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Conserved domains on  [gi|564343533|ref|XP_006235275|]
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cystatin-F isoform X2 [Rattus norvegicus]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 71-180 2.21e-26

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 96.73  E-value: 2.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533    71 PGFPKTIKTNNPGVLKAARHSVEKFNNCTNDIFLFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKTMHrQLDNCDFQTS 150
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-DLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 564343533   151 PalkrTLHCYSEVWVIPWLHSFEVPVLRCH 180
Cdd:smart00043  82 G----EKFCTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 71-180 2.21e-26

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 96.73  E-value: 2.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533    71 PGFPKTIKTNNPGVLKAARHSVEKFNNCTNDIFLFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKTMHrQLDNCDFQTS 150
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-DLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 564343533   151 PalkrTLHCYSEVWVIPWLHSFEVPVLRCH 180
Cdd:smart00043  82 G----EKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 72-179 3.32e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 78.28  E-value: 3.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533  72 GFPKTIKTNNPGVLKAARHSVEKFNNCTNDIFlFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKtmHRQLDNCDFQTSP 151
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKK--SSVPLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 564343533 152 ALKRTLHCYSEVWVIPWLHSFEVPVLRC 179
Cdd:cd00042   78 EEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 72-168 2.80e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 65.05  E-value: 2.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533   72 GFPKTIKTNNPGVLKAARHSVEKFNNCTNDiFLFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKTMhRQLDNCDFQTsp 151
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSK-KLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 564343533  152 aLKRTLHCYSEVWVIPW 168
Cdd:pfam00031  77 -EKWLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 71-180 2.21e-26

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 96.73  E-value: 2.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533    71 PGFPKTIKTNNPGVLKAARHSVEKFNNCTNDIFLFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKTMHrQLDNCDFQTS 150
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV-DLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 564343533   151 PalkrTLHCYSEVWVIPWLHSFEVPVLRCH 180
Cdd:smart00043  82 G----EKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 72-179 3.32e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 78.28  E-value: 3.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533  72 GFPKTIKTNNPGVLKAARHSVEKFNNCTNDIFlFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKtmHRQLDNCDFQTSP 151
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKK--SSVPLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 564343533 152 ALKRTLHCYSEVWVIPWLHSFEVPVLRC 179
Cdd:cd00042   78 EEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 72-168 2.80e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 65.05  E-value: 2.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564343533   72 GFPKTIKTNNPGVLKAARHSVEKFNNCTNDiFLFKESHVSKALVQVVKGLKYMLQVEIGRTTCRKTMhRQLDNCDFQTsp 151
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTDN-YYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSK-KLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 564343533  152 aLKRTLHCYSEVWVIPW 168
Cdd:pfam00031  77 -EKWLGLCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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