDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFL-SQMSVLRSKLQLVGT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564327707 195 SALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALK 239
Cdd:cd20504   83 ACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 127-240 3.39e-30

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 113.23  E-value: 3.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 127 TYLRDEH--------FLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQqNIIKTLLQLIGISALF 198
Cdd:cd20561   10 TYLREMEvkckpkvgYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSM-SVLRGKLQLVGTAAML 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564327707 199 IASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20561   89 LASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 115-240 6.10e-29

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 109.69  E-value: 6.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGI 194
Cdd:cd20568   10 PEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFL-SKRVVSLNKLQLVGI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564327707 195 SALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20568   89 SALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 130-239 3.66e-28

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 108.11  E-value: 3.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 130 RDEHF-----LQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLE 204
Cdd:cd20508   27 REEKFvvpdyLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL-SKKVVKKEKLQLLGATAILIASKFD 105

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564327707 205 EIYPPKLHQFAYVTDGACSGDEILTMELMMMKALK 239
Cdd:cd20508  106 ERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 115-238 1.69e-27

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 106.85  E-value: 1.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGI 194
Cdd:cd20560   38 EDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFL-SCMSVLRGKLQLVGT 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564327707 195 SALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKAL 238
Cdd:cd20560  117 AAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 144-240 7.74e-27

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 104.73  E-value: 7.74e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 144 RMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACS 223
Cdd:cd20567   52 KMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFL-SVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYT 130

                         90
                 ....*....|....*..
gi 564327707 224 GDEILTMELMMMKALKW 240
Cdd:cd20567  131 RKQILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 145-241 1.12e-26

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 103.64  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 145 MRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSG 224
Cdd:cd20562   41 MRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFL-SGNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTK 119

                         90
                 ....*....|....*..
gi 564327707 225 DEILTMELMMMKALKWR 241
Cdd:cd20562  120 QEVLEMEIDVLNALQFE 136
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
115-243 8.53e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 108.32  E-value: 8.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGI 194
Cdd:COG5024  182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFL-SSRVVSLEKYQLVGI 260

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564327707 195 SALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLS 243
Cdd:COG5024  261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 145-238 8.86e-26

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 99.71  E-value: 8.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 145 MRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQqNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSG 224
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATT-PVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                         90
                 ....*....|....
gi 564327707 225 DEILTMELMMMKAL 238
Cdd:cd20536   80 EQICNLECIILTKL 93
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 101-240 2.13e-24

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 98.14  E-value: 2.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 101 PRASPLPVLNWGNREEVWRIMLNKEKTYLRDEHF---LQRHplLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRY 177
Cdd:cd20515   10 RRAYRDRSPALLLDDRVLQNLLSLEERYLPSASYfkcVQTE--IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRF 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564327707 178 MaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20515   88 L-SLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 145-240 1.33e-22

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 92.63  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 145 MRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMasQQNII-KTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACS 223
Cdd:cd20565   35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFL--QNNPVpKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYT 112

                         90
                 ....*....|....*..
gi 564327707 224 GDEILTMELMMMKALKW 240
Cdd:cd20565  113 KHQIRQMEMKILRALDF 129
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 146-242 2.21e-22

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 90.84  E-value: 2.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 146 RAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGD 225
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYL-SRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                         90
                 ....*....|....*..
gi 564327707 226 EILTMELMMMKALKWRL 242
Cdd:cd20542   80 QVLRMERRVLRRLRFDL 96
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 144-240 5.44e-21

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 88.00  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 144 RMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQnIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACS 223
Cdd:cd20566   38 RMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP-VSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYT 116

                         90
                 ....*....|....*..
gi 564327707 224 GDEILTMELMMMKALKW 240
Cdd:cd20566  117 KAQIREMEMLILKELNF 133
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 151-236 9.69e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 83.03  E-value: 9.69e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707   151 DWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDgaCSGDEILTM 230
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 564327707   231 ELMMMK 236
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 115-240 2.50e-19

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 83.88  E-value: 2.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 115 EEVWRIMLNKEKTYLRDEHF---LQRHPLlqARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQL 191
Cdd:cd20573   23 DRVLQTMLKAEETCLPSVSYfkcVQKEIL--PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFL-SVEPTKKSRLQL 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564327707 192 IGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20573  100 LGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 99-240 3.48e-18

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 80.80  E-value: 3.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707  99 RPPRASPLPVLnWGNREEVWRIMLNKEKTYLRDEHF--LQRHplLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDR 176
Cdd:cd20575   10 RVPRAGPDPRL-LGDQRVLQNLLRLEERYVPRVSYFqcVQRE--IKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDR 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564327707 177 YMASQQnIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20575   87 YLSCVP-TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 102-240 1.36e-16

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 76.57  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 102 RASPLPVLNWGNReeVWRIMLNKEKTYLRD-EHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMAS 180
Cdd:cd20574   13 RALPDPNLLYDDR--VLQNLLTIEERYLPQcSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAV 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 181 QQNIiKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20574   91 VPTR-KCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 139-240 3.06e-15

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 71.10  E-value: 3.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 139 PLLQarMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYP--PKLHQF-A 215
Cdd:cd20528    2 PQLH--LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFM-DRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnR 78

                         90       100
                 ....*....|....*....|....*
gi 564327707 216 YVTDGACSGDEILTMELMMMKALKW 240
Cdd:cd20528   79 YLCNSVYSKQEYLQMELLILEFFQW 103
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 141-240 3.99e-15

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 70.67  E-value: 3.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 141 LQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQnIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDG 220
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQ-GTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCD 79

                         90       100
                 ....*....|....*....|
gi 564327707 221 ACSGDEILTMELMMMKALKW 240
Cdd:cd20517   80 CFTNLELINQEKDILEALKW 99
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 246-365 1.51e-12

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 63.80  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707  246 TIVSWLNVYVQVAYVNDTGEVL-MPQYpqqvfvqiaeLLDLCVLDVGCLEFPYGVLAASALYHFSSL-------ELMQKV 317
Cdd:pfam02984   2 TPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKTlnspewtETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 564327707  318 SGYQWCDIEKCVKWMVPFamVIREMGSSKLKHFRGVPMEDSHNIQTHT 365
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLEL--LLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 149-232 1.91e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 62.43  E-value: 1.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 149 LLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIyPPKLHQFAYVTDgaCSGDEIL 228
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFL-SKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELR 77


                 ....
gi 564327707 229 TMEL 232
Cdd:cd00043   78 KAEK 81
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 144-230 2.33e-11

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 59.64  E-value: 2.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 144 RMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMaSQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACS 223
Cdd:cd20521    2 TMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYL-MVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80


                 ....*..
gi 564327707 224 GDEILTM 230
Cdd:cd20521   81 YEDVVRM 87
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 152-242 2.28e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 57.32  E-value: 2.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 152 WLMEVCEVYKLHRETFYLAQDFFDRYMASQQNIIKtLLQLIGISALFIASKLEE----IypPKLHQFAYVTDGACSGDEI 227
Cdd:cd20526    8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPK-YLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAEV 84

                         90
                 ....*....|....*
gi 564327707 228 LTMELMMMKALKWRL 242
Cdd:cd20526   85 LRMERIILDKLHWDL 99
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 150-240 7.53e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 55.79  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 150 LDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQniIKT----LLQLIGISALFIASKLEEIYPPKLHQFA-YVTDGACSG 224
Cdd:cd20543    6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYD--LPKdkpwMLQLLAVACLSLAAKMEETDVPLLVDLQvEEPKYVFEA 83

                         90
                 ....*....|....*.
gi 564327707 225 DEILTMELMMMKALKW 240
Cdd:cd20543   84 KTIQRMELLVLSTLEW 99
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 149-241 1.07e-09

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 55.08  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 149 LLDWLMEVCEVYKLHRETFYLAQDFFDRYmASQQNIIKTLLQLIGISALFIASKLEEIYP--PKLHQFAYVTDGACSGDE 226
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRY-CSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                         90
                 ....*....|....*
gi 564327707 227 ILTMELMMMKALKWR 241
Cdd:cd20559   81 FIQMEMHILNTLNWD 95
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 153-242 1.11e-05

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 44.89  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564327707 153 LMEVCEVYKLHRETFYLAQDFFDR-YMasQQNIIKTLLQLIGISALFIASKLEEIYPPkLHQFAYVTDGA-CSGDEILTM 230
Cdd:cd20524   62 LLEFCRAFKLPDSVLATALTYFKRfYL--KNSVMEYHPKEIMLTCLYLACKVEEFNIS-IDQFVGNIKESeKTAEIILEY 138

                         90
                 ....*....|..
gi 564327707 231 ELMMMKALKWRL 242
Cdd:cd20524  139 ELLLLQGLNFHL 150
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 282-330 2.05e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 37.29  E-value: 2.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564327707 282 LLDLCVLDVGCLEFPYGVLAASALY--------HFSSLELMQKVSGYQWCDIEKCVK 330
Cdd:cd20537   27 LLELSLLDYEFLKYRPSLIAAAALYlarkilgePPPSPQLLQLVTGYSENDLQECAK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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