NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564382146|ref|XP_006250479|]
View 

protein lin-9 homolog isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
215-488 7.35e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


:

Pssm-ID: 437270  Cd Length: 272  Bit Score: 489.47  E-value: 7.35e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  215 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPITDGDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 293
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  294 VTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 373
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  374 DQPTDMRRRCEEEAQEIVRQANSASGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKNTIDAS 453
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 564382146  454 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 488
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
74-179 5.46e-62

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


:

Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 5.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146   74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 152
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80
                          90       100
                  ....*....|....*....|....*...
gi 564382146  153 DVSQF-KDLPDEIPLPLVIGTKVTARLR 179
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
215-488 7.35e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


Pssm-ID: 437270  Cd Length: 272  Bit Score: 489.47  E-value: 7.35e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  215 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPITDGDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 293
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  294 VTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 373
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  374 DQPTDMRRRCEEEAQEIVRQANSASGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKNTIDAS 453
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 564382146  454 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 488
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
74-179 5.46e-62

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 5.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146   74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 152
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80
                          90       100
                  ....*....|....*....|....*...
gi 564382146  153 DVSQF-KDLPDEIPLPLVIGTKVTARLR 179
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
215-488 7.35e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


Pssm-ID: 437270  Cd Length: 272  Bit Score: 489.47  E-value: 7.35e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  215 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPITDGDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 293
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  294 VTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 373
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146  374 DQPTDMRRRCEEEAQEIVRQANSASGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKNTIDAS 453
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 564382146  454 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 488
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
74-179 5.46e-62

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 5.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382146   74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 152
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80
                          90       100
                  ....*....|....*....|....*...
gi 564382146  153 DVSQF-KDLPDEIPLPLVIGTKVTARLR 179
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH