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Conserved domains on  [gi|564378427|ref|XP_006249013|]
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SUN domain-containing protein 1 isoform X17 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 705-839 1.27e-56

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 190.19  E-value: 1.27e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  705 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPRDFAVYGLETEYQEEGQ 784
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564378427  785 PLGRFTYDQEGDSLQMFHTLERPDQGFQIVELRVLSNWGHPEYTCLYRFRVHGEP 839
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 93-343 4.05e-55

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 188.62  E-value: 4.05e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427   93 AYSSGDGQTVDTHISTSRATPAKGRETRTVKQ-RSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQrRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAVHGPTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  248 RPPHLGHCGRM--TAGELSRVDGeslcdllvralrrtraagwsvaeamwsvlwlavtapGKAASGTFWWLgsgwYQFVTL 325
Cdd:pfam09387 135 KNTYTLKCTSTkpAQGQSQRSNA------------------------------------GKAASEVFEWL----VQFVTL 174

                         250
                  ....*....|....*...
gi 564378427  326 ISWLNVFLLTRCLRNICK 343
Cdd:pfam09387 175 ESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 481-534 9.15e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


:

Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 94.65  E-value: 9.15e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564378427 481 PDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQP 534
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
CALCOCO1 super family cl37761
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 433-596 2.04e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


The actual alignment was detected with superfamily member pfam07888:

Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  433 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKDMvgqhlqEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKS 512
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEKYKEL------SASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  513 EAIQKELEETKLRA----GSRDEEQPLLDRVQ-HLELELNLLKSQLSDWQHLRSSCEQADA---RIQETV----QLMFSE 580
Cdd:pfam07888 146 LERETELERMKERAkkagAQRKEEEAERKQLQaKLQQTEEELRSLSKEFQELRNSLAQRDTqvlQLQDTIttltQKLTTA 225

                         170
                  ....*....|....*.
gi 564378427  581 DQPGGSLEWLLQKLSS 596
Cdd:pfam07888 226 HRKEAENEALLEELRS 241
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 705-839 1.27e-56

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 190.19  E-value: 1.27e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  705 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPRDFAVYGLETEYQEEGQ 784
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564378427  785 PLGRFTYDQEGDSLQMFHTLERPDQGFQIVELRVLSNWGHPEYTCLYRFRVHGEP 839
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 93-343 4.05e-55

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 188.62  E-value: 4.05e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427   93 AYSSGDGQTVDTHISTSRATPAKGRETRTVKQ-RSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQrRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAVHGPTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  248 RPPHLGHCGRM--TAGELSRVDGeslcdllvralrrtraagwsvaeamwsvlwlavtapGKAASGTFWWLgsgwYQFVTL 325
Cdd:pfam09387 135 KNTYTLKCTSTkpAQGQSQRSNA------------------------------------GKAASEVFEWL----VQFVTL 174

                         250
                  ....*....|....*...
gi 564378427  326 ISWLNVFLLTRCLRNICK 343
Cdd:pfam09387 175 ESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 481-534 9.15e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 94.65  E-value: 9.15e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564378427 481 PDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQP 534
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 433-596 2.04e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  433 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKDMvgqhlqEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKS 512
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEKYKEL------SASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  513 EAIQKELEETKLRA----GSRDEEQPLLDRVQ-HLELELNLLKSQLSDWQHLRSSCEQADA---RIQETV----QLMFSE 580
Cdd:pfam07888 146 LERETELERMKERAkkagAQRKEEEAERKQLQaKLQQTEEELRSLSKEFQELRNSLAQRDTqvlQLQDTIttltQKLTTA 225

                         170
                  ....*....|....*.
gi 564378427  581 DQPGGSLEWLLQKLSS 596
Cdd:pfam07888 226 HRKEAENEALLEELRS 241
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
433-582 7.63e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 7.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427 433 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKdmvGQHLQEigSIEPPDAKTDFLTLHHDHEVRL-SSLEDVLRKLTEK 511
Cdd:COG4717  101 EEELEELEAELEELREELEKLEKLLQLLPLYQE---LEALEA--ELAELPERLEELEERLEELRELeEELEELEAELAEL 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564378427 512 SEAIQKELEETKLRAgsRDEEQPLLDRVQHLELELNLLKSQLsdwQHLRSSCEQADARIQETVQLMFSEDQ 582
Cdd:COG4717  176 QEELEELLEQLSLAT--EEELQDLAEELEELQQRLAELEEEL---EEAQEELEELEEELEQLENELEAAAL 241
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 486-573 9.92e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 38.44  E-value: 9.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  486 DFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEetKLRAGSRDEEQPLLDR--VQHLELELNLLKSQLSDWQHLRSsc 563
Cdd:pfam12795  27 SLLDKIDASKQRAAAYQKALDDAPAELRELRQELA--ALQAKAEAAPKEILASlsLEELEQRLLQTSAQLQELQNQLA-- 102

                          90
                  ....*....|
gi 564378427  564 eQADARIQET 573
Cdd:pfam12795 103 -QLNSQLIEL 111
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 705-839 1.27e-56

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 190.19  E-value: 1.27e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  705 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPRDFAVYGLETEYQEEGQ 784
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564378427  785 PLGRFTYDQEGDSLQMFHTLERPDQGFQIVELRVLSNWGHPEYTCLYRFRVHGEP 839
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 93-343 4.05e-55

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 188.62  E-value: 4.05e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427   93 AYSSGDGQTVDTHISTSRATPAKGRETRTVKQ-RSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQrRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAVHGPTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  248 RPPHLGHCGRM--TAGELSRVDGeslcdllvralrrtraagwsvaeamwsvlwlavtapGKAASGTFWWLgsgwYQFVTL 325
Cdd:pfam09387 135 KNTYTLKCTSTkpAQGQSQRSNA------------------------------------GKAASEVFEWL----VQFVTL 174

                         250
                  ....*....|....*...
gi 564378427  326 ISWLNVFLLTRCLRNICK 343
Cdd:pfam09387 175 ESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 481-534 9.15e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 94.65  E-value: 9.15e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564378427 481 PDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQP 534
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
SUN_cc1 cd21435
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ...
 484-533 3.63e-10

coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410603 [Multi-domain]  Cd Length: 55  Bit Score: 56.26  E-value: 3.63e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 564378427 484 KTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQ 533
Cdd:cd21435    5 QESSVKELGRLEAQLASLRQELAALTLKQEAIQKELEQTKQKTISAVGEQ 54
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 433-596 2.04e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  433 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKDMvgqhlqEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKS 512
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEKYKEL------SASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  513 EAIQKELEETKLRA----GSRDEEQPLLDRVQ-HLELELNLLKSQLSDWQHLRSSCEQADA---RIQETV----QLMFSE 580
Cdd:pfam07888 146 LERETELERMKERAkkagAQRKEEEAERKQLQaKLQQTEEELRSLSKEFQELRNSLAQRDTqvlQLQDTIttltQKLTTA 225

                         170
                  ....*....|....*.
gi 564378427  581 DQPGGSLEWLLQKLSS 596
Cdd:pfam07888 226 HRKEAENEALLEELRS 241
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
433-582 7.63e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 7.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427 433 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKdmvGQHLQEigSIEPPDAKTDFLTLHHDHEVRL-SSLEDVLRKLTEK 511
Cdd:COG4717  101 EEELEELEAELEELREELEKLEKLLQLLPLYQE---LEALEA--ELAELPERLEELEERLEELRELeEELEELEAELAEL 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564378427 512 SEAIQKELEETKLRAgsRDEEQPLLDRVQHLELELNLLKSQLsdwQHLRSSCEQADARIQETVQLMFSEDQ 582
Cdd:COG4717  176 QEELEELLEQLSLAT--EEELQDLAEELEELQQRLAELEEEL---EEAQEELEELEEELEQLENELEAAAL 241
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
420-572 2.04e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  420 QKIASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGREGLS-----LWVKDMVGQHLQEIgsieppdaktdfltlhHDH 494
Cdd:COG4913   610 AKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlaeySWDEIDVASAEREI----------------AEL 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  495 EVRLSSLE---DVLRKLTEKSEAIQKELEETKLRAGSRDEEQPLLD-RVQHLELELNLLKSQLSDWQHLRSSC--EQADA 568
Cdd:COG4913   674 EAELERLDassDDLAALEEQLEELEAELEELEEELDELKGEIGRLEkELEQAEEELDELQDRLEAAEDLARLElrALLEE 753


                  ....
gi 564378427  569 RIQE 572
Cdd:COG4913   754 RFAA 757
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 486-573 9.92e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 38.44  E-value: 9.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378427  486 DFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEetKLRAGSRDEEQPLLDR--VQHLELELNLLKSQLSDWQHLRSsc 563
Cdd:pfam12795  27 SLLDKIDASKQRAAAYQKALDDAPAELRELRQELA--ALQAKAEAAPKEILASlsLEELEQRLLQTSAQLQELQNQLA-- 102

                          90
                  ....*....|
gi 564378427  564 eQADARIQET 573
Cdd:pfam12795 103 -QLNSQLIEL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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