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Conserved domains on  [gi|564343066|ref|XP_006235105|]
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GDNF family receptor alpha-4 isoform X3 [Rattus norvegicus]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 192-286 5.80e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 90.67  E-value: 5.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066  192 CLKPLDRCERSRRCRPRLFAFQASCAPAPGSRDGCPeeGGPRCLRAYAglvgtvVTPNYLDNVSARVAPWCGCEASGNRR 271
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAYR------MTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 564343066  272 EECEAFRKLFTRNPC 286
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 98-180 9.77e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 45.98  E-value: 9.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066   98 CVEAAEACTADEQCQQLRSEYVAQClgragWRGPGSCVRSRCRRA----LRRFFARGPPALTHALLFCGCEG-----PAC 168
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNC-----QPSPESCSGCPNPARclraYRMTPNYVDNLGTSLLLWCTCKGsgnqdEEC 75

                          90
                  ....*....|..
gi 564343066  169 AERRRQTFAPAC 180
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 192-286 5.80e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 90.67  E-value: 5.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066  192 CLKPLDRCERSRRCRPRLFAFQASCAPAPGSRDGCPeeGGPRCLRAYAglvgtvVTPNYLDNVSARVAPWCGCEASGNRR 271
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAYR------MTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 564343066  272 EECEAFRKLFTRNPC 286
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 192-286 3.69e-19

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 80.38  E-value: 3.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066   192 CLKPLDRCERSRRCRPRLFAFQASCAPAPGSrdGCPEEGGPRCLRAYAglvGTVVTPNYLDNVSarVAPWCGCeaSGNRR 271
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSS--SCPGENSEACLRAYC---GLALRPFYDDNSS--VLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 564343066   272 EECEAFRKLFTRNPC 286
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 98-180 9.77e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 45.98  E-value: 9.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066   98 CVEAAEACTADEQCQQLRSEYVAQClgragWRGPGSCVRSRCRRA----LRRFFARGPPALTHALLFCGCEG-----PAC 168
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNC-----QPSPESCSGCPNPARclraYRMTPNYVDNLGTSLLLWCTCKGsgnqdEEC 75

                          90
                  ....*....|..
gi 564343066  169 AERRRQTFAPAC 180
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 192-286 5.80e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 90.67  E-value: 5.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066  192 CLKPLDRCERSRRCRPRLFAFQASCAPAPGSRDGCPeeGGPRCLRAYAglvgtvVTPNYLDNVSARVAPWCGCEASGNRR 271
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAYR------MTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 564343066  272 EECEAFRKLFTRNPC 286
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 192-286 3.69e-19

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 80.38  E-value: 3.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066   192 CLKPLDRCERSRRCRPRLFAFQASCAPAPGSrdGCPEEGGPRCLRAYAglvGTVVTPNYLDNVSarVAPWCGCeaSGNRR 271
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSS--SCPGENSEACLRAYC---GLALRPFYDDNSS--VLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 564343066   272 EECEAFRKLFTRNPC 286
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 98-180 9.77e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 45.98  E-value: 9.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343066   98 CVEAAEACTADEQCQQLRSEYVAQClgragWRGPGSCVRSRCRRA----LRRFFARGPPALTHALLFCGCEG-----PAC 168
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNC-----QPSPESCSGCPNPARclraYRMTPNYVDNLGTSLLLWCTCKGsgnqdEEC 75

                          90
                  ....*....|..
gi 564343066  169 AERRRQTFAPAC 180
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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