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Conserved domains on  [gi|564372055|ref|XP_006246461|]
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gem-associated protein 5 isoform X5 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 1.02e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 1.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKAV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  102 VTEHALHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRSDSQHLFT---EPRAIFCLTCSPhHENLVAIGYKDGIVII 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  179 IDIsKKGEVVHRLRGHDDEIHSIAWCplsgedclsinqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  336 VFnlcplkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 564372055  416 dVKNFWQGVKSKVTALCWHPNkEGCLAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 1.69e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 1.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIVFNLCPlktedGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-----DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  467 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGIVLQHNPwklsgeafdinklmrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  543 WKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  623 spitiTEPYRTLSGHTAKVTSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 564372055  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
COG3899 super family cl28481
Predicted ATPase [General function prediction only];
863-1180 2.72e-04

Predicted ATPase [General function prediction only];


The actual alignment was detected with superfamily member COG3899:

Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 45.62  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  863 DCLVLATATHARAELHED------VSADLEERFHLGLFTDRAALYRMMETEGKGHLESGHPELFHQLMLWKGDlkgvLQA 936
Cdd:COG3899   733 ELLPPDPEEEYRLALLLElaealyLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLGD----YEE 808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  937 AAERGELTDSLVAVAPVAGYSVWLWAVEAFAkqLCFQDQYVKAASYLLSIHRVYEAVELLRSNHLYREAIAVAKARLRPE 1016
Cdd:COG3899   809 AYEFGELALALAERLGDRRLEARALFNLGFI--LHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAAL 886

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1017 DPV---LKDLYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGESELAASLALRCAQEL 1093
Cdd:COG3899   887 AAAaaaAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAA 966

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1094 LLLKNWVGAQEALGLHESLQGQRLVFCLLELLCRHLEEKQPPEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPE 1173
Cdd:COG3899   967 AAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALL 1046


                  ....*..
gi 564372055 1174 QCRAALQ 1180
Cdd:COG3899  1047 AALAAAA 1053
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 1.02e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 1.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKAV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  102 VTEHALHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRSDSQHLFT---EPRAIFCLTCSPhHENLVAIGYKDGIVII 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  179 IDIsKKGEVVHRLRGHDDEIHSIAWCplsgedclsinqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  336 VFnlcplkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 564372055  416 dVKNFWQGVKSKVTALCWHPNkEGCLAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 1.69e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 1.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIVFNLCPlktedGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-----DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  467 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGIVLQHNPwklsgeafdinklmrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  543 WKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  623 spitiTEPYRTLSGHTAKVTSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 564372055  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-407 2.12e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   57 VGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPTVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  137 YWLNRSDSQH-LFTEPRAIFCLTCSPHHEnLVAIGYKDGIVIIIDIsKKGEVVHRLRGHDDEIHSIAWCPLSGedclsin 215
Cdd:cd00200    78 WDLETGECVRtLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  216 qeensepdipngkliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLPflkrrSGGVdptvkerLWLTLHwPKNQp 295
Cdd:cd00200   149 ------------------------FVASSSQDGTIKLWDLRTGKCVATLTGH-----TGEV-------NSVAFS-PDGE- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  296 tQLVSSCFGGELLLWDLTQswrrkytlFSTSAEGHNHSRIVFNLCPLkteDGKQLLLSTSMDRDVKCWDMATLECCWTLP 375
Cdd:cd00200   191 -KLLSSSSDGTIKLWDLST--------GKCLGTLRGHENGVNSVAFS---PDGYLLASGSEDGTIRVWDLRTGECVQTLS 258

                         330       340       350
                  ....*....|....*....|....*....|..
gi 564372055  376 SLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200   259 GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-667 2.08e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  328 EGHNHSriVFNLCplkTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200     6 KGHTGG--VTCVA---FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  408 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPpQISSTYHKKTVYRLAWGPPvppmslg 487
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  488 gegdrpSLTLYSCGGEGIVlqhnpwKLsgeaFDINklmrdTNSIRYKLPVHTE----ISWKGDGKVMALGNEDGSIEIFQ 563
Cdd:cd00200   147 ------GTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  564 VPNLKLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKVTS 643
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 564372055  644 LAWSPhhDG-RLVSACYDGTAQVWD 667
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 4.88e-09

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 54.98  E-value: 4.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   117 WSPTvKDLIVSGDEKGVVfcyWLNRSDSQHLFT-----EPRAIFCLTCSPHhENLVAIGYKDGIVIIIDISkKGEVVHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWTlspdkEDLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 564372055   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 629-667 3.45e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 3.45e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564372055    629 EPYRTLSGHTAKVTSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 598-709 6.66e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 6.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  598 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKVTSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 677
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 564372055  678 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 709
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
629-667 2.32e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 2.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564372055   629 EPYRTLSGHTAKVTSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 7.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 7.72e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564372055     53 PFRVVGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKIWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 348-472 1.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  348 KQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWntlSIKNNYDVKNfwqgVKSK 427
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVSIGT----IKTK 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 564372055  428 VTALCWH-PNKEG-CLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTV 472
Cdd:PLN00181  618 ANICCVQfPSESGrSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664
COG3899 COG3899
Predicted ATPase [General function prediction only];
863-1180 2.72e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 45.62  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  863 DCLVLATATHARAELHED------VSADLEERFHLGLFTDRAALYRMMETEGKGHLESGHPELFHQLMLWKGDlkgvLQA 936
Cdd:COG3899   733 ELLPPDPEEEYRLALLLElaealyLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLGD----YEE 808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  937 AAERGELTDSLVAVAPVAGYSVWLWAVEAFAkqLCFQDQYVKAASYLLSIHRVYEAVELLRSNHLYREAIAVAKARLRPE 1016
Cdd:COG3899   809 AYEFGELALALAERLGDRRLEARALFNLGFI--LHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAAL 886

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1017 DPV---LKDLYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGESELAASLALRCAQEL 1093
Cdd:COG3899   887 AAAaaaAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAA 966

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1094 LLLKNWVGAQEALGLHESLQGQRLVFCLLELLCRHLEEKQPPEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPE 1173
Cdd:COG3899   967 AAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALL 1046


                  ....*..
gi 564372055 1174 QCRAALQ 1180
Cdd:COG3899  1047 AALAAAA 1053
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 1.02e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 1.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKAV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  102 VTEHALHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRSDSQHLFT---EPRAIFCLTCSPhHENLVAIGYKDGIVII 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  179 IDIsKKGEVVHRLRGHDDEIHSIAWCplsgedclsinqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  336 VFnlcplkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 564372055  416 dVKNFWQGVKSKVTALCWHPNkEGCLAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 1.69e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 1.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIVFNLCPlktedGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-----DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  467 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGIVLQHNPwklsgeafdinklmrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  543 WKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  623 spitiTEPYRTLSGHTAKVTSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 564372055  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
295-668 1.08e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  295 PTQLVSSCFGGELLLWDLTQSWRRkytlfsTSAEGHNHS--RIVFnlcplkTEDGkQLLLSTSMDRDVKCWDMATLECCW 372
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLL------RTLTGHTGAvrSVAF------SPDG-KTLASGSADGTVRLWDLATGKLLR 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  373 TLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVG 451
Cdd:COG2319   157 TLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD--GKlLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  452 LYDTcSNKPPQISSTYHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGIVLQhnpWKLsgeafdinklmrDTNSI 531
Cdd:COG2319   230 LWDL-ATGKLLRTLTGHSGSVRSVAFSP-------DGR------LLASGSADGTVRL---WDL------------ATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  532 RYKLPVHTE----ISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHeHGSRpelsclLASGSNNAV 607
Cdd:COG2319   281 LRTLTGHSGgvnsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT------LASGSDDGT 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564372055  608 IYVHNLKAvlesnpespitiTEPYRTLSGHTAKVTSLAWSPhhDGR-LVSACYDGTAQVWDA 668
Cdd:COG2319   354 VRLWDLAT------------GELLRTLTGHTGAVTSVAFSP--DGRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
349-709 3.31e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 3.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  349 QLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKV 428
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGL----LLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  429 TALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISSTyHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGIVLQ 508
Cdd:COG2319   124 RSVAFSPDGK-TLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSP-------DGK------LLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  509 hnpWKLsgeafdinklmrDTNSIRYKLPVHTE----ISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIV 584
Cdd:COG2319   189 ---WDL------------ATGKLLRTLTGHTGavrsVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  585 WHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKVTSLAWSPhhDGR-LVSACYDGTA 663
Cdd:COG2319   254 FSPD-GRL------LASGSADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSP--DGKlLASGSDDGTV 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 564372055  664 QVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-407 2.12e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   57 VGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPTVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  137 YWLNRSDSQH-LFTEPRAIFCLTCSPHHEnLVAIGYKDGIVIIIDIsKKGEVVHRLRGHDDEIHSIAWCPLSGedclsin 215
Cdd:cd00200    78 WDLETGECVRtLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  216 qeensepdipngkliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLPflkrrSGGVdptvkerLWLTLHwPKNQp 295
Cdd:cd00200   149 ------------------------FVASSSQDGTIKLWDLRTGKCVATLTGH-----TGEV-------NSVAFS-PDGE- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  296 tQLVSSCFGGELLLWDLTQswrrkytlFSTSAEGHNHSRIVFNLCPLkteDGKQLLLSTSMDRDVKCWDMATLECCWTLP 375
Cdd:cd00200   191 -KLLSSSSDGTIKLWDLST--------GKCLGTLRGHENGVNSVAFS---PDGYLLASGSEDGTIRVWDLRTGECVQTLS 258

                         330       340       350
                  ....*....|....*....|....*....|..
gi 564372055  376 SLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200   259 GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-667 2.08e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  328 EGHNHSriVFNLCplkTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200     6 KGHTGG--VTCVA---FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  408 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPpQISSTYHKKTVYRLAWGPPvppmslg 487
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  488 gegdrpSLTLYSCGGEGIVlqhnpwKLsgeaFDINklmrdTNSIRYKLPVHTE----ISWKGDGKVMALGNEDGSIEIFQ 563
Cdd:cd00200   147 ------GTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  564 VPNLKLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKVTS 643
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 564372055  644 LAWSPhhDG-RLVSACYDGTAQVWD 667
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-479 1.20e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.66  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  154 IFCLTCSPHHENLVAIGYkDGIVIIIDIsKKGEVVHRLRGHDDEIHSIAWCPlsgedclsinqeensepdipngkliaet 233
Cdd:cd00200    12 VTCVAFSPDGKLLATGSG-DGTIKVWDL-ETGELLRTLKGHTGPVRDVAASA---------------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  234 pitKGCYLATGSKDQTIRIWSCSRGRGVMVLKlpflkrrsgGVDPTVkerlwLTLHWpkNQPTQLVSSCFG-GELLLWDL 312
Cdd:cd00200    62 ---DGTYLASGSSDKTIRLWDLETGECVRTLT---------GHTSYV-----SSVAF--SPDGRILSSSSRdKTIKVWDV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  313 TQSwRRKYTLfstsaEGHNHSriVFNLCPLKTedgKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVG 392
Cdd:cd00200   123 ETG-KCLTTL-----RGHTDW--VNSVAFSPD---GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  393 SLAIGVGDGMIRVWNTLSIKNnydVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQ-ISStyHKKT 471
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKC---LGTL-RGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQtLSG--HTNS 263


                  ....*...
gi 564372055  472 VYRLAWGP 479
Cdd:cd00200   264 VTSLAWSP 271
WD40 COG2319
WD40 repeat [General function prediction only];
55-367 6.16e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 6.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   55 RVVGELVGHTERVSGFTFSHHpGQYnLcATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPTVKDLIVSGDEKGVV 134
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPD-GKT-L-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  135 FcyWlNRSDSQHLFT---EPRAIFCLTCSPHHeNLVAIGYKDGIVIIIDIsKKGEVVHRLRGHDDEIHSIAWcplsgedc 211
Cdd:COG2319   188 L--W-DLATGKLLRTltgHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAF-------- 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  212 lsinqeenSepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLPFLKRR------------SGGVDPT 279
Cdd:COG2319   255 --------S----PDGR-----------LLASGSADGTVRLWDLATGELLRTLTGHSGGVNsvafspdgkllaSGSDDGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  280 VkeRLW----------LTLHW---------PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLFstsaeghNHSRIVFNLC 340
Cdd:COG2319   312 V--RLWdlatgkllrtLTGHTgavrsvafsPDGK--TLASGSDDGTVRLWDL-ATGELLRTLT-------GHTGAVTSVA 379

                         330       340
                  ....*....|....*....|....*..
gi 564372055  341 PlkTEDGKqLLLSTSMDRDVKCWDMAT 367
Cdd:COG2319   380 F--SPDGR-TLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 373-709 1.29e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 1.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  373 TLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTlsikNNYDVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGL 452
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL----ETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  453 YDTcsnKPPQISSTY--HKKTVYRLAWGPpvppmslggegDRPslTLYSCGGEG-IVLqhnpWKLsgeafdinklmrDTN 529
Cdd:cd00200    78 WDL---ETGECVRTLtgHTSYVSSVAFSP-----------DGR--ILSSSSRDKtIKV----WDV------------ETG 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  530 SIRYKLPVHTE----ISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHhehgsrPELSCLLASGSNN 605
Cdd:cd00200   126 KCLTTLRGHTDwvnsVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS------PDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  606 aVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKVTSLAWSPhhDGRLVSACY-DGTAQVWDALREEPLFNFRGHRGRL 684
Cdd:cd00200   200 -TIKLWDLST------------GKCLGTLRGHENGVNSVAFSP--DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSV 264

                         330       340
                  ....*....|....*....|....*
gi 564372055  685 LCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:cd00200   265 TSLAWSP-DGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-254 4.72e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 4.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   52 PPFRVVGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPTVKDLIVSGDEk 131
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  132 GVVFCYWLNRSDSQHLFTEPRAIFCLTCSPHHENLVAIGYKDGIVIIIDIsKKGEVVHRLRGHDDEIHSIAWCPlsgedc 211
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP------ 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 564372055  212 lsinqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:cd00200   272 -------------------------DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 468-716 2.01e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 2.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  468 HKKTVYRLAWGPPVPpmslggegdrpslTLYSCGGEGIVLQhnpWKLsgeafdinklmrDTNSIRYKLPVHTE----ISW 543
Cdd:cd00200     8 HTGGVTCVAFSPDGK-------------LLATGSGDGTIKV---WDL------------ETGELLRTLKGHTGpvrdVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  544 KGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNlkavlesnpes 623
Cdd:cd00200    60 SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-------ILSSSSRDKTIKVWD----------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  624 pITITEPYRTLSGHTAKVTSLAWSPHhDGRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADD 703
Cdd:cd00200   122 -VETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSD 198

                         250
                  ....*....|...
gi 564372055  704 FCVYRWLTSMQDH 716
Cdd:cd00200   199 GTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
546-709 2.35e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  546 DGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespi 625
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-------LLASASADGTVRLWDLAT---------- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  626 tiTEPYRTLSGHTAKVTSLAWSPhhDG-RLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDF 704
Cdd:COG2319   110 --GLLLRTLTGHTGAVRSVAFSP--DGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDG 184


                  ....*
gi 564372055  705 CVYRW 709
Cdd:COG2319   185 TVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 630-709 5.82e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  630 PYRTLSGHTAKVTSLAWSPHHDgRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPVDpECIYSGADDFCVYRW 709
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 4.88e-09

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 54.98  E-value: 4.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   117 WSPTvKDLIVSGDEKGVVfcyWLNRSDSQHLFT-----EPRAIFCLTCSPHhENLVAIGYKDGIVIIIDISkKGEVVHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWTlspdkEDLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 564372055   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 629-667 3.45e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 3.45e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564372055    629 EPYRTLSGHTAKVTSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 598-709 6.66e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 6.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  598 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKVTSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 677
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 564372055  678 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 709
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
629-667 2.32e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 2.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564372055   629 EPYRTLSGHTAKVTSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 539-585 4.75e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 46.12  E-value: 4.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 564372055   539 TEISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVW 585
Cdd:pfam12894   42 TSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 7.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 7.72e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564372055     53 PFRVVGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKIWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-254 4.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.10e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564372055    184 KGEVVHRLRGHDDEIHSIAWCPlsgedclsinqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-------------------------------DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
54-95 4.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 4.96e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564372055    54 FRVVGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWD 95
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG---KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 348-472 1.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  348 KQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWntlSIKNNYDVKNfwqgVKSK 427
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVSIGT----IKTK 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 564372055  428 VTALCWH-PNKEG-CLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTV 472
Cdd:PLN00181  618 ANICCVQfPSESGrSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 634-690 1.55e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564372055   634 LSGHTAKVTSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWS 690
Cdd:pfam12894   34 PDKEDLEVTSLAWRP--DGKlLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
COG3899 COG3899
Predicted ATPase [General function prediction only];
863-1180 2.72e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 45.62  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  863 DCLVLATATHARAELHED------VSADLEERFHLGLFTDRAALYRMMETEGKGHLESGHPELFHQLMLWKGDlkgvLQA 936
Cdd:COG3899   733 ELLPPDPEEEYRLALLLElaealyLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLGD----YEE 808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  937 AAERGELTDSLVAVAPVAGYSVWLWAVEAFAkqLCFQDQYVKAASYLLSIHRVYEAVELLRSNHLYREAIAVAKARLRPE 1016
Cdd:COG3899   809 AYEFGELALALAERLGDRRLEARALFNLGFI--LHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAAL 886

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1017 DPV---LKDLYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGESELAASLALRCAQEL 1093
Cdd:COG3899   887 AAAaaaAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAA 966

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1094 LLLKNWVGAQEALGLHESLQGQRLVFCLLELLCRHLEEKQPPEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPE 1173
Cdd:COG3899   967 AAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALL 1046


                  ....*..
gi 564372055 1174 QCRAALQ 1180
Cdd:COG3899  1047 AALAAAA 1053
COG3899 COG3899
Predicted ATPase [General function prediction only];
872-1232 5.87e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 44.46  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  872 HARAELHEDVSADLEERFHLGLFTDRAALYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 949
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  950 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHRVYEAVELLRSNHLYREAIAVAKARLRPEDPVLKdLYLSWGS 1029
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA-LALAAAA 964

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1030 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGESELAASLALRCAQELLLLKNWVGAQEALGLH 1109
Cdd:COG3899   965 AAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALA 1044

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055 1110 ESLQGQRLVFCLLELLCRHLEEKQPPEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCRAALQKLQDVKYPS 1189
Cdd:COG3899  1045 LLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALA 1124

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 564372055 1190 ATSNTPFRQLLLHVCHDLTLAMLSQQAASWEEAVPALLQAVVR 1232
Cdd:COG3899  1125 LAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALA 1167
PTZ00420 PTZ00420
coronin; Provisional
 593-675 1.22e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055  593 PELSCLLASGSNNAVIYVHNLKavleSNPESPITITEPYRTLSGHTAKVTSLAWSPHHDGRLVSACYDGTAQVWDALREE 672
Cdd:PTZ00420   84 PCFSEILASGSEDLTIRVWEIP----HNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159


                  ...
gi 564372055  673 PLF 675
Cdd:PTZ00420  160 RAF 162
PTZ00421 PTZ00421
coronin; Provisional
 59-118 1.22e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 1.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   59 ELVGHTERVSGFTFshHPGQYNLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWS 118
Cdd:PTZ00421  120 HLQGHTKKVGIVSF--HPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
WD40 pfam00400
WD domain, G-beta repeat;
185-254 1.76e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.76e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   185 GEVVHRLRGHDDEIHSIAWCPlsgedclsinqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-------------------------------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 672-709 1.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 564372055    672 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 394-478 2.83e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564372055   394 LAIGVGDGMI--------RVWnTLSIKNNydvknfwqgvKSKVTALCWHPNkEGCLAFGTDDGKVGLYDTcSNKPPQISS 465
Cdd:pfam12894   10 IALATEDGELllhrlnwqRVW-TLSPDKE----------DLEVTSLAWRPD-GKLLAVGYSDGTVRLLDA-ENGKIVHHF 76

                           90
                   ....*....|...
gi 564372055   466 TYHKKTVYRLAWG 478
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
672-709 8.51e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 8.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564372055   672 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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