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Conserved domains on  [gi|564347940|ref|XP_006236994|]
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kelch repeat and BTB domain-containing protein 8 isoform X1 [Rattus norvegicus]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 9( domain architecture ID 13033283)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein 9 (BTBD9) is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-129 4.39e-94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 283.80  E-value: 4.39e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   1 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLN 80
Cdd:cd18274    1 MDPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18274   81 YAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 121-217 4.30e-64

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18483:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 97  Bit Score: 204.71  E-value: 4.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 564347940 201 EREVHLPEIFAKCIRFP 217
Cdd:cd18483   81 KREMHLPEIFAKCIRMP 97
PHA03098 super family cl33709
kelch-like protein; Provisional
 24-490 1.82e-56

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 198.45  E-value: 1.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEstqKEVRIIGvEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 104 FQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 183
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 184 EEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLMEDAFIEKIpPRFAQAIVKSC---GEKGPSNTNGC---TQRLGMT 257
Cdd:PHA03098 168 EDVVLEIIIKWLTSKKNNKYKDICLIL-KVLRITFLSEEGIKKL-KRWKLRIKKKKivfNKRCIKIIYSKkynLNKILPR 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 258 ASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKppNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaeNDFWMY 337
Cdd:PHA03098 246 SSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLSV-------NSVVSY 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 338 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGR--------------------------------------------- 372
Cdd:PHA03098 317 DTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIynsislntveswkpgeskwreepplifprynpcvvnvnnliyvig 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 373 -VYEGDgrNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQG----------EFFLFYEPQKDYWGFLTPM 441
Cdd:PHA03098 397 gISKND--ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIVESYNPVTNKWTELSSL 474

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940 442 TVPRIQGLAAVYKDSIYYIAGTCgNHQRVFTVEAYDIELNKWTRKKDFP 490
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK-YEYYINEIEVYDDKTNTWTLFCKFP 522
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
435-549 1.03e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 44.38  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 435 WGFLTPMTVPRIQGLAAVYKDSIY----YIAGTCGNhqrvfTVEAYDIELNKWTRKKDFPcdqsINPYLK--LVLFQNKL 508
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYvaggLSGGSASN-----SFEVYDPATNTWSELAPLP----GPPRHHaaAVAQDGKL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940 509 HLFVRATQVTVEEHIFrtsrkNSLYQYDDIADQWMKVYETP 549
Cdd:COG3055   74 YVFGGFTGANPSSTPL-----NDVYVYDPATNTWTKLAPMP 109
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-129 4.39e-94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 283.80  E-value: 4.39e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   1 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLN 80
Cdd:cd18274    1 MDPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18274   81 YAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-217 4.30e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 204.71  E-value: 4.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 564347940 201 EREVHLPEIFAKCIRFP 217
Cdd:cd18483   81 KREMHLPEIFAKCIRMP 97
PHA03098 PHA03098
kelch-like protein; Provisional
 24-490 1.82e-56

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 198.45  E-value: 1.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEstqKEVRIIGvEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 104 FQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 183
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 184 EEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLMEDAFIEKIpPRFAQAIVKSC---GEKGPSNTNGC---TQRLGMT 257
Cdd:PHA03098 168 EDVVLEIIIKWLTSKKNNKYKDICLIL-KVLRITFLSEEGIKKL-KRWKLRIKKKKivfNKRCIKIIYSKkynLNKILPR 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 258 ASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKppNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaeNDFWMY 337
Cdd:PHA03098 246 SSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLSV-------NSVVSY 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 338 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGR--------------------------------------------- 372
Cdd:PHA03098 317 DTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIynsislntveswkpgeskwreepplifprynpcvvnvnnliyvig 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 373 -VYEGDgrNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQG----------EFFLFYEPQKDYWGFLTPM 441
Cdd:PHA03098 397 gISKND--ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIVESYNPVTNKWTELSSL 474

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940 442 TVPRIQGLAAVYKDSIYYIAGTCgNHQRVFTVEAYDIELNKWTRKKDFP 490
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK-YEYYINEIEVYDDKTNTWTLFCKFP 522
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 127-224 8.94e-34

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 123.81  E-value: 8.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  127 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 206
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90
                  ....*....|....*...
gi 564347940  207 PEIFAkCIRFPLMEDAFI 224
Cdd:pfam07707  82 PELLS-AVRLPLLSPQYL 98
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 127-226 3.02e-30

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 113.98  E-value: 3.02e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   127 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 206
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 564347940   207 PEIFaKCIRFPLMEDAFIEK 226
Cdd:smart00875  82 PELL-EHVRLPLLSPDYLLE 100
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 13-121 2.84e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 111.58  E-value: 2.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVIlTEA 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI-SEE 78

                          90       100
                  ....*....|....*....|....*....
gi 564347940   93 NVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
305-563 1.39e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.39  E-value: 1.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 305 VSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSL-LRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLK 383
Cdd:COG3055   19 ALLDGKVYVAGGLSGGS--------ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 384 SVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGE-------FFLFYEPQKDYWGFLTPMTVPRiQGLAAV--YK 454
Cdd:COG3055   91 DVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWddggnvaWVEVYDPATGTWTQLAPLPTPR-DHLAAAvlPD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 455 DSIYYIAGtcgnhqrvftvEAYDIELNKWTRKKDFPCDQSinpYLKLVLFQNKLHLFVRATQVTveehifrtsrkNSLYQ 534
Cdd:COG3055  170 GKILVIGG-----------RNGSGFSNTWTTLAPLPTARA---GHAAAVLGGKILVFGGESGFS-----------DEVEA 224

                        250       260
                 ....*....|....*....|....*....
gi 564347940 535 YDDIADQWMKVYETPdrlwdLGRHFECAV 563
Cdd:COG3055  225 YDPATNTWTALGELP-----TPRHGHAAV 248
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 24-121 1.34e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 98.15  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940    24 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 564347940   104 FQIPSIQDQCAKYMISHL 121
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 353-402 4.38e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.53  E-value: 4.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 564347940  353 ARIGCKLVYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWMTVCAMP 402
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
365-415 1.08e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 1.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 564347940   365 KMYAIGGRvyegDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKE 415
Cdd:smart00612   1 KIYVVGGF----DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
435-549 1.03e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 44.38  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 435 WGFLTPMTVPRIQGLAAVYKDSIY----YIAGTCGNhqrvfTVEAYDIELNKWTRKKDFPcdqsINPYLK--LVLFQNKL 508
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYvaggLSGGSASN-----SFEVYDPATNTWSELAPLP----GPPRHHaaAVAQDGKL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940 509 HLFVRATQVTVEEHIFrtsrkNSLYQYDDIADQWMKVYETP 549
Cdd:COG3055   74 YVFGGFTGANPSSTPL-----NDVYVYDPATNTWTKLAPMP 109
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-129 4.39e-94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 283.80  E-value: 4.39e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   1 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLN 80
Cdd:cd18274    1 MDPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18274   81 YAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-217 4.30e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 204.71  E-value: 4.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 564347940 201 EREVHLPEIFAKCIRFP 217
Cdd:cd18483   81 KREMHLPEIFAKCIRMP 97
PHA03098 PHA03098
kelch-like protein; Provisional
 24-490 1.82e-56

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 198.45  E-value: 1.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEstqKEVRIIGvEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 104 FQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 183
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 184 EEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLMEDAFIEKIpPRFAQAIVKSC---GEKGPSNTNGC---TQRLGMT 257
Cdd:PHA03098 168 EDVVLEIIIKWLTSKKNNKYKDICLIL-KVLRITFLSEEGIKKL-KRWKLRIKKKKivfNKRCIKIIYSKkynLNKILPR 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 258 ASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKppNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaeNDFWMY 337
Cdd:PHA03098 246 SSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLSV-------NSVVSY 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 338 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGR--------------------------------------------- 372
Cdd:PHA03098 317 DTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIynsislntveswkpgeskwreepplifprynpcvvnvnnliyvig 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 373 -VYEGDgrNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQG----------EFFLFYEPQKDYWGFLTPM 441
Cdd:PHA03098 397 gISKND--ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIVESYNPVTNKWTELSSL 474

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940 442 TVPRIQGLAAVYKDSIYYIAGTCgNHQRVFTVEAYDIELNKWTRKKDFP 490
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK-YEYYINEIEVYDDKTNTWTLFCKFP 522
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-130 1.32e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 154.98  E-value: 1.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVD-------HGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAES 74
Cdd:cd18273    6 DAAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSES 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564347940  75 MGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVF 130
Cdd:cd18273   86 MALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 4.32e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 138.96  E-value: 4.32e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  10 LKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVIL 89
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGE-KSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  90 TEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18238   82 TVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-129 1.64e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 129.54  E-value: 1.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVL-VAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYS 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18276   83 SDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 127-224 8.94e-34

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 123.81  E-value: 8.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  127 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 206
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90
                  ....*....|....*...
gi 564347940  207 PEIFAkCIRFPLMEDAFI 224
Cdd:pfam07707  82 PELLS-AVRLPLLSPQYL 98
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-125 6.12e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 122.18  E-value: 6.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAG-GREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSN 123
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 1.00e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 121.67  E-value: 1.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTmydEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18240    3 MACNVFNELRL---EGKLCDVVIRVN-GVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18240   79 RTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 6.51e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 116.47  E-value: 6.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVE-GREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18253   80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-128 1.13e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 116.10  E-value: 1.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18236   15 LENLRLENSLTDVILCVD-SQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQ 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18236   94 NVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 127-226 3.02e-30

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 113.98  E-value: 3.02e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   127 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 206
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 564347940   207 PEIFaKCIRFPLMEDAFIEK 226
Cdd:smart00875  82 PELL-EHVRLPLLSPDYLLE 100
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-128 3.28e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 114.89  E-value: 3.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVE-GREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18237   83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-129 4.53e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 114.50  E-value: 4.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   6 ACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTS 85
Cdd:cd18268    7 SSELLRQLNSLRQERILTDVILCTG-DKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  86 RVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18268   86 EILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-128 6.89e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 114.04  E-value: 6.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVG-MELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-130 8.74e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 113.78  E-value: 8.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18340   18 LKDLLDHNKFVDCVLKI-KEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQ 96

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVF 130
Cdd:cd18340   97 NVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 1.20e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 113.26  E-value: 1.20e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIAD-GQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-119 1.33e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 112.76  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   6 ACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTS 85
Cdd:cd18247    3 PSSGFPVMEEIRRQGKLCDVTLKVGD-QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSG 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564347940  86 RVILTEANVQALFTTASIFQIPSIQDQCAKYMIS 119
Cdd:cd18247   82 RIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-128 1.49e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 113.00  E-value: 1.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18252   81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 2.12e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 112.53  E-value: 2.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVE-GKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-129 2.67e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 112.50  E-value: 2.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18269   18 LKDLLDENKFVDCVLKIG-DKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQ 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18269   97 NVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 13-121 2.84e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 111.58  E-value: 2.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVIlTEA 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI-SEE 78

                          90       100
                  ....*....|....*....|....*....
gi 564347940   93 NVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-127 1.55e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 110.48  E-value: 1.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18270    9 YAVSLLEQLKFFYEQQLLTDIVLIVE-GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSI 127
Cdd:cd18270   88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-128 3.89e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 109.09  E-value: 3.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVD-GKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18265   83 YGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-128 4.82e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 106.45  E-value: 4.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18259   13 PSHPQSILDGLQTLRSNPKLSDVTLLVG-GREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18259   92 YTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-104 1.47e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 103.02  E-value: 1.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTA 101
Cdd:cd18186    1 LCDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                 ...
gi 564347940 102 SIF 104
Cdd:cd18186   80 DKL 82
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 8.65e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 102.12  E-value: 8.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVAD-GVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18235   81 YTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
305-563 1.39e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.39  E-value: 1.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 305 VSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSL-LRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLK 383
Cdd:COG3055   19 ALLDGKVYVAGGLSGGS--------ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 384 SVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGE-------FFLFYEPQKDYWGFLTPMTVPRiQGLAAV--YK 454
Cdd:COG3055   91 DVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWddggnvaWVEVYDPATGTWTQLAPLPTPR-DHLAAAvlPD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 455 DSIYYIAGtcgnhqrvftvEAYDIELNKWTRKKDFPCDQSinpYLKLVLFQNKLHLFVRATQVTveehifrtsrkNSLYQ 534
Cdd:COG3055  170 GKILVIGG-----------RNGSGFSNTWTTLAPLPTARA---GHAAAVLGGKILVFGGESGFS-----------DEVEA 224

                        250       260
                 ....*....|....*....|....*....
gi 564347940 535 YDDIADQWMKVYETPdrlwdLGRHFECAV 563
Cdd:COG3055  225 YDPATNTWTALGELP-----TPRHGHAAV 248
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-123 2.43e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 100.69  E-value: 2.43e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVK-IHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-128 3.61e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 100.60  E-value: 3.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFScHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYA-HRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18249   85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-129 6.52e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 100.83  E-value: 6.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI-IGVEAESMGLVLNY 81
Cdd:cd18267   21 SSYADSVLTHLNLLRQQRLFTDVLLHAGN-RSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLDY 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18267  100 AYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 121-227 8.19e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 99.23  E-value: 8.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100
                 ....*....|....*....|....*..
gi 564347940 201 EREVHLPEIFAKcIRFPLMEDAFIEKI 227
Cdd:cd18445   81 NRKEHLAELLEH-VRLPLLSPEYLVQR 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 24-121 1.34e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 98.15  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940    24 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 564347940   104 FQIPSIQDQCAKYMISHL 121
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-127 2.19e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 97.82  E-value: 2.19e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDiVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTA 101
Cdd:cd18234    1 LCD-VILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATA 79

                         90       100
                 ....*....|....*....|....*.
gi 564347940 102 SIFQIPSIQDQCAKYMISHLDPQNSI 127
Cdd:cd18234   80 CLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-122 3.88e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 97.84  E-value: 3.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKVKYQdpkEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLD 122
Cdd:cd18248   84 AYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
280-490 6.89e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 101.77  E-value: 6.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 280 CLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDhkaeNDFWMYDHSTNRWLSKPSLLRARIGCKL 359
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPL----NDVYVYDPATNTWTKLAPMPTPRGGATA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 360 VYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKE-KIYVLQGEFFLFYEPQkdyWGFL 438
Cdd:COG3055  118 LLLDGKIYVVGGW----DDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGSGFSNT---WTTL 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564347940 439 TPMTVPRIQGLAAVYKDSIYYIAGTCGNHQrvfTVEAYDIELNKWTRKKDFP 490
Cdd:COG3055  191 APLPTARAGHAAAVLGGKILVFGGESGFSD---EVEAYDPATNTWTALGELP 239
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-218 9.63e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 95.56  E-value: 9.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90
                 ....*....|....*...
gi 564347940 201 EREVHLPEIFaKCIRFPL 218
Cdd:cd18485   81 SRVQHLVELL-KQVRLEL 97
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 120-217 2.42e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 94.30  E-value: 2.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 120 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 199
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*...
gi 564347940 200 NEREVHLPEIFAKcIRFP 217
Cdd:cd18448   81 QHRKRHLDDLLSQ-VRLP 97
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 121-224 4.11e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 94.30  E-value: 4.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....
gi 564347940 201 EREVHLPEIFAKcIRFPLMEDAFI 224
Cdd:cd18457   81 NREEYLPELLSK-VRLPLLRPQFL 103
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-129 5.77e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 94.53  E-value: 5.77e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18341   18 LKELLDENKFVDCTLKAG-DKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDG 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18341   97 NVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-123 7.55e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 93.98  E-value: 7.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTI-VAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18338   80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-128 1.50e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 93.15  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRII-GVEAESMGLVLNY 81
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18254   82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-129 5.13e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 91.55  E-value: 5.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRV 87
Cdd:cd18306    4 SVLAKLNALRKNRQFCDVILQVG-GHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564347940  88 ILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18306   83 EVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 5.87e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 91.42  E-value: 5.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18251    6 HSQALLDGLVALRDSGILFDVVLVVE-GKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18251   85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 121-224 1.54e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 89.70  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18444    2 LHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLP 81

                         90       100
                 ....*....|....*....|....
gi 564347940 201 EREVHLPEIFAKcIRFPLMEDAFI 224
Cdd:cd18444   82 ERKKHLAKLLAL-IRLPLLTPQFL 104
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-123 2.40e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 90.47  E-value: 2.40e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18246   30 MNRMRQRGLLCDIVLHVG-TKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18246  109 NVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-129 1.47e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 87.79  E-value: 1.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLK-IPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 1.74e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 87.30  E-value: 1.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVE-GREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFA 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCA 114
Cdd:cd18326   85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCA 116
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 121-202 1.95e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 85.81  E-value: 1.95e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81


                 ..
gi 564347940 201 ER 202
Cdd:cd18458   82 NR 83
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 123-215 2.16e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 86.22  E-value: 2.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 123 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 202
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|...
gi 564347940 203 EVHLPEIFAKCIR 215
Cdd:cd18455   82 KVHLKDLMSSCWR 94
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-123 3.34e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 86.31  E-value: 3.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTI-VAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18339   80 IYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 145-219 4.33e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 85.19  E-value: 4.33e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564347940 145 SKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLM 219
Cdd:cd18516   25 ARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLL-ESIRFRLM 98
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 121-219 3.85e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 82.48  E-value: 3.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18459    2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFAKcIRFPLM 219
Cdd:cd18459   82 ERRPHLPQVLQH-VRLPLL 99
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-129 7.15e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 82.80  E-value: 7.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18337    6 HAEQTFKKMENYLRHKQLCDVVL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18337   85 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 121-220 7.69e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 82.13  E-value: 7.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|
gi 564347940 201 EREVHLPEIFaKCIRFPLME 220
Cdd:cd18446   81 ERLPLLPRVL-ENVRLPLLD 99
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 122-217 1.53e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 80.92  E-value: 1.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 122 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNE 201
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90
                 ....*....|....*.
gi 564347940 202 REVHLPEIFAkCIRFP 217
Cdd:cd18468   81 RKQHIAELLA-VVRLP 95
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 121-198 2.00e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 79.96  E-value: 2.00e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKE-QEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 198
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 2.02e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 81.86  E-value: 2.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADE-QRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18266   87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 121-224 4.38e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 80.91  E-value: 4.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100
                 ....*....|....*....|....
gi 564347940 201 EREVHLPEIFaKCIRFPLMEDAFI 224
Cdd:cd18452   81 EREDYLPELL-QYVRLPLLSPRYI 103
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 5.24e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 79.91  E-value: 5.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQ-GREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 121-219 2.29e-17

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 77.52  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18466    1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFAKcIRFPLM 219
Cdd:cd18466   81 KRKKHVVEVLEP-VRFPLL 98
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 10-127 4.95e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 77.16  E-value: 4.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  10 LKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVIL 89
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEAD-GSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564347940  90 TEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSI 127
Cdd:cd18263   80 SWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-202 6.11e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 75.82  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 564347940 201 ER 202
Cdd:cd18480   81 AR 82
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 121-223 6.24e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 76.58  E-value: 6.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|...
gi 564347940 201 EREVHLPEIFaKCIRFPLMEDAF 223
Cdd:cd18456   81 GRRQHVPRLM-KCVRLPLLSRDF 102
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-91 6.31e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 76.89  E-value: 6.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18287    5 HVHFLSEDIGALFLNEEYSDVTFVVE-EKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83


                 ....*..
gi 564347940  85 SRVILTE 91
Cdd:cd18287   84 GRLTLTD 90
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 17-113 7.43e-17

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 75.84  E-value: 7.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  17 YDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQA 96
Cdd:cd18314    1 YNDSEFSDVVLCVGD-RKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                         90
                 ....*....|....*..
gi 564347940  97 LFTTASIFQIPSIQDQC 113
Cdd:cd18314   80 LLMLASKYQVPDLEKLC 96
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 121-219 7.72e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 76.03  E-value: 7.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFaKCIRFPLM 219
Cdd:cd18477   81 NRQKALPTVF-ESIRFRLL 98
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 8.00e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 77.18  E-value: 8.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18271    7 HGQQILSVLQNFREQNAFFDFNIIV-KDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18271   86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTN 126
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 145-219 9.48e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 75.96  E-value: 9.48e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564347940 145 SKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLM 219
Cdd:cd18517   25 ARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIF-DCIRFRLM 98
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-129 1.14e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 76.62  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRK-IPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 122-198 1.71e-16

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 74.37  E-value: 1.71e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347940 122 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 198
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 121-197 3.59e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 73.58  E-value: 3.59e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEH 197
Cdd:cd18463    2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 6.34e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 74.46  E-value: 6.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIV-VEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAY 83
Cdd:cd18239    6 HSSVVLQGFDQLRGEGLLCDVTlVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564347940  84 TSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18239   86 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 120-224 8.67e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 73.18  E-value: 8.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 120 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 199
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....*
gi 564347940 200 NEREVHLPEIFAKcIRFPLMEDAFI 224
Cdd:cd18511   81 EQRRKDLSKLLAY-IRLPLLAPQFL 104
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 121-210 9.06e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 73.25  E-value: 9.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18469    3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                         90
                 ....*....|
gi 564347940 201 EREVHLPEIF 210
Cdd:cd18469   83 ARAAHLPELL 92
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 9.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 74.06  E-value: 9.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAE-GNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYT 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18264   90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 121-219 9.37e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 73.06  E-value: 9.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFaKCIRFPLM 219
Cdd:cd18467   81 ERQKYLAQLL-HCVRLPLL 98
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 1.22e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 73.85  E-value: 1.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18261   90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 121-254 1.39e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 73.53  E-value: 1.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564347940 201 EREVHLPEIFAKcIRFPLM-EDAFIEKIPprfAQAIVKscgekgpsNTNGCTQRL 254
Cdd:cd18512   81 VRQEHMAHLMEH-VRLPLLsREYLVQRVE---EETLVK--------NSSACKDYL 123
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 121-227 1.62e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 73.18  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100
                 ....*....|....*....|....*..
gi 564347940 201 EREVHLPEIFAKcIRFPLMEDAFIEKI 227
Cdd:cd18513   81 ARLEHMAKLMEH-VRLPLLPRDYLVQT 106
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-117 2.40e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 71.99  E-value: 2.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   9 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRII--GVEAESMGLVLNYAYTSR 86
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVG-GEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIEleGISVEVMEEILDYIYTGQ 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-116 2.89e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 71.37  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVE---AESMGLVLNYAYTSRVILTEANVQALFTT 100
Cdd:cd18307    3 DVVISVDN-HSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylsPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                         90
                 ....*....|....*.
gi 564347940 101 ASIFQIPSIQDQCAKY 116
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 121-219 3.92e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 71.59  E-value: 3.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFAKcIRFPLM 219
Cdd:cd18509   82 RRCSDLSMLLAY-IRLPLL 99
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-212 7.66e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 70.47  E-value: 7.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|..
gi 564347940 201 EREVHLPEIFAK 212
Cdd:cd18479   81 SRSQYLSSVLSQ 92
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 120-219 1.07e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 70.33  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 120 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 199
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|
gi 564347940 200 NEREVHLPEIFAKcIRFPLM 219
Cdd:cd18510   81 QNRQKDLGMLLSY-IRLPLL 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-423 2.88e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 73.27  E-value: 2.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 299 REVGILVSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCC-GKMYAIGGRVYEG- 376
Cdd:COG3055  112 RGGATALLLDGKIYVVGGWDDGG--------NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPdGKILVIGGRNGSGf 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347940 377 ----------------------DGR--------NSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGE 423
Cdd:COG3055  184 sntwttlaplptaraghaaavlGGKilvfggesGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGE 260
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-129 5.09e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 69.15  E-value: 5.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  18 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQAL 97
Cdd:cd18272   28 EDGLFADVTISVE-GKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQET 106

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  98 FTTASIFQIPSIQDQCAKYMISHLDPQNSIGV 129
Cdd:cd18272  107 YEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 120-218 5.47e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 67.77  E-value: 5.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 120 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 199
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*....
gi 564347940 200 NEREVHLPEIFAKcIRFPL 218
Cdd:cd18447   81 PNRQPYMVDILAK-VRFPL 98
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 7.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 68.37  E-value: 7.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQD-QEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18328   85 YTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 9.11e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 67.61  E-value: 9.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGlteSTQK------EVRIIGveaeSMGLV 78
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVK-GVCFKAHKNVLAAFSQYFRSLFQNS---SSQKndvfhlDIKNVG----GIGQI 72

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  79 LNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18233   73 LDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-127 2.04e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 67.15  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSgltESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTI-ATKTKSFDVHKVVMASCSEYFRNILKK---DPSLQRVELNDISPLGLATVITYAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSI 127
Cdd:cd18260   77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 123-219 3.33e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 65.60  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 123 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 202
Cdd:cd18464    2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                         90
                 ....*....|....*..
gi 564347940 203 EVHLPEIFaKCIRFPLM 219
Cdd:cd18464   82 HEVLPELL-RSVRLALL 97
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-121 4.44e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 65.72  E-value: 4.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  14 KTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRV-ILTEA 92
Cdd:cd18300    1 KLFLNKGLFSDVTFIVE-DGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApILEDG 79

                         90       100
                 ....*....|....*....|....*....
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18300   80 DCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-121 4.71e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 66.04  E-value: 4.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTqkevrIIGVEAESMGLVLN---- 80
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRV-QDKIFRAHKVVLAACSDFFRSKLVGQASPRL-----VLVSPAGKCVLDLHhvtv 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564347940  81 --------YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18228   76 tgfaplleYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 123-219 8.72e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 64.61  E-value: 8.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 123 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 202
Cdd:cd18515    2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                         90
                 ....*....|....*..
gi 564347940 203 EVHLPEIFaKCIRFPLM 219
Cdd:cd18515   82 HCYLSELL-QTVRLALL 97
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-110 9.70e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 65.30  E-value: 9.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTS-------------GLTESTQKEVRIIGVE 71
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTK-FRAHRSVLAASSPYFRELLSSplplgaaavaaapGATQSPERVLELPGVK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564347940  72 AESMGLVLNYAYTSRVIL-TEANVQALFTTASIFQIPSIQ 110
Cdd:cd18195   80 AGVFSDVLNFIYSSRVALpGSAAAKELGAAGKRLGIPFLQ 119
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 6-83 1.04e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 64.97  E-value: 1.04e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564347940   6 ACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAY 83
Cdd:cd18286    1 CSRLGKDLLQLFLNGEDSDITIKVD-GKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIY 77
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-117 1.61e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 64.19  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  11 KQLKTMYDEGQLTDIVVEV-DHGKTFSCHRNVLAAISPYFRSMFTSGL-TESTQKEVRIIGVEAESMGLVLNYAYTSRVI 88
Cdd:cd18294    3 ADMKSLINNPEFSDVKFLVgPERQEIFAHKCILAARCEVFRAMFLTGPqKESTQSPLVLSDIEPEVFRAVLEFIYTNCVT 82

                         90       100
                 ....*....|....*....|....*....
gi 564347940  89 LTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18294   83 LSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 2.48e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 64.10  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSG------LTESTQKEV-RIIGVEAESM 75
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTI-KTRGLEYRTHRAVLAACSLYFRKLFTGGgggsgdLGAGGGQDVcELDFVGPEAL 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  76 GLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCA 114
Cdd:cd18327   85 GALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACA 123
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 122-176 3.11e-12

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 61.52  E-value: 3.11e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564347940 122 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDS 176
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 3.13e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 63.91  E-value: 3.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTsgLTESTQKEVRIIGvEAESMGLVLNYA 82
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNV-QGQSFRAHKVVLAASSPYFRDHMS--LNEMSTVSISVIK-NPTVFEQLLSFC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18222   82 YTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-104 5.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 61.53  E-value: 5.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  23 TDIVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTAS 102
Cdd:cd01165    1 VVLVVE---GEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAAN 77


                 ..
gi 564347940 103 IF 104
Cdd:cd01165   78 FL 79
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 121-219 5.44e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 62.17  E-value: 5.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFaKCIRFPLM 219
Cdd:cd18514   81 KRKDYLPELL-RNVRLALL 98
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-128 5.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 63.07  E-value: 5.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   9 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK---EVRIIGVEAESMGLVLNYAYTS 85
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKIIVE-GKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564347940  86 RVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIG 128
Cdd:cd18258   83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-125 6.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 63.14  E-value: 6.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSgltestqKEVRIIGVEAESMGLVLNY 81
Cdd:cd18243   12 DPSHSDNLLHGLNLLWRKQLFCDVTLTA-QGQQFHCHKAVLASCSQYFRSLFSI-------NNLVLQGCSSIGLRLVLEY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18243   84 LYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 121-216 1.38e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 60.98  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKF-LCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 199
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*..
gi 564347940 200 NEREVHLPEIFaKCIRF 216
Cdd:cd18482   81 KERAASAAEVL-KCVRW 96
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-116 1.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 60.93  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIigveAESMGLVLNYAYT 84
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVG-GRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESF----AEVFGLLLDFFYT 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKY 116
Cdd:cd18232   76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-116 2.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 61.04  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVG-REQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKY 116
Cdd:cd18215   81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 2.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 61.03  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTsgltESTQKEVRIIG----VEAESMGLVLN 80
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVS-REQFRAHKTVLMACSGLFYSIFT----DQLKCNLSVINldpeINPEGFNILLD 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18331   82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-120 2.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 60.71  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDI-VVEVDHGKTFSCHRNVLAAISPYFRSMFTsgltESTQKEVRIIGVEA-ESMGL--VLNYAYTSRVILTEANVQAL 97
Cdd:cd18231   14 LCDVdIVLVRQRSTFPAHKGVLAAYSQFFHSLFT----QNKQLQRVELSLEAlTSQGLqqILNFIYTSKLLVNSCNVQDV 89

                         90       100
                 ....*....|....*....|...
gi 564347940  98 FTTASIFQIPSIQDQCAKYMISH 120
Cdd:cd18231   90 LNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-121 2.79e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 61.51  E-value: 2.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEV-DHgkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAY 83
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIeDH--QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMY 90

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564347940  84 TSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18244   91 YGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKI 128
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-113 3.14e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 60.33  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSgltestQKEVRIIGVE-AESMGLVLNY 81
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVD-GVDFKAHKAVLAACSEYFRMLFVD------QKDVVHLDISnAAGLGQVLEF 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18206   76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-125 3.24e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 60.83  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIG--VEAESMGLVLN 80
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGN-RHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18196   81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMS 125
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 121-220 4.69e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 59.77  E-value: 4.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRW-FEHEQ 199
Cdd:cd18461    1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhYTPEQ 80

                         90       100
                 ....*....|....*....|....
gi 564347940 200 NERE---VHLPEIFAKCIRFPLME 220
Cdd:cd18461   81 VEKDqvsLQEPPKLLEAVRFPLME 104
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-122 4.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 60.46  E-value: 4.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIG-VEAESMGLVLNY 81
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVE-GKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDiVTAQGFKAIIDF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLD 122
Cdd:cd18230   81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 5.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 60.04  E-value: 5.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMftSGLTESTQKEVRIIGvEAESMGLVLNYA 82
Cdd:cd18220    6 PEYSNTVLSQLNELRLQGKLCDIIVHI-QGQPFRAHKAVLAASSPYFRDH--SALSTMSGLSISVIK-NPNVFEQLLSFC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18220   82 YTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-113 8.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 59.59  E-value: 8.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDI--VVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRV-ILTEAN--VQA 96
Cdd:cd18297   12 MSDVtfLVE---GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVeSLDVAQddALE 88

                         90
                 ....*....|....*..
gi 564347940  97 LFTTASIFQIPSIQDQC 113
Cdd:cd18297   89 LLRAASFFQLDGLKRHC 105
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-84 8.95e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 59.26  E-value: 8.95e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564347940  11 KQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18280    3 QHFGALLESEEGADVTFNVD-GEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-117 9.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 59.22  E-value: 9.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLT-ESTQKEVRIigVEAESMGLV----LNYA 82
Cdd:cd18292    3 EFLQDIAQLYNNEELSDIVLRVG-GKVFHAHRLILAKSSDVFRVMLSNDWWsESKQSEIEL--VEDPECAAVfekfLRYL 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18292   80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114
PHA02713 PHA02713
hypothetical protein; Provisional
 2-422 1.24e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 63.88  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGL-TESTQKEVRIIGVEAESMGLVLN 80
Cdd:PHA02713   5 DIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  81 YAYTSRVilTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQ 160
Cdd:PHA02713  85 YLYNRHI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 161 EFLQLTKDQLISILDSDD-LNVDREEHVYESIIRWFEHEQNEREVHLpeIFAKCI---------RFPLMEDAFIEKIPpr 230
Cdd:PHA02713 163 AFKKTVFEILFDIISTNDnVYLYREGYKVTILLKWLEYNYITEEQLL--CILSCIdiqnldkksRLLLYSNKTINMYP-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 231 faqaivkSCGE---KGPSNTNGCTQRLgmtaseMIICFDAAHKHSGkkqtvPCL---DIVTGRVFKLCKPPNDLREVGIL 304
Cdd:PHA02713 239 -------SCIQfllDNKQNRNIIPRQL------CLVCHDTKYNVCN-----PCIlvyNINTMEYSVISTIPNHIINYASA 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 305 VSpDNDIYIAGGYR---PSSSEV---SIDHKAENDFwmydhstnrwlskPSLLRARIGCKLVYCCGKMYAIGGRvyegDG 378
Cdd:PHA02713 301 IV-DNEIIIAGGYNfnnPSLNKVykiNIENKIHVEL-------------PPMIKNRCRFSLAVIDDTIYAIGGQ----NG 362

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 564347940 379 RNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQG 422
Cdd:PHA02713 363 TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-97 1.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 58.35  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTEStQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQK-FRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYS 78

                         90
                 ....*....|...
gi 564347940  85 SRVILTEANVQAL 97
Cdd:cd18209   79 SSLFVEKSSLAAV 91
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 121-220 1.90e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 57.82  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90       100
                 ....*....|....*....|
gi 564347940 201 EREVHLPEIFAkCIRFPLME 220
Cdd:cd18462   81 KRIECAYDLLS-SIKLDLDE 99
PHA02790 PHA02790
Kelch-like protein; Provisional
 32-371 2.09e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 63.14  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  32 GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI-IGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQ 110
Cdd:PHA02790  30 GGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVcLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFII 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 111 DQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKE--QEFLQLTkdqLISILDSDDLNVDREEHVY 188
Cdd:PHA02790 110 YTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYLS---MKLILESDELNVPDEDYVV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 189 ESIIRWFEHEQNeREVHLPEIFAKCIRFPLMEDAFIEKIPPRFAQAIVKSCGEKGPSNTNGCTQRLGMTASEMIICFD-A 267
Cdd:PHA02790 187 DFVIKWYMKRRN-RLGNLLLLIKNVIRSNYLSPRGINNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNMDQIIDIFHmC 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 268 AHKHSGK-------------KQTVPCLDIVTGRVFKLcKPPNDLREVGILVSPDNDIYIAGGY-RPSSSEVsidhkaend 333
Cdd:PHA02790 266 TSTHVGEvvyliggwmnneiHNNAIAVNYISNNWIPI-PPMNSPRLYASGVPANNKLYVVGGLpNPTSVER--------- 335

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 564347940 334 fWMydHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGG 371
Cdd:PHA02790 336 -WF--HGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG 370
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-106 2.36e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 57.17  E-value: 2.36e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347940  32 GKTFSCHRNVLAAISPYFRSMFTSgltESTQKEVRII--GVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQI 106
Cdd:cd18315   10 GGSLKAHKLVLAAASPYFAALLKE---TPPDEHPVIIlpDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQI 83
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-120 3.36e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 57.68  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAiSPYFRSMFTSGLTESTQKEVRI----IGVEAESMGLVLNYAYTSRVI 88
Cdd:cd18305    6 YQTLFLNGENSDITICA-LGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIE 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  89 LTEANVQALFTTASIFQIPSIQDQCAKYMISH 120
Cdd:cd18305   84 IKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 121-194 3.86e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 56.24  E-value: 3.86e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRW 194
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 121-219 4.29e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 56.73  E-value: 4.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*....
gi 564347940 201 EREVHLPEIFAKcIRFPLM 219
Cdd:cd18460   81 HRQHFWPELLQH-VRLPFV 98
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 4.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 57.65  E-value: 4.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTS----GLTESTQKEVriigvEAESMGLVLN 80
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVE-GKEFRAHRAVLAACSEYFLQALVGqtenDLVVSLPEEV-----TARGFGPLLQ 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18278   88 FAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-113 5.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 57.67  E-value: 5.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMY-DEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQ-KEVRIIGVEAESMGLVLNYA 82
Cdd:cd18207    9 HSADMLHNLNQQRkSGGRFCDVLLRVGE-ESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVFGDILDFA 87

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18207   88 YTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 121-217 6.26e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 56.29  E-value: 6.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLnVDREEHVYESIIRWFEHEQN 200
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90
                 ....*....|....*..
gi 564347940 201 EREVHLPEIFAKcIRFP 217
Cdd:cd18476   80 ARKGYIHDLFKK-VRLQ 95
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 7.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 56.79  E-value: 7.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTsgltESTQKEVRII----GVEAESMGLVLN 80
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVG-GTPLRAHKAVLIACSGFFYSIFS----GRVGEGVSVLtlpsGLEARGFQLLLD 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18332   77 FMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 1.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 56.49  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18227    6 PDFSSTILQKLNQQRQQGQLCDISVVV-QGHLFRAHKAVLAASSPYFCDQV---LLKNSRRIVLPDVMNPRVFENILLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18227   82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-118 1.24e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 56.20  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSglteSTQKEVRIIG-VEAESMGLVLNY 81
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSVVV-KGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSF 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMI 118
Cdd:cd18290   83 CYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFL 119
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 1.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 55.60  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTD--IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGV-EAESMGLVLNY 81
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDcsILVE---GQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18329   81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 1.79e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 55.84  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFT----SGLTESTQKEVRIIGVEAesmglVLN 80
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVE-GQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKGFEP-----LIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-126 2.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 55.24  E-value: 2.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   7 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18345    3 CRLSDDLGLLFERSAFSDVTLCVG-GREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNS 126
Cdd:cd18345   82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 3.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 55.01  E-value: 3.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   7 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18343    6 CRLAEDLGNLWENSRFTDCSLFVG-GQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18343   85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-117 4.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 54.46  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFR-SMFTSGLTESTQKEVriigVEAESMGLVLNY 81
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHV-QGRVFRAHRAVLAASSPYFHdQVLLKNMSSISLPGV----MDPGAFESVLAS 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18210   77 AYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-122 4.56e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 54.61  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  18 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK-----EVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18296   13 QELSFPDVCFQVE-GHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPE 91

                         90       100       110
                 ....*....|....*....|....*....|
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHLD 122
Cdd:cd18296   92 NAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-115 4.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 54.69  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVriigVEAESMGLVLNYAYTSRV 87
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRI-HGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVL 85

                         90       100
                 ....*....|....*....|....*...
gi 564347940  88 ILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18208   86 RVSQSEALQILTAASILQIKTVIDECTR 113
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 125-198 5.01e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 53.28  E-value: 5.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564347940 125 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 198
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 9.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 53.69  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSM-FTSGLTESTQkevriIGVEAESMGLVLNY 81
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENS-LFRAHKNVLAASSGYFKSLvLHDNLIHLDQ-----DMVSPTVFQQILDF 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  82 AYTSRVI---LTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18216   75 IYTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCRS 111
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 1.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 53.43  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVriigVEAESMGLVLNYA 82
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENA-LFRAHKNILAASSMYFKSLVLHDNLINLDTDM----VNPTVFRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  83 YTSRVILT----EANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18334   77 YTGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRK 113
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-125 1.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 53.59  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTD---IVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTeSTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18281    8 TVKERFAFLFNNETLSDvhfIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18281   87 DEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-111 1.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 52.90  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDD-IYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                         90       100
                 ....*....|....*....|....*....
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQD 111
Cdd:cd18192   81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 1.95e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 52.92  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   7 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18279    3 CRLAEDLGNLWENSRFTDCCLCVG-GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18279   82 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 2.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 52.60  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVriigVEAESMGLVLNYA 82
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNA-LFRAHKNILAASSVYLKSLVVHDNLINLDHEM----VSPGIFRLILDYI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  83 YTSRVI----LTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18333   77 YTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKK 113
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-125 3.29e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 51.72  E-value: 3.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDhGKTFSCHRNVLAAISPYFRSmftsgltESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:cd18275    6 DLVIEVS-GQRIRAHKSVLAAKSDYFRA-------RLSRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77

                         90       100
                 ....*....|....*....|..
gi 564347940 104 FQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18275   78 LQMPCAAQCAVDAVRAQLCLGN 99
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 121-197 3.32e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 50.81  E-value: 3.32e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEH 197
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-117 4.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 51.66  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  25 IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGV-EAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:cd18199   23 IIVE---GRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASY 99

                         90
                 ....*....|....
gi 564347940 104 FQIPSIQDQCAKYM 117
Cdd:cd18199  100 LQMTDVINVCKTFI 113
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 353-402 4.38e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.53  E-value: 4.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 564347940  353 ARIGCKLVYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWMTVCAMP 402
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-113 5.35e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 51.21  E-value: 5.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT--SRVILTEANVQAL-- 97
Cdd:cd18302    5 LYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTdeASAVKESQNVEFLcn 84

                         90
                 ....*....|....*..
gi 564347940  98 -FTTASIFQIPSIQDQC 113
Cdd:cd18302   85 vLVIADQLLITRLKEIC 101
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-117 5.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 51.50  E-value: 5.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   9 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTES-TQKEVRIIGVEA-ESMGLVLNYAYTSR 86
Cdd:cd18201    8 LLQELNEQRKKGILCDVNIVVS-GKVFRAHKNILVAGSRFFKTLYCFTNKEScDQTTVTHLDVVAvQGFSVILDFMYSGN 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18201   87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-91 5.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 51.33  E-value: 5.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYS 79


                 ....*..
gi 564347940  85 SRVILTE 91
Cdd:cd18223   80 SKVVVKR 86
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-117 7.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 51.08  E-value: 7.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  25 IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIG-VEAESMGLVLNYAYTSRVILTEANVQALFTTASI 103
Cdd:cd18330   23 IIVE---GRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDiVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASY 99

                         90
                 ....*....|....
gi 564347940 104 FQIPSIQDQCAKYM 117
Cdd:cd18330  100 LQMTDVVNFCKGYI 113
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 24-104 8.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 49.82  E-value: 8.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  24 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI--IGVEAESMGLVLNYAYTSRVILTEA-NVQALFTT 100
Cdd:cd18190    1 DLVFCVG-GEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLDLFSVeNVHEVLEL 79


                 ....
gi 564347940 101 ASIF 104
Cdd:cd18190   80 ASKF 83
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
395-545 8.27e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 54.01  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 395 WMTVCAMPVAMEFHNAVEHKEKIYVLQGEF-------FLFYEPQKDYWGFLTPM-TVPRIQGLAAVYKDSIYYIAGTCGN 466
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSggsasnsFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 467 HQRVF---TVEAYDIELNKWTRKKDFPcdqSINPYLKLVLFQNKLHLFVRATqvtveehifRTSRKNSLYQYDDIADQWM 543
Cdd:COG3055   83 NPSSTplnDVYVYDPATNTWTKLAPMP---TPRGGATALLLDGKIYVVGGWD---------DGGNVAWVEVYDPATGTWT 150


                 ..
gi 564347940 544 KV 545
Cdd:COG3055  151 QL 152
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-115 8.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 50.63  E-value: 8.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVriigVEAESMGLVLNYAYTSRV 87
Cdd:cd18229    4 SLLETLNAQRLGGHFCDVTVRI-HDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSGSL 78

                         90       100
                 ....*....|....*....|....*...
gi 564347940  88 ILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18229   79 VVAQSEALQILTAASILQIKTVIDECTQ 106
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-125 8.80e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 51.21  E-value: 8.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  38 HRNVLAAISPYFRSMFTSGLTeSTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18346   47 HRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 125


                 ....*...
gi 564347940 118 ISHLDPQN 125
Cdd:cd18346  126 TKHLRADN 133
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-115 1.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 50.42  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKeVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVK-FRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYT 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18204   79 AKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-126 1.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 50.49  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   7 CSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18342    7 CRLADELGGLWENSRFTDCCLCV-AGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564347940  87 VILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNS 126
Cdd:cd18342   86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-109 2.92e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.41  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDI--VVEVDHgktFSCHRNVLAAISPYFRSMFTSGlTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDItlIVENVQ---FRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFI 81

                         90       100
                 ....*....|....*....|....*..
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSI 109
Cdd:cd18212   82 YTGCLQVGEKSLEQILATAQFLKVNDL 108
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 121-208 5.25e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 47.65  E-value: 5.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 200
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 564347940 201 EREVHLPE 208
Cdd:cd18451   81 ERERYFEE 88
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-105 6.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 47.56  E-value: 6.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  33 KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEAN----------VQALFTTAS 102
Cdd:cd18319   11 RCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDstdtleenelLEDLVEAAS 90


                 ...
gi 564347940 103 IFQ 105
Cdd:cd18319   91 FLQ 93
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-87 6.62e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 48.40  E-value: 6.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgltESTQKEVRIIG-----VEAESMGLVLNYAYTSRV 87
Cdd:cd18295   10 LRRLLEQGSYSDVTFNV-HGESFPAHRCILSARSPYFAEMF-----ETKWKDKREINlkhplVNPDAFRALLQYLYTGRL 83
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 6.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 47.93  E-value: 6.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgLTESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHV-QGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYS 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18200   77 GRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
289-389 7.56e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 50.92  E-value: 7.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 289 FKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaendfWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYA 368
Cdd:COG3055  187 WTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEV----------EAYDPATNTWTALGELPTPRHGHAAVLTDGKVYV 256

                         90       100
                 ....*....|....*....|.
gi 564347940 369 IGGRVYEGDGRNSLKSVECYD 389
Cdd:COG3055  257 IGGETKPGVRTPLVTSAEVYD 277
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-85 8.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 47.92  E-value: 8.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTS-GLTESTQKEVRIIGVEAESMGLVLNYAY 83
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIE-GEEYKAHKSVLAANSEYFRELFIEkGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80


                 ..
gi 564347940  84 TS 85
Cdd:cd18202   81 TS 82
Kelch smart00612
Kelch domain;
365-415 1.08e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 1.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 564347940   365 KMYAIGGRvyegDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKE 415
Cdd:smart00612   1 KIYVVGGF----DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-117 1.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 46.69  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  25 IVVEvdhGKTFSCHRNVLAAISPYFRSMFT----SGLTESTQKEVRIIGVEAesmglVLNYAYTSRVILTEANVQALFTT 100
Cdd:cd18955    6 IVVE---DQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVCRC 77

                         90
                 ....*....|....*..
gi 564347940 101 ASIFQIPSIQDQCAKYM 117
Cdd:cd18955   78 AEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-113 1.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 47.54  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDH---GKTFSCHRNVLAAISPYFRSMF-TSGLTESTQKEVRIIGVEAESMGLVLNYAY 83
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVEHqgsKEEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASFLEFVY 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 564347940  84 TSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 1.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 47.51  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdhGKT-FSCHRNVLAAISPYFRsMFTSglTESTQKEVRIIG---VEAESMGLV 78
Cdd:cd18323    4 PDHSRHLLQSLREQRHQGFLCDCTVLV--GSTqFLAHRAVLASCSPFFH-MFYK--EQLDKRDLVCINneiVTAPAFSLL 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564347940  79 LNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18323   79 LEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-113 1.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 47.09  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  10 LKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEV-RIIGVEAESMGLVLNYAYTSRVI 88
Cdd:cd18293    3 FLQLHRQQNSGVFCDVLLQAE-GESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSELE 81

                         90       100
                 ....*....|....*....|....*
gi 564347940  89 LTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELESLC 106
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 132-195 1.96e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 45.65  E-value: 1.96e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564347940 132 FADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWF 195
Cdd:cd18493   11 YAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-121 2.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 46.23  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  38 HRNVLAAISPYFRSMFTSGLTESTQkEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18282   26 HKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104


                 ....
gi 564347940 118 ISHL 121
Cdd:cd18282  105 ETSL 108
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 121-195 2.68e-06

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 46.07  E-value: 2.68e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564347940 121 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISIL-DSDDLNVDREEHVYESIIRWF 195
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILeSNQELESINERKLCQLVLEWV 76
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 22-119 2.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 46.32  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  22 LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTA 101
Cdd:cd18352   13 LSDVTFLVE-GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91

                         90
                 ....*....|....*...
gi 564347940 102 SIFQIPSIQDQCaKYMIS 119
Cdd:cd18352   92 DQYLLEGLKRLC-EYTIA 108
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 5-109 3.85e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 45.66  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRS--MFTSGLTESTQKEVRIIGVEAesmglVLNYA 82
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSV-GGRSYGVHSVILAAVSSLFRErlLGSNGPLPPLSLEVTPVGWEA-----VLTFA 74

                         90       100
                 ....*....|....*....|....*..
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSI 109
Cdd:cd18262   75 YTGVLGRNPATVGDILVAAEALGAPRV 101
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-125 4.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 46.39  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  20 GQLTDIVVEV--DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI------IGVEAESMGLVLNYAYTSRVILTE 91
Cdd:cd18241   21 GLFCDITLAFggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMrkwssePGPDPDTVEAVIQYMYTGRIRVST 100

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564347940  92 ANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18241  101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-117 4.37e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 45.67  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  11 KQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFtsglteSTQKEVRIIG-VEAESMGLVLNYAYTSRVIL 89
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLF------LMMTVVTLDSdITPEAFRRVLEFLYTGVLDE 74

                         90       100
                 ....*....|....*....|....*...
gi 564347940  90 TEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18299   75 NEDDLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-124 4.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 46.18  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  20 GQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSglteSTQKEVRIIG-VEAESMGLVLNYAYTSRVILTEANVQALF 98
Cdd:cd18289   27 GLYCDVSIVVK-GQAFKAHRAVLAASSLYFRDLFSG----NSKSAFELPAtVPPACFQQILSFCYTGKLTMAASEQLVVM 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 564347940  99 TTASIFQIPSIQDQCAKYMIS----HLDPQ 124
Cdd:cd18289  102 YTAGFLQIQHIVERGTDLMFKvsspHCDSQ 131
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-113 5.20e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 45.52  E-value: 5.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTEST---QKEVRIIGVEAesmglVLNY 81
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQ-FKAHRNVLAAFSEYFGAQYKDTEDNIVfldQSQVSADGFQK-----LLEF 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18217   75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 13-87 5.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 46.15  E-value: 5.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQL--TDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVR-----IIGVEA---ESMGLVLNYA 82
Cdd:cd18310    7 LENLLDSPDLfySDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKlelreLIPGGIvgyDAFMLVLSYL 86


                 ....*
gi 564347940  83 YTSRV 87
Cdd:cd18310   87 YSGRL 91
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-111 6.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 45.21  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGltestQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRK-FRAHKNILSASSTYFHQLFSVA-----GQVVELNFIRADIFAEILNY 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  82 AYTSRVILTEAN-VQALFTTASIFQIPSIQD 111
Cdd:cd18219   75 IYSSKIVRVRSDlLEELIKSGQLLGVKFIAE 105
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 6.76e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 45.39  E-value: 6.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAispyfRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRV 87
Cdd:cd18303    4 RLLKTVASLFDKELYSDITIKLA-DKSIPAHKFVLAA-----RSEKWSNENLASTNELDLSDISYEVVLALLRWLYTDEL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564347940  88 ILTEANVQA--LFTTASIFQIPSIQDQCAKYMISHLDPQNSI 127
Cdd:cd18303   78 DLTLDDEFLleLMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 124-216 1.04e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 44.48  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 124 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQnERE 203
Cdd:cd18470    4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQ-KRV 82

                         90
                 ....*....|...
gi 564347940 204 VHLPEIFAKcIRF 216
Cdd:cd18470   83 KYAADLLSN-IRF 94
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-121 1.56e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 44.07  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSrVILTEA 92
Cdd:cd18360    1 LGLFFNSPLLADVVFKI-QGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTD-SCCPAS 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  93 NVQA--LFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18360   79 ILQAmaLLICAEMYQVSRLQHICELYIITQL 109
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 148-219 1.88e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 43.74  E-value: 1.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564347940 148 YIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIfakC-IRFPLM 219
Cdd:cd18465   28 FTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRASASHVL---ChIRFPLM 97
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-125 2.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 44.29  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTeSTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18347    8 TVQERFAFLFNNEVLSDVHFLVGKGlgsQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQN 125
Cdd:cd18347   87 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-113 2.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 44.03  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRsMFTSGLTESTQKEVRIIG--VEAESMGLVLN 80
Cdd:cd18956    4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDAR-FPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGdiVTAPAFGRLLD 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18956   82 FMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Kelch smart00612
Kelch domain;
311-362 2.93e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.93e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 564347940   311 IYIAGGYRPSSSEvsidhkaeNDFWMYDHSTNRWLSKPSLLRARIGCKLVYC 362
Cdd:smart00612   2 IYVVGGFDGGQRL--------KSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-86 3.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 43.26  E-value: 3.01e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564347940  24 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18191    3 DLRFLLDGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHGCR 65
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 10-91 3.95e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 42.66  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  10 LKQLKTMYDEGQLT-DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK----EVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18301    5 FKKLLDEADEGDNIhDVVFQVG-GKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYT 83


                 ....*..
gi 564347940  85 SRVILTE 91
Cdd:cd18301   84 DTCDLLT 90
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-121 4.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 42.46  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  23 TDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEAN--VQALFTT 100
Cdd:cd18313    2 ADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEkfGIHLLVL 81

                         90       100
                 ....*....|....*....|.
gi 564347940 101 ASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18313   82 SHVYVVPQLKRVCEKGLEQGL 102
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 124-217 4.85e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 42.41  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 124 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNERE 203
Cdd:cd18449    4 ENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQ 83

                         90
                 ....*....|....*...
gi 564347940 204 vhlpeiFA----KCIRFP 217
Cdd:cd18449   84 ------FAaklmENIRFP 95
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-117 5.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 42.71  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFtsgltESTQKEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVD-SQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYT 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564347940  85 SRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18205   75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 148-203 6.27e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 41.91  E-value: 6.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 148 YIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVdREEHVYESIIRWFEHE----QNERE 203
Cdd:cd18489   29 FLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQlikrMEERE 87
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 12-121 8.06e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 42.64  E-value: 8.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  12 QLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILT- 90
Cdd:cd18358   10 RIKECLSKGTFSDVTFKLDDG-TINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTa 88

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  91 EANVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18358   89 DLDPLELIALANRFCLPHLVALTEQHAVQEL 119
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
435-549 1.03e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 44.38  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940 435 WGFLTPMTVPRIQGLAAVYKDSIY----YIAGTCGNhqrvfTVEAYDIELNKWTRKKDFPcdqsINPYLK--LVLFQNKL 508
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYvaggLSGGSASN-----SFEVYDPATNTWSELAPLP----GPPRHHaaAVAQDGKL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940 509 HLFVRATQVTVEEHIFrtsrkNSLYQYDDIADQWMKVYETP 549
Cdd:COG3055   74 YVFGGFTGANPSSTPL-----NDVYVYDPATNTWTKLAPMP 109
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-121 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 41.51  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  16 MYDEGQLTD---IVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEsTQKEVRIIGVEAESMGLVLNYAYTSRVILTEA 92
Cdd:cd18349    2 MFNNELMADvhfIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAE-VKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 564347940  93 NVQALFTTASIFQIPSIQDQCAKYMISHL 121
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 89-219 1.30e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 41.44  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  89 LTEANVQALFTTASIFQIPSIQDQCAKYMishldpqnsigvfifadhyghqelgDRSKEYirkkflcVTKEQEFLQLTKD 168
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFM-------------------------DRNAQE-------VLSSEGFLTLSKS 48

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564347940 169 QLISILDSDDLNVDrEEHVYESIIRWFEHEQNEREVHlPEIFaKCIRFPLM 219
Cdd:cd14822   49 ALKELLSRDSFCAP-EVDIFNAVRRWCEHNPDSKEDA-KEIL-EAVRLPLM 96
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-126 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 41.93  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  38 HRNVLAAISPYFRSMFTSGLTEStQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYM 117
Cdd:cd18348   40 HKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFL 118


                 ....*....
gi 564347940 118 ISHLDPQNS 126
Cdd:cd18348  119 ETSLSAKNA 127
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-72 1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 40.49  E-value: 1.50e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 564347940  25 IVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEA 72
Cdd:cd18320    4 VKVWVE-EQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSA 50
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-106 1.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 41.42  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   9 ILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMftSGLTESTQKEVRIIG-VEAESMGLVLNYAYTSRV 87
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLQFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQL 78

                         90
                 ....*....|....*....
gi 564347940  88 ILTEANVQALFTTASIFQI 106
Cdd:cd18311   79 EFEEKSYGKLLRTAKELNM 97
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 2.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 40.96  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSglTESTQKEVRIIG--VEAESMGLVLN 80
Cdd:cd18194    4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQ-FPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGLLLD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564347940  81 YAYTSRVILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18194   81 FMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKG 115
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-123 3.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 40.96  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFScHRNVLAAISPYFRSMFTsgLTEStqKEVRIIGVEAESMG--LVLNyA 82
Cdd:cd18214    8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPG-HKVVFAAGSPFLRDQFL--LNDS--REVQISILQNSEVGrqLLLS-C 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18214   82 YTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 305-350 3.56e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 3.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564347940  305 VSPDNDIYIAGGYRPSSSEvsidhkaeNDFWMYDHSTNRWLSKPSL 350
Cdd:pfam01344   8 VVVGGKIYVIGGFDGNQSL--------NSVEVYDPETNTWSKLPSM 45
Kelch_3 pfam13415
Galactose oxidase, central domain;
308-361 4.20e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 4.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564347940  308 DNDIYIAGGYRPSSSevsidhKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVY 361
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ------TRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 12-86 4.80e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 40.37  E-value: 4.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564347940  12 QLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSR 86
Cdd:cd18359   10 RVKECLAKGTFSDVTFMLDDG-TISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQ 83
Kelch_6 pfam13964
Kelch motif;
304-354 5.02e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 5.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564347940  304 LVSPDNDIYIAGGYrpsssevSIDHKAENDFWMYDHSTNRWLSKPSLLRAR 354
Cdd:pfam13964   7 VVSVGGYIYVFGGY-------TNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-113 6.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 40.02  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQ-FRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18325   83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-113 7.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 39.37  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   8 SILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSG----LTESTQKEVRII--GVEAESMGLVLNY 81
Cdd:cd18288    4 KLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEgfsvEEEGGVTTRRVLlgDVSGEAARCFLQY 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQC 113
Cdd:cd18288   84 LYTADTGLPPGLSPHVSELADRFGVSELVHLC 115
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-87 8.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 39.55  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   2 DPFHacSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNY 81
Cdd:cd18344    5 DPRH--MLTDDLGELWENSLFTDCCLLV-AGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGF 81


                 ....*.
gi 564347940  82 AYTSRV 87
Cdd:cd18344   82 IYTGKA 87
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 136-185 8.91e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 38.06  E-value: 8.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 564347940 136 YGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREE 185
Cdd:cd18494   15 YGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELD 64
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-101 1.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 39.04  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   5 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrIIGVEAESMGLVLNYAYT 84
Cdd:cd18224    9 HPNNLLKELNKCRLSETMCDVTIVVG-NRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFIYT 86

                         90
                 ....*....|....*..
gi 564347940  85 SRVILTEANVQALFTTA 101
Cdd:cd18224   87 SELFTDLINVGVIYEVA 103
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-113 1.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 39.19  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  21 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLT-ESTQKEVRIigVEAESMGLVLNYAY---TSRVILTEANVQA 96
Cdd:cd18351   23 EMSDVTFLVE-GRPFYAHKVLLFTASPRFKALLSNKPSaENTCIEISY--VKYHIFQLVMQYLYcggTESLLIKNNEIME 99

                         90
                 ....*....|....*..
gi 564347940  97 LFTTASIFQIPSIQDQC 113
Cdd:cd18351  100 LLSAAKFFQLEALQRHC 116
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-119 1.27e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 39.04  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVdhGKT-FSCHRNVLAAISPYFRSMFTSGLTESTQKEVriigVEAESMGLVLNY 81
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFI--GTFhFRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFALLLEM 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564347940  82 AYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMIS 119
Cdd:cd18225   78 VYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 89-122 2.81e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 36.76  E-value: 2.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 564347940  89 LTEANVQALFTTASIFQIPSIQDQCAKYMISHLD 122
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLE 34
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 3.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 37.94  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTsgLTESTQKEVRIIGVEAESMGLVLNyA 82
Cdd:cd18203    6 PGHEAATLRNMNQLRSEERFCDVTI-VADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADLLLS-C 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDP 123
Cdd:cd18203   82 YTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 444-490 3.33e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 3.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 564347940  444 PRIQGLAAVYKDSIYYIAGTCGNhQRVFTVEAYDIELNKWTRKKDFP 490
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-84 3.40e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 36.93  E-value: 3.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564347940  23 TDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQ--KEVRIIGVEAESMGLVLNYAYT 84
Cdd:cd18283    3 TDVDL-VFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEipVDLPTAGIDVPMFSALLRYLYT 65
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-115 4.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 38.10  E-value: 4.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940   3 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYA 82
Cdd:cd18324    4 PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQ-FRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564347940  83 YTSRVILTEANVQALFTTASIFQIPSIQDQCAK 115
Cdd:cd18324   83 YEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKK 115
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-99 4.33e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 38.09  E-value: 4.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  34 TFSCHRNVLAAISPYFRSMF----TSGLTESTQKEVRIIGVEAesmglVLNYAYtSRVILteanvQALFT 99
Cdd:cd18284   29 ELRCHKAILSARSPFFRNLLqrriRTGEDRTLSTPTRIVLDES-----IIPRRY-ARVLL-----HAMYT 87
Kelch smart00612
Kelch domain;
459-485 5.04e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 5.04e-03
                           10        20
                   ....*....|....*....|....*..
gi 564347940   459 YIAGTCGNHQRVFTVEAYDIELNKWTR 485
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTP 29
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-97 6.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 36.54  E-value: 6.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  18 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSgLTESTQKEVRI--IGVEAESMGLVLNYAYTSRVILTEANVQ 95
Cdd:cd18312    5 DTGEPSDITVRVG-NTTFHLHKFPLCSKSGYFKRLASS-SSESDPSEIELndFPGGAEAFELVAKFCYGMPINLTATNVV 82


                 ..
gi 564347940  96 AL 97
Cdd:cd18312   83 GL 84
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 162-219 8.22e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 36.50  E-value: 8.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564347940 162 FLQLTKDQLISILDSDDLNVdREEHVYESIIRWFEHEQNEREVHL-PE----IFAKC---IRFPLM 219
Cdd:cd18523   42 FTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWAEAECQRQQLQVtPEnkrkVLGKAlslIRFPLM 106
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-106 8.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 36.32  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347940  13 LKTMYDEGQ----LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTqkeVRIIGVEAESMGLVLNYAYTSRVI 88
Cdd:cd18226    9 LKYLNDDRQkqssFCDLVITVE-GKEFSAHKVVVAVGSSYFHACLSKNPNTDA---VTLDHVSYSVFQHLLEFLYTSEFF 84

                         90
                 ....*....|....*...
gi 564347940  89 LTEANVQALFTTASIFQI 106
Cdd:cd18226   85 VYENEIPLVLEAAKFLDI 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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