|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-762 |
3.90e-90 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 284.28 E-value: 3.90e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLAQTYILFELMNEikedgtkfkislssapqleplvvelsspgpltsalflflhsmkeaekgpl 271
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 272 SPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTeetkriqasilkafnnpttktadeetrkkvkaygkegvkmnFI 351
Cdd:cd02667 31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLRT-----------------------------------------FI 69
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 352 DRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEErtllshdrkhlrkwpseeertvgthpnsenseasplagilsne 431
Cdd:cd02667 70 DSIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDE------------------------------------------- 106
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 432 aslnesptegserdtslessvdadseasepevaykpsvllrssgdpgahgeqhphlplaselphtkethdcdeemaeama 511
Cdd:cd02667 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 512 elhlsgtvtgnrdfhrekqplnvpnnvcfsegkhtklhsaqnafqtlsqsyvtTSKECSVQSCLYQFTSMELLMGNNKLL 591
Cdd:cd02667 107 -----------------------------------------------------IKSECSIESCLKQFTEVEILEGNNKFA 133
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 592 CEDCTEkkrkcqketssaerkaggvytnARKQLLISAVPAILILHLKRFHQAGL-SLRKVNRHVDFPLTLDLAPFCAATC 670
Cdd:cd02667 134 CENCTK----------------------AKKQYLISKLPPVLVIHLKRFQQPRSaNLRKVSRHVSFPEILDLAPFCDPKC 191
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 671 KNISVGEKVLYGLYGIVEHSGSMRGGHYTAYVKVRVPSRKLSECITGRKTAPGlKEADSelgGHWVHVSDTYVQVVPESR 750
Cdd:cd02667 192 NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKSKPAADE-AGPGS---GQWYYISDSDVREVSLEE 267
|
570
....*....|..
gi 564350490 751 ALSAQAYLLFYE 762
Cdd:cd02667 268 VLKSEAYLLFYE 279
|
|
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
192-761 |
3.44e-34 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 132.95 E-value: 3.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLAQTYILFELMNEIKEDGTKFKISLSSApqleplvvelsspgpLTSALFLFLHSMKEAEKG-P 270
Cdd:pfam00443 2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSRYNKDIN---------------LLCALRDLFKALQKNSKSsS 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 271 LSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEEtkriqasilkafnNPTTKTADEetrkkvkaygkegvkmNF 350
Cdd:pfam00443 67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDGLHEDL-------------NGNHSTENE----------------SL 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 351 IDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEertllshdrkhlrkwpseeertvgthpnsenseasplagilsn 430
Cdd:pfam00443 118 ITDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPG------------------------------------------- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 431 easlnesptegserdtslessvdadseasepevaykpsvllrssgdpgahgeqhphlplaselphtkethdcdeemaeam 510
Cdd:pfam00443 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 511 aelhlsgtvtgnrdfhrekqplnvpnnvcfsegkhtklhsaqnafqtlsqsYVTTSKECSVQSCLYQFTSMELLMGNNKL 590
Cdd:pfam00443 155 ---------------------------------------------------DSAELKTASLQICFLQFSKLEELDDEEKY 183
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 591 LCEDCTEKKrkcqketssaerkaggvytNARKQLLISAVPAILILHLKRFHQAGLSLRKVNRHVDFPLTLDLAPFCAATc 670
Cdd:pfam00443 184 YCDKCGCKQ-------------------DAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLNTEVEFPLELDLSRYLAEE- 243
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 671 KNISVGEKVLYGLYGIVEHSGSMRGGHYTAYVKvrvpsrklsecitgrktapglkeadSELGGHWVHVSDTYVQVVPESR 750
Cdd:pfam00443 244 LKPKTNNLQDYRLVAVVVHSGSLSSGHYIAYIK-------------------------AYENNRWYKFDDEKVTEVDEET 298
|
570
....*....|..
gi 564350490 751 A-LSAQAYLLFY 761
Cdd:pfam00443 299 AvLSSSAYILFY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
563-762 |
7.47e-33 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 127.60 E-value: 7.47e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 563 VTTSKECSVQSCLYQFTSMELLMGNNKLLCEdctekkrkcqketssaerkaGGVYTNARKQLLISAVPAILILHLKRFHQ 642
Cdd:cd02257 93 VKGLPQVSLEDCLEKFFKEEILEGDNCYKCE--------------------KKKKQEATKRLKIKKLPPVLIIHLKRFSF 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 643 AG-LSLRKVNRHVDFPLTLDLAPFCAATCKNISVGEK-VLYGLYGIVEHSG-SMRGGHYTAYVKVRVPsrklsecitgrk 719
Cdd:cd02257 153 NEdGTKEKLNTKVSFPLELDLSPYLSEGEKDSDSDNGsYKYELVAVVVHSGtSADSGHYVAYVKDPSD------------ 220
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 564350490 720 tapglkeadselgGHWVHVSDTYVQVVPESRAL-----SAQAYLLFYE 762
Cdd:cd02257 221 -------------GKWYKFNDDKVTEVSEEEVLefgslSSSAYILFYE 255
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
570-761 |
1.98e-30 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 122.00 E-value: 1.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 570 SVQSCLYQFTSMELLMGNNKLLCEDCTEKkrkcqketssaerkaggvyTNARKQLLISAVPAILILHLKRFhqAGLSLRK 649
Cdd:cd02661 163 SLEDALEQFTKPEQLDGENKYKCERCKKK-------------------VKASKQLTIHRAPNVLTIHLKRF--SNFRGGK 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 650 VNRHVDFPLTLDLAPFCAAtckniSVGEKVLYGLYGIVEHSG-SMRGGHYTAYVkvrvpsrklsecitgrKTAPGLkead 728
Cdd:cd02661 222 INKQISFPETLDLSPYMSQ-----PNDGPLKYKLYAVLVHSGfSPHSGHYYCYV----------------KSSNGK---- 276
|
170 180 190
....*....|....*....|....*....|...
gi 564350490 729 selgghWVHVSDTYVQVVPESRALSAQAYLLFY 761
Cdd:cd02661 277 ------WYNMDDSKVSPVSIETVLSQKAYILFY 303
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
567-762 |
5.62e-30 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 118.54 E-value: 5.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 567 KECSVQSCLYQFTSMELLMGNNKLLCEDCtEKKRKcqketssaerkaggvytnARKQLLISAVPAILILHLKRFHQAGLS 646
Cdd:cd02674 82 PKVTLEDCLRLFTKEETLDGDNAWKCPKC-KKKRK------------------ATKKLTISRLPKVLIIHLKRFSFSRGS 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 647 LRKVNRHVDFPLT-LDLAPFCAATCKNISvgekVLYGLYGIVEHSGSMRGGHYTAYVKVRVPSRklsecitgrktapglk 725
Cdd:cd02674 143 TRKLTTPVTFPLNdLDLTPYVDTRSFTGP----FKYDLYAVVNHYGSLNGGHYTAYCKNNETND---------------- 202
|
170 180 190
....*....|....*....|....*....|....*..
gi 564350490 726 eadselgghWVHVSDTYVQVVPESRALSAQAYLLFYE 762
Cdd:cd02674 203 ---------WYKFDDSRVTKVSESSVVSSSAYILFYE 230
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
192-763 |
1.98e-27 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 118.83 E-value: 1.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLAQTYilfELMNEIKEDGTKFKISLSSapqlePLVVElsspGPLTSALFLFLHSMKEAEKGPL 271
Cdd:COG5560 267 GLRNLGNTCYMNSALQCLMHTW---ELRDYFLSDEYEESINEEN-----PLGMH----GSVASAYADLIKQLYDGNLHAF 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 272 SPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRtEETKRIQasILKAFNNPTTKTADEETRKKV-KAYGKEGVKMN- 349
Cdd:COG5560 335 TPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLH-EDLNRII--KKPYTSKPDLSPGDDVVVKKKaKECWWEHLKRNd 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 350 -FIDRIFIGELTSTVMCEECANISTMKDPFIDISLPiIEERTLLSHD--------RKHLRKWPSEEERTVGTHPN--SEN 418
Cdd:COG5560 412 sIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLP-LPVSMVWKHTivvfpesgRRQPLKIELDASSTIRGLKKlvDAE 490
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 419 SEASPLAGILSNEASLNESPTEGSERDTSLESSV-DADS----EASEPEVAYkPSVLLRS-SGDPGAHGEQHPHLPLASE 492
Cdd:COG5560 491 YGKLGCFEIKVMCIYYGGNYNMLEPADKVLLQDIpQTDFvylyETNDNGIEV-PVVHLRIeKGYKSKRLFGDPFLQLNVL 569
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 493 LPHT------KETHDCDEEMAEAMAELHLSGTVTG----------------NRDFHREKQP-----LNVPNNV---CFSE 542
Cdd:COG5560 570 IKASiydklvKEFEELLVLVEMKKTDVDLVSEQVRllreesspsswlkletEIDTKREEQVeeegqMNFNDAVvisCEWE 649
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 543 GKHTKLHSAQNAFQTLSQSyVTTSKECSVQSCLYQFTSMELLMGNNKLLCEDCTEKKRkcqketssaerkaggvytnARK 622
Cdd:COG5560 650 EKRYLSLFSYDPLWTIREI-GAAERTITLQDCLNEFSKPEQLGLSDSWYCPGCKEFRQ-------------------ASK 709
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 623 QLLISAVPAILILHLKRFHQAGLSLRKVNRHVDFPLT-LDLAPFCAATcknisVGEKVLYGLYGIVEHSGSMRGGHYTAY 701
Cdd:COG5560 710 QMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDdLDLSGVEYMV-----DDPRLIYDLYAVDNHYGGLSGGHYTAY 784
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564350490 702 VKvrvpsrklsecitgrktapglKEADselgGHWVHVSDTYVQVVPESRALSAQAYLLFYER 763
Cdd:COG5560 785 AR---------------------NFAN----NGWYLFDDSRITEVDPEDSVTSSAYVLFYRR 821
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
191-761 |
2.54e-27 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 113.62 E-value: 2.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 191 KGITNLGNTCFFNAVIQNLAQTYILFE-LMNEIKEDGTKFKISLSSAP-QLEPLVVELSSPGpltsalflflhsmkeaEK 268
Cdd:cd02660 1 RGLINLGATCFMNVILQALLHNPLLRNyFLSDRHSCTCLSCSPNSCLScAMDEIFQEFYYSG----------------DR 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 269 GPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRiqasilkafnnpttktadeetrkkVKAYGKEGVKM 348
Cdd:cd02660 65 SPYGPINLLYLSWKHSRNLAGYSQQDAHEFFQFLLDQLHTHYGGD------------------------KNEANDESHCN 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 349 NFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERTllshdrkhlrkwpseeertvgthpnsenseasplagil 428
Cdd:cd02660 121 CIIHQTFSGSLQSSVTCQRCGGVSTTVDPFLDLSLDIPNKST-------------------------------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 429 sneaslnesptegserdtslessvdadseasepevaykpsvllRSSGDPGAHGEQHPHLplaselphtkethdcdeemae 508
Cdd:cd02660 163 -------------------------------------------PSWALGESGVSGTPTL--------------------- 178
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 509 amaelhlsgtvtgnrdfhrekqplnvpnnvcfsegkhtklhsaqnafqtlsqsyvttskecsvQSCLYQFTSMELLmGNN 588
Cdd:cd02660 179 ---------------------------------------------------------------SDCLDRFTRPEKL-GDF 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 589 KLLCEDCtekkrkcqketssaerkagGVYTNARKQLLISAVPAILILHLKRF-HQAGLSLRKVNRHVDFPLTLDLAPFCA 667
Cdd:cd02660 195 AYKCSGC-------------------GSTQEATKQLSIKKLPPVLCFQLKRFeHSLNKTSRKIDTYVQFPLELNMTPYTS 255
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 668 ATCKNISVGE----KVLYGLYGIVEHSGSMRGGHYTAYVKVRvpsrklsecitgrktapglkeadselGGHWVHVSDTYV 743
Cdd:cd02660 256 SSIGDTQDSNsldpDYTYDLFAVVVHKGTLDTGHYTAYCRQG--------------------------DGQWFKFDDAMI 309
|
570
....*....|....*...
gi 564350490 744 QVVPESRALSAQAYLLFY 761
Cdd:cd02660 310 TRVSEEEVLKSQAYLLFY 327
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
570-764 |
5.65e-23 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 100.79 E-value: 5.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 570 SVQSCLYQFTSMELLMGNNKLLCEDCTEKKRkcqketssaerkaggvytnARKQLLISAVPAILILHLKRFHQAGLSLR- 648
Cdd:cd02659 152 NLEESLDAYVQGETLEGDNKYFCEKCGKKVD-------------------AEKGVCFKKLPPVLTLQLKRFEFDFETMMr 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 649 -KVNRHVDFPLTLDLAPFCAATCKNISVGEKV------LYGLYGIVEHSGSMRGGHYTAYVKVRVPSR-------KLSEC 714
Cdd:cd02659 213 iKINDRFEFPLELDMEPYTEKGLAKKEGDSEKkdsesyIYELHGVLVHSGDAHGGHYYSYIKDRDDGKwykfnddVVTPF 292
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 564350490 715 itgrktapGLKEADSE-LGGhwvHVSDTYVQVVPESRALSAQAYLLFYERI 764
Cdd:cd02659 293 --------DPNDAEEEcFGG---EETQKTYDSGPRAFKRTTNAYMLFYERK 332
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
549-762 |
1.46e-19 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 88.58 E-value: 1.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 549 HSAQNAFQ----TLSQSY-----VTTSKECSVQSC------LYQFTSMELLMGNNKLLCEDCTEKKrkCQKETSSAERKA 613
Cdd:cd02662 35 QDAHELFQvlleTLEQLLkfpfdGLLASRIVCLQCgesskvRYESFTMLSLPVPNQSSGSGTTLEH--CLDDFLSTEIID 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 614 GgvYTNARKQLLISAVPAILILHLKR--FHQAGLSLRKvNRHVDFPLTLDlapfcaatcknisvgeKVLYGLYGIVEHSG 691
Cdd:cd02662 113 D--YKCDRCQTVIVRLPQILCIHLSRsvFDGRGTSTKN-SCKVSFPERLP----------------KVLYRLRAVVVHYG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564350490 692 SMRGGHYTAYVKVRVPSRKLSECITGRktapgLKEADSELGGHWVHVSDTYVQVVPESRAL-SAQAYLLFYE 762
Cdd:cd02662 174 SHSSGHYVCYRRKPLFSKDKEPGSFVR-----MREGPSSTSHPWWRISDTTVKEVSESEVLeQKSAYMLFYE 240
|
|
| zf-UBP |
pfam02148 |
Zn-finger in ubiquitin-hydrolases and other protein; |
62-132 |
1.57e-16 |
|
Zn-finger in ubiquitin-hydrolases and other protein;
Pssm-ID: 460464 Cd Length: 63 Bit Score: 74.22 E-value: 1.57e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564350490 62 CSECLKErrlcdgqpvlpSDVWLCLKCGFQGCGKNSESqHSLRHFKSSGaesHCVVISLSTWVIWCYECNE 132
Cdd:pfam02148 1 CSLCGNT-----------SNLWLCLTCGHVGCGRYQNS-HALEHYEETG---HPLAVNLSTLTVYCYPCDD 56
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
567-762 |
9.41e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 75.81 E-value: 9.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 567 KECSVQSCLYQFTSMELLMGNNKLLCEDCTEKKrkcqketssaerkaggvytNARKQLLISAVPAILILHLKRFHQAGls 646
Cdd:cd02663 145 QNTSITSCLRQFSATETLCGRNKFYCDECCSLQ-------------------EAEKRMKIKKLPKILALHLKRFKYDE-- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 647 lrKVNRH------VDFPLTLDLapfcaatCKNISVGEKV--LYGLYGIVEHSGS--MRGgHYTAYVKVrvpsrklsecit 716
Cdd:cd02663 204 --QLNRYiklfyrVVFPLELRL-------FNTTDDAENPdrLYELVAVVVHIGGgpNHG-HYVSIVKS------------ 261
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 564350490 717 grktapglkeadselGGHWVHVSDTYVQVVPES--------RALSAQAYLLFYE 762
Cdd:cd02663 262 ---------------HGGWLLFDDETVEKIDENaveeffgdSPNQATAYVLFYQ 300
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
626-764 |
1.30e-14 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 74.84 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 626 ISAVPAILILHLKRFHQAGlSLRKVNRHVDFPLTLDLAPfcaatCKNISVGEKVLYGLYGIVEHSGSMRGGHYTAYVKVr 705
Cdd:COG5533 176 FVKLPKILTIQLKRFANLG-GNQKIDTEVDEKFELPVKH-----DQILNIVKETYYDLVGFVLHQGSLEGGHYIAYVKK- 248
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564350490 706 vpsrklsecitgrktapglkeadselGGHWVHVSDTYVQVVPESRAL---SAQAYLLFYERI 764
Cdd:COG5533 249 --------------------------GGKWEKANDSDVTPVSEEEAInekAKNAYLYFYERI 284
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
188-703 |
5.05e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 74.16 E-value: 5.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 188 PSVKGITNLGNTCFFNAVIQNLaqtyilfELMNEIKEdGTKFKISL-SSAPQLEplvvelsspgpltsALFLFLHSMKEA 266
Cdd:cd02671 22 LPFVGLNNLGNTCYLNSVLQVL-------YFCPGFKH-GLKHLVSLiSSVEQLQ--------------SSFLLNPEKYND 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 267 EKGPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRteetkriqasilkafnnpttktadeetrkkvkaygkegv 346
Cdd:cd02671 80 ELANQAPRRLLNALREVNPMYEGYLQHDAQEVLQCILGNIQ--------------------------------------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 347 kmNFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERTLlshdrkhlrkwPSEEERTVGTHPNSENSEASplag 426
Cdd:cd02671 121 --ELVEKDFQGQLVLRTRCLECETFTERREDFQDISVPVQESELS-----------KSEESSEISPDPKTEMKTLK---- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 427 ilsneaslnesptegserdtslessvdadseasepevaYKPSvllrssgdpgahgeqhphlplaselphtkethdcdeem 506
Cdd:cd02671 184 --------------------------------------WAIS-------------------------------------- 187
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 507 aeamaelhlsgtvtgnrdfhrekqplnvpnnvcfsegkhtklhsaqnafqtlsqsyvttskecsvqsclyQFTSMELLMG 586
Cdd:cd02671 188 ----------------------------------------------------------------------QFASVERIVG 197
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 587 NNKLLCEDCTEkkrkcqketssaerkaggvYTNARKQLLISAVPAILILHLKRFHQAGLS------LRKVNRHVDFPLTL 660
Cdd:cd02671 198 EDKYFCENCHH-------------------YTEAERSLLFDKLPEVITIHLKCFAANGSEfdcyggLSKVNTPLLTPLKL 258
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 564350490 661 dlapfcaaTCKNISVGEKV-LYGLYGIVEHSG-SMRGGHYTAYVK 703
Cdd:cd02671 259 --------SLEEWSTKPKNdVYRLFAVVMHSGaTISSGHYTAYVR 295
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
569-762 |
3.65e-13 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 71.37 E-value: 3.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 569 CSVQSCLYQFTSMELLMGNNKLLCEDCtekKRKCQKETSSAerkaggvytnarkqllISAVPAILILHLKRFH--QAGLS 646
Cdd:cd02664 134 PSVQDLLNYFLSPEKLTGDNQYYCEKC---ASLQDAEKEMK----------------VTGAPEYLILTLLRFSydQKTHV 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 647 LRKVNRHVDFPLTLDLaPFCAATCKNISVGEK---------------VLYGLYGIVEHSG-SMRGGHYTAYVKVRVPSRK 710
Cdd:cd02664 195 REKIMDNVSINEVLSL-PVRVESKSSESPLEKkeeesgddgelvtrqVHYRLYAVVVHSGySSESGHYFTYARDQTDADS 273
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 564350490 711 lseciTGRKTAPGLKEADSELGGHWVHVSDTYV-QVVPE------SRALSAQAYLLFYE 762
Cdd:cd02664 274 -----TGQECPEPKDAEENDESKNWYLFNDSRVtFSSFEsvqnvtSRFPKDTPYILFYE 327
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
570-703 |
6.32e-13 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 70.53 E-value: 6.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 570 SVQSCLYQFTSMELLMGNNKLLCEDCTEKkrkcqketssaerkaggvyTNARKQLLISAVPAILILHLKR--FHQAGLSL 647
Cdd:cd02668 157 TLEECIDEFLKEEQLTGDNQYFCESCNSK-------------------TDATRRIRLTTLPPTLNFQLLRfvFDRKTGAK 217
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 564350490 648 RKVNRHVDFPLTLDLAPFCAATCKNISVgekvlYGLYGIVEHSG-SMRGGHYTAYVK 703
Cdd:cd02668 218 KKLNASISFPEILDMGEYLAESDEGSYV-----YELSGVLIHQGvSAYSGHYIAHIK 269
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
570-763 |
5.11e-12 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 69.51 E-value: 5.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 570 SVQSCLYQFTSMELLMGNNKLLCEDCTekkrkcqketssaerkaggvYTNARKQLLISAVPAILILHLKRFHQAGLS--L 647
Cdd:COG5077 339 NLQESFRRYIQVETLDGDNRYNAEKHG--------------------LQDAKKGVIFESLPPVLHLQLKRFEYDFERdmM 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 648 RKVNRHVDFPLTLDLAPFCAATCKNiSVGEKVLYGLYGIVEHSGSMRGGHYTAYVKVRVPSRKLSECITgRKTAPGLKEA 727
Cdd:COG5077 399 VKINDRYEFPLEIDLLPFLDRDADK-SENSDAVYVLYGVLVHSGDLHEGHYYALLKPEKDGRWYKFDDT-RVTRATEKEV 476
|
170 180 190
....*....|....*....|....*....|....*..
gi 564350490 728 DSE-LGGHWVHvSDTYVQVVPESRALSaqAYLLFYER 763
Cdd:COG5077 477 LEEnFGGDHPY-KDKIRDHSGIKRFMS--AYMLVYLR 510
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
597-762 |
3.24e-11 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 65.04 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 597 EKKRKCQKETSSAERKAGGVYTnarKQLLISAVPAILILHLKRFHQAGLSLR--KVNRHVDFPLTLDLAPFCAATCknis 674
Cdd:cd02657 167 KKGLEEEIEKHSPTLGRDAIYT---KTSRISRLPKYLTVQFVRFFWKRDIQKkaKILRKVKFPFELDLYELCTPSG---- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 675 vgekvLYGLYGIVEHSG-SMRGGHYTAYVKvrvpsrklsecitgrktapglkeadSELGGHWVHVSDTYVQVVPESRALS 753
Cdd:cd02657 240 -----YYELVAVITHQGrSADSGHYVAWVR-------------------------RKNDGKWIKFDDDKVSEVTEEDILK 289
|
170
....*....|....*.
gi 564350490 754 AQ-------AYLLFYE 762
Cdd:cd02657 290 LSgggdwhiAYILLYK 305
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-376 |
9.89e-10 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 60.42 E-value: 9.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLaqtyilfELMNEIKEDGTKFKISLSSAPQleplvvelsSPGPLTSALFLFLHSMKEAEKgPL 271
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCL-------RSVPELRDALKNYNPARRGANQ---------SSDNLTNALRDLFDTMDKKQE-PV 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 272 SPKVLFNQLCQKAPRFK------GFQQQDSQELLhhlldavrteetkriqASILKAFNNpttktadeetrkkvkAYGKEG 345
Cdd:cd02657 64 PPIEFLQLLRMAFPQFAekqnqgGYAQQDAEECW----------------SQLLSVLSQ---------------KLPGAG 112
|
170 180 190
....*....|....*....|....*....|.
gi 564350490 346 VKMNFIDRIFIGELTSTVMCEECANISTMKD 376
Cdd:cd02657 113 SKGSFIDQLFGIELETKMKCTESPDEEEVST 143
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-406 |
3.05e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 58.86 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLAQTYILfelmneikedgtkfkislssapqleplvvelsspgpltSALFLFLHSMKEAEK--G 269
Cdd:cd02663 1 GLENFGNTCYCNSVLQALYFENLL--------------------------------------TCLKDLFESISEQKKrtG 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 270 PLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLdavrteetkriqasilkafnNPTTKTADEEtRKKVKAYGKEGVKM- 348
Cdd:cd02663 43 VISPKKFITRLKRENELFDNYMHQDAHEFLNFLL--------------------NEIAEILDAE-RKAEKANRKLNNNNn 101
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564350490 349 -----NFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPiIEERTLLSHdrkHLRKWPSEE 406
Cdd:cd02663 102 aepqpTWVHEIFQGILTNETRCLTCETVSSRDETFLDLSID-VEQNTSITS---CLRQFSATE 160
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-387 |
1.82e-08 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 56.73 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQNLAQT-YILFELMNEIKEDGtkfkislssAPQLEPLVVELSspgpltsaLFLFLHSMKEAEKGP 270
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAkDFRRQVLSLNLPRL---------GDSQSVMKKLQL--------LQAHLMHTQRRAEAP 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 271 lsPKVLFNQlcQKAPRFKGFQQQDSQELLHHLLDAVRTeetkriqasilkafnnpttktadeetrkkvkaygkegvkmnF 350
Cdd:cd02664 64 --PDYFLEA--SRPPWFTPGSQQDCSEYLRYLLDRLHT-----------------------------------------L 98
|
170 180 190
....*....|....*....|....*....|....*....
gi 564350490 351 IDRIFIGELTSTVMCEECANISTMKD--PFIDISLPIIE 387
Cdd:cd02664 99 IEKMFGGKLSTTIRCLNCNSTSARTErfRDLDLSFPSVQ 137
|
|
| ZnF_UBP |
smart00290 |
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger; |
62-122 |
3.57e-07 |
|
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
Pssm-ID: 197632 Cd Length: 50 Bit Score: 47.36 E-value: 3.57e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564350490 62 CSECLkerrlcdgqpvLPSDVWLCLKCGFQGCGkNSESQHSLRHFKSSGaesHCVVISLST 122
Cdd:smart00290 2 CSVCG-----------TIENLWLCLTCGQVGCG-RYQNGHALEHFEETG---HPLVVKLGT 47
|
|
| Peptidase_C19N |
cd02670 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
626-762 |
3.06e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239135 [Multi-domain] Cd Length: 241 Bit Score: 45.98 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 626 ISAVPAILILHLKRFHQAGLSLRKVNRHVDFPLTLDLAPFCAAT---CKNISVGEKVLYG--------------LYGIVE 688
Cdd:cd02670 95 FAKAPSCLIICLKRYGKTEGKAQKMFKKILIPDEIDIPDFVADDpraCSKCQLECRVCYDdkdfsptcgkfklsLCSAVC 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 689 HSG-SMRGGHYTAYVKvrvpsrklseciTGRKTAPGLKEADSElgGHWVHVSD-------TYVQVVPESRALSaQAYLLF 760
Cdd:cd02670 175 HRGtSLETGHYVAFVR------------YGSYSLTETDNEAYN--AQWVFFDDmadrdgvSNGFNIPAARLLE-DPYMLF 239
|
..
gi 564350490 761 YE 762
Cdd:cd02670 240 YQ 241
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-391 |
4.75e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 46.26 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQnlaqtyILFelMN-EIKEDGTKFKISLSSAPQLEPLVVELSSPGPLTSALFLFLHsMKEAEKGP 270
Cdd:cd02668 1 GLKNLGATCYVNSFLQ------LWF--MNlEFRKAVYECNSTEDAELKNMPPDKPHEPQTIIDQLQLIFAQ-LQFGNRSV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 271 LSPKVLFNQLcqkapRFKGFQQQDSQELLHHLLDAvrteetkrIQASILKAFNNpttktadeetrkKVKaygkegvkmNF 350
Cdd:cd02668 72 VDPSGFVKAL-----GLDTGQQQDAQEFSKLFLSL--------LEAKLSKSKNP------------DLK---------NI 117
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 564350490 351 IDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERTL 391
Cdd:cd02668 118 VQDLFRGEYSYVTQCSKCGRESSLPSKFYELELQLKGHKTL 158
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
615-762 |
9.39e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 45.01 E-value: 9.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 615 GVYTNARKQLLISAVPAILILHLKRFH-QAGLSLRKVNRHVDFPLTLDLAPfcaatcknisvgekvlYGLYGIVEHSG-S 692
Cdd:cd02658 201 KEKTTATKTTGFKTFPDYLVINMKRFQlLENWVPKKLDVPIDVPEELGPGK----------------YELIAFISHKGtS 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 693 MRGGHYTAYVKvrvpsrklsecitgrktapglKEADSElgGHWVHVSDTYVQVVPESRALSAQAYLLFYE 762
Cdd:cd02658 265 VHSGHYVAHIK---------------------KEIDGE--GKWVLFNDEKVVASQDPPEMKKLGYIYFYQ 311
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|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
192-309 |
3.31e-03 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 39.85 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564350490 192 GITNLGNTCFFNAVIQnlaqtyILFELMNEIKEDGTKFKISLSSAPQLEplvVELSSPGPLTsalflfLHSMKEAEKGP- 270
Cdd:cd02665 1 GLKNVGNTCWFSAVIQ------SLFSQQQDVSEFTHLLLDWLEDAFQAA---AEAISPGEKS------KNPMVQLFYGTf 65
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 564350490 271 LSPKVLFNQLCQKAPRFKGFQ-QQDSQELLHHLLDAVRTE 309
Cdd:cd02665 66 LTEGVLEGKPFCNCETFGQYPlQVNGYGNLHECLEAAMFE 105
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