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Conserved domains on  [gi|564350071|ref|XP_006237847|]
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minichromosome maintenance domain-containing protein 2 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM_lid super family cl39337
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 541-625 1.05e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


The actual alignment was detected with superfamily member pfam17855:

Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071  541 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 619
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80


                  ....*.
gi 564350071  620 LFEISL 625
Cdd:pfam17855  81 LLKESL 86
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 398-624 1.34e-08

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17760:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 398 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 471
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 472 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 551
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350071 552 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 624
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
 
Name Accession Description Interval E-value
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 541-625 1.05e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071  541 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 619
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80


                  ....*.
gi 564350071  620 LFEISL 625
Cdd:pfam17855  81 LLKESL 86
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 398-624 1.34e-08

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 398 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 471
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 472 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 551
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350071 552 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 624
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 385-625 4.28e-07

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 53.26  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKYGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 448
Cdd:COG1241  358 AAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGivatlnarcsvlaaanPKYGR- 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 449 FDQQMTFPIQcsfwsfVDMDSssrrnvqkasTLIGQMDcsLI------P-----ANLAEAfgLLVNCKESSPCHPLLPTV 517
Cdd:COG1241  437 FDPYEPIAEQ------IDLPP----------TLLSRFD--LIfvlrdkPdeerdRELARH--ILKVHRAGELLEQEIEEE 496

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 518 QHTLKKAVDPkgppylaskqfttEDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSL 596
Cdd:COG1241  497 TEEVKPEIDP-------------DLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRL 563

                        250       260
                 ....*....|....*....|....*....
gi 564350071 597 SEAHARLNLRNKVLREDVLIAALLFEISL 625
Cdd:COG1241  564 AEASARMRLSDTVTEEDAERAIRLVDSCL 592
MCM smart00350
minichromosome maintenance proteins;
532-625 7.77e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 42.63  E-value: 7.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071   532 YLASKQFTTEDFEKLL---------AFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLS----ANALKYLVSLS 597
Cdd:smart00350 403 HRYSHPEEDEAFEPPLsqeklrkyiAYAReKIKPKLSEEAADKLVKAYVDLRKE--DSQTESRSSipitVRQLESIIRLS 480

                           90       100
                   ....*....|....*....|....*...
gi 564350071   598 EAHARLNLRNKVLREDVLIAALLFEISL 625
Cdd:smart00350 481 EAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 547-620 1.91e-03

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 40.88  E-value: 1.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564350071 547 LAFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLREDVLIAALL 620
Cdd:cd17755  231 ISYAReHIHPKLSEEAAQELVQAYVDMRKM--GSDARKRITATPrqLESLIRLAEAHAKMRLSNVVEAEDVEEAVRL 305
 
Name Accession Description Interval E-value
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 541-625 1.05e-09

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 55.63  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071  541 EDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAAL 619
Cdd:pfam17855   1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80


                  ....*.
gi 564350071  620 LFEISL 625
Cdd:pfam17855  81 LLKESL 86
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 398-624 1.34e-08

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 56.79  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 398 IQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPGkkfgddfdQQMTFPIQCSFWSFV------DMDSSS 471
Cdd:cd17760   94 LEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAG--------LVCKLNTRTTILAATnpkgqyDPNESI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 472 RRNVQKASTLIGQMDCSLIpanlaeafglLVNCKESSPCHPLLptvqhtlKKAVDPKGPPYLASKQFTTEDFEKLLAFAK 551
Cdd:cd17760  166 SVNIALASPLLSRFDLVLV----------LLDTKNEDWDRIIS-------SFILENKGEPSKSSKLWSMEKMRTYFCLIK 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350071 552 NLNVEFSLEAERMIHGYYLASRRirTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 624
Cdd:cd17760  229 NLRPVLSDEANAILLRYYQLQRQ--SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 385-624 2.87e-08

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 55.81  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVfipgKKFGDDfdqqMTFPIQCSF--- 461
Cdd:cd17706   84 AVVRDS-ETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISI----AKAGIV----TTLNARCSIlaa 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 462 ----WSFVDMDSSSRRNVQKASTLIGQMDcsLIpanlaeaFGLLVNCKE----SSPCHPLLPTVQHTLKKAVDPKGPPYL 533
Cdd:cd17706  155 anpkGGRYNPKLSPIENINLPSPLLSRFD--LI-------FVIRDDPDEerdeELAEHIIDLHRGSDPEEQVKPEEDGIP 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 534 ASKQFTTedfeKLLAFAKNLNVEFSLEAERMIHGYYLasrRIRTDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLR 611
Cdd:cd17706  226 IDIELLR----KYILYARQIHPKISEEAREKLVRWYV---ELRKESERRSTIPITArqLESVIRLAEAHAKMRLSEVVTE 298

                        250
                 ....*....|...
gi 564350071 612 EDVLIAALLFEIS 624
Cdd:cd17706  299 EDVEEAIRLVRHS 311
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 385-624 1.49e-07

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 53.53  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQ-----LQSALESRSVTVfipgKKFGddfdQQMTF---- 455
Cdd:cd17757   84 AVVRDE-ETGDFVIEAGALMLADNGICCIDEF-----DKMDIkdqvaIHEAMEQQTISI----TKAG----IQATLnart 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 456 -------PIQCSFwsfvDMDSSSRRNVQKASTLIGQMDCslipanlaeAFGLLVNCKESSPCH--PLLPTVQHTLKKAVD 526
Cdd:cd17757  150 silaaanPVGGRY----DRSKSLKQNINISAPIMSRFDL---------FFVLLDECNEVTDYAiaSHIVDLHSKREEAIE 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 527 PkgppylaskQFTTEDFEKLLAFAKNLNVEFSLEAERMIHGYYLASRRIRTDSIHGS--KLSANALKYLVSLSEAHARLN 604
Cdd:cd17757  217 P---------PFTAEQLKRYIAYARTFKPKLTKEAKDELVEQYKELRQDDASGSTRSsyRITVRQLESLIRLSEAIARLH 287

                        250       260
                 ....*....|....*....|
gi 564350071 605 LRNKVLREDVLIAALLFEIS 624
Cdd:cd17757  288 CSDEVTPEHVEEAARLLKKS 307
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 385-625 4.28e-07

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 53.26  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKYGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 448
Cdd:COG1241  358 AAVRDDFGTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGivatlnarcsvlaaanPKYGR- 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 449 FDQQMTFPIQcsfwsfVDMDSssrrnvqkasTLIGQMDcsLI------P-----ANLAEAfgLLVNCKESSPCHPLLPTV 517
Cdd:COG1241  437 FDPYEPIAEQ------IDLPP----------TLLSRFD--LIfvlrdkPdeerdRELARH--ILKVHRAGELLEQEIEEE 496

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 518 QHTLKKAVDPkgppylaskqfttEDFEKLLAFAK-NLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSL 596
Cdd:COG1241  497 TEEVKPEIDP-------------DLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRL 563

                        250       260
                 ....*....|....*....|....*....
gi 564350071 597 SEAHARLNLRNKVLREDVLIAALLFEISL 625
Cdd:COG1241  564 AEASARMRLSDTVTEEDAERAIRLVDSCL 592
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 385-614 5.57e-06

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 48.99  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKyGTGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQLQSALESRSVTVFIPG----------------KKFGDd 448
Cdd:cd17761   85 AVVRDE-GTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGivatlnaraavlaaanPKFGR- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 449 FDQQMTFPIQcsfwsfVDMdsssrrnvqkASTLIGQMDCSLIPANLAEAfgllvnCKESSPCHPLLPTvqHTLK--KAVD 526
Cdd:cd17761  163 FDSYRPVAEQ------IDL----------PPTLLSRFDLIFVLKDTPNE------EKDRRLANHILDT--HSGGemREIK 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 527 PKGPPYLaskqfttedFEKLLAFA-KNLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNL 605
Cdd:cd17761  219 PEIDPDL---------LRKYIAYArKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPVPITARQLEALVRLSEASARMRL 289


                 ....*....
gi 564350071 606 RNKVLREDV 614
Cdd:cd17761  290 SQEVTLEDA 298
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 385-614 4.66e-05

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 45.99  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 385 TVSRDKYgTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQLQSAL----ESRSVTVFIPGkkfgddfdqqmtfpIQCS 460
Cdd:cd17759   86 TLTKDGR-SGDFALEAGALVLGDQGICGIDEF-----DKMGSQHQALleamEQQSVSLAKAG--------------VVCS 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 461 F---WSFVDMDSSSRRNVQKASTLIGQMDCSliPANLAEAFGLLVNCKESSPCHPLLPTVQHTLKKavdpkgppylaskq 537
Cdd:cd17759  146 LparTSVIAAANPVGGHYNKGKTVSENLKMG--PALLSRFDLVFILLDTPSEEHDHLLSEHHQLLR-------------- 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564350071 538 fttedfeKLLAFAK-NLNVEFSLEAERMIHGYYLASRRiRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDV 614
Cdd:cd17759  210 -------KYISYARqYVNPVLSKDASEALQEFYLELRK-QNQLADSSPITTRQLESLIRLTEARARLELREEATKEDA 279
MCM smart00350
minichromosome maintenance proteins;
532-625 7.77e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 42.63  E-value: 7.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071   532 YLASKQFTTEDFEKLL---------AFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLS----ANALKYLVSLS 597
Cdd:smart00350 403 HRYSHPEEDEAFEPPLsqeklrkyiAYAReKIKPKLSEEAADKLVKAYVDLRKE--DSQTESRSSipitVRQLESIIRLS 480

                           90       100
                   ....*....|....*....|....*...
gi 564350071   598 EAHARLNLRNKVLREDVLIAALLFEISL 625
Cdd:smart00350 481 EAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 386-624 1.75e-03

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 40.86  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 386 VSRDKyGTGAVSIQAGSALLARGGVCFIGDLtshkkDKLEQ-----LQSALESRSVTVfipgKKFGddfdQQMTFPIQCS 460
Cdd:cd17758   84 VMKDP-VTGEMTLEGGALVLADQGICCIDEF-----DKMDEsdrtaIHEVMEQQTISI----AKAG----ITTTLNARTS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 461 FwsfvdmdsssrrnVQKASTLIGQMDCSL-------IPANLAEAFGLLVNCKESSPCHPLLPTVQHTL---KKAVDPkgp 530
Cdd:cd17758  150 I-------------LAAANPAYGRYNPRRspeqninLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTyvhQHNKQP--- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350071 531 pYLASKQFTTEDFEKLLAFAKNLNVEFSLEAERMIHGYYLASRRIRTDSIHGSKLSANALKYLVSLSEAHARLNLRNKVL 610
Cdd:cd17758  214 -DSDFEPLDPKLLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVE 292

                        250
                 ....*....|....
gi 564350071 611 REDVLIAALLFEIS 624
Cdd:cd17758  293 IDDVEEALRLMEMS 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 547-620 1.91e-03

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 40.88  E-value: 1.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564350071 547 LAFAK-NLNVEFSLEAERMIHGYYLASRRIrtDSIHGSKLSANA--LKYLVSLSEAHARLNLRNKVLREDVLIAALL 620
Cdd:cd17755  231 ISYAReHIHPKLSEEAAQELVQAYVDMRKM--GSDARKRITATPrqLESLIRLAEAHAKMRLSNVVEAEDVEEAVRL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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