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Conserved domains on  [gi|564367027|ref|XP_006244458|]
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zinc finger protein 501-like isoform X4 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-474 1.11e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 109 CYECNqCGKALSSSSSLQRHDQTHvGNGSDKRETSSKSLTHHRHLQIQKTAC----DDKDLCewNQCGKPSLQLHQRTHL 184
Cdd:COG5048   64 CSYSG-CDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSLSSSssnsNDNNLL--SSHSLPPSSRDPQLPD 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 185 EMKCCEY-NQEDKLITHQNCNQEGRSNTRDPKRDYHQWGKAFACPSYLQIHERIHIGENPYECIHCGRT--FTCHSTLQM 261
Cdd:COG5048  140 LLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSysIPSSSSDQN 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 262 HERIHTGEKPYKCNQCG-KTFACKRYLQIHERIHTGEKPYKCNQCGKAFACNSYLLIH--ERIHTG-EKPFKCNQCGKAF 337
Cdd:COG5048  220 LENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNEsdSSSEKGfSLPIKSKQCNISF 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 338 ACNSYLQMHER--IHTGE--KPYKC--NQCGKAFACNSNLQKHERTHTGEKPYKC--NQCGKAFT-----CHSTLQIHER 404
Cdd:COG5048  300 SRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYK 379

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564367027 405 IHTGEKPYKC--NQCAKAFARKRYLQIHERIHTGEKPYECN--QCGKAFAYSSSLNKHERTHTGEKPFECNQRG 474
Cdd:COG5048  380 DLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-474 1.11e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 109 CYECNqCGKALSSSSSLQRHDQTHvGNGSDKRETSSKSLTHHRHLQIQKTAC----DDKDLCewNQCGKPSLQLHQRTHL 184
Cdd:COG5048   64 CSYSG-CDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSLSSSssnsNDNNLL--SSHSLPPSSRDPQLPD 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 185 EMKCCEY-NQEDKLITHQNCNQEGRSNTRDPKRDYHQWGKAFACPSYLQIHERIHIGENPYECIHCGRT--FTCHSTLQM 261
Cdd:COG5048  140 LLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSysIPSSSSDQN 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 262 HERIHTGEKPYKCNQCG-KTFACKRYLQIHERIHTGEKPYKCNQCGKAFACNSYLLIH--ERIHTG-EKPFKCNQCGKAF 337
Cdd:COG5048  220 LENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNEsdSSSEKGfSLPIKSKQCNISF 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 338 ACNSYLQMHER--IHTGE--KPYKC--NQCGKAFACNSNLQKHERTHTGEKPYKC--NQCGKAFT-----CHSTLQIHER 404
Cdd:COG5048  300 SRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYK 379

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564367027 405 IHTGEKPYKC--NQCAKAFARKRYLQIHERIHTGEKPYECN--QCGKAFAYSSSLNKHERTHTGEKPFECNQRG 474
Cdd:COG5048  380 DLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 1.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 564367027  370 NLQKHERTHTGEKPYKCNQCGKAFTC 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 246-290 3.07e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564367027 246 CIHCGRTFTCHSTLQMHERIHTgekpYKCNQCGKTFACKRYLQIH 290
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-474 1.11e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 109 CYECNqCGKALSSSSSLQRHDQTHvGNGSDKRETSSKSLTHHRHLQIQKTAC----DDKDLCewNQCGKPSLQLHQRTHL 184
Cdd:COG5048   64 CSYSG-CDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSLSSSssnsNDNNLL--SSHSLPPSSRDPQLPD 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 185 EMKCCEY-NQEDKLITHQNCNQEGRSNTRDPKRDYHQWGKAFACPSYLQIHERIHIGENPYECIHCGRT--FTCHSTLQM 261
Cdd:COG5048  140 LLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSysIPSSSSDQN 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 262 HERIHTGEKPYKCNQCG-KTFACKRYLQIHERIHTGEKPYKCNQCGKAFACNSYLLIH--ERIHTG-EKPFKCNQCGKAF 337
Cdd:COG5048  220 LENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNEsdSSSEKGfSLPIKSKQCNISF 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 338 ACNSYLQMHER--IHTGE--KPYKC--NQCGKAFACNSNLQKHERTHTGEKPYKC--NQCGKAFT-----CHSTLQIHER 404
Cdd:COG5048  300 SRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYK 379

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564367027 405 IHTGEKPYKC--NQCAKAFARKRYLQIHERIHTGEKPYECN--QCGKAFAYSSSLNKHERTHTGEKPFECNQRG 474
Cdd:COG5048  380 DLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 1.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 564367027  370 NLQKHERTHTGEKPYKCNQCGKAFTC 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
410-486 1.82e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564367027 410 KPYKCNQCAKAFARKRYLQIHERIHTGEKPYECNQCGKAFAYSSSLNKHE--RTHTGEKPFECNQRGNPKQAFACLSSL 486
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhlRTHHNNPSDLNSKSLPLSNSKASSSSL 110
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 4.59e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.59e-05
                          10        20
                  ....*....|....*....|....*.
gi 564367027  342 YLQMHERIHTGEKPYKCNQCGKAFAC 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-283 8.94e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.94e-05
                          10        20
                  ....*....|....*....|....*
gi 564367027  259 LQMHERIHTGEKPYKCNQCGKTFAC 283
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 564367027  286 YLQIHERIHTGEKPYKCNQCGKAFAC 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 564367027  426 YLQIHERIHTGEKPYECNQCGKAFAY 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 4.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.69e-04
                          10        20
                  ....*....|....*....|....*.
gi 564367027  314 YLLIHERIHTGEKPFKCNQCGKAFAC 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-477 6.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 312 NSYLLIHERIHTGEKPFKCNQCGKAFACNSYLQMHERIHTGEKPYKCNQCGKAFACNSNLQKHERTHTGEKPYKCNQCGK 391
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 392 AFTCHSTLQIHERIHTGE-------KPYKCNQCAKAFARKRYLQIHER--IHTGE--KPYEC--NQCGKAFAYSSSLNKH 458
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        170
                 ....*....|....*....
gi 564367027 459 ERTHTGEKPFECNQRGNPK 477
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSS 361
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-499 7.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 242 NPYECIHCGRTFTCHSTLQMHERIHTGEKPYKCNQCGKTFACKRY--LQIHERIHTGEKPYKCN-QCGKAFACNSYLLIH 318
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 319 ERIHTGEKPFKCNQCGKAF----------------------ACNSYLQM----------------------------HER 348
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpGNNSSSVNtpqsnslhpplpanslskdpssnlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 349 IHTGEKPYKCNQCGKAFACNSNLQKHERTHTGEKPYKCNQCGKAFTCHSTLQIH------ERIHTGEKPYKCNQCAKAFA 422
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367027 423 RKRYLQIHERIHTG-EKPYECNQCGKAFAYSSSLNKHERT--HTGE--KPFECNQRGNPKQaFACLSSLQKHEGIHTEKS 497
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKL-FSRNDALKRHILLHTSIS 350


                 ..
gi 564367027 498 SR 499
Cdd:COG5048  351 PA 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-423 9.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.60e-04
                          10        20
                  ....*....|....*....|....*
gi 564367027  399 LQIHERIHTGEKPYKCNQCAKAFAR 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 246-290 3.07e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564367027 246 CIHCGRTFTCHSTLQMHERIHTgekpYKCNQCGKTFACKRYLQIH 290
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 9.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 564367027  230 YLQIHERIHIGENPYECIHCGRTFTC 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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