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Conserved domains on  [gi|564328174|ref|XP_006229168|]
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tubby-related protein 2 isoform X7 [Rattus norvegicus]

Protein Classification

tubby family protein( domain architecture ID 11070239)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors; tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
252-501 5.14e-130

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 377.69  E-value: 5.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  252 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 331
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  332 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 403
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  404 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 483
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 564328174  484 YPLCPLQAFAICLSSFDG 501
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N super family cl24783
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-156 3.35e-22

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


The actual alignment was detected with superfamily member pfam16322:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 94.10  E-value: 3.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174    1 MVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvy 78
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE-- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564328174   79 trgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPKTHlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 156
Cdd:pfam16322  95 --------------PQDSGSELQILSVGDSPTSPPPDEEL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
252-501 5.14e-130

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 377.69  E-value: 5.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  252 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 331
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  332 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 403
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  404 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 483
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 564328174  484 YPLCPLQAFAICLSSFDG 501
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-156 3.35e-22

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 94.10  E-value: 3.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174    1 MVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvy 78
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE-- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564328174   79 trgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPKTHlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 156
Cdd:pfam16322  95 --------------PQDSGSELQILSVGDSPTSPPPDEEL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
252-501 5.14e-130

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 377.69  E-value: 5.14e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  252 PAPREHMVQCRIVRNKHGVdkGMFPSYYLYLEAEDGvavRSsplGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVG 331
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPG---DG---GKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  332 KVRSNVLGTKFTIFDN-----GVNPERNYWIPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQP 403
Cdd:pfam01167  75 KLRSNFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174  404 QNDqDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFR 483
Cdd:pfam01167 155 QSE-SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYR 233

                         250
                  ....*....|....*...
gi 564328174  484 YPLCPLQAFAICLSSFDG 501
Cdd:pfam01167 234 YPLSAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-156 3.35e-22

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 94.10  E-value: 3.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328174    1 MVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyvGDGSGERAPLLSPRGAvy 78
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG--GDGKGIDGPAAFLTEE-- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564328174   79 trgngpavrhlcwlPDSSDSDVEEVTMEDIPVISRPPKTHlanrrrgwlasPGPGISEEEEVEPKDARVEDKTPSPDP 156
Cdd:pfam16322  95 --------------PQDSGSELQILSVGDSPTSPPPDEEL-----------QEPGASGEEESSKQDLGDEMQKKGISS 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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