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Conserved domains on  [gi|564371516|ref|XP_006246230|]
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T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 20-126 2.77e-64

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


:

Pssm-ID: 409574  Cd Length: 107  Bit Score: 199.22  E-value: 2.77e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516  20 ASYTVVQGHSVTLPCIYSTTYRDEMVPTCWGRGECRSSYCTRSLIWTNGYKVTYQRSNRYQLKGNISEGNVSLTIENTVV 99
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 564371516 100 SDSGPYCCIAEIPGAFYFVDYLLEVKA 126
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 20-126 2.77e-64

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 199.22  E-value: 2.77e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516  20 ASYTVVQGHSVTLPCIYSTTYRDEMVPTCWGRGECRSSYCTRSLIWTNGYKVTYQRSNRYQLKGNISEGNVSLTIENTVV 99
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 564371516 100 SDSGPYCCIAEIPGAFYFVDYLLEVKA 126
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-117 7.68e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 7.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516   23 TVVQGHSVTLPCIYSTTYRDEMVPTCWGRGECRSSYCTRSLIWTNGYKvTYQRSNRYQLKGNISEGNVSLTIENTVVSDS 102
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSE-EGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90
                  ....*....|....*
gi 564371516  103 GPYCCIAEIPGAFYF 117
Cdd:pfam07686  86 GTYTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-124 2.94e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 2.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516    21 SYTVVQGHSVTLPCIYSttyrDEMVPTCWgrgecrssyctrsliWTNGYKVTYQRSNRYQLKGNisEGNVSLTIENTVVS 100
Cdd:smart00410   3 SVTVKEGESVTLSCEAS----GSPPPEVT---------------WYKQGGKLLAESGRFSVSRS--GSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....
gi 564371516   101 DSGPYCCIAEIPGAFYFVDYLLEV 124
Cdd:smart00410  62 DSGTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 20-126 2.77e-64

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 199.22  E-value: 2.77e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516  20 ASYTVVQGHSVTLPCIYSTTYRDEMVPTCWGRGECRSSYCTRSLIWTNGYKVTYQRSNRYQLKGNISEGNVSLTIENTVV 99
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGNLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 564371516 100 SDSGPYCCIAEIPGAFYFVDYLLEVKA 126
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-117 7.68e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 7.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516   23 TVVQGHSVTLPCIYSTTYRDEMVPTCWGRGECRSSYCTRSLIWTNGYKvTYQRSNRYQLKGNISEGNVSLTIENTVVSDS 102
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSE-EGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90
                  ....*....|....*
gi 564371516  103 GPYCCIAEIPGAFYF 117
Cdd:pfam07686  86 GTYTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-124 2.94e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 2.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516    21 SYTVVQGHSVTLPCIYSttyrDEMVPTCWgrgecrssyctrsliWTNGYKVTYQRSNRYQLKGNisEGNVSLTIENTVVS 100
Cdd:smart00410   3 SVTVKEGESVTLSCEAS----GSPPPEVT---------------WYKQGGKLLAESGRFSVSRS--GSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....
gi 564371516   101 DSGPYCCIAEIPGAFYFVDYLLEV 124
Cdd:smart00410  62 DSGTYTCAATNSSGSASSGTTLTV 85
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 81-107 6.43e-04

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 39.10  E-value: 6.43e-04
                         10        20
                 ....*....|....*....|....*..
gi 564371516  81 LKGNISEGNVSLTIENTVVSDSGPYCC 107
Cdd:cd05713   70 LKDAIAEGSVALRIHNVRPSDEGQYTC 96
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-116 1.93e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 37.38  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371516  22 YTVVQGHSVTLPCIYSTTYRDEMVPTC-WGRGECrssyctrSLIWTNGYkvtYQRSNRYQLKGNISEGNVSLTIENTVVS 100
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCkWGSEGC-------QTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKE 76

                         90
                 ....*....|....*.
gi 564371516 101 DSGPYCCIAEIPGAFY 116
Cdd:cd05716   77 DAGWYWCGVGDDGDRG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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