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Conserved domains on  [gi|564329787|ref|XP_006229808|]
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transforming growth factor beta activator LRRC32 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 82-305 5.83e-28

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  82 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 151
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 152 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 223
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 224 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 283
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 564329787 284 -LHFPDLAMF-PRLIYLNVSNNLI 305
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-575 2.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 153 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 232
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 233 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 310
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 311 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 390
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 391 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 466
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 467 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 546
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 564329787 547 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 575
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-305 5.83e-28

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  82 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 151
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 152 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 223
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 224 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 283
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 564329787 284 -LHFPDLAMF-PRLIYLNVSNNLI 305
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-371 8.89e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 8.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  78 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 157
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 158 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 237
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 238 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 316
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564329787 317 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 371
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-575 2.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 153 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 232
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 233 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 310
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 311 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 390
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 391 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 466
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 467 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 546
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 564329787 547 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 575
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-464 1.81e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  70 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 123
Cdd:PLN00113 251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 124 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 203
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 204 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 280
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 281 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 357
Cdd:PLN00113 485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 358 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 437
Cdd:PLN00113 539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                        410       420
                 ....*....|....*....|....*..
gi 564329787 438 AsLQRLNLQGNqVSPCGGQAEPGPPGC 464
Cdd:PLN00113 595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-602 1.21e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 150 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 226
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 227 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 299
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 300 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 377
Cdd:PLN00113 243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 378 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 432
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 433 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 512
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 513 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 591
Cdd:PLN00113 439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                        490
                 ....*....|.
gi 564329787 592 RRLYLQGNPLS 602
Cdd:PLN00113 502 MQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-451 3.45e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 3.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 226 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 304
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 305 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 381
Cdd:cd21340   58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564329787 382 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 451
Cdd:cd21340  108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
177-237 3.09e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.09e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564329787  177 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
343-403 4.42e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564329787  343 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 403
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-305 5.83e-28

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  82 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 151
Cdd:cd00116   56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 152 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 223
Cdd:cd00116  136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 224 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 283
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                        250       260
                 ....*....|....*....|....
gi 564329787 284 -LHFPDLAMF-PRLIYLNVSNNLI 305
Cdd:cd00116  296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-371 8.89e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 8.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  78 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 157
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 158 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 237
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 238 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 316
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564329787 317 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 371
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-575 2.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 153 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 232
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 233 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 310
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 311 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 390
Cdd:COG4886  174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 391 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 466
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 467 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 546
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 564329787 547 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 575
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-449 3.44e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 3.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  66 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRlaagmalns 145
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 146 gGLGRLPLVVSLDLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIeDGAFEALP 225
Cdd:COG4886  108 -ELSNLTNLESLDLSGNQL--TDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 226 QLTHLNLSRNSLTCISD--FSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPDLAMFPRLIYLNVSN 302
Cdd:COG4886  183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 303 NLIqlpTGLPQDSEdlhapsegwsasllsnpsrnasihpLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSF 382
Cdd:COG4886  260 NQL---TDLPPLAN-------------------------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564329787 383 EARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ 449
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-437 1.00e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  65 GLSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALN 144
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 145 SGGLGRLPLVVSLDLSGNslhgslveRLLGEAPRLRTLSLAENSLTRLARHtFWGMPAMEQLDLHSNVLMDIEDgAFEAL 224
Cdd:COG4886   89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 225 PQLTHLNLSRNSLTCISDF--SLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNV 300
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDL---PEPLGNLtNLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 301 SNNLIqlpTGLPqdsedlhapsegwsasllsnpsrnaSIHPLSQLLNLDLSYNEIELVPagFLEHLTSLRFLNLSRNCLR 380
Cdd:COG4886  236 SNNQL---TDLP-------------------------ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564329787 381 SFEARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGL 437
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-602 2.23e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 295 LIYLNVSNNLIQLPTGLPQDSEDLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNL 374
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 375 SRNclrsfeaRRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPyTFAGLASLQRLNLQGNQVSPCG 454
Cdd:COG4886  104 SGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 455 gqaepgppgcVDFSGIPTLHFLNMAGNSMETLragsflHTPLTELDlsanpgldvatgalvgleaSLEVLELQGNGLVVL 534
Cdd:COG4886  176 ----------EELGNLTNLKELDLSNNQITDL------PEPLGNLT-------------------NLEELDLSGNQLTDL 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564329787 535 RVDLPCFRRLKRLNLAENRLSHLPAWTRAVSLEVLDLRNNSFSLLPGNamGGLeTSLRRLYLQGNPLS 602
Cdd:COG4886  221 PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-464 1.81e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  70 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 123
Cdd:PLN00113 251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 124 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 203
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 204 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 280
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 281 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 357
Cdd:PLN00113 485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 358 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 437
Cdd:PLN00113 539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                        410       420
                 ....*....|....*....|....*..
gi 564329787 438 AsLQRLNLQGNqVSPCGGQAEPGPPGC 464
Cdd:PLN00113 595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-448 4.65e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.57  E-value: 4.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  70 QVPSVLSL--DIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALNSGG 147
Cdd:PLN00113 203 QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 148 LGRLplvVSLDLSGNSLHGSLVErLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQL 227
Cdd:PLN00113 283 LQKL---ISLDLSDNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 228 THLNLSRNSLT-------CISDfslqQLQVLDLSCNSIETfQTAPESQAQFQLAWLDLRENKLL-HFP-DLAMFPRLIYL 298
Cdd:PLN00113 359 TVLDLSTNNLTgeipeglCSSG----NLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPsEFTKLPLVYFL 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 299 NVSNNLIQLptglpqdsedlHAPSEGWSASLLS--NPSRNASIHPL------SQLLNLDLSYNEI-ELVPAGFLEhLTSL 369
Cdd:PLN00113 434 DISNNNLQG-----------RINSRKWDMPSLQmlSLARNKFFGGLpdsfgsKRLENLDLSRNQFsGAVPRKLGS-LSEL 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 370 RFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEA-LELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGN 448
Cdd:PLN00113 502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-238 7.84e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 7.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  79 IQALYLSGNRLQSIlvSPLSFYTALRHLDLSDNEISFLQPgvFQALPYLEHLNLAHNRLAagmalNSGGLGRLPLVVSLD 158
Cdd:cd21340   26 LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-----VVEGLENLTNLEELH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 159 LS------GNSLHgSLVERLLGEAPRLRTLSLAENSLTRLArhTFWGMPAMEQLDLHSNVLMDIED--GAFEALPQLTHL 230
Cdd:cd21340   97 IEnqrlppGEKLT-FDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLREL 173


                 ....*...
gi 564329787 231 NLSRNSLT 238
Cdd:cd21340  174 DLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-602 1.21e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 150 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 226
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 227 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 299
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 300 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 377
Cdd:PLN00113 243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 378 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 432
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 433 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 512
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 513 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 591
Cdd:PLN00113 439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                        490
                 ....*....|.
gi 564329787 592 RRLYLQGNPLS 602
Cdd:PLN00113 502 MQLKLSENKLS 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-504 4.67e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  66 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSfytaLRHLDLSDNEISFLQPGVFqaLPYLEHLNLAHNRLAAGMALNS 145
Cdd:PLN00113  87 SAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSS----LRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 146 GGLGRLPLvvsLDLSGNSLHGSlVERLLGEAPRLRTLSLAENSLTRLARHTF-------W-----------------GMP 201
Cdd:PLN00113 161 GSFSSLKV---LDLGGNVLVGK-IPNSLTNLTSLEFLTLASNQLVGQIPRELgqmkslkWiylgynnlsgeipyeigGLT 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 202 AMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCI---SDFSLQQLQVLDLSCNSIETfqTAPESQAQFQ-LAWLD 277
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPippSIFSLQKLISLDLSDNSLSG--EIPELVIQLQnLEILH 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 278 LRENKLL-HFPD-LAMFPRLIYLNV-SNNLI-QLPTGLPQDSE----DLHAPS------EGWSAS-------LLSNpSRN 336
Cdd:PLN00113 315 LFSNNFTgKIPVaLTSLPRLQVLQLwSNKFSgEIPKNLGKHNNltvlDLSTNNltgeipEGLCSSgnlfkliLFSN-SLE 393

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 337 ASIHP----LSQLLNLDLSYNEI--ELvPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEALELGT 410
Cdd:PLN00113 394 GEIPKslgaCRSLRRVRLQDNSFsgEL-PSEFTK-LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 411 KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQVSpcggqaepgppGCV--DFSGIPTLHFLNMAGNSMETLRA 488
Cdd:PLN00113 472 FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS-----------GEIpdELSSCKKLVSLDLSHNQLSGQIP 540

                        490
                 ....*....|....*..
gi 564329787 489 GSFLHTP-LTELDLSAN 504
Cdd:PLN00113 541 ASFSEMPvLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-451 3.45e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 3.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 226 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 304
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 305 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 381
Cdd:cd21340   58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564329787 382 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 451
Cdd:cd21340  108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
154-406 3.46e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 3.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 154 VVSLDLSGNSLHgSLVERLLGEaprLRTLSLAENSLTRLARhtfwGMP-AMEQLDLHSNVLMDIEdgafEALPQ-LTHLN 231
Cdd:PRK15370 201 ITTLILDNNELK-SLPENLQGN---IKTLYANSNQLTSIPA----TLPdTIQEMELSINRITELP----ERLPSaLQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 232 LSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPEsqaqfqlawldlrenkllHFPDlamfpRLIYLNV-SNNLIQLPTG 310
Cdd:PRK15370 269 LFHNKISCLPENLPEELRYLSVYDNSIRTL---PA------------------HLPS-----GITHLNVqSNSLTALPET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 311 LPQDSEDLHAPSEgwsaSLLSNPsrnASIHPlsQLLNLDLSYNEIELVPAGFLEHLTSlrfLNLSRNCLRSFEArragSL 390
Cdd:PRK15370 323 LPPGLKTLEAGEN----ALTSLP---ASLPP--ELQVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPE----NL 386

                        250
                 ....*....|....*..
gi 564329787 391 P-CLVLLDLSHNVLEAL 406
Cdd:PRK15370 387 PaALQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
177-237 3.09e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.09e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564329787  177 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 68-238 7.11e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 61.73  E-value: 7.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  68 LLQVPSVLSLDIQALYLsGNRLQSILVSPLSFYTALRHLDLSDNEISflQPGV---FQALPY---LEHLNLAHNRL-AAG 140
Cdd:COG5238  204 LTQNTTVTTLWLKRNPI-GDEGAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIgAEG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 141 MALNSGGLGRLPLVVSLDLSGNSLHG----SLVERLLGEAPrLRTLSLAENSLT-----RLARHtFWGMPAMEQLDLHSN 211
Cdd:COG5238  281 AIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQGNKT-LHTLNLAYNGIGaqgaiALAKA-LQENTTLHSLDLSDN 358

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564329787 212 VLMDIedGAfEAL-------PQLTHLNLSRNSLT 238
Cdd:COG5238  359 QIGDE--GA-IALakylegnTTLRELNLGKNNIG 389
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 206-401 2.38e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 206 LDLHSNVLMDIEDgaFEALPQLTHLNLSRNSLTCISDF-SLQQLQVLDLSCNSI---ETFQTAPEsqaqfqlawldLREn 281
Cdd:cd21340   29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRIsvvEGLENLTN-----------LEE- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 282 kllhfpdlamfprliyLNVSNNliQLPTGLpqdsedlhapsegwsaSLLSNPsrnASIHPLSQ-LLNLDLSYNEI-ELVP 359
Cdd:cd21340   95 ----------------LHIENQ--RLPPGE----------------KLTFDP---RSLAALSNsLRVLNISGNNIdSLEP 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 564329787 360 agfLEHLTSLRFLNLSRNCLRSFE--ARRAGSLPCLVLLDLSHN 401
Cdd:cd21340  138 ---LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
228-542 4.48e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 4.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 228 THLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESqAQFQLAWLDLRENKLLHFPdlAMFPRLI-YLNVS-NNLI 305
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLILDNNELKSL---PEN-LQGNIKTLYANSNQLTSIP--ATLPDTIqEMELSiNRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 306 QLPTGLPqdsedlhapsegwsasllsnpsrnasihplSQLLNLDLSYNEIELVPAGFLEhltSLRFLNLSRNCLRSFEAR 385
Cdd:PRK15370 255 ELPERLP------------------------------SALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAH 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 386 ragsLPC-LVLLDLSHNVLEALElGTKVLGsLKTLLLQDNTLRELPpytfAGLA-SLQRLNLQGNQVSPCggqAEPGPPg 463
Cdd:PRK15370 302 ----LPSgITHLNVQSNSLTALP-ETLPPG-LKTLEAGENALTSLP----ASLPpELQVLDVSKNQITVL---PETLPP- 367

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564329787 464 cvdfsgiptlhflnmagnsmetlragsflhtPLTELDLSANPGLDVATGalvgLEASLEVLELQGNGLVVLRVDLPCFR 542
Cdd:PRK15370 368 -------------------------------TITTLDVSRNALTNLPEN----LPAALQIMQASRNNLVRLPESLPHFR 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
67-271 1.78e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.78  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  67 SLLQVPSVLSLDIQALYLSGNRLQSIlvsPLSFYTALRHLDLSDNEISFLQpgvfQALPY-LEHLNLAHNRLAA------ 139
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISClpenlp 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 140 ----GMALNSGGLGRLPL-----VVSLDLSGNSLhGSLVERLlgeAPRLRTLSLAENSLTRLARHTfwgMPAMEQLDLHS 210
Cdd:PRK15370 283 eelrYLSVYDNSIRTLPAhlpsgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSK 355

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564329787 211 NVLMDIEdgafEALP-QLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESQAQF 271
Cdd:PRK15370 356 NQITVLP----ETLPpTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL---PESLPHF 410
LRR_8 pfam13855
Leucine rich repeat;
82-137 3.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564329787   82 LYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRL 137
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
103-164 6.34e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 6.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564329787  103 LRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmALNSGGLGRLPLVVSLDLSGNSL 164
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
343-403 4.42e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564329787  343 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 403
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 415-580 1.17e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 415 SLKTLLLQDNTLRELPPYTFagLASLQRLNLQGNQVSPCGGqaepgppgcvdFSGIPTLHFLNMAGNSMETLragSFLH- 493
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV---EGLEn 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 494 -TPLTELDLSAN---PG--LDVATGALVGLEASLEVLELQGNGLVVLRvDLPCFRRLKRLNLAENRLSHLPAWTRAVS-- 565
Cdd:cd21340   89 lTNLEELHIENQrlpPGekLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                        170
                 ....*....|....*..
gi 564329787 566 --LEVLDLRNNSFSLLP 580
Cdd:cd21340  168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
542-601 2.10e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564329787  542 RRLKRLNLAENRLSHLP--AWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPL 601
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
393-450 2.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564329787  393 LVLLDLSHNVLEALELGT-KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQV 450
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
206-258 2.82e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564329787  206 LDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCISDFSLQ---QLQVLDLSCNSI 258
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglpSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 389-605 9.09e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 389 SLPCLVLLDLSHNVL--EALELGTKVL---GSLKTLLLQDNTLRELPPYT------FAGLASLQRLNLQGNQVSPcggqa 457
Cdd:cd00116   21 KLLCLQVLRLEGNTLgeEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGP----- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 458 ePGPPGCVDFSGIPTLHFLNMAGNSMET----LRAGSFLHTP--LTELDLSAN----PGLDVATGALVGLeASLEVLELQ 527
Cdd:cd00116   96 -DGCGVLESLLRSSSLQELKLNNNGLGDrglrLLAKGLKDLPpaLEKLVLGRNrlegASCEALAKALRAN-RDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 528 GN-----GLVVLRVDLPCFRRLKRLNLAENRLSH---------LPAWTravSLEVLDLRNNSFSLLP----GNAMGGLET 589
Cdd:cd00116  174 NNgigdaGIRALAEGLKANCNLEVLDLNNNGLTDegasalaetLASLK---SLEVLNLGDNNLTDAGaaalASALLSPNI 250

                        250
                 ....*....|....*.
gi 564329787 590 SLRRLYLQGNPLSCCG 605
Cdd:cd00116  251 SLLTLSLSCNDITDDG 266
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 338-505 9.91e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 9.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 338 SIHPLSQLLNLDLSY---NEIELVPAgfLEHLTSLRFLNLSRNCLRSFEarRAGSLPCLVLLDLSHN---VLEALELgtk 411
Cdd:cd21340   16 KIDNLSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNrisVVEGLEN--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 412 vLGSLKTLLLQDNTLRELPPYTF-----AGLA-SLQRLNLQGNQVSpcggqaEPGPpgcvdFSGIPTLHFLNMAGN---S 482
Cdd:cd21340   89 -LTNLEELHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNID------SLEP-----LAPLRNLEQLDASNNqisD 156

                        170       180
                 ....*....|....*....|....
gi 564329787 483 METLrAGSFLHTP-LTELDLSANP 505
Cdd:cd21340  157 LEEL-LDLLSSWPsLRELDLTGNP 179
PLN03150 PLN03150
hypothetical protein; Provisional
 537-602 3.18e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 3.18e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564329787 537 DLPCFRRLKRLNLAENRL-SHLPAWTRAV-SLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPLS 602
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIrGNIPPSLGSItSLEVLDLSYNSFNGSIPESLGQL-TSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 118-190 7.77e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 7.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564329787 118 PGVFQALPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERlLGEAPRLRTLSLAENSLT 190
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPS---LGSITSLEVLDLSYNSFNGSIPES-LGQLTSLRILNLNGNSLS 503
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 128-377 4.07e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 128 EHLNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGSLVERL---LGEAPRLRTLSLAENSLT-----RLARHtFWG 199
Cdd:COG5238  156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGdegaeILAEA-LKG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 200 MPAMEQLDLHSNvlmDIEDGAFEAL-------PQLTHLNLSRNSLTCISDFSL-------QQLQVLDLSCNSIetfqTAP 265
Cdd:COG5238  235 NKSLTTLDLSNN---QIGDEGVIALaealknnTTVETLYLSGNQIGAEGAIALakalqgnTTLTSLDLSVNRI----GDE 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 266 ESQAQFQLawldLRENKLLHFPDLAmfprliYLNVSNnliqlptglpqdsedlhapsEGWSAsLLSNPSRNASIHplsql 345
Cdd:COG5238  308 GAIALAEG----LQGNKTLHTLNLA------YNGIGA--------------------QGAIA-LAKALQENTTLH----- 351

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 564329787 346 lNLDLSYNEIE----LVPAGFLEHLTSLRFLNLSRN 377
Cdd:COG5238  352 -SLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKN 386
PLN03150 PLN03150
hypothetical protein; Provisional
 363-451 6.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 363 LEHLTSLrflNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGLASLQR 442
Cdd:PLN03150 441 LRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLGQLTSLRI 494


                 ....*....
gi 564329787 443 LNLQGNQVS 451
Cdd:PLN03150 495 LNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
125-213 2.10e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  125 PYLEHLNLAHNRLaagmalnsgglgrlplvvsldlsgNSLHGSLVERLlgeaPRLRTLSLAENSLTRLARHTFWGMPAME 204
Cdd:pfam13855   1 PNLRSLDLSNNRL------------------------TSLDDGAFKGL----SNLKVLDLSNNLLTTLSPGAFSGLPSLR 52


                  ....*....
gi 564329787  205 QLDLHSNVL 213
Cdd:pfam13855  53 YLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
225-283 2.34e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564329787  225 PQLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSIETFqtapeSQAQFQ----LAWLDLRENKL 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
342-377 3.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564329787  342 LSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 377
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 243-498 3.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 243 FSLQQLQVLDLSCNSIETF---QTAPESQAQFQLAWLDLRENKLLHFPD--------LAMFPRLIYLNVSNN-------- 303
Cdd:cd00116   20 PKLLCLQVLRLEGNTLGEEaakALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNalgpdgcg 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 304 -LIQLPTGLPQDSEDLHAPSEGWSA------SLLSNPSRnasihplsqLLNLDLSYNEIELVP----AGFLEHLTSLRFL 372
Cdd:cd00116  100 vLESLLRSSSLQELKLNNNGLGDRGlrllakGLKDLPPA---------LEKLVLGRNRLEGAScealAKALRANRDLKEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 373 NLSRNCLRSFEARRAG----SLPCLVLLDLSHNVLE-----ALELGTKVLGSLKTLLLQDNTLRELPPYTFA-----GLA 438
Cdd:cd00116  171 NLANNGIGDAGIRALAeglkANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAALAsallsPNI 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787 439 SLQRLNLQGNQVSPCGGQAEPGPpgCVDFsgiPTLHFLNMAGNsmETLRAGSFLHTPLTE 498
Cdd:cd00116  251 SLLTLSLSCNDITDDGAKDLAEV--LAEK---ESLLELDLRGN--KFGEEGAQLLAESLL 303
PLN03150 PLN03150
hypothetical protein; Provisional
 79-168 3.56e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  79 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMalnSGGLGRLPLVVSLD 158
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI---PESLGQLTSLRILN 496

                         90
                 ....*....|
gi 564329787 159 LSGNSLHGSL 168
Cdd:PLN03150 497 LNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
415-481 3.87e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  415 SLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ---VSPcggqaepgppgcVDFSGIPTLHFLNMAGN 481
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 79-167 4.61e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329787  79 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmalnsgglGRLPLVvsld 158
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS----------GRVPAA---- 509


                 ....*....
gi 564329787 159 LSGNSLHGS 167
Cdd:PLN03150 510 LGGRLLHRA 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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