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Conserved domains on  [gi|564330829|ref|XP_006230249|]
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aquaporin-8 isoform X1 [Rattus norvegicus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-249 5.75e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 166.27  E-value: 5.75e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  39 CVVELLGSALFIFIGCLSVI----ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPY 114
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 115 WVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVA------EALGVEIVMTMLLVLAVCMGAVNEKTM--GPL 186
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSpgvsngNAFFVEFIGTFILVLVVFATTDDPNGPppGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564330829 187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAG---YWDFHWIYWLGPLLAGLFVGLLIRLF 249
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-249 5.75e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 166.27  E-value: 5.75e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  39 CVVELLGSALFIFIGCLSVI----ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPY 114
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 115 WVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVA------EALGVEIVMTMLLVLAVCMGAVNEKTM--GPL 186
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSpgvsngNAFFVEFIGTFILVLVVFATTDDPNGPppGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564330829 187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAG---YWDFHWIYWLGPLLAGLFVGLLIRLF 249
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 36-251 8.80e-49

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 160.68  E-value: 8.80e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  36 IQPCVVELLGSALFIFIGCLSVI---ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLI 112
Cdd:COG0580    3 MKRLLAEFLGTFILVLLGCGVVAvlaGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 113 PYWVSQLFGGMIGAALAKVVSP----EERFWNASGAAFAIV-QEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLA 187
Cdd:COG0580   83 PYIIAQLLGAFLGAALVYLIYGghfdATEDGGAKLGVFATSpAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 188 PFSIGFSVIVDILAGGGISGACMNPARAFGPAVMA------GYWDFHWIYWLGPLLAGLFVGLLIRLFIG 251
Cdd:COG0580  163 PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALFG 232
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 35-245 4.33e-48

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 158.63  E-value: 4.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829   35 YIQPCVVELLGSALFIFIGCLSVI------ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKT 108
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALgvkklvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  109 MLLIPYWVSQLFGGMIGAALAKVVSPeeRFWNASGAAFAiVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEK--TMGPL 186
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV--GLQRAGLFANT-LAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRngSLGTV 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564330829  187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLL 245
Cdd:pfam00230 164 APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALV 222
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 42-245 2.37e-39

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 135.89  E-value: 2.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829   42 ELLGSALFIFIGCLSVIENSP--------NTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIP 113
Cdd:TIGR00861   2 EFLGTFLLVFFGVGSALGVNVagaygavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVPV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  114 YWVSQLFGGMIGAALAKVVSPEERFWNA-----SGAAFAIVQeqeqvaeALGVEIVMTMLLVLAVCMGAV--NEKTMGPL 186
Cdd:TIGR00861  82 YIVAQLIGAILGAALLYGLTSGLFPGNLavngsASAGVSSGQ-------AFFVEFIGTAILVLVIFATTDdrNRVPRGGF 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564330829  187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAG--YWDFHWIYWLGPLLAGLFVGLL 245
Cdd:TIGR00861 155 APLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALV 215
PLN00027 PLN00027
aquaporin TIP; Provisional
 40-249 1.37e-36

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 129.91  E-value: 1.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  40 VVELLGSALFIFIGCLS------VIENSPNT--GLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLL 111
Cdd:PLN00027  24 LAEFISTLIFVFAGEGSgmafnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 112 IPYWVSQLFGGMIGAALAKVVSPeerfwNASGAAFAIvQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEK--TMGPLAPF 189
Cdd:PLN00027 104 ILYWIAQLLGSVVACLLLKFSTG-----GLETSAFSL-SSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKkgDLGIIAPI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 190 SIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLF 249
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-249 5.75e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 166.27  E-value: 5.75e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  39 CVVELLGSALFIFIGCLSVI----ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPY 114
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 115 WVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVA------EALGVEIVMTMLLVLAVCMGAVNEKTM--GPL 186
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSpgvsngNAFFVEFIGTFILVLVVFATTDDPNGPppGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564330829 187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAG---YWDFHWIYWLGPLLAGLFVGLLIRLF 249
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 36-251 8.80e-49

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 160.68  E-value: 8.80e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  36 IQPCVVELLGSALFIFIGCLSVI---ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLI 112
Cdd:COG0580    3 MKRLLAEFLGTFILVLLGCGVVAvlaGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 113 PYWVSQLFGGMIGAALAKVVSP----EERFWNASGAAFAIV-QEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLA 187
Cdd:COG0580   83 PYIIAQLLGAFLGAALVYLIYGghfdATEDGGAKLGVFATSpAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 188 PFSIGFSVIVDILAGGGISGACMNPARAFGPAVMA------GYWDFHWIYWLGPLLAGLFVGLLIRLFIG 251
Cdd:COG0580  163 PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALFG 232
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 35-245 4.33e-48

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 158.63  E-value: 4.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829   35 YIQPCVVELLGSALFIFIGCLSVI------ENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKT 108
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALgvkklvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  109 MLLIPYWVSQLFGGMIGAALAKVVSPeeRFWNASGAAFAiVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEK--TMGPL 186
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV--GLQRAGLFANT-LAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRngSLGTV 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564330829  187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLL 245
Cdd:pfam00230 164 APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALV 222
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 42-245 2.37e-39

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 135.89  E-value: 2.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829   42 ELLGSALFIFIGCLSVIENSP--------NTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIP 113
Cdd:TIGR00861   2 EFLGTFLLVFFGVGSALGVNVagaygavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVPV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  114 YWVSQLFGGMIGAALAKVVSPEERFWNA-----SGAAFAIVQeqeqvaeALGVEIVMTMLLVLAVCMGAV--NEKTMGPL 186
Cdd:TIGR00861  82 YIVAQLIGAILGAALLYGLTSGLFPGNLavngsASAGVSSGQ-------AFFVEFIGTAILVLVIFATTDdrNRVPRGGF 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564330829  187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAG--YWDFHWIYWLGPLLAGLFVGLL 245
Cdd:TIGR00861 155 APLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALV 215
PLN00027 PLN00027
aquaporin TIP; Provisional
 40-249 1.37e-36

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 129.91  E-value: 1.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  40 VVELLGSALFIFIGCLS------VIENSPNT--GLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLL 111
Cdd:PLN00027  24 LAEFISTLIFVFAGEGSgmafnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 112 IPYWVSQLFGGMIGAALAKVVSPeerfwNASGAAFAIvQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEK--TMGPLAPF 189
Cdd:PLN00027 104 ILYWIAQLLGSVVACLLLKFSTG-----GLETSAFSL-SSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKkgDLGIIAPI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 190 SIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLF 249
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 42-251 2.87e-34

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 123.89  E-value: 2.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  42 ELLGSALFIFIGCLSVIENSPNT--------GLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIP 113
Cdd:PLN00166  24 EFIATLLFVFAGVGSAIAFAKLTsdaaldpaGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITGFF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 114 YWVSQLFGGMIGAALAKVVSpeerfwNASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEK--TMGPLAPFSI 191
Cdd:PLN00166 104 YWIAQCLGSIVACLLLVFVT------NGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKkgSLGTIAPIAI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564330829 192 GFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLI-RLFIG 251
Cdd:PLN00166 178 GFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYgDVFIG 238
PLN00184 PLN00184
aquaporin NIP1; Provisional
 35-261 7.21e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 105.49  E-value: 7.21e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  35 YIQPCVVELLGSALFIFIGCLSVIENSPNTGLLQ---PALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLL 111
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCASVVVNMQNDNVVTlpgIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 112 IPYWVSQLFGGMIGAALAKVV-SPEERFWNASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFS 190
Cdd:PLN00184 133 PAYVISQVIGSTLAAATLRLLfGLDHDVCSGKHDVFIGSSPVGSDLQAFVMEFIVTFYLMFIISGVATDNRAIGELAGLA 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564330829 191 IGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLL---AGLFVGLLIRLfiGDEKTRLILKS 261
Cdd:PLN00184 213 IGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLgaiAGAWVYNTVRY--TDKPLREITKS 284
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 37-247 1.45e-26

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 104.61  E-value: 1.45e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  37 QPCVVELLGSALFIFIGCLSVIENSPNTGLLQ-PAL--AHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIP 113
Cdd:PLN00182  43 QKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITfPGIcvTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 114 YWVSQLFGGMIGA---ALAKVVSPEerfwnasgaAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFS 190
Cdd:PLN00182 123 YIGAQLTGSLLASltlRLMFNVTPE---------AFFGTTPTDSSGQALVAEIIISFLLMFVISGVATDSRAVGELAGIA 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 191 IGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLL---AGLFVGLLIR 247
Cdd:PLN00182 194 VGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVgiiAGGFVYNLIR 253
PRK05420 PRK05420
aquaporin Z; Provisional
 37-254 5.83e-26

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 101.58  E-value: 5.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  37 QPCVVELLGSALFIFIGCLSVI--ENSPNTG--LLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLI 112
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVlaAAFPELGigFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 113 PYWVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQ------VAEALGVEIVMTMLLVLaVCMGAVNEKTMGPL 186
Cdd:PRK05420  83 PYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNGYGEHspggysLLAALVCEVVLTAFFLL-VILGATDKRAPAGF 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 187 APFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFH--WIYWLGPLLAGLFVGLLIRLFIGDEK 254
Cdd:PRK05420 162 APIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEqlWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 64-245 8.11e-24

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 96.51  E-value: 8.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  64 TGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWVSQLFGGMIGAALAKVVSPEERFwnasg 143
Cdd:PLN00167  58 SSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHV----- 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 144 AAFAIVQEQEQVAEALgVEIVMTMLLVLAV-CMGAVNEKTMGPLAPFSIGFSVIVDILAGGGISGACMNPARAFGPAVMA 222
Cdd:PLN00167 133 PTYKIAEEMTGFGASV-LEGVLTFGLVYTVyAAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVA 211

                        170       180
                 ....*....|....*....|...
gi 564330829 223 GYWDFHWIYWLGPLLAGLFVGLL 245
Cdd:PLN00167 212 GSFKNQAVYWVGPLLGGAVAGLL 234
PLN00026 PLN00026
aquaporin NIP; Provisional
 42-240 3.42e-19

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 84.91  E-value: 3.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  42 ELLGSALFIFIGCLSVIENSPNTG---LLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWVSQ 118
Cdd:PLN00026  77 EFVGTFILIFAATAGPIVNQKYDGaetLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQ 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 119 LFGGMIGA-ALAKVVSPeerfWNASGAAFAIVQeqeqVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIV 197
Cdd:PLN00026 157 VSASICASfALKGVFHP----FMSGGVTVPSVS----TGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVML 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564330829 198 DILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGL 240
Cdd:PLN00026 229 NILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGAL 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 42-248 1.38e-18

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 82.60  E-value: 1.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  42 ELLGSalFIFIGCLSVIENSP-----NTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWV 116
Cdd:PLN00183  51 EMVGT--FILMFCVCGIIASTqlsggEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYIT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 117 SQLFGGMIGAALAKVVSpeerfwnASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVI 196
Cdd:PLN00183 129 AQTVGSVLATYVGVSVY-------GVKADLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQPQSLGHLSGFVIGIAIG 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564330829 197 VDILAGGGISGACMNPARAFGPAVMAgyWDFH--WIYWLGPLLAGLFVGLLIRL 248
Cdd:PLN00183 202 LAVLITGPVSGGSMNPARSLGPAIVS--WDFKdiWIYITAPTIGAVAGALMFHL 253
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 32-251 2.86e-17

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 79.40  E-value: 2.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  32 YEQYIQPCVVELLGSALFIFIG---CLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKT 108
Cdd:PTZ00016  46 YRPNVREYVAEFLGTFVLLFFGegvVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 109 MLLIPYWVSQLFGGMIGAALAKVV------------SPEERFWNASGAAFAIVQEQEQVAeALGVEIVMTMLLVLAVCmg 176
Cdd:PTZ00016 126 KKLPGYFVAQLLGAFVGAACVYGLyygffkdhgipeLPWETMANGFAGVFATYPREGNFY-AIFSELILTAILLLVIL-- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829 177 AVNEKTMGPLA---PFSIGFSVIVDILAGGGISGACMNPARAFGPAVM------------AGYwdFHWIYWLGPLLAGLF 241
Cdd:PTZ00016 203 AITDPNNCPAFnylPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFsailwgsevftkDNY--YFWVPLVAPFVGAVL 280

                        250
                 ....*....|
gi 564330829 242 VGLLIRLFIG 251
Cdd:PTZ00016 281 GMFLYDKFIP 290
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-126 9.79e-05

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 42.29  E-value: 9.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829   40 VVELLGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIP-YWVSQ 118
Cdd:TIGR00861 126 FVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGNHWvYWVGP 205


                  ....*...
gi 564330829  119 LFGGMIGA 126
Cdd:TIGR00861 206 IIGAILGA 213
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 35-132 1.18e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564330829  35 YIQPCVVELLGSALFIFIGCLSVIENSPNTGLlqPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLV-----GGLKTM 109
Cdd:COG0580  130 LGAAFLTEIIGTFVLVFVILGITDKRAAPGGL--APLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkGGSDWG 207

                         90       100
                 ....*....|....*....|...
gi 564330829 110 LLIPYWVSQLFGGMIGAALAKVV 132
Cdd:COG0580  208 YLWVPIVAPILGAALAALLYRAL 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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