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Conserved domains on  [gi|564371981|ref|XP_006246429|]
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protein Shroom1 isoform X1 [Rattus norvegicus]

Protein Classification

shroom family protein( domain architecture ID 10282073)

shroom family protein is a PDZ (PSD-95, Dlg, and ZO-1/2) domain-containing protein that functions in cell morphology by coordinating the assembly of both microtubule and actin cytoskeletons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 552-830 2.14e-82

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


:

Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 266.05  E-value: 2.14e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  552 ELVQELARLDPFLSDTLAAQPGPEPPLGLLDGLFPAEEIRsAMRPAREEAG-----------EKAGASEEGSCGCHFTQE 620
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFPEDTLR-AMKPDLGEAYkkapseegseeEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  621 LPTSQEASRSENSTPDPVPDQSSGQGF-PEGNSTQAKKVELARLLQKMLQDLHAEQERLRGKAADWTRHNGALEAAVSQA 699
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEeELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  700 CTPRELERFRRFMTDLERVLGLLLLLGSRLTRVNLALARAGSDSDPDERASLLQRLLLLQRQQEDAKELKEHVARREQTL 779
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564371981  780 RQVLERELPAEHLRSYCVLLAAKARILSQQRSLDDRIRFLKEQLDTIWSDL 830
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 super family cl07346
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 150-275 3.06e-17

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


The actual alignment was detected with superfamily member pfam08688:

Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 80.46  E-value: 3.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  150 YALTAEAEATTRTAEP------PSPPASRA-AYRQRLQGAQRRVLRETSFQRKELRMSLPGRLRPAL-PARPPTGHVRSA 221
Cdd:pfam08688   9 FQLEGEDEAEWSWRRPrgdepmSDADGSFNrAYREKLKDAQSRVLRATSFRRRDLQPSVPPVPWHLSsRPRPASAHLRSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564371981  222 SS-------------SQELGEAEPARAAVPALGAAGRGHLASQQRLCCFSEPGKLHRVGWSGGPTGE 275
Cdd:pfam08688  89 EApisaspsphtpreRHSVTPGDRLAGPPAVRRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEPEPA 155
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 552-830 2.14e-82

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 266.05  E-value: 2.14e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  552 ELVQELARLDPFLSDTLAAQPGPEPPLGLLDGLFPAEEIRsAMRPAREEAG-----------EKAGASEEGSCGCHFTQE 620
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFPEDTLR-AMKPDLGEAYkkapseegseeEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  621 LPTSQEASRSENSTPDPVPDQSSGQGF-PEGNSTQAKKVELARLLQKMLQDLHAEQERLRGKAADWTRHNGALEAAVSQA 699
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEeELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  700 CTPRELERFRRFMTDLERVLGLLLLLGSRLTRVNLALARAGSDSDPDERASLLQRLLLLQRQQEDAKELKEHVARREQTL 779
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564371981  780 RQVLERELPAEHLRSYCVLLAAKARILSQQRSLDDRIRFLKEQLDTIWSDL 830
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 pfam08688
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 150-275 3.06e-17

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 80.46  E-value: 3.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  150 YALTAEAEATTRTAEP------PSPPASRA-AYRQRLQGAQRRVLRETSFQRKELRMSLPGRLRPAL-PARPPTGHVRSA 221
Cdd:pfam08688   9 FQLEGEDEAEWSWRRPrgdepmSDADGSFNrAYREKLKDAQSRVLRATSFRRRDLQPSVPPVPWHLSsRPRPASAHLRSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564371981  222 SS-------------SQELGEAEPARAAVPALGAAGRGHLASQQRLCCFSEPGKLHRVGWSGGPTGE 275
Cdd:pfam08688  89 EApisaspsphtpreRHSVTPGDRLAGPPAVRRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEPEPA 155
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 552-830 2.14e-82

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 266.05  E-value: 2.14e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  552 ELVQELARLDPFLSDTLAAQPGPEPPLGLLDGLFPAEEIRsAMRPAREEAG-----------EKAGASEEGSCGCHFTQE 620
Cdd:pfam08687   1 ELVKELVPKDKSLADILDPKPSRKTTMDLMEGLFPEDTLR-AMKPDLGEAYkkapseegseeEASGTSSLSSCSAYYTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  621 LPTSQEASRSENSTPDPVPDQSSGQGF-PEGNSTQAKKVELARLLQKMLQDLHAEQERLRGKAADWTRHNGALEAAVSQA 699
Cdd:pfam08687  80 APKAELLTKMKDLTTLPSPDQPEEQGEeELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  700 CTPRELERFRRFMTDLERVLGLLLLLGSRLTRVNLALARAGSDSDPDERASLLQRLLLLQRQQEDAKELKEHVARREQTL 779
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDSDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564371981  780 RQVLERELPAEHLRSYCVLLAAKARILSQQRSLDDRIRFLKEQLDTIWSDL 830
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
ASD1 pfam08688
Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which ...
 150-275 3.06e-17

Apx/Shroom domain ASD1; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.


Pssm-ID: 462562 [Multi-domain]  Cd Length: 179  Bit Score: 80.46  E-value: 3.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564371981  150 YALTAEAEATTRTAEP------PSPPASRA-AYRQRLQGAQRRVLRETSFQRKELRMSLPGRLRPAL-PARPPTGHVRSA 221
Cdd:pfam08688   9 FQLEGEDEAEWSWRRPrgdepmSDADGSFNrAYREKLKDAQSRVLRATSFRRRDLQPSVPPVPWHLSsRPRPASAHLRSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564371981  222 SS-------------SQELGEAEPARAAVPALGAAGRGHLASQQRLCCFSEPGKLHRVGWSGGPTGE 275
Cdd:pfam08688  89 EApisaspsphtpreRHSVTPGDRLAGPPAVRRIGGRKRLTAEQKKRSYSEPEKMNEVGVSPEPEPA 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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