|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-462 |
1.07e-155 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 447.45 E-value: 1.07e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 21 ALVMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAegpvmnllsnrsrGIKDFSTRAAVYQWSTETQGIIFSSISY 100
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 101 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSK 180
Cdd:cd17318 68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 181 LTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMiyddpmhhpcisvkekeyitssvaqqsssp 260
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL------------------------------ 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 261 rrsipikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRN 340
Cdd:cd17318 198 -----------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 341 LLSLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTA 420
Cdd:cd17318 267 ILSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 564391476 421 GIISSTTTGFLISQD-SESGWRNVFFLSAAVNMFGLIFYLIFG 462
Cdd:cd17318 347 GIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
1-477 |
2.21e-141 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 413.76 E-value: 2.21e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 1 MDEKPTTRKGSGFCSLRYALALVMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAEGPVmnllsnrsrgikdFSTR 80
Cdd:TIGR00894 1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 160
Cdd:TIGR00894 68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQA-LGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHP 239
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 240 CISVKEKEYITSSVAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPF 319
Cdd:TIGR00894 228 CISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPY 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 320 IAASSCTILGGQMADFLLSRNLLSLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTL 399
Cdd:TIGR00894 308 LFAWLCSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSL 387
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564391476 400 DVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYLIFGQAEIQNWAKERTLTR 477
Cdd:TIGR00894 388 DLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
20-462 |
1.10e-100 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 307.48 E-value: 1.10e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 20 LALVMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASAEGPVMNLLSNRSRgikdfSTRAAVYQWSTETQGIIFSSIS 99
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEH-----NETGKKYDWDAETQGWILGSFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 100 YGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERS 179
Cdd:cd17381 76 YGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 180 KLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpcisvkekeyitssvaqqsss 259
Cdd:cd17381 156 RLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV---------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 260 prrsipikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSR 339
Cdd:cd17381 208 -------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREK 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 340 NLLSLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLT 419
Cdd:cd17381 275 QNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATI 354
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 564391476 420 AGIISSTTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYLIFG 462
Cdd:cd17381 355 PGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
35-462 |
2.96e-74 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 238.39 E-value: 2.96e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 35 RVSLSIAIIAMVNSTQHQDPANASAEGPVMNllsnrsrgikdfstraavyqWSTETQGIIFSSISYGIILTLIPSGYLAG 114
Cdd:cd17382 15 RCNLGVAIVRMVNNFTDAYGGKVIVHKAEFN--------------------WTPETVGLIESSFFWGYLVTQIPGGFIAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 115 IFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSF 194
Cdd:cd17382 75 KFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 195 IILCVGGLISQALGWPFIFYIFGSIGCVCCVLWftmiyddpmhhpcisvkekeyitssvaqqsssprrsipikaMVRCLP 274
Cdd:cd17382 155 VGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-----------------------------------------MLVSMP 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 275 LWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLSLITVRKLFSSL 354
Cdd:cd17382 194 VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 355 GLLLPSLCAVALPFVTSSYIAtIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQ 434
Cdd:cd17382 274 GFGMEATFLLVVAFSHSPTVA-ISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKH 352
|
410 420
....*....|....*....|....*...
gi 564391476 435 DSESGWRNVFFLSAAVNMFGLIFYLIFG 462
Cdd:cd17382 353 KTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
81-462 |
4.83e-61 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 203.56 E-value: 4.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 160
Cdd:cd17380 26 AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpc 240
Cdd:cd17380 106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 241 isvkekeyitssvaqqsssprrsipikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLhVNIRDSGVLSSLPFI 320
Cdd:cd17380 177 --------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 321 AASSCTILGGQMADFLLSRNLlSLITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIpGTSNLCDSGFIINTLD 400
Cdd:cd17380 224 VMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVAL-GLSAFSSSGVLVNHQD 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564391476 401 VAPRYASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLIFG 462
Cdd:cd17380 302 IAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
84-462 |
5.68e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 117.28 E-value: 5.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWT 163
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 164 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFtmiyddpmhhpcisv 243
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF--------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 244 kekeyitssvaqqsssprrsipikamvrclplWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAAS 323
Cdd:COG2271 183 --------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 324 SCTILGGQMADFLLSRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAP 403
Cdd:COG2271 231 VGSLLGGWLSDRLGRRRKLVLAIG---------LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 404 -RYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIFG 462
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
85-460 |
6.75e-27 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 111.12 E-value: 6.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 85 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGMSWTG 164
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 165 QFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDdpmhhpcisvk 244
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 245 ekeyitssvaqqsssprrsipikamvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASS 324
Cdd:cd17319 181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 325 CTILGGQMADFLLSRNllslitvRKLFSSLGLLLPSLCAVALPFVTSSYIAtIVLLILIPGTSNLCDSGFIINTLDVAPR 404
Cdd:cd17319 231 GMILGGRLSDRLLRGA-------RRLVIIIGLLLAAVGLLLAYLTTSPVVA-VILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 564391476 405 -YASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLI 460
Cdd:cd17319 303 eAAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
81-459 |
2.77e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.27 E-value: 2.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGM 160
Cdd:cd06174 23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG--RFLLGLGSGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQAL--GWPFIFYIFGSIGCVCCVLWFTMIYDDPMHH 238
Cdd:cd06174 101 IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 239 pcisvkekeyitSSVAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLP 318
Cdd:cd06174 181 ------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 319 FIAASSCTILGGQMADFLLSRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINT 398
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIGRKPLLLIGL---------LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564391476 399 LDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQDseSGWRNVFFLSAAVNMFGLIFYL 459
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
84-425 |
4.73e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.02 E-value: 4.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMSWT 163
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 164 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPcisv 243
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 244 kekeyitssvAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYIsTVLHVNIRDSGVLSSLPFIAAS 323
Cdd:pfam07690 181 ----------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 324 SCTILGGQMADFLLSRNLLSLITVrklfsslgLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAP 403
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALL--------LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 564391476 404 -RYASFLMGISRGFGLTAGIISS 425
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
92-461 |
4.76e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.40 E-value: 4.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--LLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIyddpmhhpcisvkeKEYITS 251
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL--------------PEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 252 SVAQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQ 331
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 332 MADFLlsrnllslitVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYASFLMG 411
Cdd:cd17325 258 LSDRI----------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 564391476 412 ISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIF 461
Cdd:cd17325 328 LFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
81-461 |
1.47e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.24 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGM 160
Cdd:COG2223 32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLL--GLLLGIGGGG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPc 240
Cdd:COG2223 110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 241 isvkekeyitssvaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 320
Cdd:COG2223 189 ----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 321 AASSCTILGGQMADFLLSRNLLSLITVrklfsslgllLPSLCAVALPFVTSS-YIATIVLLILIPGTSNLCDSGFIINTL 399
Cdd:COG2223 253 LGALGRPLGGWLSDRIGGRRVLLIVFA----------LMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564391476 400 DVAPRYASFLMGISRGFGLTAGIISSTTTGFLIsqDSESGWRNVFFLSAAVNMFGLIFYLIF 461
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
81-342 |
2.29e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.18 E-value: 2.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGM 160
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL--LAARFLQGLGAGA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPmhhpc 240
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 241 isvkekeyitssvaqQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 320
Cdd:COG2814 190 ---------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL 254
|
250 260
....*....|....*....|..
gi 564391476 321 AASSCTILGGQMADFLLSRNLL 342
Cdd:COG2814 255 GGVLGALLAGRLADRFGRRRLL 276
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
92-433 |
2.61e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.42 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLERSKLTSIAGSGAAF-GSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHhPCISVKEKEYIT 250
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPNE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 251 SSVAQQSSSPRRSIPIKAMVRCL----PLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCT 326
Cdd:TIGR00881 190 EPDGDAEKKEEELTKKQIFLQYVllnkVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 327 ILGGQMADFLLSRNLLSLITVRKLFSSLGLllpslcAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYA 406
Cdd:TIGR00881 270 LLAGWLSDKLFNGRRGPLAVFFMALIIVSL------LVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKA 343
|
330 340
....*....|....*....|....*...
gi 564391476 407 SFLMGISRGF-GLTAGIISSTTTGFLIS 433
Cdd:TIGR00881 344 AGTAAGFVGFfAYLGGILAGLPLGYLAD 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
87-459 |
2.07e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.51 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQF 166
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--RALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 167 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCV-LWFTMIYDDPMHHPcisvke 245
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLPSLPPKKPG------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 246 keyITSSVAQQSSSPRRSIPIKAMVrclplwAIFMGFFSHFwlctIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSC 325
Cdd:cd17324 184 ---SLGLLSSLLLLLRNPRLRLAYL------ITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 326 TILGGQMADFLLSRNLLSLITVrklfsslglllPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRY 405
Cdd:cd17324 251 SPLAGRLADRGGRRALLIALLL-----------LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 564391476 406 ASFLMGISRGFGLTAGIISSTTTGFLISQDsesGWRNVFFLSAAVNMFGLIFYL 459
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHG---GWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
81-230 |
1.01e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 68.68 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGM 160
Cdd:COG0477 41 AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTM 230
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
84-460 |
8.61e-11 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 63.80 E-value: 8.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 84 YQWSTETQGIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLF--TPLAADFGVILVIVIRTVQGMAQG 159
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYGLSKFV--MGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 160 MSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALG---WPFIFYIFGSIGCVCCVLWFTMIYDDPM 236
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 237 HH--PCISV----KEKEYITSSVAQQSSSPRrsIPIKAMVRCLPLWAI-FMGFFSHFwLCTIIITYLPTYISTVLHVNIR 309
Cdd:cd17345 191 SEglPPIEEykgdYPEEADGEEEEQELSAWE--IFVKYVLKNKLLWYIaIANVFVYL-VRYGILDWAPTYLSEVKGFSKA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 310 DSGVLSSLPFIAASSCTILGGQMADFLL--SRNLLSLITVrklfsslglLLPSLCAVALPFVTSSYIATIVLLILipgts 387
Cdd:cd17345 268 QAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTGIIFM---------ILVIVALIVYWLAPNVLVDLIALIAL----- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 388 nlcdsGFII---------NTLDVAPRYASflmGISRGF-GLTAGIISST--TTGFLISQDSeSGWRNVFFLSAAVNMFGL 455
Cdd:cd17345 334 -----GFLIygpvmliglQALELVPKKAA---GTAAGLtGLFGYLGGSVlaTALIGIIVDH-FGWNGGFIVLLASCILAI 404
|
....*
gi 564391476 456 IFYLI 460
Cdd:cd17345 405 IFLAL 409
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-340 |
5.62e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.10 E-value: 5.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGM 160
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF--LVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 161 SWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLwFTMIYDDPMhhpc 240
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL-FWLFYREPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 241 isvkekeyITSSVAQQSSSPRRSipIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFI 320
Cdd:cd17475 176 --------AASAATESASTLLRS--LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQL 245
|
250 260
....*....|....*....|
gi 564391476 321 AASSCTILGGQMADFLLSRN 340
Cdd:cd17475 246 GGALGRIGLGRVSDRVFGGR 265
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
92-461 |
4.86e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 58.05 E-value: 4.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSWTGQFTIW 169
Cdd:cd17312 41 GIIGSafLIAYAVGKFI--SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG--LNGLFQSMGWPPCVKLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 170 AKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHhpcisvkekeyi 249
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 250 tssvaqqsssprrsipikamvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILG 329
Cdd:cd17312 185 -------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 330 GQMADFLLSRNllslitvRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGF-IINTLDVAPRYA-S 407
Cdd:cd17312 240 GLLSDKLFGGR-------RAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIgGAAAQDIGRKEAaG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 564391476 408 FLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVNMFGLIFYLIF 461
Cdd:cd17312 313 TATGFVGLFGYLGASLAGLPLGYIIDH---YGWSTVFYFLISAALLSVLLLLSL 363
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
92-226 |
8.37e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.19 E-value: 8.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVL--IIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 226
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
83-231 |
2.98e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 2.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 83 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSW 162
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--LLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564391476 163 TGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 231
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
76-238 |
1.26e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 53.92 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 76 DFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTV 153
Cdd:TIGR00711 31 DLGSSLSQVQWVI---------TSYMLANaISIPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL--ELMIIFRVI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 154 QGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGC-VCCVLWFTMIY 232
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVVVAFFILPR 179
|
....*.
gi 564391476 233 DDPMHH 238
Cdd:TIGR00711 180 DKPAAS 185
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
97-226 |
1.68e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 97 SISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAP 174
Cdd:cd17503 37 ITSYLLALaIMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--IIFRILQGFGGGVLIPLAQTILLRIYP 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 564391476 175 PLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 226
Cdd:cd17503 115 PEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
92-308 |
3.12e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.21 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVKekeyits 251
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAG------- 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 564391476 252 svaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFShfwlctiIITYLPTYISTVLHVNI 308
Cdd:cd17489 185 -----TRAFRRLVEKKVLPPALILFLASIAYGA-------ISTFLPLYAAERGISNA 229
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
96-346 |
1.63e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 50.33 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 96 SSISY-GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAP 174
Cdd:cd17327 47 NTVFYvGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGL--IALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 175 PLERSKLTSI----AGSGAAFGSFI------ILCVGGLisqaLGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVK 244
Cdd:cd17327 125 REEQAKRIAFfyaaAGLGSIFGGLLaygvfkILGVGGL----AGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 245 EKEYITSSVAQ-QSSSPRRSIPIKAMVRCLPLWAIFMGFFSHF--WLCT-IIITYLPTYISTVLHVNIrDSGVLSSLPFI 320
Cdd:cd17327 201 EKELAVERLRAnQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFcsQITNnGISNFLPLILKSLGFYSL-QTNLLSVPIGA 279
|
250 260
....*....|....*....|....*.
gi 564391476 321 AASSCTILGGQMADFLLSRNLLSLIT 346
Cdd:cd17327 280 LGAVSLLIAALLSDRFKKRGLFAIFA 305
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
106-226 |
2.02e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.57 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 106 LIPSGYLAGIFGAKQILGAGlliSSLLTLFTpLAADF--GVILVIVIRTVQGMAQGMSWTGQFTIWAK-WAPPLERSKLT 182
Cdd:cd17476 50 ILIFGRLGDIYGHKKMFVIG---SFWFAIWS-LIAGFspNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVF 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 564391476 183 SIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 226
Cdd:cd17476 126 SLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
106-226 |
3.39e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.09 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 106 LIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIA 185
Cdd:cd17321 48 LLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW 125
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 564391476 186 GSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL 226
Cdd:cd17321 126 GAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
81-231 |
3.41e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.10 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGA--KQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQ 158
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLF--LAGFGL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564391476 159 GMSWTGQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 231
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
92-345 |
4.62e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLfTPLAADfGVILVIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV-AGLFLD-SLYALLASRALLGIGVAGIMTLATALIGD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQaLGWPFIFYIFG-SIGCVCCVLWFtmiyddpmhhpcisVKEKEYIT 250
Cdd:cd17473 116 YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVLLF--------------LPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 251 SSVAQQSSSPRRSIPIKamvrclPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGG 330
Cdd:cd17473 181 KSAASPGAATAAALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFG 254
|
250
....*....|....*
gi 564391476 331 QMADFLLSRNLLSLI 345
Cdd:cd17473 255 RLKRRLGKRRLLAIG 269
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
82-461 |
1.02e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 82 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMS 161
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF--LLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 162 WTGQFTIwAKWAPPLERSKLTSIAGSGAAFGSFI-ILCVGGLISQALG--WPFIFYIFGSIGCVCCVLWFTMIYDDPMHH 238
Cdd:COG0738 114 DVAANPY-VAALGPETAASRLNLLHAFFSLGALLgPLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 239 PcisvkekeyitSSVAQQSSSPRRSIPIKAmvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLP 318
Cdd:COG0738 193 E-----------EEAAGSAASLKSLLKNPR------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 319 FIAASSCTILGGQMADFLLSRNLLSLITVrklfsslglllPSLCAVALPFVTSSYIATIVLLILIP-GTSNLCDSGFIIn 397
Cdd:COG0738 256 WGGMTIGRFLGGFLLKRFGPVRLLRLSAL-----------LAAVGLLLALLAPGPWLALIGLALVGlGLSLMFPTIFSL- 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564391476 398 TLDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAvnMFGLIFYLIF 461
Cdd:COG0738 324 ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLV--CYLLILLLAL 382
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-456 |
2.84e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQF 166
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 167 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLI----SQALGWpFIFYIFGSIGCVCCVLWFtmiyddpmhhpcis 242
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGW-RILFLIGALPALLALLLR-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 243 vkekeyitssvaqqsssprrsipiKAMVRCLPLWAIFMGFFshfwlcTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAA 322
Cdd:cd17316 177 ------------------------RRTLLLILLWFFISFGY------YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 323 SSCTILGGQMADFllsrnllslITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVA 402
Cdd:cd17316 227 LVGALIAGLLSDR---------IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 564391476 403 P-RYASFLMGISRGFGLTAGIISSTTTGFLISqdSESGWRNVFFLSAAVNMFGLI 456
Cdd:cd17316 298 PtEVRATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
87-344 |
3.36e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.20 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQF 166
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 167 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVccVLWFTMIY-------------- 232
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLMRFlpesidflvskrpe 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 233 ---------DDPMHHPCISVKEKEyitSSVAQQSSSPRRSIPIKAMVRCLP-LW-AIFMGFFSHFWLctiiITYLPTYIS 301
Cdd:TIGR00895 206 tvrrivnaiAPQMQAEAQSALPEQ---KSTQGTKRSVFKALFQGKTARITVlLWlLYFMLLVGVYFL----TNWLPKLMV 278
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 564391476 302 TVLHVNIRDSGVLSSLPFIAASSCtILGGQMADFLLSRNLLSL 344
Cdd:TIGR00895 279 ELGFSLSLAATGGALFNFGGVIGS-IIFGWLADRLGPRVTALL 320
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
92-217 |
6.92e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.95 E-value: 6.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQFTIWAK 171
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA--RLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFG 217
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGG 176
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
92-235 |
1.00e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 44.63 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDP 235
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-459 |
1.89e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.76 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 107 IPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAG 186
Cdd:cd17328 52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 187 SGAAFGSFIILCVGGLISQA-LGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCISVKEKEYITSSVAQqsssprrsip 265
Cdd:cd17328 130 FAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 266 IKAMVRCLPLWAIFMGFFshfwlCTIIITY-----LPTYISTVLHVNI----RDSGVLSSLPFIAASSCTILGGQMADFL 336
Cdd:cd17328 200 LKALAKNPSFILSTLGFT-----AVSFVTGalafwAPTFFLRAFGVGDlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 337 LSRNllslITVRKLFSSLGLLLPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTL--DVAPRYASFLMGISR 414
Cdd:cd17328 275 RRKT----PRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILlyVVIPTRRSTASAIQI 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 564391476 415 ---------GFGLTAGIISS-TTTGFLISQDSESGWRNVFFLSAAVNMFGLIFYL 459
Cdd:cd17328 351 llshllgdaGSPYLIGLISDlLRQNKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
92-230 |
2.14e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMSWTGQFTIWAK 171
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF--LLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 564391476 172 WAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTM 230
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
87-231 |
4.63e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.19 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQF 166
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--RFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564391476 167 TIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMI 231
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
110-215 |
5.34e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 110 GYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVilVIVIRTVQGMAQGMSWTGqFTIWAKWAPPLERSKLTSIAGSGA 189
Cdd:cd17504 52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--LIAGRALQGIGGAVFPLA-FALVREEFPPERVPVAQGILSATF 128
|
90 100
....*....|....*....|....*.
gi 564391476 190 AFGSFIILCVGGLISQALGWPFIFYI 215
Cdd:cd17504 129 GIGAGIGLPLGGWIVQHLGWRWIFWT 154
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
92-436 |
7.01e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLER-SKLTSIAGSGAAFGSFIIlcvGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPMHHPCisvkekeyit 250
Cdd:cd17333 114 EESSATRlNVLHGFFGLGALIGPLIA---TSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARN---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 251 ssvaQQSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGG 330
Cdd:cd17333 181 ----PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 331 QMADFLLSRNLLSLITVrklfsslglllpSLCAVALPFVTSSYIATIVLLILIPGT--SNLCDSGFIInTLDVAPRYASF 408
Cdd:cd17333 257 PISRRIKPHTLLVLSGS------------GALLGLLILLLAPTLVVGLVATALLGLfmAALFPTILSL-GISNLPYAKGK 323
|
330 340
....*....|....*....|....*...
gi 564391476 409 LMGISRGFGLTAGIISSTTTGFLISQDS 436
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
82-193 |
8.19e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 82 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMS 161
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF--LLGFGFGLL 313
|
90 100 110
....*....|....*....|....*....|..
gi 564391476 162 WTGQFTIWAKWAPPLERSKLTSIAGSGAAFGS 193
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
124-334 |
1.03e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 124 AGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAP-----PLERSKLTSIAGSGAAFGSFIILC 198
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 199 VGGLI------SQALGWPFIFYIFGSIGCVCCVLwftmiyddpmhhPCISVKEKEYitssVAQQSSSPRRSipIKAMVRC 272
Cdd:COG2211 166 LPPPLvaafggDAALGYRLTALIFAVLGLLAFLL------------TFFGTKERPV----PEEEKVSLKES--LKALLKN 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564391476 273 LPLWAIFMGFFShFWLCTIII-TYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMAD 334
Cdd:COG2211 228 RPFLLLLLAYLL-FFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK 289
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
87-224 |
1.27e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSisYGI--ILTLIPSGYLAGIFGA-KQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMsWT 163
Cdd:cd17490 29 SLSMIGIILGA--YGIsqMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPSPWGLLIA--RFLSGIAAAT-WV 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564391476 164 GQFTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVGGLISQALGWPFIFY---IFGSIGCVCC 224
Cdd:cd17490 104 SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLlaaLAGVLGFILS 167
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
85-300 |
1.56e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.75 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 85 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMSWTG 164
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGF--AALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 165 QFTIWAKWAPPLERSKLTSIAGSGAAFGSFII-LCVGGLISQALGWPFIFYIFGSIGCVCCVLWFTMIYDDPmhhpcisv 243
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGP-------- 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 564391476 244 kekeyitssvaqqSSSPRRSIPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYI 300
Cdd:cd06180 180 -------------SAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIA 223
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
87-461 |
2.04e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.33 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLA-ADFGVILVIVIRTVQGMAQGMSWTGQ 165
Cdd:pfam00083 44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkGKWSVYQLIVGRVLVGIGVGGASVLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 166 FTIWAKWAPPLERSKLTSIAGSGAAFGSFIILCVG---GLISQALGWPFIFY---IFGSIGCVCCVLW------------ 227
Cdd:pfam00083 124 PMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGlqlVPALLLIIGLLFLpesprwlvekgr 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 228 ---FTMIYDDPMHHPCISVKEKEYITSSVAQQSSSPRRSIPIKAMvrCLPLWAIFMGFFSHFW--LCTI-IITYLPTYIS 301
Cdd:pfam00083 204 leeAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFST--KTRRQRLLIGVMLQIFqqLTGInAIFYYSTTIF 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 302 TVLHVN--IRDSGVLSSLPFIAasscTILGGQMADFLLSRNLLSLITVrklfsSLGLLLPSLCAVALPFVTSSYIATIVL 379
Cdd:pfam00083 282 ENLGLSdsFLVTIIVGVVNFVF----TFIAIFLVDRFGRRPLLLLGAA-----GMAICFVILGIVALLGVSKSDWAGIVA 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 380 LILI--------PGTSNLCdsgFIINTLDVAPRYASFLMGISRGFGLTAGIISSTTTGFLISQdseSGWRNVFFLSAAVN 451
Cdd:pfam00083 353 IVFIalfiaffaMGWGPVP---WVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA---IGLGYTFFIFAGLL 426
|
410
....*....|
gi 564391476 452 MFGLIFYLIF 461
Cdd:pfam00083 427 VLFIIFVFFF 436
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
278-461 |
2.05e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 278 IFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFLLSRNLLSLITVrklfsslgll 357
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 358 lPSLCAVALPFVTSSYIATIVLLILIPGTSNLCDSGFIINTLDVAPRYA-SFLMGISRGFGLTAGIISSTTTGFLISQds 436
Cdd:pfam07690 71 -LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180
....*....|....*....|....*
gi 564391476 437 eSGWRNVFFLSAAVNMFGLIFYLIF 461
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
110-232 |
2.54e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 110 GYLAGIFGAKQILGAGL---LISSLLTLFTPlaadfGVILVIVIRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAG 186
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIvifELGSLLCGLAP-----NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIG 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 564391476 187 SGAAFGSFIILCVGGLISQALGWPFIFYIFGSIGCVCCVL----WFTMIY 232
Cdd:cd17502 126 AVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALlrtiLLSSIF 175
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
109-228 |
3.39e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.00 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 109 SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSG 188
Cdd:TIGR00898 147 FGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--RLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 564391476 189 AAFGSFIILCVGGLISQalgWPFIFYIFGSIGCVCCVLWF 228
Cdd:TIGR00898 225 FSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSW 261
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
92-461 |
3.84e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGMSWTGQFTIWAK 171
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLL--AGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 172 WAPPLERSK----LTSIAGSGAAFGSFIilcvGGLISqALGWPFIFYIFGSIGCVCCVLWFTMIYDdpmhhpcisvkeke 247
Cdd:cd17474 115 LFEGGERAKamglYEAALGLGIAVGPLL----GGLLA-AISWRYPFFLLAALIPVAFLAILFLLPE-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 248 yiTSSVAQQSSSPRRSIPIKAMvRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDSGVLSSLPFIA-ASSCT 326
Cdd:cd17474 176 --PKEKAKSSSATKLRDLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLlALGSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 327 ILGGQMADFLLSRNLLSLITVrklfsslgllLPSLCAVALPFVTSSYIATIVLLI--LIPGTSNLCDSGFIINTLDVAPR 404
Cdd:cd17474 253 FVGRLLKKRFGARRILVIGLL----------LYALSLLLLGFVPSLALLLIAIVLfgLGLGLNLPLLTTLVTELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 564391476 405 yaSFLMGISRGFGLTAGIISSTTTGFLIsqdSESGWRNVFFLSAAVNMFGLIFYLIF 461
Cdd:cd17474 323 --GTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
110-344 |
9.81e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 110 GYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMSWTGQFTIWAKWAPPLERSKLTSIAGSGA 189
Cdd:cd17371 55 GILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL--RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGW 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 190 AFGSFIILCVGGLI----SQALGWPFIFYiFGSIGCVccVLWFTMIYddpmhhpcisVKEKEYITSSVAQQSSSPRRSIP 265
Cdd:cd17371 133 AVGWLLATLLAALLfpllPPEIAWRVLFL-LGALPAL--LVLFIRRF----------VKEPPQWQAARAARRHFADRPSL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564391476 266 I----KAMVRCLPLWAIF-----MGFFShfwlctiIITYLPTYISTVLHVNIRDSGVLSSLPFIAASSCTILGGQMADFL 336
Cdd:cd17371 200 RelfsPPLLRTTLLASLLatgalGGYYG-------ITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI 272
|
....*...
gi 564391476 337 LSRNLLSL 344
Cdd:cd17371 273 GRRNNFAL 280
|
|
| |
