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Conserved domains on  [gi|564395684|ref|XP_006255625|]
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U3 small nucleolar RNA-associated protein 4 homolog isoform X1 [Rattus norvegicus]

Protein Classification

WD40 and YncE domain-containing protein( domain architecture ID 11455443)

WD40 and YncE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319  267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395684 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319  338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391  114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564395684 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391  188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319  267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395684 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319  338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  96 TLDAFGGPIWSMTASPSGsQLLVGC-EDGSVKLFEVTPDKIQFArnFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDV 173
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 174 KSGSitrkmvLDRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200  165 RTGK------CVATLTGHTGE---VNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564395684 253 VGTAEGTVFHFQLVSvtsnssekqWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200  236 SGSEDGTIRVWDLRT---------GECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391  114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564395684 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391  188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-590 6.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 445 FSEDSTKLFVASNQGSLHVIHLSEGSFkhLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPA 524
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564395684 525 YNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQYtewsrsVQKQGFHQLWlqrdtpITHISIHP 590
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------LTTLRGHTDW------VNSVAFSP 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 8.32e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  107 MTASPSGSQLLVGCEDGSVKLFEVTPDKIqFARNFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDVKSGSITRKmvLD 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHH--FS 77

                          90
                  ....*....|....*..
gi 564395684  186 RQHLGVTksrCIVWGVA 202
Cdd:pfam12894  78 AGSDLIT---CLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564395684    92 NIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 7.18e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILE 85
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  86 YDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSI 165
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 166 D-YISVFDVKSGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319  267 DgTVRLWDLATGELLRTL---TGHSGG------VNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395684 244 VADQEDSFVVGTAEGTVfhfQLVSVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319  338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  96 TLDAFGGPIWSMTASPSGsQLLVGC-EDGSVKLFEVTPDKIQFArnFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDV 173
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 174 KSGSitrkmvLDRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200  165 RTGK------CVATLTGHTGE---VNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564395684 253 VGTAEGTVFHFQLVSvtsnssekqWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200  236 SGSEDGTIRVWDLRT---------GECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
17-260 5.36e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 5.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRGTeALCWA-EGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVR-SVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQfaRNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVK 174
Cdd:COG2319  241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 175 SGSITrkmvldRQHLGVTKSrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319  319 TGKLL------RTLTGHTGA---VRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389


                 ....*..
gi 564395684 254 GTAEGTV 260
Cdd:COG2319  390 GSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
55-550 2.87e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 2.87e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  55 FPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDK 134
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 135 IqfARNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVKSGSITRkmVLDRQHLGVtksrcivWGVAFLSDG-TVISV 212
Cdd:COG2319  112 L--LRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLR--TLTGHSGAV-------TSVAFSPDGkLLASG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 213 DSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVfhfQLVSVTSNssekQWVRTkpFQHHTHDVRT 292
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLWDLATG----KLLRT--LTGHSGSVRS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 293 VAHSP--TALISGGTDthlvirplmekvevknydaalrkitfphrrliscskrrqlllfqfaHHLELWRLgstaATGKNG 370
Cdd:COG2319  252 VAFSPdgRLLASGSAD----------------------------------------------GTVRLWDL----ATGELL 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 371 DTLplsknadhllhlktKGPENIICSCVspcgswiaystasrfflyrlkyerdnislqrvsklpaflrsalhilFSEDST 450
Cdd:COG2319  282 RTL--------------TGHSGGVNSVA----------------------------------------------FSPDGK 301

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 451 KLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPAYNFPVT 530
Cdd:COG2319  302 LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                        490       500
                 ....*....|....*....|
gi 564395684 531 ALAIAPNTNNLVIAHSDQQV 550
Cdd:COG2319  377 SVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
16-513 2.50e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.50e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKY 95
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKiqFARNFDRQKSRILSLSWHPAGTHVAAGSIDY-ISVFDVK 174
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 175 SGSITRKMvldRQHLGVtksrciVWGVAFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319  193 TGKLLRTL---TGHTGA------VRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 254 GTAEGTVfhfQLVSVTSnsseKQWVRTkpFQHHTHDVRTVAHSP--TALISGGTDthlvirplmekvevknydaalrkit 331
Cdd:COG2319  264 GSADGTV---RLWDLAT----GELLRT--LTGHSGGVNSVAFSPdgKLLASGSDD------------------------- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 332 fphrrliscskrrqlllfqfaHHLELWRLgstaATGKNGDTLplsknadhllhlktKGPENIICSCVspcgswiaystas 411
Cdd:COG2319  310 ---------------------GTVRLWDL----ATGKLLRTL--------------TGHTGAVRSVA------------- 337

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 412 rfflyrlkyerdnislqrvsklpaflrsalhilFSEDSTKLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLA 491
Cdd:COG2319  338 ---------------------------------FSPDGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTS---VA 379

                        490       500
                 ....*....|....*....|..
gi 564395684 492 VSPDGNWLAASGTSAGVHIYDL 513
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
109-550 1.67e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 109 ASPSGSQLLVGCEDGSVKLFEVTPDkiQFARNFDRQKSRILSLSWHPAGTHVAAGSIDYISVFDVKSGSITRKMVLDRQH 188
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALG--ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 189 LgvtksrciVWGVAFLSDGTVI-SVDSVGKVQLWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVfhfQLVS 267
Cdd:COG2319   80 A--------VLSVAFSPDGRLLaSASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV---RLWD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 268 VTSnsseKQWVRTkpFQHHTHDVRTVAHSP--TALISGGTDthlvirplmekvevknydaalrkitfphrrliscskrrq 345
Cdd:COG2319  149 LAT----GKLLRT--LTGHSGAVTSVAFSPdgKLLASGSDD--------------------------------------- 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 346 lllfqfaHHLELWRLgstaATGKNGDTLplsknadhllhlktKGPENIICS-CVSPCGSWIAYSTASRF-FLYRLKyerd 423
Cdd:COG2319  184 -------GTVRLWDL----ATGKLLRTL--------------TGHTGAVRSvAFSPDGKLLASGSADGTvRLWDLA---- 234

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 424 niSLQRVSKLPAFLRSALHILFSEDSTKLFVASNQGSLHVIHLSEGsfKHLHTFQPQSGTVEAmclLAVSPDGNWLAASG 503
Cdd:COG2319  235 --TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNS---VAFSPDGKLLASGS 307

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 564395684 504 TSAGVHIYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQV 550
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-411 8.26e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 8.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQFarnfdRQKSRILSL---SWHPAGTHVAAGSIDY-ISVF 171
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----TLKGHTGPVrdvAASADGTYLASGSSDKtIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 172 DVKSGSITRKMVldrqhlGVTKSrciVWGVAFLSDGTVISVDSV-GKVQLWDSATGTLVKSHLIANADVQSIAVaDQEDS 250
Cdd:cd00200   79 DLETGECVRTLT------GHTSY---VSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 251 FVV-GTAEGTVFhfqLVSVTSNSSEKQwvrtkpFQHHTHDVRTVAHSPTA--LISGGTDTHLVIRPLMEKVEVKNYDAAL 327
Cdd:cd00200  149 FVAsSSQDGTIK---LWDLRTGKCVAT------LTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 328 RKITF----PHRRLISCSKRRQlllfqfahHLELWRLgstaATGKNGDTLPLSKNAdhllhlktkgpenIICSCVSPCGS 403
Cdd:cd00200  220 NGVNSvafsPDGYLLASGSEDG--------TIRVWDL----RTGECVQTLSGHTNS-------------VTSLAWSPDGK 274


                 ....*...
gi 564395684 404 WIAysTAS 411
Cdd:cd00200  275 RLA--SGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
8-131 3.47e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 3.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684   8 RVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRGTeALCW-AEGQRLFSAGLNGEILEY 86
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVR-SVAFsPDGKTLASGSDDGTVRLW 357

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564395684  87 DLQALNIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFEVT 131
Cdd:COG2319  358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-129 1.72e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRGTeALCWAEGQRLF-SAGLNGEILEYDLQALNIKY 95
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVN-SVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQ 255

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564395684  96 TLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:cd00200  256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
442-547 5.22e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 442 HILFSEDSTKLFVA-SNQGSLHVIHLSEGSFkhLHTFQPQSGTVEamclLAVSPDGNWLAASGTSAG-----VHIYDLHH 515
Cdd:COG3391  114 GLAVDPDGGRLYVAdSGNGRVSVIDTATGKV--VATIPVGAGPHG----IAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564395684 516 LKLHCTVPAYNFPVtALAIAPNTNNLVIAHSD 547
Cdd:COG3391  188 GKVVATIPVGGGPV-GVAVSPDGRRLYVANRG 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-590 6.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 445 FSEDSTKLFVASNQGSLHVIHLSEGSFkhLHTFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPA 524
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564395684 525 YNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQYtewsrsVQKQGFHQLWlqrdtpITHISIHP 590
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------LTTLRGHTDW------VNSVAFSP 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 8.32e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  107 MTASPSGSQLLVGCEDGSVKLFEVTPDKIqFARNFDRQKSRILSLSWHPAGTHVAAGSID-YISVFDVKSGSITRKmvLD 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHH--FS 77

                          90
                  ....*....|....*..
gi 564395684  186 RQHLGVTksrCIVWGVA 202
Cdd:pfam12894  78 AGSDLIT---CLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564395684    92 NIKYTLDAFGGPIWSMTASPSGSQLLVGCEDGSVKLFE 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
10-226 2.58e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  10 RFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRGTEALCWAEGQRLF-SAGLNGEILEYDL 88
Cdd:COG3391   18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684  89 QALNIKYTLDAFGGPiWSMTASPSGSQLLVGCEDGSvKLFEVTPDKIQFARNFDRQKSrILSLSWHPAGTHVAAGSID-- 166
Cdd:COG3391   98 ATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNG-RVSVIDTATGKVVATIPVGAG-PHGIAVDPDGKRLYVANSGsn 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395684 167 ----YISVFDVKSGSITRKMVLDRQhlgvtksrciVWGVAFLSDGTVI---------SVDSVGKVQLWDSATG 226
Cdd:COG3391  175 tvsvIVSVIDTATGKVVATIPVGGG----------PVGVAVSPDGRRLyvanrgsntSNGGSNTVSVIDLATL 237
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 387-511 3.37e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 387 TKGPENIICSCVSPCGSWIAYST--ASRFFLYRlkYERDNISLQRVSKLPAFLRSALhilFSEDSTKLFVASNQGS---L 461
Cdd:COG0823   27 TNSPGIDTSPAWSPDGRRIAFTSdrGGGPQIYV--VDADGGEPRRLTFGGGYNASPS---WSPDGKRLAFVSRSDGrfdI 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564395684 462 HVIHLSEGSFKHLhTFQPQSGtveamcllAVSPDGNWLA-ASGTSAGVHIY 511
Cdd:COG0823  102 YVLDLDGGAPRRL-TDGPGSP--------SWSPDGRRIVfSSDRGGRPDLY 143
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
 103-173 6.84e-03

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 39.49  E-value: 6.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564395684  103 PIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQFArnfdrqKSRILS--LSWHPAGTHVAAGSID-YISVFDV 173
Cdd:pfam11768 261 PVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLA------QAAVTPhlIRWHPAGAIILVCSAQgELQIFDM 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 490-559 7.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 7.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395684 490 LAVSPDGNWLAASGTSAGVHIYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQ 559
Cdd:cd00200   15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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