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Conserved domains on  [gi|564365920|ref|XP_006244036|]
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cAMP-regulated phosphoprotein 21 isoform X1 [Rattus norvegicus]

Protein Classification

R3H and SUZ domain-containing protein( domain architecture ID 10119061)

R3H and SUZ domain-containing protein may bind single-stranded nucleic acids through its R3H domain and RNA through its SUZ domain, similar to Zea mays DBF1-interactor protein 1 that is a potential regulator of DBF1 activity in stress responses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 2.05e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.60  E-value: 2.05e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564365920 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-299 8.10e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


:

Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 63.49  E-value: 8.10e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564365920  244 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 299
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 591-819 1.28e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.88  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  591 QLSMSRQSSGDTPEPPSgPVYPASLMQAAQPPSYVITSAGQQLSTG--GFSDSGPPISQQVLQA----PPSPQGFVQQPP 664
Cdd:pfam09770  99 QVRFNRQQPAARAAQSS-AQPPASSLPQYQYASQQSQQPSKPVRTGyeKYKEPEPIPDLQVDASlwgvAPKKAAAPAPAP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  665 PAQMSvyyypsgqyPTSTTQQYRPLASVQY--SAQRSQQIPQTAQQA-------GYQPVLSGQQSFQGLMGVQQSAHSQG 735
Cdd:pfam09770 178 QPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQQQPQQ 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  736 VMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQTGQ--GSLPATGMPVYCNITPPSPQNN 808
Cdd:pfam09770 249 QPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPGVQPAP 328

                         250
                  ....*....|.
gi 564365920  809 LRLMGPHCPSS 819
Cdd:pfam09770 329 AHQAHRQQGSF 339
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 336-792 6.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  336 SSGRTSGSRQSSSETELRWPDHQRAWSSTDSD--SSNRNLKPTMTKTASfggitvltrgDSTSSTRSAGKLSKTGSESSS 413
Cdd:pfam03154  41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEapSPLKSAKRQREKGAS----------DTEEPERATAKKSKTQEISRP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  414 SAGSSGSLSRTH------------PPLQSTALTSSVAAGSP-----GCMAYSENGMGGQVPPSSTSYILLPLESATGIPP 476
Cdd:pfam03154 111 NSPSEGEGESSDgrsvndegssdpKDIDQDNRSTSPSIPSPqdnesDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  477 GSILLN--PHTGQPFVNPDGTPAIYNPPGSQQTLRGTVSGQPQQPPPQQPSPQPQQQVQASQPQMTGPLVTqSVQGLQPS 554
Cdd:pfam03154 191 TTQAATagPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV-SPQPLPQP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  555 SQSVQYPAVSFP----PQHLLPVSPTQHFPLREEMAAQFSQLSMSRQSSGDTPEPPSGPVyPASLMQAAQPPSYvitsag 630
Cdd:pfam03154 270 SLHGQMPPMPHSlqtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPP-SQSQLQSQQPPRE------ 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  631 QQLSTGGFS--DSGPPISQQVLQApPSPQG-----FVQQPPPAQM-SVYYYPSGQYPTSTTQQYRPLASVQYSAQ---RS 699
Cdd:pfam03154 343 QPLPPAPLSmpHIKPPPTTPIPQL-PNPQShkhppHLSGPSPFQMnSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpQS 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  700 QQIPQTAQQAgyqPVLSGQQSFQGLMGVQQSAHSQGVMSSQQGAPVHGVMVSYPT-MSSYQVPMTQGSQAVPqqTYQPPI 778
Cdd:pfam03154 422 QQLPPPPAQP---PVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPpITPPSGPPTSTSSAMP--GIQPPS 496

                         490
                  ....*....|....
gi 564365920  779 MLPSQTGqGSLPAT 792
Cdd:pfam03154 497 SASVSSS-GPVPAA 509
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 2.05e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.60  E-value: 2.05e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564365920 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-299 8.10e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 63.49  E-value: 8.10e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564365920  244 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 299
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
146-223 8.81e-13

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 64.24  E-value: 8.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920   146 IDLHEFLINTLKNNSRDRMILLKMEQEMIDFIAdSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 223
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 164-222 8.11e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 60.97  E-value: 8.11e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564365920  164 MILLKMEQEMIDFIADSNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 222
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 591-819 1.28e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.88  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  591 QLSMSRQSSGDTPEPPSgPVYPASLMQAAQPPSYVITSAGQQLSTG--GFSDSGPPISQQVLQA----PPSPQGFVQQPP 664
Cdd:pfam09770  99 QVRFNRQQPAARAAQSS-AQPPASSLPQYQYASQQSQQPSKPVRTGyeKYKEPEPIPDLQVDASlwgvAPKKAAAPAPAP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  665 PAQMSvyyypsgqyPTSTTQQYRPLASVQY--SAQRSQQIPQTAQQA-------GYQPVLSGQQSFQGLMGVQQSAHSQG 735
Cdd:pfam09770 178 QPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQQQPQQ 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  736 VMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQTGQ--GSLPATGMPVYCNITPPSPQNN 808
Cdd:pfam09770 249 QPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPGVQPAP 328

                         250
                  ....*....|.
gi 564365920  809 LRLMGPHCPSS 819
Cdd:pfam09770 329 AHQAHRQQGSF 339
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 568-763 1.10e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  568 QHLLPVSPTQHFPLRE-EMAAQFSQLSMSRQSSgdtpEPPSGpVYPASLMQAAQPPSYVITSAGQqlSTGGFSDSGPPIS 646
Cdd:PRK10263  681 QHDVPVNAEDADAAAEaELARQFAQTQQQRYSG----EQPAG-ANPFSLDDFEFSPMKALLDDGP--HEPLFTPIVEPVQ 753

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  647 QQVLQAPPSPQGFVQQPPPAQMSVYYYPsgQYPTSTTQQYR-PLASVQYSAQRSQ-QIPQTAQQAGYQPV--LSGQQSFQ 722
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAPQPQYQQP--QQPVAPQPQYQqPQQPVAPQPQYQQpQQPVAPQPQYQQPQqpVAPQPQYQ 831

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 564365920  723 glmgvqqsAHSQGVMSSQQGAPVHGVMVSYPTMSSYQVPMT 763
Cdd:PRK10263  832 --------QPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTT 864
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 582-718 1.21e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  582 REEMAAQFSQLSM-SRQSSGDTPEPPSgpvypaslmqAAQPPSYviTSAGQQLSTG---GFSDSGPPISQQVLQAPPSPQ 657
Cdd:TIGR01628 368 RAHLQDQFMQLQPrMRQLPMGSPMGGA----------MGQPPYY--GQGPQQQFNGqplGWPRMSMMPTPMGPGGPLRPN 435

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564365920  658 GFVQQPPPAQMSVYYYPSGQYPTSTTQQYRPLASVQYSAQRSQQIPQTAQQAGYQPVLSGQ 718
Cdd:TIGR01628 436 GLAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQV 496
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 336-792 6.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  336 SSGRTSGSRQSSSETELRWPDHQRAWSSTDSD--SSNRNLKPTMTKTASfggitvltrgDSTSSTRSAGKLSKTGSESSS 413
Cdd:pfam03154  41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEapSPLKSAKRQREKGAS----------DTEEPERATAKKSKTQEISRP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  414 SAGSSGSLSRTH------------PPLQSTALTSSVAAGSP-----GCMAYSENGMGGQVPPSSTSYILLPLESATGIPP 476
Cdd:pfam03154 111 NSPSEGEGESSDgrsvndegssdpKDIDQDNRSTSPSIPSPqdnesDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  477 GSILLN--PHTGQPFVNPDGTPAIYNPPGSQQTLRGTVSGQPQQPPPQQPSPQPQQQVQASQPQMTGPLVTqSVQGLQPS 554
Cdd:pfam03154 191 TTQAATagPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV-SPQPLPQP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  555 SQSVQYPAVSFP----PQHLLPVSPTQHFPLREEMAAQFSQLSMSRQSSGDTPEPPSGPVyPASLMQAAQPPSYvitsag 630
Cdd:pfam03154 270 SLHGQMPPMPHSlqtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPP-SQSQLQSQQPPRE------ 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  631 QQLSTGGFS--DSGPPISQQVLQApPSPQG-----FVQQPPPAQM-SVYYYPSGQYPTSTTQQYRPLASVQYSAQ---RS 699
Cdd:pfam03154 343 QPLPPAPLSmpHIKPPPTTPIPQL-PNPQShkhppHLSGPSPFQMnSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpQS 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  700 QQIPQTAQQAgyqPVLSGQQSFQGLMGVQQSAHSQGVMSSQQGAPVHGVMVSYPT-MSSYQVPMTQGSQAVPqqTYQPPI 778
Cdd:pfam03154 422 QQLPPPPAQP---PVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPpITPPSGPPTSTSSAMP--GIQPPS 496

                         490
                  ....*....|....
gi 564365920  779 MLPSQTGqGSLPAT 792
Cdd:pfam03154 497 SASVSSS-GPVPAA 509
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 2.05e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.60  E-value: 2.05e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564365920 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-299 8.10e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 63.49  E-value: 8.10e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 564365920  244 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 299
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
146-223 8.81e-13

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 64.24  E-value: 8.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920   146 IDLHEFLINTLKNNSRDRMILLKMEQEMIDFIAdSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 223
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 166-222 4.81e-12

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 61.48  E-value: 4.81e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564365920 166 LLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINK 222
Cdd:cd02325    1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 164-222 8.11e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 60.97  E-value: 8.11e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564365920  164 MILLKMEQEMIDFIADSNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 222
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 591-819 1.28e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.88  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  591 QLSMSRQSSGDTPEPPSgPVYPASLMQAAQPPSYVITSAGQQLSTG--GFSDSGPPISQQVLQA----PPSPQGFVQQPP 664
Cdd:pfam09770  99 QVRFNRQQPAARAAQSS-AQPPASSLPQYQYASQQSQQPSKPVRTGyeKYKEPEPIPDLQVDASlwgvAPKKAAAPAPAP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  665 PAQMSvyyypsgqyPTSTTQQYRPLASVQY--SAQRSQQIPQTAQQA-------GYQPVLSGQQSFQGLMGVQQSAHSQG 735
Cdd:pfam09770 178 QPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQQQPQQ 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  736 VMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQTGQ--GSLPATGMPVYCNITPPSPQNN 808
Cdd:pfam09770 249 QPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPGVQPAP 328

                         250
                  ....*....|.
gi 564365920  809 LRLMGPHCPSS 819
Cdd:pfam09770 329 AHQAHRQQGSF 339
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 568-763 1.10e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  568 QHLLPVSPTQHFPLRE-EMAAQFSQLSMSRQSSgdtpEPPSGpVYPASLMQAAQPPSYVITSAGQqlSTGGFSDSGPPIS 646
Cdd:PRK10263  681 QHDVPVNAEDADAAAEaELARQFAQTQQQRYSG----EQPAG-ANPFSLDDFEFSPMKALLDDGP--HEPLFTPIVEPVQ 753

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  647 QQVLQAPPSPQGFVQQPPPAQMSVYYYPsgQYPTSTTQQYR-PLASVQYSAQRSQ-QIPQTAQQAGYQPV--LSGQQSFQ 722
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAPQPQYQQP--QQPVAPQPQYQqPQQPVAPQPQYQQpQQPVAPQPQYQQPQqpVAPQPQYQ 831

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 564365920  723 glmgvqqsAHSQGVMSSQQGAPVHGVMVSYPTMSSYQVPMT 763
Cdd:PRK10263  832 --------QPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTT 864
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 606-797 1.12e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  606 PSGPVYPASLMQAAQPPSYVITSAGQQLStggfsdsGPPISQQVLQapPSPQGFVQQPPPAQMSVYYYPSGQYPTSTTQQ 685
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAWQPVP-------GPQTGEPVIA--PAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQP 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  686 YRPLASVQYSAQrsQQIPQTAQQAGYQPVLSGQqsfqglmgVQQSAHSQGVMSSQQGaPVHGVMVSYPTMSSYQVPMTQG 765
Cdd:PRK10263  407 YYAPAAEQPAQQ--PYYAPAPEQPAQQPYYAPA--------PEQPVAGNAWQAEEQQ-STFAPQSTYQTEQTYQQPAAQE 475

                         170       180       190
                  ....*....|....*....|....*....|..
gi 564365920  766 SQAVPQQTYQPPIMLPSQTGQGSLPATGMPVY 797
Cdd:PRK10263  476 PLYQQPQPVEQQPVVEPEPVVEETKPARPPLY 507
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 582-718 1.21e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  582 REEMAAQFSQLSM-SRQSSGDTPEPPSgpvypaslmqAAQPPSYviTSAGQQLSTG---GFSDSGPPISQQVLQAPPSPQ 657
Cdd:TIGR01628 368 RAHLQDQFMQLQPrMRQLPMGSPMGGA----------MGQPPYY--GQGPQQQFNGqplGWPRMSMMPTPMGPGGPLRPN 435

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564365920  658 GFVQQPPPAQMSVYYYPSGQYPTSTTQQYRPLASVQYSAQRSQQIPQTAQQAGYQPVLSGQ 718
Cdd:TIGR01628 436 GLAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQV 496
PRK10927 PRK10927
cell division protein FtsN;
632-745 2.02e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.20  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920 632 QLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTTQQyrplasvQYSAQRSQQIPQTAQQAGY 711
Cdd:PRK10927 135 QLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQA-------APVQAQPRQSKPASTQQPY 207

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564365920 712 QPVLsgqqsfqglmgvQQSAHSQGVMSSQQGAPV 745
Cdd:PRK10927 208 QDLL------------QTPAHTTAQSKPQQAAPV 229
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
598-721 2.69e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920 598 SSGDTPEPPSGP---VYPASLMQAAQPPSYVITSAGQQLSTGGFSDSgPPISQQVLQAPPSPQGFVQQPPPAQMSVyyyP 674
Cdd:PRK14971 364 QKGDDASGGRGPkqhIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQ-PSAPQSATQPAGTPPTVSVDPPAAVPVN---P 439

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564365920 675 SGQYPTSTTQQYRP---------LASVQYSAQRSQQIPQTAQQAGYQPVLSGQQSF 721
Cdd:PRK14971 440 PSTAPQAVRPAQFKeekkipvskVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQKE 495
R3H_sperm-antigen cd02636
R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. ...
 168-207 3.46e-03

R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100065  Cd Length: 61  Bit Score: 36.54  E-value: 3.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564365920 168 KMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGL 207
Cdd:cd02636    3 SMEKEVSKFIKDSVRTREKFQPMDKVERSIVHDVAEVAGL 42
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 582-803 3.72e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  582 REEMAAQFSQlsMSRQSSGDTPEPPSgPVYPASLMQAAQPPSYVITSAGQQLSTGGFSDSGP-PISQQVLQAPPSpQGFV 660
Cdd:PRK10263  661 QDELARQFAQ--TQQQRYGEQYQHDV-PVNAEDADAAAEAELARQFAQTQQQRYSGEQPAGAnPFSLDDFEFSPM-KALL 736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  661 QQPPPAQMsvyyYPSGQYPTSTTQQyRPLASVQYSAQRSQQIPQTAQQAGYQPVLSGQQSFQGLMGVQQSAHSQGVMSSQ 740
Cdd:PRK10263  737 DDGPHEPL----FTPIVEPVQQPQQ-PVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPV 811

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564365920  741 QGAPvhgvmvsyptmsSYQVPMtqgSQAVPQQTYQPPIMLPSQTGQGSL----------------PATGMPVYCNITPP 803
Cdd:PRK10263  812 APQP------------QYQQPQ---QPVAPQPQYQQPQQPVAPQPQDTLlhpllmrngdsrplhkPTTPLPSLDLLTPP 875
R3H_Smubp-2_like cd02641
R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and ...
 176-220 6.95e-03

R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.


Pssm-ID: 100070  Cd Length: 60  Bit Score: 35.79  E-value: 6.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 564365920 176 FIADSNNHYKKFP-QMSSYQRMLVHRVAAYFGLDHNVDQTGKSVII 220
Cdd:cd02641   11 FMKDPKATELEFPpTLSSHDRLLVHELAEELGLRHESTGEGSDRVI 56
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 336-792 6.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  336 SSGRTSGSRQSSSETELRWPDHQRAWSSTDSD--SSNRNLKPTMTKTASfggitvltrgDSTSSTRSAGKLSKTGSESSS 413
Cdd:pfam03154  41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEapSPLKSAKRQREKGAS----------DTEEPERATAKKSKTQEISRP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  414 SAGSSGSLSRTH------------PPLQSTALTSSVAAGSP-----GCMAYSENGMGGQVPPSSTSYILLPLESATGIPP 476
Cdd:pfam03154 111 NSPSEGEGESSDgrsvndegssdpKDIDQDNRSTSPSIPSPqdnesDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  477 GSILLN--PHTGQPFVNPDGTPAIYNPPGSQQTLRGTVSGQPQQPPPQQPSPQPQQQVQASQPQMTGPLVTqSVQGLQPS 554
Cdd:pfam03154 191 TTQAATagPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV-SPQPLPQP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  555 SQSVQYPAVSFP----PQHLLPVSPTQHFPLREEMAAQFSQLSMSRQSSGDTPEPPSGPVyPASLMQAAQPPSYvitsag 630
Cdd:pfam03154 270 SLHGQMPPMPHSlqtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPP-SQSQLQSQQPPRE------ 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  631 QQLSTGGFS--DSGPPISQQVLQApPSPQG-----FVQQPPPAQM-SVYYYPSGQYPTSTTQQYRPLASVQYSAQ---RS 699
Cdd:pfam03154 343 QPLPPAPLSmpHIKPPPTTPIPQL-PNPQShkhppHLSGPSPFQMnSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpQS 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  700 QQIPQTAQQAgyqPVLSGQQSFQGLMGVQQSAHSQGVMSSQQGAPVHGVMVSYPT-MSSYQVPMTQGSQAVPqqTYQPPI 778
Cdd:pfam03154 422 QQLPPPPAQP---PVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPpITPPSGPPTSTSSAMP--GIQPPS 496

                         490
                  ....*....|....
gi 564365920  779 MLPSQTGqGSLPAT 792
Cdd:pfam03154 497 SASVSSS-GPVPAA 509
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 540-688 9.28e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365920  540 TGPLVTQSVQGLQPSSQSVQYPAVSFPPQHLLPvSPTQHFPlreemAAQFSQLSMSRQSSGDTPEPPSGPVYPASLMQAA 619
Cdd:PRK10263  343 TPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP-APEGYPQ-----QSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPA 416

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564365920  620 QPPSYVITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTTQQYRP 688
Cdd:PRK10263  417 QQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVE 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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