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Conserved domains on  [gi|564399804|ref|XP_006257226|]
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probable G-protein coupled receptor 174 isoform X1 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606879)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
20-303 1.45e-176

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 490.39  E-value: 1.45e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15152    1 FIYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTpgNRTKCFVDLPIRNVNL 179
Cdd:cd15152   81 VNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDT--NPTCCFADLPLRNVGL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15152  159 TTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15152  239 KIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
 
Name Accession Description Interval E-value
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
20-303 1.45e-176

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 490.39  E-value: 1.45e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15152    1 FIYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTpgNRTKCFVDLPIRNVNL 179
Cdd:cd15152   81 VNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDT--NPTCCFADLPLRNVGL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15152  159 TTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15152  239 KIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
36-292 1.09e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 145.52  E-value: 1.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804   36 GNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASIYFLVCIS 113
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  114 VRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLaqsVAMITIGEV 191
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEgNVTVCFIDFPEDLSKP---VSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  192 VGFITPLMIVLYCTWKTALSLQNKYPISQHLGE---KKKALRMILTCAAVFLICFAPYHFSFPLDFLvksneIKSCLARR 268
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERtqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSL-----ALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 564399804  269 VILIFHSVALCLASLNSCLDPVIY 292
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
20-318 1.89e-30

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 117.96  E-value: 1.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVvFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:PHA03087  41 TILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDI-YLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLacLLFPLLRTNDDTPGNRTK-CFVDLPIRNV 177
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTvKYGYIVSLVIWIISII--ETTPILFVYTTKKDHETLiCCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITigEVVGFITPLMIVLYCTWKTALSLQNkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:PHA03087 198 NWKLFINFEI--NIIGMLIPLTILLYCYSKILITLKG----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHI 271
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSRqelpdSIQLQTKS 318
Cdd:PHA03087 272 LHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK-----SLKLMFTS 327
 
Name Accession Description Interval E-value
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
20-303 1.45e-176

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 490.39  E-value: 1.45e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15152    1 FIYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTpgNRTKCFVDLPIRNVNL 179
Cdd:cd15152   81 VNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDT--NPTCCFADLPLRNVGL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15152  159 TTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15152  239 KIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
21-303 2.40e-109

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 319.82  E-value: 2.40e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15153    2 LYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTkCFVDLPIRNVNLA 180
Cdd:cd15153   82 NMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRS-CFADLGMKKLNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15153  161 AAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 261 IKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15153  241 ITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
22-303 3.53e-105

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 309.20  E-value: 3.53e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYV 100
Cdd:cd14982    3 FPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGgWWPFGDFLCRLTGLLFYI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQK-YDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirnVNL 179
Cdd:cd14982   83 NMYGSILFLTCISVDRYLAVVHPLKSRRLRRKrYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLS---EWL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd14982  160 ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14982  240 FIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
21-303 9.80e-54

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 177.81  E-value: 9.80e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15155    2 LYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLA 180
Cdd:cd15155   82 NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKTY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIgEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15155  162 LSKITIFI-EVVGFIIPLLLNLTCSSLVLRTLRKPATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 261 IKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15155  241 IANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
21-303 3.60e-52

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 173.78  E-value: 3.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKY 99
Cdd:cd15158    2 VYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKgQWLFGDFLCRISSYALY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLLFpLLRTNDDTPGNRTKCFvDLPIRNVN 178
Cdd:cd15158   82 VNLYCSIYFMTAMSFTRFLAIVFPVQnLNLVTVKKARIVCVGIWIFVTLTSSPF-LMSGSHDTETNKTKCF-EPPQSNQQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPLMIVLYCTWKTALSL-QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15158  160 LTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLlKNTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15158  240 SRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
24-300 1.51e-51

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 171.75  E-value: 1.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYlNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15165    5 VVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSS-KKQWPLGRTLCSFLESLYFVNMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLyisivgwLIICLACLLFPLLRTN-----DDTPGNRTKCFVDLPirnvN 178
Cdd:cd15165   84 GSILIIVCISVDRYIAIRHPFLAKRLRSPRKA-------AIVCLTIWVFVWAGSIpiysfHDKPTNNTRCFHGFS----N 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15165  153 KTWSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKN 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 259 NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15165  233 DIINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFR 274
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
21-303 1.86e-50

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 169.12  E-value: 1.86e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL--NHdWPFGPGLCMFCFYLK 98
Cdd:cd15161    2 LFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLsgNH-WPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLAclLFPLLRTNDDTPGNRTKCFVDLPIRNv 177
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKsMKIRKPLYAHVVCGFLWVIVTVA--MAPLLVSPQTVEVNNTTVCLQLYREK- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 nlAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15161  158 --ASRGALVSL--AVAFTIPFVTTVTCYLLIIRSLRTGKREEKPL--KDKAIKMIILVLTIFLICFVPYHISRYIYILSH 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15161  232 NGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
26-303 1.04e-49

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 167.17  E-value: 1.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPL-RIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd14985    7 YIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLwATYTANQYDWPFGAFLCKVSSYVISVNMFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPF---RFNDCKQKYdlYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLA 180
Cdd:cd14985   87 SIFLLTCMSVDRYLAIVHPVasrRLRRRRQAR--VTCALIWVVACLLSLPTFLLRSLQAIENlNKTACIMLYPHEAWHFG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITigevVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEK-KKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd14985  165 LSLELNI----LGFVLPLLIILTCYFHIARSLRKRYERTGKNGRKrRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14985  241 AIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
21-297 8.91e-48

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 162.33  E-value: 8.91e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLR-TNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15156   82 NMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAvWLTVLAGSLPASFFQsTNNQLNNNSETCFENFSSKTWK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIgEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15156  162 TYLSKIVIFI-EIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRT 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 259 NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTN 297
Cdd:cd15156  241 QTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSE 279
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
21-303 1.42e-47

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 161.90  E-value: 1.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKY 99
Cdd:cd15921    2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVlNSHWPFGDIACRIILYVLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRF-NDCKQKYDLYISIVGWLIICLACLLFpLLRTNDDTPGNRTKCFvDLPIRNVN 178
Cdd:cd15921   82 VNMYSSIYFLTALSVFRYLALVWPYLYlRVQTHSVAGIICGLIWILMGLASSPL-LFAKSKQHDEGSTRCL-ELAHDAVD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIgeVVGFITPLMIVLYCTWKTALS-LQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15921  160 KLLLINYVTL--PVGFVVPFMTVIFCYIFIIKNlLKPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15921  238 RQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
24-303 2.43e-47

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 161.33  E-value: 2.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNM 102
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACL-LFPLLRTNddTPGNRTKCFVDLPIRNVNLA 180
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRsLGKLKKRHAVAISVAVWILVLLQLLpILFFATTG--RKNNRTTCYDTTSPEELNDY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGevVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15168  163 VIYSMVLTG--LGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 261 IK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15168  241 GTaSCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
24-303 5.20e-46

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 157.55  E-value: 5.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNM 102
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLAC-LLFPLLRTNDDTPgNRTKCFVDLPI----RN 176
Cdd:cd15160   85 YASIGFLCCIAVDRYLAVVHPLRFRGLRTrRFALKVSASIWVLELGTHsVFLGHDELFRDEP-NHTLCYEKYPMegwqAS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSvamitigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15160  164 YNYARF--------LVGFLIPLSLILFFYRRVLRAVRQSPSLERE--EKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15160  234 ELVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
24-300 2.59e-45

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 155.69  E-value: 2.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIfYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPgnrtKCFvdlpiRNVNLAQS 182
Cdd:cd15923   84 VSIFTITAISVDRYVAIRYPLRARELRSpRKAAVVCAVIWVLVVTISIPYFLLDSSNEKT----MCF-----QRTKQTES 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNeiK 262
Cdd:cd15923  155 LKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKS--Y 232
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 564399804 263 SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15923  233 SCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
24-301 1.16e-44

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 154.14  E-value: 1.16e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15162    5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHgNNWIFGEALCRLVTVAFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQK-YDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLA 180
Cdd:cd15162   85 YCSILLLTCISIDRYLAIVHPMGHRRLRARrYALGTCLAIWLLALLVTLPLYLVKQTIFLPAlDITTCHDVLPEQLLVGD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGeVVGFITPLMIVLYC---TWKTALSLQNKYPISQhlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15162  165 WFYYFLSLA-IVGFLIPFILTASCyvaTIRTLAALEDENSEKK----KKRAIKLAATVLAIFIICFAPSNLLLLAHYSLI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 258 SNEIKSCLARRVILifhsvALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15162  240 SSSGTGHLYFAYLL-----ALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
26-303 4.86e-44

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 152.51  E-value: 4.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15159    7 YSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYaLGFDWPFGDWLCRLTALLFYINTYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRF-NDCKQKYDLYISIVGWLIICLacLLFPLL-RTNDDTPGNRTKCfVDLPirNVNLAQS 182
Cdd:cd15159   87 GVNFMTCLSVDRYIAVVHPLRRhRLRKVKVVRYICVFVWVLVFL--QTLPLLfMPMTKEMGGRITC-MEYP--NFEKIKR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGE-VVGFITPLMIVLYCTWKTALSL---QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFpLDFLVKS 258
Cdd:cd15159  162 LPLILLGAcVIGFGVPVGIILFCYSQITLKLcrtAKENPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNI-IQFMIRK 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 259 NEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15159  241 LLYQpSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
24-303 6.74e-44

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 152.23  E-value: 6.74e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15154    5 VGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLAQS 182
Cdd:cd15154   85 GSCLFLMCINVDRYLAIVHPLRFRHLRRpKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESFSDNDWKG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 V-AMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQhlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15154  165 LlPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQ--GRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRANLV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 262 K-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15154  243 EdTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
24-303 8.86e-43

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 149.13  E-value: 8.86e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15373    5 VSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADeNDWPFSEALCKIVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRF-NDCKQKYDLYISIVGWLII--CLACLLFpLLRTNDDtpGNRTKCFVDLPIRNVNl 179
Cdd:cd15373   85 YCSILFLLCISVHRFLGVCYPVRSlRWLKVRYARIVSVVVWVIVlaCQSPVLY-FVTTSDK--GGNITCHDTSSPELFD- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 aQSVAMITIGEVVGFITPLMIVLYCTWKTALSL-QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15373  161 -QFVVYSSVMLVLLFCVPFVVILVCYALMVRKLlKPSAGTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 259 NEIkSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15373  240 MDL-SCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
21-303 4.15e-42

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 147.55  E-value: 4.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKY 99
Cdd:cd15157    2 IYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLmGSHWVFGDIACRIMSYSLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLlfPLLRTNDDTPGNRTKCfvdLPIRNVN 178
Cdd:cd15157   82 VNMYCSIYFLTVLSIVRFLAIVHPFKlWKVTSIKYARILCAVIWIFVMAASS--PLLSKGTSKYNSQTKC---LDLHPSK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPL--MIVLYCTWKTALsLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15157  157 IDKLLILNYIVLVVGFILPFctLSICYILIIKAL-LKPRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHLMQ 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLARRVILIfhsvALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15157  236 WSEGQCNLRLHKAVVI----TLCLAAANSCLDPLLYYFAGENFKERL 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
36-292 1.09e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 145.52  E-value: 1.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804   36 GNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASIYFLVCIS 113
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  114 VRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLaqsVAMITIGEV 191
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEgNVTVCFIDFPEDLSKP---VSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  192 VGFITPLMIVLYCTWKTALSLQNKYPISQHLGE---KKKALRMILTCAAVFLICFAPYHFSFPLDFLvksneIKSCLARR 268
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERtqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSL-----ALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 564399804  269 VILIFHSVALCLASLNSCLDPVIY 292
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
21-303 1.78e-40

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 143.35  E-value: 1.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFyGYMKETKR---AVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFY 96
Cdd:cd15147    2 LFPIVYSIIFVLGLIANCYVLWVF-ARLYPSKKlneIKIFMVNLTIADLLFLITLPFWIVYYHNEgNWILPKFLCNVAGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLAC---LLFPLLRTNDDTPGNRTKCFVDL 172
Cdd:cd15147   81 LFFINTYCSVAFLGVISYNRYQAVTRPIKtAQSTTRKRGIIISVAIWVIIVASAsyfLFMDSTNTVKIDSGNFTRCFEGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 173 PIRNVNlaqSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKyPISQHL--GEKKKALRMILTCAAVFLICFAPYHF-S 249
Cdd:cd15147  161 EKDNSK---PVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQ-PVQGQRnaGVKRRALWMVCTVLAVFVICFVPHHVvQ 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 250 FPLDFLV-KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15147  237 GPWTLAVlQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
21-299 3.65e-39

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 139.32  E-value: 3.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIfYYLNHDWPFGPgLCMFCFYLKYV 100
Cdd:cd15164    2 IQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVL-YFLKHSWPDDE-LCLVLQSIYFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCK--QKYDLYISIVGWLIICLACLLFPLLRTNDdtpgnrTKCFV-DLPIRNV 177
Cdd:cd15164   80 NRYMSIYIITAIAVDRYIAIKYPLKAKSLRspRKAALTCGLLWVLVIISVSLRLAWEEQEE------NFCFGkTSTRPSK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLaqsvamiTIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHlGEK--KKALRMILTCAAVFLICFAPYHFSFPLDFL 255
Cdd:cd15164  154 RT-------LIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPH-EEKliQKAIYIVSANLIVFIVCFLPLHIGLLVRFV 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 256 VKSNEIkSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEF 299
Cdd:cd15164  226 MESNKA-SCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
16-302 8.21e-39

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 139.51  E-value: 8.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  16 DFRYFIYAVTYTVILVPGLIGNILALW-VFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFY-YLNHDWPFGPGLCMF 93
Cdd:cd15190    7 KPSYALIPVIYMLVFVLGLSGNGLVLWtVFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYtALGYHWPFGSFLCKL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  94 CFYLKYVNMYASIYFLVCISVRRFWFLMYPfrFNDCKQKYD---LYISIVGWLIICLACLLFPLLR-TNDDTPGNRTKCF 169
Cdd:cd15190   87 SSYLVFVNMYASVFCLTGLSFDRYLAIVRS--LASAKLRSRtsgIVALGVIWLLAALLALPALILRtTSDLEGTNKVICD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 170 VD---LPIRNVNLAQSVAMITIGEVVGFITPL--MIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFA 244
Cdd:cd15190  165 MDysgVVSNESEWAWIAGLGLSSTVLGFLLPFliMLTCYFFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWL 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 245 PYHFSFPLDFLVKSNEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15190  245 PFHLVKTLYALMYLGILPfSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
24-303 3.27e-38

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 137.24  E-value: 3.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNM 102
Cdd:cd15374    5 VSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNhWPFGVVACKIVRFLFYANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLaCLLFPLLRTNDDTPGNRTKCFVDlpIRNVNLAQ 181
Cdd:cd15374   85 YCSILFLTCISVHRYVGICHPIRaLRWVKPRHAYLICASVWLVVTV-CLVPNLIFVTTSRKDNITLCHDT--TRPEEFDH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSL-QNKYPISQHLGE--KKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15374  162 YVHYSSAVMVLLFGIPCLVIVVCYGLMARRLcKPRVGSSRQQGPssKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 259 NEIKsCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15374  242 LKAD-CDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
24-300 4.57e-38

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 136.85  E-value: 4.57e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACL-LFPLLRTNDDTPGNRTKCFVDLPIRNVNLAQ 181
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIWLLILLVTIpLYLVKQTVFIPALDITTCHDVLPEQLLVGDM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15370  165 FNYFLSLA-IGVFLFPAFLTAVAYVLMIRALKSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQG 243
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 262 KSCLarrviLIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15370  244 QSSV-----YAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
22-295 3.30e-36

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 131.64  E-value: 3.30e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLfPLLRTNDDTPGNRTKCFVDLPIRNVNL 179
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALiWLLSLLLALP-PLLGWGVYDYGGYCCCCLCWPDLTLSK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMItigeVVGFITPLMIVLYCTWKTALSL----------QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFS 249
Cdd:cd00637  160 AYTIFLF----VLLFLLPLLVIIVCYVRIFRKLrrhrrrirssSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFIL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 250 FPLDFLVKSNeiksclaRRVILIFHSVALCLASLNSCLDPVIYYFT 295
Cdd:cd00637  236 LLLDVFGPDP-------SPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
21-303 4.04e-36

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 131.81  E-value: 4.04e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKY 99
Cdd:cd15368    2 ILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQrNHWIFGKPLCNVVTVLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLAclLFPLLRTN---DDTPGNRTKCFvDLPIR 175
Cdd:cd15368   82 ANMYSSILTMTCISIERYLGVVYPMRSMRWrKKRYAVAACIGMWLLVLTA--LSPLERTDltyYVKELNITTCF-DVLKW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NV--NLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypiSQHLG--EKKKALRMILTCAAVFLICFAPYhfsfp 251
Cdd:cd15368  159 TMlpNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQT---SERYGreQKRRAIYLALIVLLVFITCFAPN----- 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 252 lDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15368  231 -NFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
19-303 5.38e-36

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 131.57  E-value: 5.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  19 YFIYAVtYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYL 97
Cdd:cd15377    1 YYLPAV-YILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKtDWIFGDAMCKLQRFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRN 176
Cdd:cd15377   80 FHVNLYGSILFLTCISVHRYTGVVHPLKsLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIgeVVGFITPLMIVLYC---TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLD 253
Cdd:cd15377  160 LRSYFIYSMCTT--VAMFCVPFILILGCyglIVRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLN 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 254 FLVKSN--EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15377  238 LRARLDfqTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
26-302 1.10e-35

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 130.67  E-value: 1.10e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15968    7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15968   87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFPHYVPYG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITigEVVGFITPLMIVLYCTWKTALSL--QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIK 262
Cdd:cd15968  167 MAL--TVSGFLLPFSIILWCYCLVVRTLcrTLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGV 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 564399804 263 SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15968  245 PCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
24-303 1.59e-35

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 130.26  E-value: 1.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYsYGYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLlfPLLRTNDDTPGNR---TKCFVDLPiRNVNL 179
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSL--PTFYFRDTYYIEElgvNACIMAFP-NEKYA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15191  162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMG 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15191  242 VINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
31-301 1.05e-34

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 127.86  E-value: 1.05e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  31 VPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASIYFL 109
Cdd:cd15201   12 VLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGkHWKFGDIPCRIVLFMLAMNRAGSIFFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 110 VCISVRRFWFLMYPF-RFNDCKQKYDLYISIVGWLIICLAClLFPLLRTNDDTPGNRTKC--FVDLPIRNVNLAQSVAMI 186
Cdd:cd15201   92 TAVAVDRYFRVVHPHhRINSISVRKAAIIACGLWLLTIAMT-VYLLTKKHLFPRGNATQCesFNICTGTDSSSNWHEAMF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 187 tigeVVGFITPLMIVLYCTWKTALSLQNKyPISQHlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLA 266
Cdd:cd15201  171 ----LLEFFLPLAIILYCSVRIIWQLRGR-QLDRH-AKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNEDCQY 244
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 564399804 267 -RRVILIFHsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15201  245 yRSVDLAFY-ITISFTYFNSMLDPVVYYFSSPSFKN 279
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
24-303 3.97e-34

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 126.64  E-value: 3.97e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFND----CKQKydlYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirNVNL 179
Cdd:cd14970   85 TSIFCLTVMSVDRYLAVVHPVKSLRfrtpRKAK---LVSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQWP--DPPD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPIS-QHLGEKKKAL----RMILTCAAVFLICFAPYHFsfpldF 254
Cdd:cd14970  160 YWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLStSGAREKRRARrkvtRLVLVVVAVFVVCWLPFHV-----F 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 255 LVKSNEIKSCLARRVILIFHsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14970  235 QIVRLLIDPPETLTVVGVFL-FCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
26-303 4.87e-34

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 126.02  E-value: 4.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFygyMKETKR--AVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15372    7 YTLVFLVGLPANGLALWVL---ATQVKRlpSTIFLINLAVADLLLILVLPFKISYHfLGNNWPFGEGLCRVVTAFFYGNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCK-QKYDLYISIVGWLIICLACLLFPLLR-TNDDTPGNRTKCFVDLPiRNVNLA 180
Cdd:cd15372   84 YCSVLLLMCISLDRYLAVVHPFFARTLRsRRFALCMCTAIWLIAAALTLPLTLQRqSYPLERLNITLCHDVLP-LDEQDT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGEVVGFITPLMIVLYC---TWKTALSLQNKYpisqhlgekKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15372  163 YLFYYFACLAVLGFLLPLVVILFCygsVLHTLLRSGQRY---------GHAMKLTVLVLVSFVLCFTPSNLLLLLHYSDP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEiksclARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15372  234 TLD-----DGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-302 5.71e-34

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 126.04  E-value: 5.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15189    9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQK-YDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRrYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDlNITACVLLYPHEAWHFAHIVL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MitigEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEK-KKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKS 263
Cdd:cd15189  169 L----NIVGFLLPLLVITFCNYNILQALRTREESTRCEDRNdSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDE 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 264 CLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15189  245 CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
24-303 1.15e-33

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 125.02  E-value: 1.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHdWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG-WVFGSFLCKLVSALYTINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFpLLRTNDDTPGNRTKCFVDLPiRNVNLAQS 182
Cdd:cd14984   84 SGILFLACISIDRYLAIVHAvSALRARTLLHGKLTCLGVWALALLLSLPE-FIFSQVSEENGSSICSYDYP-EDTATTWK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYC---TWKTALSLQNKypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd14984  162 TLLRLLQNILGFLLPLLVMLFCysrIIRTLLRARNH--------KKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLG 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 260 EIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14984  234 IISrSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
26-294 2.15e-33

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 124.52  E-value: 2.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15366    7 YIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDnWIHGPESCKLFGFIFYTNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWlIICLACLLFPLLRTN-DDTPGNRTKCFVDLPirnvnLAQS 182
Cdd:cd15366   87 SIAFLCCISVDRYLAVAHPLRFAKVRRvKTAVAVSAVVW-AIEIGANSAPLFHDElFRDRYNHTFCFEKYP-----MEDW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEV-VGFITPLMIVLYCTWKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15366  161 VAWMNLYRVfVGFLFPWVLMLFSYRGILRAVRGNVSTEQQ--EKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGKP 238
                        250       260       270
                 ....*....|....*....|....*....|...
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYF 294
Cdd:cd15366  239 CDCGFEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
24-303 3.58e-33

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 124.10  E-value: 3.58e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNM 102
Cdd:cd16001    5 VTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDrWPFGDFLCKLVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLAcLLFPLLRTNDDTPGNRTKCFvDLPIRNvNLAQ 181
Cdd:cd16001   85 YGSILFLTCISVHRFLGVCYPIRsLAYRTRRLAVIGSAATWILVVLQ-LLPTLVYARTGSINNRTVCY-DLTSPD-NFGN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGE-KKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd16001  162 YFPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAaRAKSIRTILLVCGLFALCFVPFHITRTIYLFVRVYL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 261 IKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd16001  242 VQDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
26-302 3.85e-33

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 124.22  E-value: 3.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15379    7 YSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDyWPFGDFTCRLVRFQFYTNLHG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCK--QKYDLYISIVGWLIICLACL-LFPLLRTNddTPGNRTKCFvDL--PIRNVNL 179
Cdd:cd15379   87 SILFLTCISVQRYLGICHPLASWHKKkgKKLTWLVCGAVWLVVIAQCLpTFVFASTG--TQRNRTVCY-DLspPARSTAY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIgevVGFITPLMIVL--YCTWKTALSLQNKY-PISQHLGEKK-KALRMILTCAAVFLICFAPYHFSFPLDFL 255
Cdd:cd15379  164 FPYGITLTR---TGFLLPFAARLacYCSMATILCRVVIAvAVVAAPGEKRgKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 256 VKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15379  241 VRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
21-303 3.87e-33

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 123.57  E-value: 3.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMiNLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKY 99
Cdd:cd14974    2 VSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFL-NLALADFLFCLFLPFLIVYIAmGHHWPFGSVLCKLNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd14974   81 LNMFASVFLLTAISLDRCLLVLHPvWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDLR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISqhlgeKKKALRMILTCAAVFLICFAPYHFSFPLDfLVKS 258
Cdd:cd14974  161 RSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAK-----SSKPLRVLLAVVVAFFLCWLPYHVFALLE-LVAA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 259 NEIKSclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14974  235 AGLPE-----VVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
24-301 3.96e-33

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 123.76  E-value: 3.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYylnHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY---QNTAGPLSFCKIVGAFFYLNMY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPF-RFNDCKQKYDLYISIVGWLIIcLACLLFPLLRTNDDTPGNRtKCFvdlPIRNVNLaqS 182
Cdd:cd15920   82 ASILFLSLISLDRYLKIIKPLqQFKIHTVPWSSAASGGVWLLL-LACMIPFLFESRNEGPCDN-KCF---HFRSKGL--T 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMIL---TCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15920  155 AGGINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIktfIVLAIFIVCFVPYHIVRVPYVLAQID 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15920  235 VISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
24-303 1.53e-32

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 122.15  E-value: 1.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTaMEYHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIS-IVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLA 180
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTcIVIWLLAGVASLPAIIHRDVFFIENtNITVCAFHYPSQNSTLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 qsVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15192  165 --VGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 261 IKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15192  243 IQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
28-302 3.31e-32

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 121.41  E-value: 3.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRpACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEyNITACVLDYPSEGWHVALNIL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MitigEVVGFITPLMIVLYCTWKTALSLQ-NKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKS 263
Cdd:cd15381  169 L----NVVGFLIPLSIITFCSTQIIQVLRnNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISG 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 264 CLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15381  245 CRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
26-303 4.06e-32

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 120.95  E-value: 4.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCM---FCFYLkyvN 101
Cdd:cd15967    7 YILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLkGRKWIFGQVFCKitrFCFNL---N 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACL--LFpLLRTNDDTpgnrTKCFVDLPIRNVn 178
Cdd:cd15967   84 LYGSIGFLTCISVYRYLAIVHPMRvMGRITTTHSVVISALVWLLVVIQSLpdLF-FSKTNSNG----TKCFDTTFNDYL- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 laQSVAMITIG-EVVGFITPLMIVLYCTWKTALSLQNKYPISQHLgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15967  158 --ESYLTYSLGwTVTGFVIPLLIILGCYGHVVVVLCRNNNVDKGL--KQRCLKLVIILIVLFSVCYIPYHVFRNLNLLSR 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 258 --SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15967  234 ilQKQGSCTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
30-303 1.27e-31

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 119.86  E-value: 1.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  30 LVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNMYASIYF 108
Cdd:cd14991   11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRSASIAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 109 LVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLacLLFPLLRTNDDTP-GNRTKCfvdLPIRNVNlAQSVAMI 186
Cdd:cd14991   91 LTAVALDRYFKVVHPhHRVNRMSVKAAAGVAGLLWALVLL--LTLPLLLSTLLTVnSNKSSC---HSFSSYT-KPSLSIR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 187 --TIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGeKKKALRMILTCAAVFLICFAPyHFSFPLDFLVKSNEIKSC 264
Cdd:cd14991  165 whNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQAR-VQRAIRLVFLVVIVFVLCFLP-SIIAGLLALVFKNLGSCR 242
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 265 LARRVILIFHsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14991  243 CLNSVAQLFH-ISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
23-303 1.19e-30

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 116.99  E-value: 1.19e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFyGYMKETKRAV-VFMINLAIADLLQILSLPLRIFYYLNHdWPFGPGLCMFCFYLKYVN 101
Cdd:cd15178    4 CVIYVLVFLLSLPGNSLVVLVI-LYNRRSRSSTdVYLLHLAIADLLFALTLPFWAVSVVKG-WIFGTFMCKLVSLLQEAN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTP-GNRTKCFVDLpiRNVNLA 180
Cdd:cd15178   82 FYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPnSGRTVCYENL--GNESAD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 Q-SVAMITIGEVVGFITPLMIVLYCTWKTALSLqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15178  160 KwRVVLRILRHTLGFLLPLVVMLFCYGFTIKTL-----LQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTK 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 260 EIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15178  235 LITeTCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
28-302 1.83e-30

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 116.82  E-value: 1.83e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPlriFYYLN----HDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15380    9 AICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLP---FWAENirnqFNWPFGNFLCRVISGVIKANLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPF-----RFNDCKQKYDLYISIVGWLiicLACLLFpLLRTNDDTPG-NRTKCFVDLPIRNV 177
Cdd:cd15380   86 ISIFLVVAISQDRYRTLVHTMtsrrqRSRRQAQVICLLIWVFGGL---LSIPTF-LFRSVKHVPDlNISACILLFPHEAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMitigEVVGFITPLMIVLYCTWKTALSLQNKYPIS-QHLGEKK--KALRMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15380  162 HFARRVEL----NIVGFLLPLAAIVFFNFHIIASLRERTEESrKRCGGLKdtKATRLILTLVLMFLVCWTPYHFFAFLDF 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 255 LVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15380  238 LFQVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
20-318 1.89e-30

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 117.96  E-value: 1.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVvFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:PHA03087  41 TILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDI-YLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLacLLFPLLRTNDDTPGNRTK-CFVDLPIRNV 177
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTvKYGYIVSLVIWIISII--ETTPILFVYTTKKDHETLiCCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITigEVVGFITPLMIVLYCTWKTALSLQNkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:PHA03087 198 NWKLFINFEI--NIIGMLIPLTILLYCYSKILITLKG----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHI 271
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSRqelpdSIQLQTKS 318
Cdd:PHA03087 272 LHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK-----SLKLMFTS 327
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
21-303 2.30e-30

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 116.93  E-value: 2.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLvSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTPGNRTK------CFVDL 172
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAiWVIAIIIMLPLLVVYELEEIISSEPGtitiyiCTEDW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 173 PIRNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSL-----------QNKYPISQHLGEKKKALRMILTCAAVFLI 241
Cdd:cd14993  162 PSPELRKAYNVALF----VVLYVLPLLIISVAYSLIGRRLwrrkppgdrgsANSTSSRRILRSKKKVARMLIVVVVLFAL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 242 CFAPYHFsfpLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14993  238 SWLPYYV---LSILLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
24-303 4.80e-30

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 115.56  E-value: 4.80e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLnHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV-HGWIFGTGLCKLAGAVFKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIvgwLIICLACLLFPL-----LRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15180   84 CGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSC---LIVWLFCLLLSIpdfifLEATKDPRQNKTECVHNFPQSDTY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITigEVVGFITPLMIVLYCTWKTALSLQnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15180  161 WWLALRLLY--HIVGFLLPLAVMVYCYTSILLRLL----RSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 259 NEI-KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15180  235 SVLdRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
21-296 1.77e-29

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 114.09  E-value: 1.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKY 99
Cdd:cd15367    2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDnWTYSELLCKICGILLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI---- 174
Cdd:cd15367   82 ENIYISIGFLCCISVDRYLAVVHPFRFHAFRTmKAATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCFEHYPIkawe 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSvamitigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKalRMILTCAAVFLICFAPYHfsfpLDF 254
Cdd:cd15367  162 HNINYYRF--------YAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIK--RLVLSTVVIFLVCFGPYH----ILL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 255 LVKSNEIKSC-LARRVILIFHsVALCLASLNSCLDPVIYYFTT 296
Cdd:cd15367  228 LVRSVFERDCnFAEGIFNYYH-FSLLLTSFNCVADPVLYCFAS 269
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
26-303 1.00e-28

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 112.17  E-value: 1.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15369    7 YTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSgNDWLFGEAMCRVVTAAFYCNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTPG-NRTKCFvDLPIRNVNLAQS 182
Cdd:cd15369   87 SILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAiWLLSIAGVVPLLLSEQTIQIPDlGITTCH-DVLNEQLLMGYY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHlGEKKKALRMILTCAAVFLICFAP------YHFSfpldFLV 256
Cdd:cd15369  166 VYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANS-SKKTRALFMAVAVFCVFVICFGPtnvlllAHYV----RFA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLARRVilifhsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15369  241 YTSTNDASYFAYL------LCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
24-301 1.03e-28

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 112.09  E-value: 1.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNM 102
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGEsWIFGEFMCKFIRFIFHFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLACLLFPLLRTNDDTpGNRTKCfVDLPiRNVNLAQ 181
Cdd:cd15375   85 YGSILFLTCFSIFRYVVIVHPLRAFQVqKRRWAIVACAVVWVISLAEVSPMTFLITTKEK-NNRTIC-LDFT-SSDNLNT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQnKYPISQhLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15375  162 IWWYNWILTVLGFLLPLVIVTLCYTRIIYTLA-KGPHTG-SASKQKARRLIILILLVFYVCFLPFHILRVVRIETRLPPV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 564399804 262 KSCLARRVILIFhSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15375  240 SCCLKHQVHAIY-IITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
23-301 2.45e-28

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 110.94  E-value: 2.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVN 101
Cdd:cd15148    4 AVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNqWTLGPLLCKVVGNLFYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFR---FNDCKQKydLYISIVGWLIICLACLLFPLLRTNDdtpGNRTKCFvdlPIRNVN 178
Cdd:cd15148   84 MYISIILLGFISLDRYLKINRSSRrqkFLTRKWS--IVACGVLWAVALVGFVPMIVLTEKN---EESTKCF---QYKDRK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPLMIVLYCTWKTA---LSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFsFPLDFL 255
Cdd:cd15148  156 NAKGKAIFNFLIVAMFWLVFLLLILSYGKIAkklLRISRDKPDFPNAAKYNRTARKSFFVLFIFTVCFVPYHA-FRIFYI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 256 VKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15148  235 TSQLQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
24-303 3.38e-28

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 110.64  E-value: 3.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15364    5 VVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNnHKWPWGSLACKITGYIFFCNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKydlYISIVGWLIICLACLL--FPLLRTNDDTPGNRTKCF----VDLPIRN 176
Cdd:cd15364   85 YISILLLCCISIDRFVAVVYALESRGRRRQ---RIAAFISFLIFIVVGLvhSPVFIMREGQTEGSHTCFetlqMDTQVAG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSvamitigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTcaAVFLICFAPYHfsfpLDFLV 256
Cdd:cd15364  162 FYYARF--------CIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVI--VIFLICFAPYH----LVLLV 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 257 KS-----NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15364  228 RAiafslYPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
26-303 3.75e-28

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 110.58  E-value: 3.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILalwVFYGY---MKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15378    7 YSIEFVLGFIGNTI---VILGYifcLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLACL-LFPLLrtNDDTPGNRTKC--FVDLPIRNVN 178
Cdd:cd15378   84 YSSILFLTFISIDRYLLIKYPFREHILqKKRSAVAISLAIWVLVTLELLpILTFI--GPNLKDNVTKCkdYASSGDATNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15378  162 LIYSLFLT----VTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 259 NEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15378  238 DSIGvSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
23-303 4.57e-28

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 110.67  E-value: 4.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVV--FMINLAIADLLQILSLPL-RIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd14976    4 SVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSESnkFVFNLALTDLIFVLTLPFwAVEYALDFVWPFGTAMCKVVRYVTK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFL---MYPFRFNDCKQKYDLYISIvgWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPiRN 176
Cdd:cd14976   84 LNMYSSIFFLTALSVTRYIAVaraLKHGWIRKAFGAFATTIAI--WAAAALAAIPEAIFSTDTWSSVNHTLCLLRFP-KN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIGE----VVGFITPLMIVLYCTWKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHFSFPL 252
Cdd:cd14976  161 SSVTRWYNWLGMYQlqkvVLGFFLPLGIITLSYLLLLRFLQRKRGGSKR--RKSRVTKSVFIVVLSFFICWLPNQALSLW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 253 DFLVKSNEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14976  239 SALIKFDDVPfSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
27-301 9.57e-28

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 109.42  E-value: 9.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15922    8 SLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFsLGSHWPFGQFLCQLKVFLLSTHMYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLM-YPFRFNDCKQKYDLYISIVGWLIICLACL-LFPLLRTNDDtpGNRTKCfvdLPIRNVNLAQSV 183
Cdd:cd15922   88 IYFLMLISIHRYVTVVhYNWKSLWKKKSFMKKLCLGVWLLLFVQGLpFFFVLKTSVI--DGKTKC---LSIHQSELSLLY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 184 AMITIGEVV-GFITPLMIVLYCTWKTALSLQNKYPISQH-LGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15922  163 FVWNFVLLIlGFLLPFGVSLTCYALLGASIAKMNSNNARgRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15922  243 ESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
20-296 1.40e-27

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 108.71  E-value: 1.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLK 98
Cdd:cd15365    1 YLFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDnWTLSGFVCIFSAFLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIIclaCLLFPLLRTNDDTPGNRTK---CFVDLPI 174
Cdd:cd15365   81 YTNFYTSTALLTCIALDRYLAVVHPLKFMHLrTIRTALSVSVAIWLLE---ICFNAVILTWEDSFHESSShtlCYDKFPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIgevvGFITPLMIVLYCTWKTALSLQ-NKYPISQhlgEKKKALRMILTCAAVFLICFAPYHFSFpld 253
Cdd:cd15365  158 EDWQARLNLFRICL----GYLLPLLIILFCYWKIYQAVRsNQATEDQ---EKKKIFKLLLLITVTFVICFTPYHVVL--- 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 254 FLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTT 296
Cdd:cd15365  228 LIRSIVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-302 1.93e-27

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 108.32  E-value: 1.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFmINLAIADLLQILSLPLRIFY-YLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15115    5 VVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWF-LNLAVADLLCCLSLPFSIAHlLLNGHWPYGRFLCKLLPSIIVLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTpGNRTKCFVDLpirnvnlaq 181
Cdd:cd15115   84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCiWILALLLCLPVFIYRTTVTD-GNHTRCGYDF--------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQNkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFsFPLDFLVKSNEI 261
Cdd:cd15115  154 LVAITITRAVFGFLLPLLIIAACYSFIAFRMQR----GRFAKSQSKTFRVIIAVVVAFFVCWAPYHI-IGILSLYGDPPL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 262 KSCLARrviliFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15115  229 SKVLMS-----WDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
24-300 6.15e-27

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 107.15  E-value: 6.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYlNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15172    5 VIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYE-AHQWIFGNFSCKLLRGIYAINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMY---PFRFNDCKQKYDLYISIVGWLI-ICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNL 179
Cdd:cd15172   84 SGMLLLACISVDRYIAIVQatkSFRLRSRTLAYSKLICAAVWLLaILISLPTFIFSEVYDFGLEEQYVCEPKYPKNSTAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHlgekkKALRMILTCAAVFLICFAPYHFSFPLDFLVKsN 259
Cdd:cd15172  164 MWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRH-----KAVRVVVAVVLVFLVCQVPYNIVLLIEAINL-G 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15172  238 EQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
24-302 1.24e-26

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 106.37  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPL-RIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFwAASTALGGQWLFGEGLCKLSSFIIAVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLM-----YPFRFNDCKQKYDLYISIVGwLIICLACLLFPLLRTNDDTpgnrtkcfVDLPIRNV 177
Cdd:cd15193   85 CSSILFLTGMSVDRYLAVVklldsRPLRTRRCALITCCIIWAVS-LVLGIPSLVYRNLINESVC--------VEDSSSRF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgevvGFITPLMIVLYCTWKTALSLQNKYPISQHLGEK-KKALRMILTCAAVFLICFAPYH-FSFPLDFL 255
Cdd:cd15193  156 FQGISLATLFL----TFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRrRNSLRIVFAIVTAFVLSWLPFNtLKAVRLLL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 256 VKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15193  232 ELGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-303 1.74e-26

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 105.95  E-value: 1.74e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMiNLAIADLLQILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15114    5 VLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFL-NLAVADLLCCLSLPILAVpIAQDGHWPFGAAACKLLPSLILLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI-SIVGWLiicLACLL----FPLLRTNDDTPGNRTKCFVDLpirNV 177
Cdd:cd15114   84 YASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIaCGAAWL---LALLLtvpsFIYRRIHQEHFPEKTVCVVDY---GG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQnkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFsfpLDFLVK 257
Cdd:cd15114  158 STGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTW-----SRRRQKSRRTLKVVTAVVVGFFLCWTPYHV---VGLIIA 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEIKSCLARRVILIfHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15114  230 ASAPNSRLLANALKA-DPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
21-301 2.50e-26

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 104.95  E-value: 2.50e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLvALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFND--CKQKYDLYISIVgWLI-ICLACLLFPLLRTNDDTPGNRTKCFvdlpirn 176
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQlmTKKRALIMIAAV-WVYsLLISLPPLVGWRDETQPSVVDCECE------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 vnLAQSVAMITIGEVVGFITPLMIVLYCTWKTalslqnkYPISQHlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLv 256
Cdd:cd14967  153 --FTPNKIYVLVSSVISFFIPLLIMIVLYARI-------FRVARR---ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF- 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 257 ksneiksCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14967  220 -------CPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
21-303 5.47e-26

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 104.84  E-value: 5.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFyylnHDWPFGPG-----LCMFCF 95
Cdd:cd15924    2 LFPVLYTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMILTFPFKIL----SDAGLGPWqlrtfVCRVTS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  96 YLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI 174
Cdd:cd15924   77 VLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSvSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIGEvvgFITPLMIVLYCTWKTALSLQNKYPISQHLGE--KKKALRMILTCAAVFLICFAPYHFSFPL 252
Cdd:cd15924  157 LGLKWHEIVNYICQVI---FWIVFLLMIVCYTAITKKVYRSYRRVFRSSSsrRKKSNVKIFIIVAVFFVCFVPYHFARIP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 DFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15924  234 YTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
24-303 1.09e-25

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 104.07  E-value: 1.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMiNLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15116    5 VIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFL-NLAVADFLFTFFLPFSIAYTaMDFHWPFGRFMCKLNSFLLFLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLI-ICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLA 180
Cdd:cd15116   84 FTSVFLLTVISIDRCISVVFPvWSQNHRSVRLASLVSLAVWVVaFFLSSPSFIFRDTAPSQNNNKIICFNNFSLSGDNSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSV---------AMITIGEVVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYHFsfp 251
Cdd:cd15116  164 PEVnqlrnmrhqVMTITRFLLGFLIPFTIIICCYAAIVLKLKR-----NRLAKSSKPFKIIAAVIVTFFLCWAPYHI--- 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 252 LDFLVKSNEIKSclaRRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15116  236 LNLLEMEATRSP---ASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
20-301 1.74e-25

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 103.27  E-value: 1.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAV--VFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKRRSTtnVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDlyiSIVGWLIICLACLLF--PLLRTND----DTPGNRTKCFV 170
Cdd:cd15098   81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRN---ALLGVLVIWVLSLAMasPVAVHQDlvhhWTASNQTFCWE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPirnvNLAQSVAMITIGEVVGFITPLMIVLYCTWKT--ALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15098  158 NWP----EKQQKPVYVVCTFVFGYLLPLLLITFCYAKVlnHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHI 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 249 --------SFPLDflvksneiksclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15098  234 ihlwvefgDFPLT--------------QASFVLRITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
23-303 2.65e-25

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 102.90  E-value: 2.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd14999    3 GTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLI---ICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNL 179
Cdd:cd14999   83 HASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGVIWLLsllLTLPMAIMIRLVTVEDKSGGSKRICLPTWSEESYK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 aqsvAMITIGEVVGFITPLMIVLYC-------TWKTALSLQNKypiSQHLGEKKKALRMILTCAAVFLICFAPyhfsFPL 252
Cdd:cd14999  163 ----VYLTLLFSTSIVIPGLVIGYLyirlarkYWLSQAAASNS---SRKRLPKQKVLKMIFTIVLVFWACFLP----FWI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 DFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14999  232 WQLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
21-303 7.39e-25

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 101.37  E-value: 7.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKY 99
Cdd:cd15088    2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAiDGQWYFGEVMCKIITALDA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15088   82 NNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGlWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDDL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIgevvGFITPLMIVLYCTWKTALSLQNKY-PISQHLGEK--KKALRMILTCAAVFLICFAPYHFSfpldFL 255
Cdd:cd15088  162 YWFTIYHFIL----GFAVPLVVITVCYILILHRLARGVaPGNQSHGSSrtKRVTKMVILIVVVFIVCWLPFHVV----QL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 256 VKSNEIKSCLARRVILIFhsvALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15088  234 VNLAMNRPTLAFEVAYFL---SICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
24-300 9.29e-25

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 101.36  E-value: 9.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPlriFYYLN--HDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLP---FWAADavNGWVLGTAMCKITSALYTMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKqKYDLYISIVGWLI---ICLACLLFPLLRTNDDtpgnRTKCFVDLPIRNVN 178
Cdd:cd15176   82 FSCGMQFLACISVDRYVAITKATSRQFTG-KHCWIVCLCVWLLailLSIPDLVFSTVRENSD----RYRCLPVFPPSLVT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQsvAMITIGEVV-GFITPLMIVLYCTWKTALSLqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHF-SFPLDFLV 256
Cdd:cd15176  157 SAK--ATIQILEVLlGFVLPFLVMVFCYSRVARAL-----SRTPNVKKSRALKVLLAVVGVFIVTQLPYNVvKFYRAIDV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 257 KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15176  230 IYLLITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
26-295 1.30e-24

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 100.64  E-value: 1.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVvFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15371    7 YIIVVVLGVPSNAIILWMLFFRLRSVCTAI-FYANLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNLAQS 182
Cdd:cd15371   86 SILLLTCISINRYLAIVHPFIYRSLpKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKElNITTCHDVLPECEQNSNFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLqNKYPISQHLGEKKKALRMIltcaaVFLICFAPYHFsfpldFLVKSNEIK 262
Cdd:cd15371  166 FYYFISMAVFGFLIPLVITIFCYISIIRTL-NAYEHKWFWYVKITALVLI-----IFTICFAPSNV-----ILIIHHFNY 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 564399804 263 SCLARRVILIFHSVALCLASLNSCLDPVIYYFT 295
Cdd:cd15371  235 YYFNNDNLYSIYLIALCLGSLNSCLDPFLYFLM 267
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
26-305 2.34e-24

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 100.20  E-value: 2.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMK-ETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd14983    7 YVLTILLGLPSNLLALYAFVNRARlRLTPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDT------PGNRTKCFVDLPIRNV 177
Cdd:cd14983   87 STCFLTAISAGRYLGVAFPIKYQLYKKpLYSCLVCVAIWALVIFHVTLVFILETSGGTldintpVGNSSTCYENFTPEQL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITigEVVGFITPLMIVLYCTWKTALSLqnkypISQHLGE--KKKALRMILTCAAVFLICFAPYHFSFPLDFL 255
Cdd:cd14983  167 ALLAPVRLEL--SLVLFFLPLAITAFCYVRCIRIL-----VRSRLHErrKRRAVRVAVSTLLTFVVCFGPYNISHVVGFV 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 256 VKSNeiksclarrviLIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSR 305
Cdd:cd14983  240 RHES-----------VWWRKLALLTSTCNAFLDPLIFYFLSSSMERGFVH 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
21-301 3.31e-24

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 99.81  E-value: 3.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd14992    2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLmALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLaCLLFP-LLRTNDDTPGNRTKCFVD----LPI 174
Cdd:cd14992   82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSL-LLAIPqLYYATTEVLFSVKNQEKIfccqIPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIgEVVGFITPLMIVLYC-------TW-KTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd14992  161 VDNKTYEKVYFLLI-FVVIFVLPLIVMTLAyarisreLWfRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPF 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 247 HFSFPLDFLVKSNEIKsclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14992  240 HLFFLLRDFFPLIMKE-----KHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
26-303 5.82e-24

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 99.06  E-value: 5.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPlriFYYLN--HDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15174    7 YWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLP---FWATAasSGWVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLL-FP-LLRTNDDTPGNRTKCFVDLPIrNVNLAQ 181
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFVWLLSTILsLPeILFSQSKEEESVTTCTMVYPS-NESNRF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYC-TWKTALSLQNKYpisqhlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN- 259
Cdd:cd15174  163 KVAVLALKVTVGFFLPFVVMVICyTLIIHTLLQAKR------FQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNi 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15174  237 TITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
24-300 9.13e-24

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 97.94  E-value: 9.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYlnhdwpFGPGLCMFCFYLK----Y 99
Cdd:cd15163    5 VINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMY------YSAGNCLTCSFVHifsyF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLacLLFPLLRTNDDTPgnrtkcfvdlpirnvn 178
Cdd:cd15163   79 VNMYCSILFLTCICVDRYLAIVQVEASRRWRNpNYAKGICVFIWLFAIV--VTFSILTTAIKFA---------------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 lAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFlvks 258
Cdd:cd15163  141 -SCCLSKLFALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAVA---- 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 259 neIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15163  216 --FNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
26-292 1.31e-23

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 98.23  E-value: 1.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFY-GYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15376    7 LGVEFLVAVLGNGLALWLFVtRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYpPKNWRFGEAACKLERFLFTCNLY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGW-LIICLAC--LLFPLLRTNddtPGNRTKC--FVDLPIRNV 177
Cdd:cd15376   87 GSIFFITCISLNRYLGIVHPfFTRSHVRPKHAKLVSLAVWlLVAALSApvLSFSHLEVE---RHNKTEClgTAVDSRLPT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMIVLYCTWkTALSLQNKYPIsqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15376  164 YLPYSLFLAVVGCGLPFLLTLASYLAIVW-AVLRSPGITTL-----EKRKVAALVAVVVALYAVSFVPYHILRNLNLYRR 237
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 564399804 258 SNEIKSCLARRVILIFHsVALCLASLNSCLDPVIY 292
Cdd:cd15376  238 LQWLKAAASLRIYFAYQ-VTKGLVTLNMCIHPLLY 271
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
21-301 2.49e-23

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 97.33  E-value: 2.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15091    2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDL-YISIVGWLI-----ICLACLLFPLLRTNDDTpgnrTKCFVDLPI 174
Cdd:cd15091   82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAkIINICIWLLsssvgISAIVLGGTKVREDVDS----TECSLQFPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIGeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLgEKKKAL----RMILTCAAVFLICFAPYHFSF 250
Cdd:cd15091  158 DDYSWWDTFMKICVF-IFAFVIPVLIIIVCYTLMILRLKSVRLLSGSR-EKDRNLrritRLVLVVVAVFVVCWTPIHIFI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 251 PLDFLVKSNEIKSCLARRVILIfhsvalCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15091  236 LVEALGSVSHSTAAVSSYYFCI------ALGYTNSSLNPILYAFLDENFKR 280
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
20-303 4.07e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 96.89  E-value: 4.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWlIICLACLLFPLLRTNDDTP-GNRTKCFVDLPIRNV 177
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIW-LYGLFWALPPLFGWSSYVPeGGGTSCSVDWYSKDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 N-LAQSVAMItigeVVGFITPLMIVLYCTW----------KTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd14969  160 NsLSYIVSLF----VFCFFLPLAIIIFCYYkiyrtlrkmsKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPY 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 247 HFsFPLDFLVKSNEIKSclarrviLIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14969  236 AV-VSLYVSFGGESTIP-------PLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
24-301 4.23e-23

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 96.98  E-value: 4.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLfVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLlfPLLRT-----NDDTPGNRTKCFVdlpirN 176
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGiWIVILVANI--PVLFLhgvvsYGFSSEAYSYCTF-----L 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIG-EVVGFITPLMI--VLYCT-----WKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15096  158 TEVGTAAQTFFTSfFLFSYLIPLTLicVLYMLmlrrlRRQKSPGGRRSAESQR--GKRRVTRLVVVVVVVFAICWLPIHI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 SFPLDFLVKsneIKSCLARRVILIfhsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15096  236 ILLLKYYGV---LPETVLYVVIQI---LSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
26-301 4.68e-23

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 96.56  E-value: 4.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15089    7 YSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQKYDL-YISIVGWL---IICLACLLFPLLRTNDDtpgNRTKCFVDLPIRNVnLAQ 181
Cdd:cd15089   87 IFTLTMMSVDRYIAVCHPVKALDFRTPAKAkLINICIWVlssGVGVPIMVMAVTKTPRD---GAVVCMLQFPSPSW-YWD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLgEKKKAL----RMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15089  163 TVTKICVF-IFAFVVPILVITVCYGLMILRLRSVRLLSGSK-EKDRNLrritRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNeiksclaRRVILIFHSVALCLA--SLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15089  241 ID-------RRNPLVVAALHLCIAlgYANSSLNPVLYAFLDENFKR 279
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
20-301 5.20e-23

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 96.90  E-value: 5.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRfNDCKQKYDLYISIVGWLIICLACLlfPLLR-------TNDDTPGNRTKCFVD 171
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTR-PRMSKRHALLIIALIWILSLLLSL--PLAIfqelsdvPIEILPYCGYFCTES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPIRNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLG------------EKKKALRMILTCAAVF 239
Cdd:cd15203  158 WPSSSSRLIYTISVL----VLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRtlssrrrrselrRKRRTNRLLIAMVVVF 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 240 LICFAPYH-FSFPLDFLVKSNEIKsclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15203  234 AVCWLPLNlFNLLRDFEPLPQIDG-----RHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
24-303 5.23e-23

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 96.38  E-value: 5.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd14988    5 ILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLeVMLDYTWLWGSFLCKFTHYFYFANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFndcKQKYDLYISIVGWLIICLACLLFPLLRT--NDDTPGNRTKCFVDLPIRNVN-L 179
Cdd:cd14988   85 YSSIFFLTCLSVDRYLTLTSSSPF---WQQHQHRIRRALCAGIWVLSAIIPLPEVvhMQLLDGVEPMCLFLAPFETYDeW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQnkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd14988  162 ALAVSLLTL--IIGFLIPFSIIAVFNVLTARYIR-----TAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSH 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14988  235 ISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
21-303 6.26e-23

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 96.39  E-value: 6.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKY 99
Cdd:cd15151    2 VFPVLYTVLFLVGLILNSVAAWIFF-HIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGlGPWQLRAFVCRFSAVVFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPF-RFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCfvDLPIRNVN 178
Cdd:cd15151   81 ITMYISIILLGLISFDRYLKIVRPFgKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKKC--ASLKSPLG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFIT-PLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15151  159 LKWHEVVNYICQFIFWGVfALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 258 SNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15151  239 TGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
21-303 6.58e-23

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 96.50  E-value: 6.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAV-VFMINLAIADLLQILSLPL-RIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15926    2 IISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSInLFVTSLAVTDFQFVLTLPFwAVENALDFTWLFGKAMCKIVSYVT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDL-YISIVGWLIICLACLLFPLLRTNdDTPGNRTKCFVDLPIRNV 177
Cdd:cd15926   82 AMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAkWLCVLIWVLAILASLPNAIFSTT-ATVSNEELCLVKFPDNRG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEV-VGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15926  161 NAQFWLGLYHAQKVlLGFLIPLGIISLCYLLLVRFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 257 KSNEIKSCLARRVILIF-HSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15926  241 KLNVVHFSYEYFTTQVYiFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
33-300 7.20e-23

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 96.01  E-value: 7.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  33 GLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYASIYFLVC 111
Cdd:cd15199   14 GLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNrWSLGGGTCKALLFMLSLSRGVSIAFLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 112 ISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIicLACLLFPLLRTNDdtPGNRTKCFVDLPIRNVNLAqsvamITIGE 190
Cdd:cd15199   94 VALDRYFRVVHPrGKKNSLSLQAAPYISFLVWLL--LVGLTIPTLLASQ--PKNFTECNSFSPKDDEDFS-----DTWQE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 191 VV---GFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEikSCLAR 267
Cdd:cd15199  165 AVfflQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQNKE--SCNAL 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 564399804 268 RVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15199  243 NIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
21-303 7.92e-23

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 96.04  E-value: 7.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKY 99
Cdd:cd15150    2 IFPLLYTVLFIVGLTMNGLAMRVFF-QIPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKlGSWPLRGFVCQVTSVIFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI-SIVGWLIICLACLLFPLLRTNDDTPGNRTKCFvdlpirnvn 178
Cdd:cd15150   81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKIlSTVIWASMFALSLPNMILTNRQPTPKNVKKCS--------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITP------LMIVLYCTWKTALSLQNKYPISQHLGE--KKKALRMILTCAAVFLICFAPYHFSF 250
Cdd:cd15150  152 LLKSEFGLVWHEIVNYICQvifwvnFLIVIVCYTLITKELYKSYKRTRGVGKvsRKKVNVKVFIIIAVFFICFVPFHFAR 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 251 PLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15150  232 IPYTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
30-294 1.26e-22

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 95.24  E-value: 1.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  30 LVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFL 109
Cdd:cd14975   11 FAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 110 VCISVRRFWFLMYPFRFNDCKQKYDLY-ISIVGWLI-ICLACLLFPlLRTNDDTPGNrTKCFVdlpiRNVNLAQSVAMIT 187
Cdd:cd14975   91 TLMSLERFLAVSRPFVSQGWRAKALAHkVLAIIWLLaVLLATPVIA-FRHVEETVEN-GMCKY----RHYSDGQLVFHLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 188 IGEVVGFITPLMIVLYCTWKTALSLQNKYpisqhLGEKKKALRMILTCAAVFLICFAPYHFSFPLDF--LVKSNEIKSCL 265
Cdd:cd14975  165 LETVVGFAVPFTAVVLCYSCLLRRLRRRR-----FRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVvsELIGGSKMAGT 239
                        250       260
                 ....*....|....*....|....*....
gi 564399804 266 ARRVILIFHSVALCLASLNSCLDPVIYYF 294
Cdd:cd14975  240 LGKVAEAGRPIAGALAFLSSSINPLLYAF 268
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
24-303 1.31e-22

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 95.57  E-value: 1.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMiNLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15117    5 VIYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFL-NLAVADFAFCLFLPFSVVYTaLGFHWPFGWFLCKLYSTLVVFNL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLP-------IR 175
Cdd:cd15117   84 FASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFDpwnetaeDP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIGE----VVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFP 251
Cdd:cd15117  164 VLWLETVVQRLSAQVitrfVLGFLVPLVIIGGCYGLIAARLWR-----EGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 252 LDfLVKSNEIKSCLARRVILIFhSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15117  239 LE-LVVILNQKEDLNPLLILLL-PLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
21-303 2.02e-22

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 94.88  E-value: 2.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADiMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACLLFPLLRTND----DTPGNRTKCFVDLPIR 175
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVI-WTLALAFALPHAICSKLEtfkySEDIVRSLCLEDWPER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGE--------KKKALRMILTCAAVFLICFAPYH 247
Cdd:cd15202  161 ADLFWKYYDLALF--ILQYFLPLLVISFAYARVGIKLWASNMPGDATTEryfalrrkKKKVIKMLMVVVVLFALCWLPFN 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 248 FSFPLDFLVKSNEIKSCLArrVILIFHSVALClaslNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15202  239 IYVLLLSSKPDYLIKTINA--VYFAFHWLAMS----STCYNPFIYCWLNERFRIEF 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
20-301 2.65e-22

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 94.46  E-value: 2.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVF--YGYMKETKRavVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVarNKPMRSTTN--LFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCK-QKYDLYISIVGWLIICL-ACLLFPLLRTNDDTPGNRTKCFVDLPI 174
Cdd:cd14971   79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRtPRNALAASGCIWVVSLAvAAPVLALHRLRNYTPGNRTVCSEAWPS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGE----KKKALRMILTCAAVFLICFAPYHFSF 250
Cdd:cd14971  159 RAHRRAFALCTF----LFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGsrraKRKVTRLVLVVVVLFAACWGPIHAIL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 251 PLDFLVKSNEIKSCLARRVilifhsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14971  235 LLVALGPFPLTYATYALRI------WAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
24-303 3.03e-22

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 94.12  E-value: 3.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15166    5 VFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAClLFPLLRTND--DTPGNRTKCfvdLPIRNVNLAQ 181
Cdd:cd15166   85 IALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLAS-TFPLLFLYEdpDKASNFTTC---LKMLDIIHLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVV-GFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15166  161 EVNVLNFTRLIfFFLIPLFIMIGCYLVIIHNLVHGRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQNGDN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 261 IKSCLArrvilifhSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15166  241 SYNPWA--------AFTTFLMNLSTCLDVILYYIVSKQFQARV 275
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
26-301 5.95e-22

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 93.52  E-value: 5.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15090    7 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI-SIVGWLIICLACLLFPLLRTNDDTPGNrTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15090   87 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIvNVCNWILSSAIGLPVMFMATTKYRQGS-IDCTLTFSHPSWYWENLLK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITIgeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLgEKKKAL----RMILTCAAVFLICFAPYHFSFPLDFLVKsne 260
Cdd:cd15090  166 ICVF--IFAFIMPVLIITVCYGLMILRLKSVRMLSGSK-EKDRNLrritRMVLVVVAVFIVCWTPIHIYVIIKALVT--- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 261 IKSCLARRVILIFhsvALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15090  240 IPETTFQTVSWHF---CIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
26-303 8.95e-22

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 92.81  E-value: 8.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLnHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15182    7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHS-SGWIFGEILCKAVTSIFYIGFYSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKC-FVDLPIRNVNLAQSV 183
Cdd:cd15182   86 ILFLTLMTIDRYLAVVHPLSALRSrKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCeYSSIKWKLGYYYQQN 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 184 AMitigevvgFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLvKSNEIKS 263
Cdd:cd15182  166 LF--------FLIPLGIIVYCYVRILQTLMR-----TRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSL-KDLTIPI 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 564399804 264 CLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15182  232 CECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
23-303 1.09e-21

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 92.90  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVN 101
Cdd:cd14987    4 SFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNqWPMGEFTCKITHLIFSIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLaCLLFP---LLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd14987   84 LFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAF-VASLPdtyFLKTVTSPSNNETYCRSFYPEESFK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 lAQSVAMITIGEVVGFITPLMI--VLYCTWKTALSlqnkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd14987  163 -EWLIGMELVSIVLGFVIPFPIiaVFYFLLARAIS-------ASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 257 KSNEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14987  235 FLHLIPfSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
25-301 1.15e-21

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 92.71  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  25 TYTVILVPGLIGNILALWVFYGYMKETKRAV-VFMINLAIADLLQILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15170    6 VYIITFLIGLPANLLAFYTFIRKVRRKPTPIdILLLNLTVSDLIFLLFLPFKMAeAASGMIWPLPYFLCPLSSFIFFSTI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTP----GNRTKCFVD------ 171
Cdd:cd15170   86 YISTLFLTAISVERYLGVAFPIKYKlRRRPLYAVIASVFFWVLAFSHCSIVYIVEYHIDSEntsvTNNSRCYDNftpeql 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 ---LPIRnVNLAqsvamitigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15170  166 kilLPVR-LELF----------LVLFCIPFLITCFCYINFIRILSSLPHISRQ--RKQRAIGLAVATLLNFIVCFAPYNI 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 SFPLDFLVKSNEIksclarrviliFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15170  233 SHVVGFIQRKSPE-----------WRMYALLLSTLNACLDPIIFYFSSSAVRR 274
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
24-303 2.23e-21

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 92.11  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWvFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15119    5 VIYIVAFVLGVPGNAIVIW-VTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVaLDFHWPFGVWLCKINSFVAVLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI--RNVNL 179
Cdd:cd15119   84 FASVLFLTVISLDRYISLAHPvWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKhdGDLIV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypisqHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15119  164 MRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRR-----TLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHS 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EikscLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15119  239 S----YLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
24-303 3.20e-21

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 91.38  E-value: 3.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAV-VFMINLAIADLLQILSLPLRIFYYLNHdWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVLLLYVPKKKKMTeVYLLNLAVSDLLFLVTLPFWAMYVAWH-WVFGSFLCKFVSTLYTINF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCK-QKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRnvNLAQ 181
Cdd:cd15188   84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRtRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGH--HTIW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQhlgekKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15188  162 KLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQ-----GRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15188  237 GNCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
21-303 3.53e-21

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 91.39  E-value: 3.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFyylnHD-----WPFGPGLCMFCF 95
Cdd:cd15969    2 VFPVLYLIIFIGSILLNGLAVWIFF-HIRNKTSFIFYLKNIVIADLLMTLTFPFKII----QDsglgpWNFNFFLCRYTS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  96 YLKYVNMYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI 174
Cdd:cd15969   77 VLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRmYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIgevVGFITPLMIVLYCTWKTALSLQ--NKYPISQHlGEKKKALRMILTCAAVFLICFAPYHFSFPL 252
Cdd:cd15969  157 LGVKWHTAVSYINI---CIFVAVLVILIVCYISISRYIYksSKQFISSS-SRTRKHNQSIRVVVAVFFVCFLPYHLCRIP 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 DFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15969  233 FTFSQLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
23-303 5.35e-21

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 90.96  E-value: 5.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNhDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15181    4 PLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIA-GWVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIiclaCLLFPL-----LRTNDDTPGNRTKCFvdlpIRN 176
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAIHsYRHRRLRSVHLTCGSIWLV----CFLLSLpnlvfLEVETSTNANRTSCS----FHQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMIT---IGEVVGFITPLMIVLYCTWKTALSLQNkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLD 253
Cdd:cd15181  155 YGIHESNWWLTsrfLYHVVGFFLPLLIMGYCYATIVVTLCQ----SSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLD 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 254 FLVKSNEI-KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15181  231 TLDDLKAVvKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
17-300 5.67e-21

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 90.98  E-value: 5.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  17 FRYFIYavtytVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCF 95
Cdd:cd15167    3 FTYFYY-----LIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLgIAPWKLKIFHCQVTA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  96 YLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQK-YDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCfVDLPi 174
Cdd:cd15167   78 CLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPgFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGC-ADFK- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIGEVVGFITPLMIVLYctwkTALSLQNKY--PISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPL 252
Cdd:cd15167  156 TEFGRHWHVLTNFICMAIFLNFSAIILIS----NFLVIRKLYrnKDSEEYRNARQALVNILLVTAGYVICFVPYHIVRIP 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 253 DFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15167  232 YTLSQSEVITDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
27-302 9.31e-21

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 90.21  E-value: 9.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15200    8 GIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGW-LIICLACLLFPLlrtndDTPGNRTKCFVDLPIRNVNLAQSV 183
Cdd:cd15200   88 IVFLTAIALNRYLKVVHPHHqLSKASVGCAAKVAAGLWiLILLLNIHLLLL-----DHVQSNSTCLSYDHGTDPSASDRW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 184 AMITIGevVGFITPLMIVLYCTWKTALSLQNKYPISQhlGEKKKALRMILTCAAVFLICFAPYhFSFPLDFLVkSNEIKS 263
Cdd:cd15200  163 HRILFF--LEFFLPLGIILFCIFSIILTLKQRKLAKQ--AGPQRAVKVLAVIVLVYTVCFLPS-ILFALASLV-AFKVSQ 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 264 CLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15200  237 CRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
26-301 1.21e-20

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 89.97  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15970    7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYP-----FRFNDCKQKYDLYISIVGWLIIcLACLLFPLLRTNDDtpgNRTKCFVDLPIRNVNLA 180
Cdd:cd15970   87 IYCLTVLSIDRYIAVVHPikaarYRRPTVAKMVNLGVWVFSILVI-LPIIIFSNTAPNSD---GSVACNMQMPEPSQRWL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIgeVVGFITPLMIVLYCTWKTALSLQN---KYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15970  163 AVFVVYTF--LMGFLLPVIAICLCYILIIVKMRVvalKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 258 SNEIKsclarrviliFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15970  241 QHDAT----------VSQLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
21-303 2.03e-20

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 89.52  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFyylnHDWPFGPGL-----CMFCF 95
Cdd:cd15149    2 VIPVFYSLVFIVGILLNGVNFWIFF-YVPSNKSFIVYLKNIVFADLLMSLTFPFKIL----SDVELGPWQlnvivCRYSA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  96 YLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI 174
Cdd:cd15149   77 VIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNvGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMITIGeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15149  157 LGIQWHKASNYICVS-IFWVVFLLLIIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 255 LVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15149  236 LSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
20-303 5.11e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 88.16  E-value: 5.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQI-LSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITlLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACL-------LFPLLRTNDDTpgnRTKCFVD 171
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAII-WIMASCLSLphaiyqkLVEFEYSNERT---RSRCLPS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPIRNVNLAQSVAMITIgeVVGFITPLMI--VLYCTWKTALSLQN---KYPISQ---HLGEKKKALRMILTCAAVFLICF 243
Cdd:cd15389  157 FPEPSDLFWKYLDLATF--ILQYVLPLLIigVAYTRVAKKLWLRNaigDVTTEQyvaQRRKKKKTIKMLMLVVLLFAICW 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 244 apyhfsFPLDF---LVKSNEIKSCLArrVILIFHSVALClaslNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15389  235 ------LPLNCyhvLLSSHPIRSNSA--LFFAFHWLAMS----STCYNPFIYCWLNDSFRSEL 285
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
20-301 7.22e-20

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 87.92  E-value: 7.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACL-LFPLLRTNDDTPGNrtKCFVDLPiRNV 177
Cdd:cd15094   81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTpFIAKVVCATTWSISFLVMLpIILYASTVPDSGRY--SCTIVWP-DSS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPI---SQHLGEKKKALRMILTCAAVFLICFAPYhFSFPLDF 254
Cdd:cd15094  158 AVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKnksKEKRRSHRKVTRLVLTVISVYIICWLPY-WAFQVHL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSNeiKSCLARRVILIFhSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15094  237 IFLPP--GTDMPKWEILMF-LLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
20-300 1.13e-19

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 87.35  E-value: 1.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKetKRAVV--FMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFY 96
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKR--MRTVTnyFLVNLAVADLLISAFNTVFNFTYlLYNDWPFGLFYCKFSNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLacLLFPLL------RTNDDTPGNRTKCFV 170
Cdd:cd15390   79 VAITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVI-WLASFL--LALPQLlystteTYYYYTGSERTVCFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPIRNVNLAQSVAMITIgEVVGFITPLMIVLYC-------TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICF 243
Cdd:cd15390  156 AWPDGPNSLQDFVYNIVL-FVVTYFLPLIIMAVAytrvgveLWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICW 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 244 APYHFSFPLDFLVksNEIKSclARRVILIFHSVALcLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15390  235 LPYHLYFILTYLY--PDINS--WKYIQQIYLAIYW-LAMSNSMYNPIIYCWMNKRFR 286
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
26-301 1.51e-19

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 86.83  E-value: 1.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15973    7 YALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirnvNLAQSVA 184
Cdd:cd15973   87 VFCLTVLSVDRYIAVVHPLRAARYRRpTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWP----HPAWSAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITIGEVVGFITPLMIVLYCTWKTALSLQN---KYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsnei 261
Cdd:cd15973  163 FVIYTFLLGFLLPVLAIGLCYILIIGKMRAvalKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLP---- 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 564399804 262 ksclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15973  239 ------RLDATVNHASLILSYANSCANPILYGFLSDNFRR 272
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
22-303 2.06e-19

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 86.39  E-value: 2.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIfYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15187    3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQA-YYLLDQWVFGNAMCKIVSGAYYIG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLlfPLLRTNDD-TPGNRTKCFVDLPirNVNL 179
Cdd:cd15187   82 FYSSMFFITLMSIDRYLAIVHAvYALKVRTASHGTILSLALWLVAILASV--PLLVFYQVaSEDGRLQCIPFYP--GQGN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15187  158 SWKVFTNFEVNILGLLIPFSILIFCYHNILRNLRR-----CHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLH 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 260 EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15187  233 IIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
26-303 3.30e-19

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 85.98  E-value: 3.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLnHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15177    7 YLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETL-QGWIFGNAMCKLIQGLYAINFYSG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQKYDLYiSIVGWLIICLACLLFPL---LRTNDDTPGNRTKCFVDLPiRNVNLAQS 182
Cdd:cd15177   86 FLFLTCISVDRYVVIVRATSAHRLRPKTLFY-SVLTSLIVWLLSILFALpqlIYSRVENRSELSSCRMIFP-EVVSRTVK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFL-VKSNEI 261
Cdd:cd15177  164 GATALTQVVLGFAIPLIVMAVCYAAIGRTL-----LAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTAdLLATLE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15177  239 LSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
21-301 5.20e-19

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 85.49  E-value: 5.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLR-IFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmAVFCVPFSfIALLILQYWPFGEFMCPVVNYLQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKqKYDLYISIVGWLIICLACL---LFPLLRTNDDTPGNRTKCFVDLPIR 175
Cdd:cd15392   82 AVSVFVSAFTLVAISIDRYVAIMWPLRPRMTK-RQALLLIAVIWIFALATALpiaITSRLFEDSNASCGQYICTESWPSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYP--------ISQHLGEKKKALRMILTCAAVFLICFAPYH 247
Cdd:cd15392  161 TNRYIYSLVLM----ILQYFVPLAVLVFTYTRIGIVVWAKRTpgeaennrDQRMAESKRKLVKMMITVVAIFALCWLPLN 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564399804 248 FsfpldFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15392  237 I-----LNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
20-301 5.74e-19

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 85.21  E-value: 5.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLrIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15173    1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLL-FPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15173   80 INLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLVWVISLLLsLPQFIYSEVRNLSSKICSMVYPPDAIE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITigevVGFITPLMIVLYCTWKTALSLQNKYPISQHlgekkKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15173  160 VVVNIIQMT----VGFFLPLLAMIICYSVIIKTLLHAKGFQKH-----KSLKIIFVVVAVFILTQLPYNIMKLIRTLHIE 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIKSCLARRVIlifhsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15173  231 NTDSTNFKYAIL-----ITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
24-303 6.38e-19

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 85.18  E-value: 6.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFwfLMYPFRFNDCKQKYDLY-----ISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15087   85 SSIYFLTVMSVDRY--LVVLATVRSRRMPYRTYraakiVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVLSFPSPESL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIgeVVGFITPL--MIVLYCTWKTALSLQNKYPISQHLGE-KKKALRMILTCAAVFLICFAPYHFSFPLDFL 255
Cdd:cd15087  163 WFKASRIYTL--VLGFAIPVstICILYTMMLYKLRNMRLNSNAKALDKaKKKVTLMVLVVLAVCLFCWTPFHLSTVVALT 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 256 VKSNEIKsclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15087  241 TDLPQTP------LVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
22-303 8.43e-19

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 84.63  E-value: 8.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKetKRAV--VFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15001    2 VIIVYVITFVLGLIGNSLVIFVVARFRR--MRSVtnVFLASLATADLLLLVfCVPLKTAEYFSPTWSLGAFLCKAVAYLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICL--ACLLFPLLRTNDDTPGNRTK--CFVDLP 173
Cdd:cd15001   80 LLSFICSVLTLTAISIERYYVILHPMKAKSfCTIGRARKVALLIWILSAIlaSPVLFGQGLVRYESENGVTVyhCQKAWP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMItigeVVGFITPLMIVLYCtwktalslqnkYPisqhLGEKKKALRMILTCAAVFLICFAPYhfsFPLD 253
Cdd:cd15001  160 STLYSRLYVVYLA----IVIFFIPLIVMTFA-----------YA----RDTRKQVIKMLISVVVLFAVCWGPL---LIDN 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 254 FLVKSNEIKSC---LARRVILIFHsvalCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15001  218 LLVSFDVISTLhtqALKYMRIAFH----LLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
28-303 1.41e-18

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 84.35  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL----QILSlplRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd14986    9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvaffTVLT---QIIWEATGEWVAGDVLCRIVKYLQVVGLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLIICLACL----LFPLLRTNDDTPgnrtKCFVDLPirnvNL 179
Cdd:cd14986   86 ASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMI-VVAWVLSFLFSIpqlvIFVERELGDGVH----QCWSSFY----TP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYC-------TWKTALS--------------LQNKYPISQHLGE--KKKALRMILTCA 236
Cdd:cd14986  157 WQRKVYITWLATYVFVIPLIILSYCygrilrtIWIRSRQktdrpiaptamscrSVSCVSSRVSLISraKIKTIKMTLVII 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 237 AVFLICFAPYhfsFPLDFLVKSNEIKSCLARRVIlifhsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14986  237 LAFILCWTPY---FIVQLLDVYAGMQQLENDAYV-----VSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
26-303 1.52e-18

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 84.03  E-value: 1.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIfYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15184    7 YSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA-HYAANEWVFGNAMCKLLTGLYHIGFFSG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFpLLRTNDDTPGNRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15184   86 IFFIILLTIDRYLAIVHAvFALKARTVTFGVVTSVVTWVVAVFASLPG-IIFTKSQKEGSHYTCSPHFPPSQYQFWKNFQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITIgEVVGFITPLMIVLYC---TWKTALSLQNKypisqhlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15184  165 TLKM-NILGLVLPLLVMIICysgILKTLLRCRNE-------KKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15184  237 NNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
20-301 2.64e-18

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 83.31  E-value: 2.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGWLIIClaCLLFPLLRTNDDTPGNRTkCFVDLPiRNVN 178
Cdd:cd15974   81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRpRVAKLINATVWTLSF--LVVLPVIIFSDVQPDLNT-CNISWP-EPVS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LaQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQN---KYPISQHLGEKKKALRMILTCAAVFLICFAPYHFS--FPLD 253
Cdd:cd15974  157 V-WSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSsglRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLniVNLI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 254 FLVKSNEIKsclarrVILIFHSVALCLAslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15974  236 VILPEEPAF------VGVYFFVVVLSYA--NSCANPILYGFLSDNFKQ 275
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
26-303 2.88e-18

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 83.38  E-value: 2.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15183    7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTkCFVDLPIRNVNLAQSVA 184
Cdd:cd15183   87 IFFIILLTIDRYLAIVHAvFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHT-CSAHFPRKSLIRWKRFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITIgEVVGFITPLMIVLYCtWKTALSLQNKYPISQhlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSC 264
Cdd:cd15183  166 ALKL-NLLGLILPLLVMIIC-YTGIINILLRRPNEK----KAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSC 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 265 LARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15183  240 EQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
26-303 4.06e-18

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 82.95  E-value: 4.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15185    7 YSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGnRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd15185   87 IFFIILLTIDRYLAIVHAvFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFE-EFLCSPLYPEDTEDSWKRFH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITIgEVVGFITPLMIVLYC---TWKTALSLQNKypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEI 261
Cdd:cd15185  166 ALRM-NIFGLALPLLIMVICytgIIKTLLRCPSK--------KKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFE 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 262 KSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15185  237 TDCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-301 4.89e-18

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 82.51  E-value: 4.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15093    7 YAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGW---LIICLACLLFPLLRTNddtPGNRTKCFVDLPirNVNLAQ 181
Cdd:cd15093   87 IFCLTVMSVDRYLAVVHPIKSARWRRpRVAKVVNLAVWvasLLVILPVVVFAGTREN---QDGSSACNMQWP--EPAAAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQN---KYPISQHLGEKKKALRMILTCAAVFLICFAPyhfsFPLDFLVKS 258
Cdd:cd15093  162 SAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSaglRAGWQQRKRSERKVTRMVVMVVVVFVICWLP----FYVLQLVNV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIKSCLARRVILIFHSVALCLAslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15093  238 FVQLPETPALVGVYHFVVILSYA--NSCANPILYGFLSDNFKK 278
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
27-301 5.39e-18

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 82.56  E-value: 5.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15121    8 SLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirnvNLAQSVAM 185
Cdd:cd15121   88 FLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAiWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHP----SVGHEAFQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 186 ITIGEVVGFITPLMIVLYCTWKTALSLQnkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFL-VKSNEIKSC 264
Cdd:cd15121  164 YLFETITGFLLPFTAIVTCYSTIGRRLR-----SARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAgALQNQAGNA 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 564399804 265 LARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15121  239 SVLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIR 275
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
23-301 8.46e-18

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 81.84  E-value: 8.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPiRNVNLAQS 182
Cdd:cd15092   84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIP-TPQDYWDP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGeVVGFITPLMIVLYCTWKTALSLQNKYPISQHlGEKKKAL----RMILTCAAVFLICFApyhfsfPLDFLVKS 258
Cdd:cd15092  163 VFGICVF-LFSFIIPVLIISVCYSLMIRRLRGVRLLSGS-KEKDRNLrritRLVLVVVAVFVGCWT------PIQIFVLA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15092  235 QGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKA 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
26-303 9.67e-18

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 81.74  E-value: 9.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYgYMKETKRAV-VFMINLAIADLLQILSLPlriFYYLN--HDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15175    7 YSVICFLGLLGNGLVILTYI-YFKRLKTMTdIYLLNLALADILFLLTLP---FWAASaaKKWVFGEEMCKAVYCLYKMSF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYdLYISIVGWLIICLACLLFP---LLRTNDDTPGNRTKCfvdLPIRNVNL 179
Cdd:cd15175   83 FSGMLLLMCISIDRYFAIVQAASAHRHRSRA-VFISKVSSLGVWVLAFILSipeLLYSGVNNNDGNGTC---SIFTNNKQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTW---KTALSLQNKypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15175  159 TLSVKIQISQMVLGFLVPLVVMSFCYSviiKTLLQARNF--------EKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLS 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 257 KSN-EIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15175  231 SFKgNTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
24-303 1.04e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 81.94  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYmKETKRAVVFMI-NLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRH-REMRTVTNYYIvNLAVTDLaFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLLFPLLR--TNDDTPGNRTKCFVDLPIRNvn 178
Cdd:cd15095   84 VQATCLTLTALSVDRYYAIVHPIRsLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYrlEEGYWYGPQTYCREVWPSKA-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 lAQSVAMITIGEVVGFItPLMIVLYCT-------WKTALSLQNKYPISQ--HLGEKKKALRMILTCAAVFLICFAPYHFs 249
Cdd:cd15095  162 -FQKAYMIYTVLLTYVI-PLAIIAVCYglilrrlWRRSVDGNNQSEQLSerALRQKRKVTRMVIVVVVLFAICWLPNHV- 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564399804 250 FPLDFLVKSNEIKSclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15095  239 LNLWQRFDPNFPET----YATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
23-303 1.54e-17

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 81.46  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAV-VFMINLAIADLLQILSLPL-RIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15925    4 ALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPIdVFVFNLALADFGFALTLPFwAVESALDFHWPFGGAMCKMVLTATVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFL-MYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTkCFVDLPIRNVNL 179
Cdd:cd15925   84 NVYASVFLLTAMSVTRYWVVaSAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVEL-CLLKFPSNYWLG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15925  163 AYHLQRV----VVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 260 EIKsclARRVILIFHS----VALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15925  239 AVP---WNSTFYFIHTyvfpVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
26-301 1.66e-17

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 81.04  E-value: 1.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15971    7 YFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQ-KYDLYISIVGW---LIICLACLLFPLLRTNDDtpgnRTKCFVDLPirNVNLAQ 181
Cdd:cd15971   87 IFCLTVMSIDRYLAVVHPIKSAKWRKpRTAKMINMAVWgvsLLVILPIMIYAGVQTKHG----RSSCTIIWP--GESSAW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIGEVVGFITPLMIVLYCTWKTALSLQN---KYPISQHLGEKKKALRMILTCAAVFLICFAPYHFsfpldFLVKS 258
Cdd:cd15971  161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSsgiRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYI-----FNVSS 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIKSCLARRVILIFHSVALcLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15971  236 VSVSISPTPGLKGMFDFVVV-LSYANSCANPILYAFLSDNFKK 277
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
24-301 1.77e-17

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 81.06  E-value: 1.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYgYMKETKRAV-VFMINLAIADLLQILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVN 101
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALV-FKRGVRRLIdIFISNLAASDFIFLVTLPLWVDKEVVLGpWRSGSFLCKGSSYIISVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI-SIVGWLIICLacLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLA 180
Cdd:cd15194   84 MYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVcCTCVWMLSCL--LGLPTLLSRELKKYEEKEYCNEDAGTPSKVI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 qsVAMITIgeVVGFITPLMIVLYC----TWKTALSLQNKYPISQHLgekKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15194  162 --FSLVSL--IVAFFLPLLSILTCyctiIWKLCHHYQKSGKHQKKL---RKSIKIVFIVVAAFVFSWMPFNLFKALAIAS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 257 KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15194  235 GLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
24-303 1.85e-17

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 81.39  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYL----K 98
Cdd:cd14996    5 IIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKgFYWKYQSTQCRIANFFgtlvI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLM---------------YPFRFNDCKQ--KYDLYISIVGWLIICLACLLFPLLRT-NDD 160
Cdd:cd14996   85 HVSMCVSILILSWIAISRYATLMkhdsatqkqscyekiFYGHFLKRFRqpKFARYLCIYIWGVVLCIIIPVVVYYSvREA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 161 TPGNRTKCF---VDLPIRNVNLAQSVAMITIgevvGFITPLMIVLYCTWKTALS-LQNKYPISQHLGEKKKALRMILTCA 236
Cdd:cd14996  165 DEDGESLCYnrqVELGAKGSQIAGLIATTFF----FLFFLVVLLSYYSFVNHLRrIQKNTCISEKDLIYRSVKRNILIIQ 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 237 AVFLICFAPYHFSFPLDFLVKSNEikSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14996  241 ALLVVCFLPYHIFKPVFYVLHQRE--DCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
26-303 2.27e-17

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 80.65  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHdWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15186    7 YSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE-WGLHNAMCKLTTAFFFIGFFGG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFW-FLMYPFRFNDCKQKYDLYISIVGW---LIICLACLLFPLLRTNDdtpgnrtkCFVDLPIRNVNLAQ 181
Cdd:cd15186   86 IFFITVISIDRYLaIVLAANSMNNRTVQHGVTISLGVWaaaILVAVPQFMFTKMKENE--------CLGDYPEVLQEIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIgEVVGFITPLMIVLYCTW---KTALSLQNKypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15186  158 VLRNVEL-NFLGFLLPLLIMSYCYFriiQTLFSCKNH--------KKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLY 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 259 NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15186  229 DFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
25-302 3.51e-17

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 80.52  E-value: 3.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  25 TYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15195    6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMvTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLIICLACL----LFPLLRTNDDtPGNRTKCfVDLPiRNVNL 179
Cdd:cd15195   86 LSSFMLVVIALDRVFAILSPLSANQARKRVKIML-TVAWVLSALCSIpqsfIFSVLRKMPE-QPGFHQC-VDFG-SAPTK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNK------YPISQHLG--------EKKKALRMILTCAAVFLICFAP 245
Cdd:cd15195  162 KQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMakrardTPISNRRRsrtnslerARMRTLRMTALIVLTFIVCWGP 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 246 YHFSFPLDFLVKSNEIKscLARRVILIFhsvaLCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15195  242 YYVLGLWYWFDKESIKN--LPPALSHIM----FLLGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
21-303 8.85e-17

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 79.06  E-value: 8.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMiNLAIADLLQILSLP-LRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15120    2 LIAVALFVTFLVGLVVNGLYLWVLGFKMRRTVNTLWFL-HLILSNLIFTLILPfMAVHVLMDNHWAFGTVLCKVLNSTLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRfndCKQ----KYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPI- 174
Cdd:cd15120   81 VGMFTSVFLLTAISLDRYLLTLHPVW---SRQhrtnRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYALs 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQS--------VAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypisqHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd15120  158 TNWESAEVqasrqwihVAMFVFRFLLGFLLPFLIITFCYVRMALKMKER-----GLARSSKPFKVMFTAVVSFFVCWLPY 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564399804 247 HFSFPLdfLVKSNEIKSCLArrvilIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15120  233 HLHSGL--VLTRGRPPSLTD-----ITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
26-303 1.55e-16

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 78.33  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVP-GLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYyLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd14989    6 YTIFLFPiGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFN-LNEKYYDIAVLCTFMSLFLQINMYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISI-VGWLIICLACLLfPLLRTNDDTPGNRTKCFVDLPirnvnlaqsv 183
Cdd:cd14989   85 SIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCgLIWMASISATLL-PFTAVQAQHTGEVHFCFADVR---------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 184 aMITIGEV-VGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE-- 260
Cdd:cd14989  154 -EIQWLEVtLGFIIPFSIIGLCYSLIVRVLVRAQKHRRLRPRRQKALRMILVVVLVFFICWLPENVFISIQLLQGTQEps 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 261 --IKSCLARRVILIFHSVALCLASlNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14989  233 esYDESFRHNHPLTGHIVNLAAFS-NSCLNPLIYSFLGETFRDKL 276
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
33-302 2.37e-16

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 77.92  E-value: 2.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  33 GLIGNILALWVFYGYMKETKRAV--VFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLV 110
Cdd:cd15122   14 GLPGNGFIIWSILWKMKARGRSVtcILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 111 CISVRRFWFLMYPFRFNDCKQKyDLYISIVG--WLI-ICLACLLFPLLRTNDDTPGNRTKCFVDLPIRnvnlAQSVAMIT 187
Cdd:cd15122   94 LMSLDRCLAVTRPYLAQSLRKK-ALVRKILLaiWLLaLLLALPAFVYRHVWKDEGMNDRICEPCHASR----GHAIFHYT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 188 IGEVVGFITPLMIVLYCTWKTALSLQNKYpisqhLGEKKKALRMILTCAAVFLICFAPYHfsfpldfLVKSNEIKSCLAR 267
Cdd:cd15122  169 FETLVAFVLPFGVILFSYSVILVRLKGAR-----FRRRARVEKLIAAIVVAFALLWVPYH-------VVNLLQVVANLAP 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 268 RVIL--------IFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15122  237 GEVLeklggaakAARAGATALAFFSSSVNPLLYVFAAGDLIKT 279
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
33-303 3.26e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 77.54  E-value: 3.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  33 GLIGNILALWVFYGYMKETKrAVVFMINLAIADLLQILSLPLRIFYY-LNHDWPFGPGLCMFCFYLKYVNMYASIYFLVC 111
Cdd:cd15118   14 GIVENLLILWVVGFRLRRTV-ISIWILNLALSDLLATLSLPFFTYYLaSGHTWELGTTFCRIHSSIFFLNMFVSGFLLAA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 112 ISVRRFWFLMYP-FRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVD----LPIRNVNLA----QS 182
Cdd:cd15118   93 ISLDRCLLVVKPvWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNfalfSPSPDNNHPickqRQ 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypisqHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEik 262
Cdd:cd15118  173 EGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHR-----CRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQH-- 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 263 scLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15118  246 --SLRPLVIQGLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
19-301 3.95e-16

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 77.31  E-value: 3.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  19 YFIYAVtYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYL 97
Cdd:cd15927    1 YVVPIL-FALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDSWPFGEFLCKLSEFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLLFPLLR-----TNDDTPGNRTkCFVD 171
Cdd:cd15927   80 KDTSIGVSVFTLTALSADRYFAIVNPMRkHRSQATRRTLVTAASIWIVSILLAIPEAIFShvvtfTLTDNQTIQI-CYPY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPIRNVNLAQSVAMITIgeVVGFITPLMI--VLYCT-----WKTALSLQNKYPISQ--HLGEKKKALRMILTCAAVFLIC 242
Cdd:cd15927  159 PQELGPNYPKIMVLLRF--LVYYLIPLLIigVFYVLmarhlIRSTRNIGSGQNQAAqrQIEARKKVAKTVLAFVVLFAVC 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564399804 243 FAPYH-----FSFPLDFLVKSNEiksclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15927  237 WLPRHvfmlwFHFAPNGLVDYNA--------FWHVLKIVGFCLSFINSCVNPVALYLLSGSFRR 292
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
24-301 4.30e-16

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 77.15  E-value: 4.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15972    5 LVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWL---IICLACLLFpllrtnDDTPGNRTKCFVDLPiRNVNL 179
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSKWrKPPVAKTVNATVWAlsfLVVLPVVIF------SGVPGGMGTCHIAWP-EPAQV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSvAMITIGEVVGFITPLMIVLYC----TWKTALSLQNKYPISQ-HLGEKKKALRMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15972  158 WRA-GFIIYTATLGFFCPLLVICLCylliVVKVRSSGRRVRATSTkRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSNEIKSCLArrviLIFHSVALCLAslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15972  237 VCPLPEEPSLFG----LYFFVVVLSYA--NSCANPIIYGFLSDNFKQ 277
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
21-303 8.76e-16

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 76.51  E-value: 8.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFygyMKETK-RAVV--FMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd15207    2 LFIVSYSLIFLLCVVGNVLVCLVV---AKNPRmRTVTnyFILNLAVSDLLvGVFCMPFTLVDNILTGWPFGDVMCKLSPL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPF--RFNdckQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTK----CFV 170
Cdd:cd15207   79 VQGVSVAASVFTLVAIAVDRYRAVVHPTepKLT---NRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQtvhiCVE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPIRNVNLAQSVAMItigeVVGFITPLMI--VLYC-----TWKTALSLQNKYP---ISQHLGEKKKALRMILTCAAVFL 240
Cdd:cd15207  156 FWPSDEYRKAYTTSLF----VLCYVAPLLIiaVLYVrigyrLWFKPVPGGGSASreaQAAVSKKKVRVIKMLIVVVVLFA 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 241 ICFAPYHFSFPL-DFLVKSNEIksclaRRVILIF-HSVALCLASLNSCLDPVIY-YFTTNeFRRRL 303
Cdd:cd15207  232 LSWLPLHTVTMLdDFGNLSPNQ-----REVLYVYiYPIAHWLAYFNSCVNPIVYgYFNRN-FRKGF 291
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
26-303 1.17e-15

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 76.01  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15391    7 YQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLiMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKqKYDLYISIVGWLI-ICLACLLFPLLRTNddTPGNRTKCFVDLPIRNVNLAQSV 183
Cdd:cd15391   87 SVLTNTAIGIDRFFAVIFPLRSRHTK-SRTKCIIASIWAIsFSLSSVQLFAGRTQ--RYGQYSEGRVLCGESWPGPDTSR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 184 AMITIGEVVG-FITPLMIVLYC-------TWK-TALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYH-FSFPLD 253
Cdd:cd15391  164 SAYTVFVMLLtYIIPLLILTSTygyvgfrLWNrTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHlFNLVQD 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 254 FLVKSNEIKSCLARRVILIFHSVALClaslNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15391  244 FSTVFRNMPQHTTRLIYGACHWIAMS----NSFVNPIIYLFMNDSFRSIL 289
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-252 1.35e-15

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 75.65  E-value: 1.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKY 99
Cdd:cd16004    2 LWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHnDWYFGLEFCRFQNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAC-LLFPLLRTNDDTpgnRTKCFVDLPIR--- 175
Cdd:cd16004   82 TAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFpQCFYSTVTMDQG---RTKCIVAWPGDsgg 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSL--------QNKYPISQHLGEKKKALRMILTCAAVFLICFAPYH 247
Cdd:cd16004  159 KHQLTYHLAVI----VLIYLLPLAVMFVTYSIIGITLwrsavpghQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYH 234

                 ....*
gi 564399804 248 FSFPL 252
Cdd:cd16004  235 LYFIL 239
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
20-301 6.37e-15

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 73.98  E-value: 6.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAC--LLFPLLRTNDDTPGNRTKCFVD--LPI 174
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALpvALALRVEELTDKTNNGVKPFCLpvGPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSL-QNKYPIS------QHLGE-KKKALRMILTCAAVFLICFAPY 246
Cdd:cd15393  161 DDWWKIYNLYLV----CVQYFVPLVIICYAYTRIAVKIwGTKAPGNaqdvrdDEILKnKKKVIKMLIIVVALFALCWLPL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 247 HFsfpldFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15393  237 QT-----YNLLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
20-303 8.20e-15

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 73.70  E-value: 8.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNiLALWVFYGYMKETKRAV-VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYL 97
Cdd:cd15395    1 FTLALAYSAVIILGVSGN-LALIIIILKQKEMHNVTnILIVNLSFSDLLmTIMCLPFTFVYTLMDHWVFGEAMCKLNSMV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACLLFPLLRTNDDTP-----------GNRT 166
Cdd:cd15395   80 QCISITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVI-WVLAVLTSLPFLIFQVLTDEPfknvnvsldayKGKY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 167 KCFVDLPIRNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQ-----------NKYPISqhlgEKKKALRMILTC 235
Cdd:cd15395  159 VCLDQFPSDTIRLSYTTCLL----VLQYFGPLCFIFICYLKIYIRLKrrnnmmdkmrdNKYRSS----ETKRINIMLISI 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564399804 236 AAVFLICFAPYhFSFPLDFLVKSNEIKSCLARRVILIFHSVALClaslNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15395  231 VVAFAVCWLPL-NIFNAVFDWNHEAIATCNHNLLFLICHLTAMI----STCVNPIFYGFLNKNFQRDL 293
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
21-302 1.36e-14

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 72.94  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAV-VFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15097    2 IVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTnLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFFI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDlyiSIVGWLIICLACLLF--PLLRTNDDTP-GNRTKCfvdlpIR 175
Cdd:cd15097   82 YLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRN---AVAAIALIWGLSLLFagPYLSYYDLIDyANSTVC-----MP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALR----MILTCAAVFLICFAPYHF--- 248
Cdd:cd15097  154 GWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRkvtkMIIIVTALFCLCWLPHHVvil 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 249 -----SFPLDflvksneiksclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRR 302
Cdd:cd15097  234 cylygDFPFN--------------QATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKG 278
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-301 1.79e-14

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 72.35  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNIL---ALWVfygymkETKRAVV---FMINLAIADLL-QILSLPLRIFYYLNHD-WPFGPGLCMFCFYLK 98
Cdd:cd15052    8 LLLVIATIGGNILvclAISL------EKRLQNVtnyFLMSLAIADLLvGLLVMPLSILTELFGGvWPLPLVLCLLWVTLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRF--NDCKQKYDLYISIVgWLI-ICLACLLFPLLRTNDDTPGNRTKCFVDLPir 175
Cdd:cd15052   82 VLFCTASIMHLCTISLDRYMAIRYPLRTrrNKSRTTVFLKIAIV-WLIsIGISSPIPVLGIIDTTNVLNNGTCVLFNP-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 nvnlaqsvAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGekkkalrmilTCAAVFLICFAPYhfsFPLDFL 255
Cdd:cd15052  159 --------NFVIYGSIVAFFIPLLIMVVTYALTIRLLSNEQKASKVLG----------IVFAVFVICWCPF---FITNIL 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 256 VKSNEIKSClarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15052  218 TGLCEECNC---RISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRR 260
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
21-301 2.45e-14

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 71.53  E-value: 2.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVIL-VPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15210    1 YFAAVWGIVFmVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFcAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLfPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15210   81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFL-PLWLGIWGRFGLDPKVCSCSILRDKK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 lAQSVAMITIgeVVGFITPLMIVLYCTWKTalslqnkypisqhlgEKKKALRMILTCAAVFLICFAPYhfsfpldFLVKS 258
Cdd:cd15210  160 -GRSPKTFLF--VFGFVLPCLVIIICYARR---------------EDRRLTRMMLVIFLCFLVCYLPI-------TLVNV 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEiksclARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15210  215 FD-----DEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-301 3.96e-14

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 71.65  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILAlwVFYGYMKETKRAV--VFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15208    5 ALYILVFIVGLVGNVLV--CFAVWRNHHMRTVtnYFIVNLSLADFLVIIiCLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACL-------LFPLLRTNDDTPgNRTKCFVDLP 173
Cdd:cd15208   83 SVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILII-WIVSLLIMIpqaivmeCSRVVPLANKTI-LLTVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMItigeVVGFITPL--MIVLY-----CTWK-----TALSLQNKYPISQH---------LGEKKKALRMI 232
Cdd:cd15208  161 DSIYQKVYHICFF----LVTYLLPLclMILAYfqifrKLWCrqipgTSSVVQRKWNKPRKsavaaeekqLRSRRKTAKML 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 233 LTCAAVFLICFAPYHFsfpLDFLVKSNEIKScLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15208  237 IVVVIMFAICYLPVHL---LNILRYVFGLFT-VDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
21-303 5.69e-14

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 70.94  E-value: 5.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCvGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVN 178
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTvWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDRE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFITPL--MIVLYCTWKTALSLqnkypiSQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15012  161 MFNSKLYDTINFIVWYLIPLliMTVLYSKISIVLWK------SSSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLArrviLIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15012  235 EPYRCDSNWN----ALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
36-301 7.02e-14

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 70.46  E-value: 7.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  36 GNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKYVNMYASIYFLVCIS 113
Cdd:cd15067   16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLvGSIVMPFSILHEMtGGYWLFGRDWCDVWHSFDVLASTASILNLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 114 VRRFWFLMYPFRFND--CKQKYDLYISIVgWliICLACLLFPLL---RTNDDTPGNRTKC-FVDlpirnvnlaqSVAMIT 187
Cdd:cd15067   96 LDRYWAITDPISYPSrmTKRRALIMIALV-W--ICSALISFPAIawwRAVDPGPSPPNQClFTD----------DSGYLI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 188 IGEVVGFITPLMIVLYCTWKTalslqnkYPISQHlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNeiksCLAR 267
Cdd:cd15067  163 FSSCVSFYIPLVVMLFTYYRI-------YRAAAK---EQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSN----CVSN 228
                        250       260       270
                 ....*....|....*....|....*....|....
gi 564399804 268 RVILifHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15067  229 PDIL--FPLVTWLGYINSGMNPIIYACSSRDFRR 260
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
22-301 1.66e-13

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 69.30  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKY 99
Cdd:cd15053    3 WALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLvAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirnvnl 179
Cdd:cd15053   83 MCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNP------ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 aqsvAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypisqhlgekKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd15053  157 ----DFIIYSSISSFYIPCIVMLLLYYRIFRALRRE----------KKATKTLAIVLGVFLFCWLPFFTLNILNAICPKL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 260 EIKSClarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15053  223 QNQSC---HVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
22-301 2.09e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 69.37  E-value: 2.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVT--YTVILVPGLIGNILALWVFYG--YMKETKRavVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd14977    1 YVIMslSLVIFAVGIIGNLMVLCIVCTnyYMRSVPN--ILIASLALGDLLLLLlCVPLNAYNLLTKDWLFGDVMCKLVPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICL----ACLLFPLLRTNDDTPGNRTKCFVD 171
Cdd:cd14977   79 IQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAViWVGSVLlavpEAVLSTVARESSLDNSSLTVCIMK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPIRNVNLAQSVAMITIGEVVgFITPLMIVLYC---TWKTALSLQNKYPIS--QHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd14977  159 PSTPFAETYPKARSWWLFGCY-FCLPLAFTAVCyllMARTLIRAAKEYTRGtkKHMKQRRQLAKTVLCLVLVFAFCWLPE 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 247 HFSFPL-DFLVKSNEIKSclaRRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14977  238 HISNILrATLYNEVLIDT---RSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
24-300 2.45e-13

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 69.03  E-value: 2.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFyGYMKETKRAV-VFMINLAIADLLQILSLPlriFYYLN--HDWPFGPGLCMFCFYLKYV 100
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVM-GYQKKSRTMTdKYRLHLSVADLLFVLTLP---FWAVDaaANWYFGNFLCKAVHVIYTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLa 180
Cdd:cd15179   81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFEL- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGEVVGFITPLMIVL--YCTWKTALSLQNKYpisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS 258
Cdd:cd15179  160 WVVAFRFQHILVGLVLPGLVILtcYCIIISKLSHSKGH-------QKRKALKTTVILILAFFACWLPYYIGISIDTFMLL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15179  233 EIIKqSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 2.51e-13

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 69.19  E-value: 2.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAsMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAcllFP--LLRTNDDTPGnRTKCFVDLPirnV 177
Cdd:cd16003   82 TSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLA---FPqcLYSKTKVMPG-RTLCFVAWP---G 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLM-------IVLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSF 250
Cdd:cd16003  155 GPDQHFTYHIIVIVLVYCLPLLvmgitytIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYF 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 251 PLDFLVKSneikscLAR-RVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd16003  235 IVTGLYQQ------LNRwKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
24-303 3.34e-13

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 68.98  E-value: 3.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVV--FMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARKGKPSLIdsLILNLSAADLLlLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACL---LFPLLRTNDDTPgnrtKCFVDLPIrnv 177
Cdd:cd15002   84 CMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLPLpqwLFRTVKQSEGVY----LCILCIPP--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 nLAQSV--AMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHL---GEKKKALRMILTCAAVFLICFAPYHFSFpl 252
Cdd:cd15002  157 -LAHEFmsAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLrnqIRSRKLTHMLLSVVLAFTILWLPEWVAW-- 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 dfLVKSNEIKSCLARrvILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15002  234 --LWLIHIKSSGSSP--PQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
25-303 7.71e-13

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 68.11  E-value: 7.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  25 TYTVILVPGLIGNILalwVFYGYMKETKRAV----VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15382    6 VYSVLFLIAAVGNLT---VLLILLRNRRRKRsrvnILLMHLAIADLLvTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLI--ICLACLLFPLLRTNDDTPGNRTKC--FVDLPIR 175
Cdd:cd15382   83 FGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIML-AVAWVIsfLCSIPQSFIFHVESHPCVTWFSQCvtFNFFPSH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVA-MITIgevvgFITPLMIVLYC----TWKTALSLQNKYPISQHLGE---------------KKKALRMILTC 235
Cdd:cd15382  162 DHELAYNIFnMITM-----YALPLIIIVFCysliLCEISRKSKEKKEDVSEKSSsvrlrrssvglleraRSRTLKMTIVI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 236 AAVFLICFAPYHFSFPLDFLVKSNEIK-SCLARRVILIFhsvalclASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15382  237 VLVFIICWTPYFIMSLWYWFDRESASKvDPRIQKGLFLF-------AVSNSCMNPIVYGYFSIDLRREL 298
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
21-303 8.72e-13

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 67.53  E-value: 8.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILalwVFYGYMKETKRAV--VFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYL 97
Cdd:cd15339    2 ILPSFIGILCSTGLVGNIL---VLFTIIRSRKKTVpdIYVCNLAVADLVHIIVMPFLIHQWArGGEWVFGSPLCTIITSL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKY-DLYISIVGWL---IICLACLLFPLLRTNDDtpgNRTKCFVDLP 173
Cdd:cd15339   79 DTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSkTIRINLLVWAasfILVLPVWVYAKVIKFRD---GLESCAFNLT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMitigEVVGFITPLMIVLYC-------TWKtaLSLQNK----YPISQHLGEKKKALRMILTCAAVFLIC 242
Cdd:cd15339  156 SPDDVLWYTLYQ----TITTFFFPLPLILICyililcyTWE--MYRKNKkagrYNTSIPRQRVMRLTKMVLVLVGVFLVS 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 243 FAPYHFSFPLDFLVKSNEIKSCLArrvilifHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15339  230 AAPYHVIQLVNLSVSQPTLAFYVS-------YYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-300 9.61e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 67.58  E-value: 9.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd16002    2 LWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEAsMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAcllFPL--LRTNDDTPGnRTKCFVDLPIRNV 177
Cdd:cd16002   82 AAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLA---FPQgyYSDTEEMPG-RVVCYVEWPEHEE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgEVVGFITPLMIVLYC-------TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSF 250
Cdd:cd16002  158 RKYETVYHVCV-TVLIYFLPLLVIGCAytvvgitLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYF 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 251 PLDFLVksneiKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd16002  237 LLQYFH-----PELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
24-301 1.32e-12

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 67.32  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVN 101
Cdd:cd14997    5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALVETWAREpWLLGEFMCKLVPFVELTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLAC---LLFPLLRTNDDTPGNRtkcfVDLPIRNV 177
Cdd:cd14997   85 AHASVLTILAISFERYYAICHPLQAKYvCTKRRALVIIALIWLLALLTSspvLFITEFKEEDFNDGTP----VAVCRTPA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMI--VLYCT-----WKTALSLQNKYPISQ--HLGEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd14997  161 DTFWKVAYILSTIVVFFVVPLAIlsGLYSVicrrlVGHPALESRRADAANrhTLRSRRQVVYMLITVVVLFFVCLLPFRV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 sFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14997  241 -VTLWIIFAPDEDLQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRS 292
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
23-303 1.96e-12

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 66.62  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYtVILVPGLIGNILALW-VFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15383    5 AVTF-VLFVLSACSNLAVLWsATRNRRRKLSHVRILILHLAAADLLvTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPG-NRTKCFVDLPIRNVNL 179
Cdd:cd15383   84 AMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPvNFTQCATHGSFPAHWQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVvgFITPLMIVLYCTWKTALSLQNKYPISQHLGEKK---------------KALRMILTCAAVFLICFA 244
Cdd:cd15383  164 ETLYNMFTFFCL--FLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEvalrsssdnipkarmRTLKMTIVIVSSFIVCWT 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 245 PY------HFSFPLDFLVKSNEIKSclarRVILIFhsvalclASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15383  242 PYyllglwYWFSPEMLEQTVPESLS----HILFLF-------GLLNACLDPLIYGLFTISFRRGL 295
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
23-301 3.17e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 66.22  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLN-HDWPFGPGLCMFCFYLKYV 100
Cdd:cd14979    4 TAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLvGLPVELYNFWWqYPWAFGDGGCKLYYFLFEA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDC--KQKYDLYISIVGWLIICLACLLFPLLRT------NDDTPGNRTKCFVDL 172
Cdd:cd14979   84 CTYATVLTIVALSVERYVAICHPLKAKTLvtKRRVKRFILAIWLVSILCAIPILFLMGIqylngpLPGPVPDSAVCTLVV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 173 PIRNVNLAQSVAMItigevVGFITPLMIVLYCTWKTALSL-----QNKYPISQHLGE---------KKKALRMILTCAAV 238
Cdd:cd14979  164 DRSTFKYVFQVSTF-----IFFVLPMFVISILYFRIGVKLrsmrnIKKGTRAQGTRNvelslsqqaRRQVVKMLGAVVIA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 239 FLICFAPYHFSfPLDFLVKSNEIKSCLarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14979  239 FFVCWLPFHAQ-RLMFSYASKEDTFLF--DFYQYLYPISGILFYLSSAINPILYNLMSSRFRV 298
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
21-301 3.53e-12

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 65.96  E-value: 3.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15205    2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLiTFFCIPFTLLQNISSNWLGGAFMCKMVPFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLIICLACLLFPLLRTN------DDTPGNRTKCFVDlp 173
Cdd:cd15205   82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFT-MLGLVWIVSVIVGSPMLFVQqlevkyDFLYEKRHVCCLE-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 iRNVNLAQSVAMITIGEVVGFITPL--MIVLYCT-----W-------KTALSLQNKYPISQHLGEKKKALRMILTCAAVF 239
Cdd:cd15205  159 -RWYSPTQQKIYTTFILVILFLLPLttMLFLYSRigyelWikkrvgdASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLF 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 240 LICFAPYHFSFPLDFLvkSNEIKSCLARRVILIFHSVALcLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15205  238 AVCWAPFHVVHMMIEY--SNLENKYDGVTIKLIFAIVQL-IGFSNSFNNPIVYAFMNENFKK 296
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
26-300 3.57e-12

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 66.00  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15399    7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMvNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLL--FPLLRTNDDTPGNRTK-CFVDLPIRNVNLAQ 181
Cdd:cd15399   87 STVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLaiFREYSVIEISPDFKIQaCSEKWPNGTLNDGT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 --SVAMITIgevvGFITPLMIVLYCTWKTALSLQNKYPIS----QHLGEKKKALRMILTCAAVFLICFAPYHfSFPLDFL 255
Cdd:cd15399  167 iySVSMLLI----QYVLPLAIISYAYIRIWTKLKNHVSPGggndHYHQRRRKTTKMLVCVVVVFAVSWLPFH-AFQLASD 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 256 VKSNEIKSCLARRVILIFHSVALCLASLNscldPVIYYFTTNEFR 300
Cdd:cd15399  242 IDSKVLDLKEYKLIYTIFHVIAMCSTFAN----PLLYGWMNNNYR 282
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
23-300 3.94e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 65.65  E-value: 3.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMPLEVYeMWSNYPFLFGPVGCYFKTALFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWLIICLACL--------LFPLLRTNDDTPGNRTkCFVD 171
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHPFRAKlNSTRERALKIIVVLWVLSVLFSIpntsihgiKLQYFPNGTLIPDSAT-CTVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPIRNVNLaqsvaMITIGEVVGFITPLMI--VLYCTWKTAL----SLQ-NKYPISQHLGEKKKALRMILTCAAVFLICFA 244
Cdd:cd15357  163 KPLWIYNL-----IIQITSLLFYVLPMGVisVLYYLMGLKLrgdkSLEaDEMNVNIQRPSRKSVTKMLFVLVLVFAICWA 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 245 PYH-----FSFPLDFlvksneiKSCLARRVILIfHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15357  238 PFHvdrlfFSFVVEW-------TEPLANVFNLI-HVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
18-303 4.52e-12

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 65.34  E-value: 4.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  18 RYFIYavtytVILVPGLIGNILAL-WVFYGYMKETKRAVVFMINLAIADLLQILSLPL--------RIFYYLNHDWPFGP 88
Cdd:cd14980    4 RIFIW-----IIGILALIGNILVIiWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIiaiadqyyRGRYAQYSEEWLRS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  89 GLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLiICLACLLFPLLRTNDDTPGNR--T 166
Cdd:cd14980   79 PPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWL-FSIIFAAIPILYSINQPGDNRlyG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 167 KCFVDLPIRNVNLAQSVAMITIgEVVGFITPLMIV-----LYCTWKTALSLQNKypiSQHLGEKKKALRMILTCAAVfLI 241
Cdd:cd14980  158 YSSICMPSNVSNPYYRGWLIAY-LLLTFIAWIIICilyilIFISVRKSRKSARR---SSSKRDKRIAIRLALILITD-LI 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 242 CFAPYHFSFpLDFLVKSNEIKSclarrVILIFhsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14980  233 CWLPYYIVI-FSGLLTSTEIDI-----HVLQF--IAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
27-303 6.09e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 65.05  E-value: 6.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLI---GNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15083    5 IFILIIGLIgvvGNGLVIYAFCRFKSLRTPANYLIINLAISDfLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTP-GNRTKCFVDLPIRNVNLAQ 181
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLeGLLTSCSFDYLSRDDANRS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMITIgevVGFITPLMIVLYCTW---------KTALSLQNKYPISQHLGEKKKALR-------MILTCAAVFLICFAP 245
Cdd:cd15083  165 YVICLLI---FGFVLPLLIIIYCYSfifravrrhEKAMKEMAKRFSKSELSSPKARRQaevktakIALLLVLLFCLAWTP 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 246 YhfsfpldflvksnEIKSCLA-----RRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15083  242 Y-------------AVVALIGqfgylEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-294 1.00e-11

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 64.75  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVgLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISiVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPirnvNLAQS 182
Cdd:cd15197   85 YASTYVLVALSIDRYDAICHPMNFSQSGRQARVLIC-VAWILSALFSIPMLIIFEKTGLSNGEVQCWILWP----EPWYW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYC-------TWKTALSLQNKYPISQHLGE-------------KKKALRMILTCAAVFLIC 242
Cdd:cd15197  160 KVYMTIVAFLVFFIPATIISICyiiivrtIWKKSKIQVTINKAGLHDGSsrrsssrgiipraKIKTIKMTFVIVTVFIIC 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 243 FAPYhfsFPLDFLVKSNEIKSCLARRVILIFHSvalCLASLNSCLDPVIYYF 294
Cdd:cd15197  240 WSPY---FVFDLLDVFGLLPRSKTKIAAATFIQ---SLAPLNSAINPLIYCL 285
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
20-303 1.19e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 64.58  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGymKETKRAV-VFMINLAIADLL----QILSLPLRIFYYLNHDWPFG--PGLCM 92
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVLTR--KSMRSSTnVYLAALAVSDILvllsALPLFLLPYIADYSSSFLSYfyAYFLP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  93 FCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLACLLFPL---LRTNDDTPGNRTKC 168
Cdd:cd14978   79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTwCTPRRARRVILIIIIFSLLLNLPRFFeyeVVECENCNNNSYYY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 169 FVDLPIRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKY-----------PISQHLGEKKKALRMILTCAA 237
Cdd:cd14978  159 VIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKkrrrllrrrrrLLSRSQRRERRTTIMLIAVVI 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 238 VFLICFAPYHFSFPLDFLVksneiKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd14978  239 VFLICNLPAGILNILEAIF-----GESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
24-292 1.24e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 64.38  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYgYMKETKRAV-VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15384    5 VVLAVMFVISFIGNLLTIIQIY-RLRRSRRTIySLLLHLAIADLLvTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLIICLACL----LFPLLRtnDDTPGNRTKCFVDLPIRNV 177
Cdd:cd15384   84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMV-TVAWILSPIFSIpqavIFHVER--GPFVEDFHQCVTYGFYTAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgeVVGFITPLMIVLYC----------TWK----TALSLQNKYPISQHLGEK--KKALRMILTCAAVFLI 241
Cdd:cd15384  161 WQEQLYNMLSL--VFMFPIPLVIMVTCyvlifitlskSSRdfqgLEIYTRNRGPNRQRLFHKakVKSLRMSAVIVTAFIL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 242 CFAPYHFSFpLDFLVKSNEIKSCLARRVILIFhsvalclASLNSCLDPVIY 292
Cdd:cd15384  239 CWTPYYVIM-IWFLFFNPYPLNDILFDVIFFF-------GMSNSCVNPLIY 281
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
26-303 1.49e-11

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 64.06  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILalwVFYGYMKETKRAV------VFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLK 98
Cdd:cd15338    7 FGVICFLGIIGNSI---VIYTIVKKSKFRCqqtvpdIFIFNLSIVDLLFLLGMPFLIHQLLgNGVWHFGETMCTLITALD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQkydlyiSIVGWLIICLACLLFPLLRTN-------DDTPGNRTKCFVD 171
Cdd:cd15338   84 TNSQITSTYILTVMTLDRYLATVHPIRSTKIRT------PRVAVAVICLVWILSLLSITPvwmyaglMPLPDGSVGCALL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 172 LPirnvNLAQSVAMITIGE-VVGFITPLMIVLYCTWKTALSLQNKY-PISQHLGE--KKKALRMILTCAAVFLICFAPYH 247
Cdd:cd15338  158 LP----NPETDTYWFTLYQfFLAFALPLVVICVVYFKILQNMASTVaPLPQRSLRvrTKKVTRMAVAICLAFFICWAPFY 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 248 FSfpldflvksnEIKSCLARRVILIFH---SVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15338  234 IL----------QLAHLSIDRPSLAFLyayNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
21-301 2.86e-11

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 63.37  E-value: 2.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15980    2 VFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLvGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDT-------PGNRTK----C 168
Cdd:cd15980   82 ISVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKnyrvvlgSQNKTSpvywC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 169 FVDLPirNVNLAQSVAMITIGEVVGFITPLMIVLY-----CTWKTALSLQNKYPISQHLG---EKKKALRMILTCAAVFL 240
Cdd:cd15980  162 REDWP--NQEMRKIYTTVLFANIYLAPLSLIVIMYarigiTLFKTAMPHTGKHNQEQRHVvsrKKQKVIKMLLIVALLFI 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 241 ICFAPYHFSFPLDFLVKSNEIKsclaRRVILIF-HSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15980  240 LSWLPLWTLMMLSDYANLSPNQ----LQIINIYiYPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
20-230 4.20e-11

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 62.59  E-value: 4.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15079    1 YLLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWlIICLACLLFPLLRT-NDDTP-GNRTKCFVDLPIRNV 177
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIW-LYALPWALLPLLFGwGRYVPeGFLTSCSFDYLTRDW 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 178 NlaqSVAMITIGEVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALR 230
Cdd:cd15079  160 N---TRSFVATIFVFAYVIPLIIIIYCYSF----------IVKAVFAHEKALR 199
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
24-303 8.12e-11

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 62.72  E-value: 8.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYgYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHdWPFGPGLCMFCFYLKYVNMY 103
Cdd:PHA02638 103 IFYIIIFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEFDQ-WIFGDFMCKVISASYYIGFF 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFndckQKY-----DLYISIVGWLIICL-----------ACLLFPLLRTNDDTPGNRTK 167
Cdd:PHA02638 181 SNMFLITLMSIDRYFAILYPISF----QKYrtfniGIILCIISWILSLIitspayfifeaSNIIFSAQDSNETISNYQCT 256
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 168 CFVDLPIRNVNLAQSVAMITIgEVVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYH 247
Cdd:PHA02638 257 LIEDNEKNNISFLGRILQFEI-NILGMFIPIIIFAFCYIKIILKLKQ-----LKKSKKTKSIIIVSIIIICSLICWIPLN 330
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 248 FSFPLDFLVKSNEIKSCLARRVI-LIFHSVALCLASLNS----CLDPVIYYFTTNEFRRRL 303
Cdd:PHA02638 331 IVILFATMYSFKGFNSIISEHICgFIKLGYAMMLAEAISlthcCINPLIYTLIGENFRMHL 391
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
1-301 9.36e-11

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 61.84  E-value: 9.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804   1 MTDNFTCNKTDG-----DNTDFRYFIyAVTYTVILVPGLIGNILALWVFYgymkeTKRAV----VFMINLAIADLLQILS 71
Cdd:PHA02834   6 VVDNYSYYFEEEcdfemVNSDVNYFV-IVFYILLFIFGLIGNVLVIAVLI-----VKRFMfvvdVYLFNIAMSDLMLVFS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  72 LPLRIFYYLNhDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLL 151
Cdd:PHA02834  80 FPFIIHNDLN-EWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILSMP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 152 FPLLRTNDDTPGNRTKCFVDlpiRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRM 231
Cdd:PHA02834 159 AMVLYYVDNTDNLKQCIFND---YHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKN-----CKNKNKTRSIKI 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 232 ILTCAAVFLICFAPYHFSFPLDFLVKSNEIK-SCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:PHA02834 231 ILTVVTFTVVFWVPFNIVLFINSLQSVGLIDiGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKK 301
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-301 9.64e-11

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 61.51  E-value: 9.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILS-LPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15125    7 YLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFR-------FNDCKQKydLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCfVDLPIRNV 177
Cdd:cd15125   87 SVFTLTALSADRYKAIVNPMDiqtssavLRTCLKA--IAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTAC-IPYPQTDE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgeVVGFITPLMIV---LYCTWKTALSLQNKYP--ISQH----LGEKKKALRMILTCAAVFLICFAPYHf 248
Cdd:cd15125  164 MHPKIHSVLIF--LVYFLIPLAIIsiyYYHIAKTLIKSAHNIPgeYSEHskrqMETRKRLAKIVLVFVGLFAFCWFPNH- 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 249 sfpLDFLVKS---NEIKSCLARRVILIfhsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15125  241 ---VLYMYRSfnyNEIDSSLGHMIVTL---VARVLSFCNSCVNPFALYLLSESFRR 290
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
61-301 9.88e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 61.42  E-value: 9.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  61 LAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRfndckqkYDLYISI 139
Cdd:cd15055   42 LAVADFLvGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLL-------YPTKITI 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 140 -VGWLIICL-----ACLLFPLLRTNDDTPGNRTkcfVDLPIRNVNLAQSVAMITIGEVVGFITP--LMIVLYC------- 204
Cdd:cd15055  115 rRVKICICLcwfvsALYSSVLLYDNLNQPGLIR---YNSCYGECVVVVNFIWGVVDLVLTFILPctVMIVLYMrifvvar 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 205 -------TWKTALSLQNKYPISQHLGEKK--KALRMILtcaAVFLICFAPYHFSFPLDFLVKSNEIKSclarrvilifhS 275
Cdd:cd15055  192 sqarairSHTAQVSLEGSSKKVSKKSERKaaKTLGIVV---GVFLLCWLPYYIVSLVDPYISTPSSVF-----------D 257
                        250       260
                 ....*....|....*....|....*.
gi 564399804 276 VALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15055  258 VLIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
20-301 1.02e-10

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 61.18  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPgLIGNILALWVFYgyMKETKRAV--VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd15049    2 LICIATGSLSLVT-VGGNILVILSFR--VNRQLRTVnnYFLLSLACADLIiGLVSMNLYTVYLVMGYWPLGPLLCDLWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPF--RFNDCKQKYDLYIsIVGWLI-ICL---ACLLFPLLRTNDDTPGNRtkCFv 170
Cdd:cd15049   79 LDYVASNASVMNLLLISFDRYFSVTRPLtyRAKRTPKRAILMI-ALAWVIsFVLwapAILGWQYFVGERTVPDGQ--CY- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 dlpirnVNLAQSVAMITIGEVVGFITPL--MIVLYCTwktalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15049  155 ------IQFLDDPAITFGTAIAAFYLPVlvMTILYWR------------IYRETARERKAARTLSAILLAFIITWTPYNI 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 sfpldFLVKSNEIKSCLARRVilifHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15049  217 -----LVLVSTFCAKCIPDTL----WSFGYWLCYINSTINPFCYALCNKTFRK 260
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
23-301 1.10e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 61.25  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYgyMKETKRAV--VFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15206    4 IPLYSVIFLLAVVGNILVIVTLV--QNKRMRTVtnVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRT--KCFVDLPIRNV 177
Cdd:cd15206   82 VSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGghKCREVWPNEIA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFItpLMIVLYCTWKTALslqnkypisqhLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15206  162 EQAWYVFLDLMLLVIPGL--VMSVAYGLISWTL-----------LEAKKRVIRMLFVIVVEFFICWTPLYVINTWKAFDP 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 258 SNeikscLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15206  229 PS-----AARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
21-301 1.17e-10

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 61.29  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMK-ETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGpGLCMFCFYLK 98
Cdd:cd15057    2 ITGCILYLLVLLTLLGNALVIAAVLRFRHlRSKVTNYFIVSLAVSDLLvAILVMPWAAVNEVAGYWPFG-SFCDVWVSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNrTKCFVDLPIRNV 177
Cdd:cd15057   81 IMCSTASILNLCVISVDRYWAISSPFRYErRMTRRRAFIMIAVAWTLSALISFIPVQLGWHRADDTS-EALALYADPCQC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMIVLYC---TWKTA-------LSLQNKYPISQH--------LGEKKKALRMILTCAAVF 239
Cdd:cd15057  160 DSSLNRTYAISSSLISFYIPVAIMIVTytrIYRIArrqirriAALERAAQESTNpdsslrssLRRETKALKTLSIIMGVF 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 240 LICFAPYhfsFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFtTNEFRR 301
Cdd:cd15057  240 VCCWLPF---FILNCVLPFCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRK 297
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
21-301 1.27e-10

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 61.17  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLvGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYP---FRFNDCKQKYDLYISIvgWLIICL----ACLLFPLLRTNDDTPGNrtKCFVDL 172
Cdd:cd15048   82 TLCTASALTIVLISLDRYLSVTKAvkyRAKQTKRRTVLLMALV--WILAFLlygpAIIGWDLWTGYSIVPTG--DCEVEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 173 PirnvnlaQSVAMITIGEVVGFITPLMIV------LYCT-WK-TALSLQNKYPISQ---------------HLGEKKKAL 229
Cdd:cd15048  158 F-------DHFYFTFITSVLEFFIPFISVsffnllIYLNiRKrSRRRPLRSVPILPasqnpsrarsqreqvKLRRDRKAA 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 230 RMILTCAAVFLICFAPYHFSfpldFLVKSNEIKSClarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15048  231 KSLAILVLVFLICWAPYTIL----TIIRSFCSGSC----VDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
27-303 1.45e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 60.71  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL----QIL-SLPLRIFYYLnhdwpFGPG-LCMFCFYLKYV 100
Cdd:cd15196    8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLvalfNVLpQLIWDITYRF-----YGGDlLCRLVKYLQVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVgWLIICLACLLFPLLRTNDDTPGNRTKCfvdLPIRNVNL 179
Cdd:cd15196   83 GMYASSYVLVATAIDRYIAICHPLSsHRWTSRRVHLMVAIA-WVLSLLLSIPQLFIFSYQEVGSGVYDC---WATFEPPW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSvAMITIGEVVGFITPLMIVLYC-------TWKTalslqnkypisqhlgeKKKALRMILTCAAVFLICFAPYhFSFPL 252
Cdd:cd15196  159 GLR-AYITWFTVAVFVVPLIILAFCygricyvVWRA----------------KIKTVKLTLVVVACYIVCWTPF-FVVQM 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 DFLVKSNEIKSCLARRVILIfhsvalcLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15196  221 WAAWDPTAPIEGPAFVIIML-------LASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
24-301 1.71e-10

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 60.81  E-value: 1.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFY--GYMKETKRAVVFmiNLAIADLLQ-ILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKY 99
Cdd:cd15134    5 IIYGIIFVTGVVGNLCTCIVIArnRSMHTATNYYLF--SLAVSDLLLlILGLPFELYTIWQqYPWVFGEVFCKLRAFLSE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFR---FNDCKQKYDLYISIvgWLIICLACLLFPLL-----RTNDDTPGNRTK---- 167
Cdd:cd15134   83 MSSYASVLTITAFSVERYLAICHPLRshtMSKLSRAIRIIIAI--WIIAFVCALPFAIQtrivyLEYPPTSGEALEesaf 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 168 CFVdlpirNVNLAQSVAMITIGEVVGFITP--LMIVLYC-----TWKTALSLQNKYPIS---QHLGEKKKALRMILTCAA 237
Cdd:cd15134  161 CAM-----LNEIPPITPVFQLSTFLFFIIPmiAIIVLYVliglqLRRSTLLRRGQRSVSggrRSSQSRRTVLRMLVAVVV 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564399804 238 VFLICFAPYHFSfPLDFLVKSNEIKSCLarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15134  236 AFFICWAPFHAQ-RLLTVYAKNMTPPYL--FINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
34-301 1.87e-10

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 60.52  E-value: 1.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVV---FMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFL 109
Cdd:cd15050   12 LITVILNLLVLYAVRTERKLHTVgnlYIVSLSVADLIvGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 110 VCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-------WLIICLACLLFpllrTNDDTPGNR-TKCfvDLPIRNVNLAQ 181
Cdd:cd15050   92 FILCIDRYRSVQQPLKYLKYRTKTRASLMISGawllsflWVIPILGWHHF----ARGGERVVLeDKC--ETDFHDVTWFK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMItigevVGFITP--LMIVLYCTwktalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsN 259
Cdd:cd15050  166 VLTAI-----LNFYIPslLMLWFYAK------------IFKAVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCK-N 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 260 EIKSCLarrvilifHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15050  228 CCNENL--------HMFTIWLGYINSTLNPFIYPLCNENFKK 261
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
23-303 2.21e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 60.52  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15397    4 VVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACLLFPLLRTNDDTP-----------GNRTKCFV 170
Cdd:cd15397   84 VTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVI-WMLACFISLPFLAFHILTDEPyknlshffaplADKAVCTE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPIRNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPI-------SQHLGEKKKALRMILTCAAVFLICF 243
Cdd:cd15397  163 SWPSEHHKLAYTTWLL----LFQYCLPLLFILVCYLRIYLRLRRRKDMlerrgeyNRRAGHSKRINVMLVSLVAAFALCW 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 244 APYH-FSFPLDFlvksnEIKSCLARRVILIFhSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15397  239 LPLNvFNAIADW-----NHEAIPHCQHNLIF-SLCHLAAMASTCVNPIIYGFLNSNFKKEV 293
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
20-300 2.33e-10

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 60.64  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQI-LSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15976    1 YINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIiIDIPINVYKLLAEDWPFGVEMCKLVPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLI-ICLA---CLLFPLLRTndDTPGNRTKCFVDLP 173
Cdd:cd15976   81 KASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLiWVVsIILAvpeAIGFDMITM--DYKGELLRICLLHP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMITIGEVVGF--ITPLMIV-LYCTWKTALSLQNK----YPISQHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd15976  159 IQKTAFMQFYKTAKDWWLFSFyfCLPLACTaVFYTLMTCEMLRKKngmqIALNDHLKQRREVAKTVFCLVLVFALCWLPL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 247 HFSFPLDF-LVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15976  239 HLSRILKLtIYDEKDPNRCELLSFFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
23-301 2.52e-10

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 60.20  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15062    4 GVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLlSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWlIICLACLLFPLLRTNDDTPGNRTKCfvdlpirnvNLA 180
Cdd:cd15062   84 CTASIMSLCVISVDRYIGVRYPLNYPTiVTARRATVALLIVW-VLSLVISIGPLLGWKEPAPADEQAC---------GVN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGEVVGFITPLMIVLYCTWKTalslqnkYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNE 260
Cdd:cd15062  154 EEPGYVLFSSLGSFYLPLAIILVMYCRV-------YVVAFKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 261 IKSCLarrvilifHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15062  227 PPEPV--------FKVVFWLGYFNSCLNPIIYPCSSREFKR 259
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
21-301 2.80e-10

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 60.14  E-value: 2.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLaVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLfPLLRTND--DTPGNRTKCfvdlpirn 176
Cdd:cd15060   82 LCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVvWALSALISVP-PLIGWNDwpENFTETTPC-------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 vNLAQSVAMITIGEVVGFITPL--MIVLYCTWKTALSlqnkypisqhlgEKKKALRMILTCAAVFLICFAPyhfsFPLDF 254
Cdd:cd15060  153 -TLTEEKGYVIYSSSGSFFIPLliMTIVYVKIFIATS------------KERRAARTLGIIMGVFVVCWLP----FFLMY 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSNEIKSCLARRVILIFhsvaLCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15060  216 VILPFCETCSPSAKVVNFI----TWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
26-303 2.88e-10

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 60.14  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILS-LPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMY 103
Cdd:cd15394    7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVTVY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRfNDCKQKYDLYISIVGWLIICLACLlfpllrtnddtPGNRTKCFVDLPIRNVNLA--- 180
Cdd:cd15394   87 VSVFTLTAIAVDRYYVTVYPLR-RRISRRTCAYIVAAIWLLSCGLAL-----------PAAAHTYYVEFKGLDFSICeef 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 ------QSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKY---PISQHLGE-----KKKALRMILTCAAVFLICFAPY 246
Cdd:cd15394  155 wfgqekQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVvpgSMTQSQAEwdrarRRKTFRLLVVVVVAFAICWLPL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564399804 247 H-FSFpldflVKSNEIKSCLARRVILIFHSVALClASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15394  235 HiFNV-----IRDIDIDLIDKQYFNLIQLLCHWL-AMSSACYNPFLYAWLHDSFRGEL 286
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
21-300 3.05e-10

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 59.98  E-value: 3.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSL-PLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15074    2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNdCKQKYDLYISIVGwliICLACLLF---PLLRTNDDTP-GNRTKCFVDLPIR 175
Cdd:cd15074   82 LFGCCSINTLTAISIYRYLKICHPPYGP-KLSRRHVCIVIVA---IWLYALFWavaPLVGWGSYGPePFGTSCSIDWTGA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIgEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLG---------EKKKALRMILTCAAvFLICFAPY 246
Cdd:cd15074  158 SASVGGMSYIISI-FIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDsrskrqhkiERKVTKVAVLICAG-FLIAWTPY 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564399804 247 HFSFPLDFLVKSNEIKSclarrvilIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15074  236 AVVSMWSAFGSPDSVPI--------LASILPALFAKSSCMYNPIIYLLFSSKFR 281
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
23-301 3.12e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 59.92  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15401    4 AGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLvVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDckqkydLYISIVGWLIICLACLLFPLLRTNDDTPGNRTkcfVDLPIRNVNLAQ 181
Cdd:cd15401   84 VIGSVFNITAIAINRYCYICHSLRYDK------LYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQ---YDPRIYSCTFAQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVA---MITIgEVVGFITPLMIVLYCTWKT-ALSLQNKYPISQHLGEKKKA--LRMILTCAAVFL---ICFAPYHFsfpL 252
Cdd:cd15401  155 TVSssyTITV-VVVHFIVPLSIVTFCYLRIwVLVIQVKHRVRQDSKQKLKAndIRNFLTMFVVFVlfaVCWGPLNF---I 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 253 DFLVKSNEIKscLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15401  231 GLAVAINPLK--VAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
21-301 5.51e-10

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 59.14  E-value: 5.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILS-LPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15325    2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCfvdlpirnvNL 179
Cdd:cd15325   82 LCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETIC---------QI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVL--YCtwktalslqNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15325  153 TEEPGYALFSALGSFYLPLAIILvmYC---------RVYVVALKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFP 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 258 SNEIKSCLARrvilifhsVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15325  224 AYKPSDTVFK--------ITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
23-301 8.71e-10

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 58.88  E-value: 8.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15051    4 GVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLlGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVML 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPL---LRTNDDTPGN---RTKCFVDLpir 175
Cdd:cd15051   84 CTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhlgWNTPDGRVQNgdtPNQCRFEL--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITigevvgFITPLMIV------LYCTWKTALSLQNKYPISQHLGEKKKAL-----RMILTCAAV---FLI 241
Cdd:cd15051  161 NPPYVLLVAIGT------FYLPLLIMcgvylrIFRIAREQAKRINALTPASTANSSKSAAtarehKATVTLAAVlgaFII 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 242 CFAPYHFSFPLDFLVKSNeiksclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15051  235 CWFPYFTYFTYRGLCGDN---------INETALSVVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
21-301 1.02e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 58.59  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15073    2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFndCKQKYDLYIS-IVGWLIICLACLLFPLL---RTNDDTPGnrTKCFVDLPiR 175
Cdd:cd15073   82 FFGMASIGLLTVVAVDRYLTICRPDLG--RKMTTNTYTVmILLAWTNAFFWAAMPLVgwaSYALDPTG--ATCTINWR-K 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLqNKYPISQHL-------GEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15073  157 NDSSFVSYTMSVI--VVNFIVPLAVMFYCYYNVSRFV-KKVLASDCLesvnidwTDQNDVTKMSVIMIVMFLVAWSPYSI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 SFPLDFLVKSNEIKSclarrvilIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15073  234 VCLWASFGEPKKIPP--------WMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
24-300 1.46e-09

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 58.27  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVF--YGYMKETKRavVFMINLAIADLLQILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIgrSRDMRTTTN--LYLSSLAVSDLLIFLVLPLDLYrLWRYRPWRFGDLLCRLMYFFSET 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISI-VGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNL 179
Cdd:cd15928   83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIaVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVgFITPLMI--VLYCTWKTALSLQNK----YPISQHLGEKKKALRMILTCAAVFLICFAPYH-----F 248
Cdd:cd15928  163 GLLSVMLWVSTSF-FFVPMVClsLLYGLIGRALWDRRQrsrtAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHvgrviF 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 249 SFPLDFLVKSNEIKSclarrvilIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15928  242 NHSRASTKHLHYVSQ--------YFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
57-301 1.76e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 57.61  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  57 FMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRF----WFLMYPFRFNDCKQ 131
Cdd:cd15327   38 FIVNLAIADLLlSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYvgvkHSLKYPTIMTERKA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 132 KYDLYISIVGWLIICLAcllfPLLRTNDDTPGNRTKCfvdlpirnvNLAQSVAMITIGEVVGFITPLMIVLYCTWKTals 211
Cdd:cd15327  118 GVILVLLWVSSMVISIG----PLLGWKEPPPPDESIC---------SITEEPGYALFSSLFSFYLPLMVILVMYFRV--- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 212 lqnkYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLARrvilifhsVALCLASLNSCLDPVI 291
Cdd:cd15327  182 ----YVVALKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSEMVFK--------VIFWLGYFNSCVNPII 249
                        250
                 ....*....|
gi 564399804 292 YYFTTNEFRR 301
Cdd:cd15327  250 YPCSSKEFKR 259
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
30-301 1.86e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.61  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  30 LVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYF 108
Cdd:cd15402   11 IVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLvVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 109 LVCISVRRFWFLMYPFRFNDC-KQKYDLYISIVGWLIICLACLlfPLLRTNDDTpgnrtkcfVDLPIRNVNLAQSV-AMI 186
Cdd:cd15402   91 ITGIAINRYCYICHSLKYDKLySDKNSLCYVLLIWVLTVAAIV--PNLFVGSLQ--------YDPRIYSCTFAQSVsSAY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 187 TIGEVV-GFITPLMIVLYC---TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFL---ICFAPYHFsfpLDFLVKSN 259
Cdd:cd15402  161 TIAVVFfHFILPIIIVTFCylrIWILVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVlfaVCWAPLNF---IGLAVAVD 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 260 eiKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15402  238 --PETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
21-301 1.96e-09

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 57.37  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLvGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFvdlpirnvnL 179
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCY---------Y 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPyhfsFPLDFLVKSn 259
Cdd:cd15061  152 TYDKGYRIYSSMGSFFLPLLLMLFVYLR----------IFRVIAKERKTAKTLAIVVGCFIVCWLP----FFIMYLIEP- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 564399804 260 eIKSCLARRVILIFhsvALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15061  217 -FCDCQFSEALSTA---FTWLGYFNSVINPFIYAFYNKDFRR 254
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
57-300 2.91e-09

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 56.77  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  57 FMINLAIADLL-QILSLPLRIFY-YLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNdcKQKYD 134
Cdd:cd15308   38 FIVSLAVADLLlALLVLPLYVYSeFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYN--RRQGS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 135 L-YISIVGWLIICLACLLFPLLRTNDDTPgNRTKCFVDLPIRNVNLAQSVAMITIGevvgfiTPLMIVLYCTwktalslq 213
Cdd:cd15308  116 VrQLLLISATWILSFAVASPVIFGLNNVP-NRDPAVCKLEDNNYVVYSSVCSFFIP------CPVMLVLYCA-------- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 214 nkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLArrvilifhSVALCLASLNSCLDPVIYY 293
Cdd:cd15308  181 ----MFRGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLI--------SIVTWLGYVNSALNPVIYT 248

                 ....*..
gi 564399804 294 FTTNEFR 300
Cdd:cd15308  249 VFNAEFR 255
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
21-301 2.96e-09

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 57.24  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILS-LPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15123    2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFndckQKYDLYISIVG-----WLIICLACL---LFPLLRTNDDTPGNRT-KCFV 170
Cdd:cd15123   82 TSVGVSVFTLTVLSADRYRAIVKPLEL----QTSDAVLKTCCkagcvWIVSMLFAIpeaVFSDLYSFRDPEKNTTfEACA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPIRNVNLAQSVAMITIgeVVGFITPLMIV---LYCTWKTALSLQNKYPISQH------LGEKKKALRMILTCAAVFLI 241
Cdd:cd15123  158 PYPVSEKILQEIHSLLCF--LVFYIIPLSIIsvyYFLIARTLYKSTFNMPAEEHsharkqIESRKRVAKTVLVLVALFAF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 242 CFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSValcLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15123  236 CWLPNHILYLYRSFTYHTSVDSSAFHLIATIFSRV---LAFSNSCVNPFALYWLSKSFRQ 292
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
59-301 3.64e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 56.51  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  59 INLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRF--NDCKQKYDL 135
Cdd:cd15329   40 VSLAVSDLLvALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYavKRTPKRMAL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 136 YISIVgWLIICLACLLfPLL--RTNDDTPGnrtKCFVdlpirnvnlAQSVAMITIGEVVGFITPL--MIVLYctwktals 211
Cdd:cd15329  120 MIAIV-WLLSALISIP-PLFgwKNKVNDPG---VCQV---------SQDFGYQIYATFGAFYIPLivMLVLY-------- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 212 lqnkYPISQHLGEKKKALRMILTCAAVFLICFAPYhfsFPLDFL--VKSNEIKSCLARRVILIFhsvaLCLASLNSCLDP 289
Cdd:cd15329  178 ----YKIYRAAKSERKAIKTLGIIMGAFTLCWLPF---FILALLrpFLKPIKCSCIPLWLSRLF----LWLGYANSFLNP 246
                        250
                 ....*....|..
gi 564399804 290 VIYYFTTNEFRR 301
Cdd:cd15329  247 IIYAKFNREFRT 258
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
28-301 5.08e-09

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 56.59  E-value: 5.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15065    8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLvALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLI-ICLACLLFPL---LRTNDDTPGNRTK------CFVDLpir 175
Cdd:cd15065   88 LNLCAISLDRYIHIKKPLKYERwMTTRRALVVIASVWILsALISFLPIHLgwhRLSQDEIKGLNHAsnpkpsCALDL--- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 nvNLAQSVamitIGEVVGFITP--LMIVLYC---------------TWKTALSLQ-------NKYPISQHLGEKKKA--L 229
Cdd:cd15065  165 --NPTYAV----VSSLISFYIPclVMLLIYSrlylyarkhvvniksQKLPSESGSkfqvpslSSKHNNQGVSDHKAAvtL 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 230 RMILtcaAVFLICFAPYhfsfpldFLVksNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15065  239 GIIM---GVFLICWLPF-------FII--NIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 5.11e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 56.32  E-value: 5.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15209    9 VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQKYD--LYISIVgWLIICLACLLFPLLRTNDDTPGNRTKCFvdlpIRNVNLAQSVA 184
Cdd:cd15209   89 FNITAIAINRYCYICHSLQYDRLYSLRNtcCYLCLT-WLLTVLAVLPNFFIGSLQYDPRIYSCTF----AQTVSTVYTIT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MItigeVVGFITPLMIVLYC---TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFL---ICFAPYHFsfpLDFLVKS 258
Cdd:cd15209  164 VV----VIHFLLPLLIVSFCylrIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVlfaVCWAPLNF---IGLAVAI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 259 NEIKscLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15209  237 NPKE--MAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
56-301 7.70e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 55.76  E-value: 7.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  56 VFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDL 135
Cdd:cd14972   35 ILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 136 YISIVGWLIICLACLLFPLLRTNDDTPgNRTKCFVDLPIrnvnLAQSVAMITigeVVGFITPL--MIVLY-----CTWK- 207
Cdd:cd14972  115 KVLIALVWVWSVLLALLPVLGWNCVLC-DQESCSPLGPG----LPKSYLVLI---LVFFFIALviIVFLYvrifwCLWRh 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 208 ---TALSLQNKYPisQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIksclarrvilIFHSVALCL--AS 282
Cdd:cd14972  187 anaIAARQEAAVP--AQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCD----------IQAVFYYFLvlAL 254
                        250
                 ....*....|....*....
gi 564399804 283 LNSCLDPVIYYFTTNEFRR 301
Cdd:cd14972  255 LNSAINPIIYAFRLKEMRR 273
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
57-301 8.12e-09

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 55.67  E-value: 8.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  57 FMINLAIADLLQILS-LPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDL 135
Cdd:cd15326   38 FIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 136 YISIVGWLIICLACLLFPLLRTNDDTPGNRTKCfvdlpirnvNLAQSVAMITIGEVVGFITPLMIVL--YCtwktalslq 213
Cdd:cd15326  118 ILALLGVWVLSTVISIGPLLGWKEPAPPDDKVC---------EITEEPFYALFSSLGSFYIPLIVILvmYC--------- 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 214 NKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsneiksclARRVILIFHSVALCLASLNSCLDPVIYY 293
Cdd:cd15326  180 RVYIVALKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS--------HLKPPETLFKIIFWLGYFNSCLNPIIYP 251

                 ....*...
gi 564399804 294 FTTNEFRR 301
Cdd:cd15326  252 CSSKEFKR 259
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
20-303 8.85e-09

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 55.61  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYP--FRFNDCKQKYDLYISIVGWLIICLACLLF------PL--LRTNDDTPGNRTKC 168
Cdd:cd15396   81 SVSVSVSIFSLVLIAIERYQLIVNPrgWKPSASHAYWGIVLIWLFSLMISIPFLIFhqltdePFrnLSSHSDFYKDKVVC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 169 FVDLPIRNVNLAQSVAMItigeVVGFITPLMIVLYCTWKTALSLQNKYPI-------SQHLGEKKKALRMILTCAAVFLI 241
Cdd:cd15396  161 IEAWPSETERLIFTTSLL----VFQYFVPLGFIFICYLKIFVCLKKRNSKidrmrenESRLSENKRINTMLISIVVTFAA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 242 CFAPYHFsFPLDFLVKSNEIKSCLARRVILIFHSVALclasLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15396  237 CWLPLNI-FNVVFDWNHEVLMSCHHNLVFTLCHLVAM----VSTCINPIFYGFLNKNFQKDL 293
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-254 9.75e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 55.75  E-value: 9.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHD--WPFGPGLCMFCFYLKYV 100
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLvAVFCLPFEMDYYVVRQrsWTHGDVLCAVVNYLRTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgW---LIICLACLLFPllRTNDDTPGNRTKCFVDLPIRNV 177
Cdd:cd15204   85 SLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALV-WvvsLLLAIPSAVYS--KTTPYANQGKIFCGQIWPVDQQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgeVVGFITPLMIVLYC-------TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYH-FS 249
Cdd:cd15204  162 AYYKAYYLFLF--VLEFVLPVLIMTLCylrivrkVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYgYA 239

                 ....*
gi 564399804 250 FPLDF 254
Cdd:cd15204  240 IVRDF 244
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
23-304 1.34e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 55.30  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15305    4 ALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLvGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPF---RFNDcKQKYDLYISIVgWLIICLACLLFPLLRTNDDtpgnrTKCFVDlpirNV 177
Cdd:cd15305   84 FSTASIMHLCAISLDRYVAIRNPIehsRFNS-RTKAMMKIAAV-WTISIGISMPIPVIGLQDD-----EKVFVN----GT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPL--MIVLYCTWKTALSLQnkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFL 255
Cdd:cd15305  153 CVLNDENFVLIGSFVAFFIPLiiMVITYCLTIQVLQRQ------QAINNERRASKVLGIVFFLFLIMWCPFFITNILSVL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 256 VKsneiKSClARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLS 304
Cdd:cd15305  227 CK----EAC-DQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFS 270
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
22-301 1.56e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.96  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15307    3 WALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMvAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIV-GWLIICLACLLFPLLRTND--DTPGNRTkCFVDLPIRNV 177
Cdd:cd15307   83 FCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVfVWLLSIAMSLPLSLMYSKDhaSVLVNGT-CQIPDPVYKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 nlaqsvamitIGEVVGFITPL--MIVLYCTWKTALSLQNKYPiSQHLGEKKKALRMILTCAAVFLICFAPYhfsFPLDFL 255
Cdd:cd15307  162 ----------VGSIVCFYIPLgvMLLTYCLTVRLLARQRSRH-GRIIRLEQKATKVLGVVFFTFVILWSPF---FVLNLL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 256 VksneikSCLARRVILIFH---SVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15307  228 P------TVCAECEERISHwvfDVVTWLGYASSMVNPIFYTIFNKVFRQ 270
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
23-300 2.20e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 54.26  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15064    4 SVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLvAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFW----FLMYPFRFNDCKQKydLYISIVGWLIICLAclLFPLL--RTNDDTPGNrtKCFVdlpir 175
Cdd:cd15064   84 CTASILHLCVIALDRYWaitdAVEYAHKRTPKRAA--VMIALVWTLSICIS--LPPLFgwRTPDSEDPS--ECLI----- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 nvnlAQSVAMITIGEVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPyhfsfpldFL 255
Cdd:cd15064  153 ----SQDIGYTIFSTFGAFYIPLLLMLILYWK----------IYRAAARERKAAKTLGIILGAFIVCWLP--------FF 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 256 VKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15064  211 LVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
23-300 2.51e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.17  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYV 100
Cdd:cd15304    4 ALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADmLLGFLVMPVSMLTILYgYRWPLPSKLCAVWIYLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPF---RFNDCKQKYDLYISIvgWLIICLACLLFPLLRTNDDtpgnrTKCFVDlpiRNV 177
Cdd:cd15304   84 FSTASIMHLCAISLDRYIAIRNPIhhsRFNSRTKAFLKIIAV--WTISVGISMPIPVFGLQDD-----SKVFKE---GSC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSvAMITIGEVVGFITPLMIVLYCTWKTALSLQnkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15304  154 LLADE-NFVLIGSFVAFFIPLTIMVITYFLTIKSLQ------QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564399804 258 sneiKSClARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15304  227 ----ESC-NEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
22-301 2.67e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 54.21  E-value: 2.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKY 99
Cdd:cd15310    3 YALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLvATLVMPWVVYLEVTGGvWNFSRICCDVFVTLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFN-----DCKQKYDLYISIVGWLIICLAC-LLFPLlrtndDTPGNRTKCFVDLP 173
Cdd:cd15310   83 MMCTASILNLCAISIDRYTAVVMPVHYQhgtgqSSCRRVSLMITAVWVLAFAVSCpLLFGF-----NTTGDPTVCSISNP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IrnvnlaqsvaMITIGEVVGFITPLMIVLYCTWKTALSLQnkypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLD 253
Cdd:cd15310  158 D----------FVIYSSVVSFYLPFGVTLLVYVRIYVVLL----------REKKATQMLAIVLGAFIVCWLPFFLTHILN 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 254 flvksneiKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15310  218 --------THCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
34-303 2.96e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 54.13  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ--------ILSLPLRIFYYLN-HDWPFGpGLCMFCFYLKYVNMYA 104
Cdd:cd15137   15 LLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMgvylliiaSVDLYYRGVYIKHdEEWRSS-WLCTFAGFLATLSSEV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLI-ICLAclLFPLL--RTNDDTPGNRTKCFvDLPIRNVNLA- 180
Cdd:cd15137   94 SVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIgLLLA--VLPLLpwDYFGNFYGRSGVCL-PLHITDERPAg 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 --QSVAMITIGEVVGFITPLM--IVLYCTWKTALSLQNKypiSQHLGEKKKALRMILTCAAVFLiCFAPYhfsFPLDFLV 256
Cdd:cd15137  171 weYSVFVFLGLNFLAFVFILLsyIAMFISIRRTRKAAAS---RKSKRDMAVAKRFFLIVLTDFL-CWIPI---IVIGILA 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 257 ksneikscLARRVI--LIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15137  244 --------LSGVPIpgEVYAWVAVFVLPINSALNPILYTLSTPKFRKKL 284
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
28-247 4.41e-08

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 53.66  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILAL-WVFYGyMKETKRAVVFMINLAIADLLQILSLPLR--IFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15198    9 VILVAGVAGNTTVLcWLCGG-RRRKSRMNFLLLQLALADLLVIGGTALSqiIWELLGDRWMAGDVACRLLKLLQASARGA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFrfndcKQKYDLY-ISIVGWLIICLACL--LFPLLRTNDDTPGNR----TKC---FVDLPI 174
Cdd:cd15198   88 SANLVVLLALDRHQAIRAPL-----GQPLRAWkLAALGWLLALLLALpqAYVFRVDFPDDPASAwpghTLCrgiFAPLPR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNlaqsvAMITIGEVVGFITPLMIVLYC--------------------TWKTALSLQNKYPISQHLGEKK-KALRMIL 233
Cdd:cd15198  163 WHLQ-----VYATYEAVVGFVAPVVILGVCygrlllkwweranqapgakkPWKKPSKSHLRATAPSALPRAKvKTLKMTL 237
                        250
                 ....*....|....
gi 564399804 234 TCAAVFLICFAPYH 247
Cdd:cd15198  238 VIALLFVGCSLPYF 251
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-300 5.35e-08

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 53.30  E-value: 5.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIF-YYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLlGMPLELYeLWQNYPFLLGSGGCYFKTFLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDC--KQKYDLYISIVGWL-IICLACLLFPL-LRTNDDTPGNRTKCFVDLPIRNV 177
Cdd:cd15133   85 CLASILNVTALSVERYIAVVHPLAARTCstRPRVTRVLGCVWGVsMLCALPNTSLHgIKFLGSGVPASAQCTVRKPQAIY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLaqsvaMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPIS----------------QHLGEKKKALRMILTCAAVFLI 241
Cdd:cd15133  165 NM-----IPQHTGHLFFVLPMAVISVLYLLMALRLARERGLDatgagskigtrtgqllQHPRTRAQVTKMLFILVVVFAI 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564399804 242 CFAPYH-----FSFPLDFlvksneikSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15133  240 CWAPFHidrlmWSFISDW--------TDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
21-301 5.42e-08

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 53.26  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15296    2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLvGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNdcKQKYDLYISIVGWLIICLACLLF--PLLRTNDDTPGN----RTKCFVDlp 173
Cdd:cd15296   82 LLCTASVFNIVLISYDRFLSVTRAVSYR--AQKGMTRQAVLKMVLVWVLAFLLygPAIISWEYIAGGsiipEGECYAE-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 irnvnLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypiSQHLGEKKKALRMILTCAAVFLICFAPYhfsfPLD 253
Cdd:cd15296  158 -----FFYNWYFLMTASTLEFFTPFISVTYFNLSIYLNIQKR---RFRLSRDKKVAKSLAIIVCVFGLCWAPY----TLL 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 564399804 254 FLVKSneikSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15296  226 MIIRA----ACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRR 269
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
27-292 5.53e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 53.40  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAV--VFMINLAIADLLQILSL-PLRIFYYLNHDWPFGP-------GLCMFCFY 96
Cdd:cd14981    8 ALMFVFGVLGNLLALIVLARSSKSHKWSVfyRLVAGLAITDLLGILLTsPVVLAVYASNFEWDGGqplcdyfGFMMSFFG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LkyvnmyASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDT---PGnrTKCFVDLP 173
Cdd:cd14981   88 L------SSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVlqyPG--TWCFLDFY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNV-NLAQSVAMITIGEVVGFITPLMIVLYCtwKTALSLQNKYPISQ-----HLGEKKKALRMILTCAA---VFLICFA 244
Cdd:cd14981  160 SKNTgDAAYAYLYSILGLLILLVTLLCNLLVI--ITLLRMRRRKKRHRrsrrsARRQKRNEIQMVVLLLAitvVFSVCWL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 245 P-YHFSFPLDFLVKSNEIKSCLarrvilifhsVALCLASLNSCLDPVIY 292
Cdd:cd14981  238 PlMIRVLINATGDSEKNGKTDL----------LAVRMASWNQILDPWVY 276
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
26-294 6.18e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 53.20  E-value: 6.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGP-GLCMFCFYLKYVNMYA 104
Cdd:cd14964    5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPqALCYLIYLLWYGANLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDtpGNRTKCFVDLPIRNVNLAQSVA 184
Cdd:cd14964   85 SIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAI--PRYNTLTGSCYLICTTIYLTWG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 185 MITigevVGFITPLMIVLYCTWKTALSLQNK-----YPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSN 259
Cdd:cd14964  163 FLL----VSFLLPLVAFLVIFSRIVLRLRRRvrairSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAG 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 564399804 260 EIKSclarrvilIFHSVALCLASLNSCLDPVIYYF 294
Cdd:cd14964  239 QGLN--------LLSILANLLAVLASTLNPFIYCL 265
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 6.54e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 53.24  E-value: 6.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPG-LCMFCFYLKYVNMYASI 106
Cdd:cd15388    9 IIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDvLCRLVKYLQVVGMFASS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPF-RFNDCKQKYDLYIsIVGWLIICLACL--LFPLLRTNDDTpgNRTKCFvdlpirnVNLAQS- 182
Cdd:cd15388   89 YMIVAMTFDRHQAICRPMvTFQKGRARWNGPV-CVAWAISLILSLpqVFIFSKVEVAP--GVYECW-------ACFIEPw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 --VAMITIGEVVGFITPLMIVLYCTWKTALSLQ-NKYPISQHL-GEKK--------------------KALRMILTCAAV 238
Cdd:cd15388  159 glKAYVTWITLVVFVLPTLIITVCQVLIFKEIHiNIYLKSQIIvAVVKkkqllssrassvaevskamiKTVKMTLVIVLV 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 239 FLICFAPYhfsfpldFLVKSNEIKSCLARRVILIFhSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15388  239 YVLCWAPF-------FLVQLWSVWDPKAPTEGATF-TILMLLASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
23-301 7.21e-08

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 52.73  E-value: 7.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILalwVFYGYMKETK-RAV--VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15059    4 SSIVSVVILLIIVGNVL---VIVAVLTSRKlRAPqnWFLVSLAVADILvGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRT--KCfvdlpirn 176
Cdd:cd15059   81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAepQC-------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 vNLAQSVAMITIGEVVGFITPL--MIVLYCtwktalslqNKYPIsqHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15059  153 -ELSDDPGYVLFSSIGSFYIPLliMIIVYA---------RIYRA--AKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSneikSCLARRVILIFHSVALClaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15059  221 VCKT----CGVPELLFKFFFWLGYC----NSALNPVIYTIFNKDFRR 259
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
22-301 7.33e-08

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 53.00  E-value: 7.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15321    9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILvATLIIPFSLANELMGYWYFRKTWCEIYLALDVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLY-ISIVGWLIICLACLLfPLLRTND--DTPGNRTKCfvdlpirnv 177
Cdd:cd15321   89 FCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKcIILIVWLIAAVISLP-PLIYKGKqkDEQGGLPQC--------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKypisqhlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVK 257
Cdd:cd15321  159 KLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKNR---------EKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICP 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 258 sneiKSC-LARRVILIFHSVALClaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15321  230 ----ELCkVPHSLFQFFFWIGYC----NSSLNPVIYTIFNQDFRR 266
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
26-248 1.09e-07

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 52.49  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFygyMKETKRAVVFM--INLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMY 103
Cdd:cd14994    8 YSVVLIGGVIGVILMSFLL---VKMNTRSVTTTavINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMH 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFwflmypFRFNDCKQKYDLY-------ISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFV---DLP 173
Cdd:cd14994   85 LTFLFYVIILVIRY------LIFFQRKDKMEFYrklhavaASAVVWVLVLLIVVPVFVKEYGSSSSYNSDQCFKfhkELE 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564399804 174 IRNV-NLAQSVAMITIGEVVGFITPLMIVLYctwKTALSLQNKYPISQHLGEKKKALRMIltcaAVFLICFAPYHF 248
Cdd:cd14994  159 VHYVkVLNYIIICIVLIVTLALLGFQVFILG---HVYRKLRASLLSHQEFWAQMKSLFFI----VVIIVCFVPYNL 227
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
20-301 2.07e-07

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 51.44  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVpGLIGNILALWVFYGYMKETKRAVVFMINLAIAD------LLQILSLPLRIFY-YLNH--DWPFGPGL 90
Cdd:cd15964    2 FLRIVVWFVNLL-AILGNVFVLLILLTSHYKLTVPRFLMCNLAFADfcmgiyLLLIASVDLHTRSeYYNHaiDWQTGPGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  91 CMFCFYLKYVNMYaSIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWLIiCLACLLFPLLRTNddtpgNRTKCF 169
Cdd:cd15964   81 NTAGFFTVFASEL-SVYTLTVITLERWYAITFAMRLDrKIRLRHASAIMLGGWVF-CFLLALLPLVGVS-----SYAKVS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 170 VDLPIRNVNLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQNKYpisQHLGEK--KKALRMILTCAAVFlICFAPYH 247
Cdd:cd15964  154 ICLPMDTETPLAQAYIVFV--LMLNIIAFVIICACYIKIYITVRNPQ---YKSGDKdtKIAKRMAVLIFTDF-ICMAPIS 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564399804 248 FsFPLDFLVKSNEIKSCLARRVILIFHSvalclasLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15964  228 F-YALSAILNKPLITVSNSKILLVLFYP-------LNSCANPFLYAIFTKAFRR 273
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
20-300 2.55e-07

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 51.37  E-value: 2.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPF-----GPGLCMF 93
Cdd:cd15128    1 YINTVVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIViDLPINVYKLLAMDWPFgdqpfGQFLCKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  94 CFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgwLIICLACLL-------FPLLRTNDDTPGNRT 166
Cdd:cd15128   81 VPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIV--MIWMLSAVLavpeaigFDMVRFNYKGVTLRT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 167 kCFVDLPIRNVNLAQSVAMITIGEVVgFITPLMI------VLYCTWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFL 240
Cdd:cd15128  159 -CLLRPETSFMKFYIDVKDWWLFGFY-FCLPLVCtaifytLMTCEMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 241 ICFAPYHFSFPLDFLV-KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15128  237 LCWLPLHLSRILKLTVyDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
24-300 2.72e-07

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 51.42  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNH-DWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15131    5 VTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYrPWNFGDLLCKLFQFVSESCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFND--CKQKYDLYISIVGWLIICLACLLFPLL---RTNDDTPGNRTKC-FVDLPIRN 176
Cdd:cd15131   85 YSTILNITALSVERYFAICFPLRAKVvvTKRRVKLVILVLWAVSFLSAGPIFVLVgveHENGTNPIDTNECkATEYAVRS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAqsvAMITIGEVVGFITPL-MIVLYC-----TWKTalSLQNKYPISQHLGEK-KKALRMILTCAAVFLICFAPYHFS 249
Cdd:cd15131  165 GLLT---IMVWVSSVFFFLPVFcLTVLYSligrkLWRR--RRENIGPNASHRDKNnRQTVKMLAVVVFAFVLCWLPFHVG 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 250 FPLdfLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15131  240 RYL--FSKSFEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
28-303 2.90e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 51.06  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGymKETKRAV--VFMINLAIADLLQILSLPLRIFY-------YLNH--DWPFGPGlCMFCFY 96
Cdd:cd15136    9 FVFLLALVGNIIVLLVLLT--SRTKLTVprFLMCNLAFADFCMGIYLGLLAIVdaktlgeYYNYaiDWQTGAG-CKTAGF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLI-ICLACLlfPLLRTNDdtpgnRTKCFVDLPI 174
Cdd:cd15136   86 LAVFSSELSVFTLTVITLERWYAITHAMHLNKrLSLRQAAIIMLGGWIFaLIMALL--PLVGVSS-----YSKTSICLPF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQS--VAMITIGEVVGFItplmIVLYCTWKTALSLQNKYPISQHlGEKKKALRMILTCAAVFLiCFAPYHFsFPL 252
Cdd:cd15136  159 ETETPVSKayVIFLLLFNGLAFL----IICGCYIKIYLSVRGSGRAANS-NDTRIAKRMALLVFTDFL-CWAPIAF-FGL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 253 DFLVKSNEIkSCLARRVILIFhsvalcLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15136  232 TAAFGLPLI-SVSNAKILLVF------FYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
24-151 3.47e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 50.98  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15981    5 LAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLvGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSV 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRfndckQKYDLYISIVGWLIICLACLL 151
Cdd:cd15981   85 SASVFTLVAIAVERFRCIVHPFR-----QKLTLRKAIVTIVIIWVLALI 128
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
23-301 5.43e-07

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 50.22  E-value: 5.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15008    3 SLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLlSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYIsIVGWLIIclACLLFPLLRTNDDTPGNRTKCFvdLPIRNVNLAQ 181
Cdd:cd15008   83 PGVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMI-AASWLFD--AAFVSPALFFYGSNWGPHCNFF--LPDSWDGAAY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 182 SVAMItigeVVGFITP--LMIVLY-----CTWK------TALSLQNKYPISqhlgeKKKALRMILTCAAVFLICFAPYHf 248
Cdd:cd15008  158 AIIHL----LVGFLVPsiLIILFYqkvikYIWRigtdgrTVRRTMNIVPRT-----KVKTIKMFLMLNSMFLLSWLPFY- 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 sfpldfLVKSNEIKSCLARRVILIFHSVALCLASlNSCLDPVIYYFTTNEFRR 301
Cdd:cd15008  228 ------VVQLWHPRESDYRQSSLVFLAVTWISFS-SSASKPTLYSVYNANFRR 273
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
28-313 5.46e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 50.33  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVvFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIY 107
Cdd:cd14973    9 LLSLCGLVGNGLVLWLLGFRIKRNPFSV-YILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 108 FLVCISVRRFWFLMYPFRFNDCKQKydlYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVnlaQSVAMIt 187
Cdd:cd14973   88 LLAAISTERCLSVLFPIWYRCHRPK---HLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESACRTFNF---LSALLF- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 188 igevvGFITPLMIVlyctwkTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNeiksclar 267
Cdd:cd14973  161 -----LLLFLVMCV------SSLTLLIRVQCSSQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNY-------- 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 564399804 268 rVILIFHSVALCLASLNSCLDPVIYYFtTNEFRRRLSRQELPDSIQ 313
Cdd:cd14973  222 -LFHTFHPISDLLSCVNSSANPIIYFF-VGSLRGRRLREPLRVVLQ 265
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
34-305 7.38e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 49.82  E-value: 7.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCI 112
Cdd:cd15295   15 VLGNALVIIAFVVDKNLRHRSNYFFLNLAISDfFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 113 SVRRFWFLMYPFRFNDcKQKYDLYISIVGWLIICLACLLF-PLLRTNDDTPGNRTKCfvdlpirNVNLAQSVAMITIGEV 191
Cdd:cd15295   95 SYDRYQSVSNAVSYRN-QQTATLRIVTQMVAVWVLAFLVHgPAILVSDSWKTEDGEC-------EPEFFSNWYILAITSV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 192 VGFITPLMIVLYCTWKTALSLQNKypisqhLGEKK--KALRMILtcaAVFLICFAPYHFsFPLDFLVKSNEIKSclarrv 269
Cdd:cd15295  167 LEFLVPVILVAYFNTQIYWSLWKR------LRDRKlaKSLAIIL---GTFAICWAPYSL-FTIIRAACEKHRGS------ 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 564399804 270 ilIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSR 305
Cdd:cd15295  231 --PWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLK 264
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
20-300 8.33e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 49.90  E-value: 8.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15977    1 YVNTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILiAIPINVIKLIAEDWPFGVHVCKLYPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRF-----WFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTndDTPGNRTKCFVDLP 173
Cdd:cd15977   81 KASVGITVLSLCALSIDRYravasWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEI--DYRGQTLLVCMLPM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQN-------KYPISQHLGEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd15977  159 EQTSSFMRFYQDVKDWWLFGFYFCLPLACTGVFYTLMSCEMlsikngmRIALNDHMKQRREVAKTVFCLVVIFALCWLPL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564399804 247 HFSFPLDFLVKS-NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15977  239 HLSRILKKTIYDvKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKFK 293
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
34-303 8.74e-07

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 49.36  E-value: 8.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHD-WPFGPGLCMFCFYLKYVNMYASIYFLVC 111
Cdd:cd15302   15 VIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLiGLESMPFYTVYVLNGDyWPLGWVLCDLWLSVDYTVCLVSIYTVLL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 112 ISVRRFWFLMYPFRFNDCK-QKYDLYISIVGWLIICLacLLFPLLR-----TNDDTPGNRTKCFVDL---PIRNVNLAQS 182
Cdd:cd15302   95 ITIDRYCSVKIPAKYRNWRtPRKVLLIIAITWIIPAL--LFFISIFgwqyfTGQGRSLPEGECYVQFmtdPYFNMGMYIG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIgevvgfitPLMIVLYctwktalslqnkYPISQHLGEKKKALRMILTCAAVFLICFAPYHFsfpLDFLVKSNEIK 262
Cdd:cd15302  173 YYWTTL--------IVMLILY------------AGIYRAANRARKALRTITFILGAFVICWTPYHI---LATIYGFCEAP 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 263 SClarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15302  230 PC----VNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
20-303 1.05e-06

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 49.51  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILS-LPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15124    1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPF--RFNDCKQKYDLYISIVGWLIICLAC--LLFPLLRTNDDTPGNRTkcFVDL-P 173
Cdd:cd15124   81 LTSVGVSVFTLTALSADRYKAIVRPMdiQASNALMKICLKAALIWILSMLLAIpeAVFSDLHPFYDKSTNKT--FVSCaP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 IRNVNLAQSVAMITIGEVVGFITPLMIV-LYCTWKTALSLQNKYPI--------SQHLGEKKKALRMILTCAAVFLICFA 244
Cdd:cd15124  159 YPHSNELHPKIHSMASFLIFYVIPLSIIsVYYYFIAKNLIRSAYNLpvegnvhvRRQIESRKRLAKTVLVFVGLFAFCWL 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564399804 245 PYHfsfpLDFLVKS---NEIKSCLARRVILIfhsVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15124  239 PNH----IIYLYRSyhySEVDTSMLHFVSSI---CARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
24-303 1.25e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 49.04  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYgyMKETKRAVV--FMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLG--LNKRLRTVTnsFLLSLALSDLmLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACLLFPLLRTNDDTP-GNRT---KCFVDLPIR 175
Cdd:cd15979   83 SVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAAtWLLSGLIMIPYPVYSVTVPVPvGDRPrghQCRHAWPSA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIGevvgFITP--LMIVLYCTWKTALSLQnkypisqhLGEKKKALRMILTCAAVFLICFAPYhFSFPLD 253
Cdd:cd15979  163 QVRQAWYVLLLLIL----FFIPgvVMIVAYGLISRELYRG--------LLAKKRVIRMLVVIVAMFFLCWLPI-FSANTW 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 254 FLVKSNEIKSCLARRVILIFHsvalCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15979  230 RAFDPLSAHRALSGAPISFIH----LLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
61-300 1.48e-06

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 48.89  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  61 LAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFL--MYPFRfNDCKQKYDLYI 137
Cdd:cd15331   42 LAVADLMvAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVtnIDYIR-RRTAKRILIMI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 138 SIVgW---LIICLACLLFPLLRTNDDTPGNRTKCfvdlpirnvNLAQSVAMITIGEVVGFITPLMIVLYCTWKtalslqn 214
Cdd:cd15331  121 AVV-WfvsLIISIAPLFGWKDEDDLDRVLKTGVC---------LISQDYGYTIFSTVGAFYVPLLLMIIIYWK------- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 215 kypISQHLGEKKKALRMILTCAAVFLICFAPyhfsfpldFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYF 294
Cdd:cd15331  184 ---IYQAAKRERKAARTLAIITGAFVVCWLP--------FFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTI 252

                 ....*.
gi 564399804 295 TTNEFR 300
Cdd:cd15331  253 FSPDFR 258
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
23-305 1.54e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 49.06  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15306    4 ALLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLvGLFVMPIALLTILfEAMWPLPLVLCPIWLFLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISI-VGWLIIclACLLFPL----LRTNDDTPGNRTKCFVDLPIR 175
Cdd:cd15306   84 FSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKItVVWLIS--IGIAIPVpikgIETDVDNPNNITCVLTKERFG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NvnlaqsvaMITIGEVVGFITPLMIVLYCTWKTALSLQNkypisQHLGEKKKALRMILTCAAVFLICFAPYHFSFpldfl 255
Cdd:cd15306  162 D--------FILFGSLAAFFTPLAIMIVTYFLTIHALRK-----QTITNEQRASKVLGIVFFLFLLMWCPFFITN----- 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 256 VKSNEIKSClARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSR 305
Cdd:cd15306  224 ITSVLCDSC-NQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-301 1.66e-06

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 48.70  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCI 112
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALyPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 113 SVRRFWFLMYPFRFNDCKQKYD--LYISIVgWLIICLACLLFPLLRTNDDTPGNRTKCFVdlpiRNVNLAQSVAMItige 190
Cdd:cd15400   95 AINRYCYICHSFAYDKLYSRWNtlLYVCLI-WALTVVAIVPNFFVGSLEYDPRIYSCTFV----QTASSSYTIAVV---- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 191 VVGFITPLMIVLYC---TWKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLI---CFAPYHFsfpLDFLVKSNeiKSC 264
Cdd:cd15400  166 VIHFIVPITVVSFCylrIWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIfaiCWAPLNL---IGLAVAIN--PQE 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 564399804 265 LARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15400  241 MAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
22-301 2.74e-06

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 48.11  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  22 YAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYV 100
Cdd:cd15309    3 YAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLvATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFRFN---DCKQKYDLYISIVGWLIICLAC-LLFPLLRTNDDTpgnrtkCFVDLPirn 176
Cdd:cd15309   83 MCTASILNLCAISIDRYTAVAMPMLYNtrySSKRRVTVMISVVWVLSFAISCpLLFGLNNTDQNE------CIIANP--- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 vnlaqsvAMITIGEVVGFITPLMIVLYCTWKTALSLQnkypisqhlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15309  154 -------AFVVYSSIVSFYVPFIVTLLVYVQIYIVLQ----------KEKKATQMLAIVLGVFIICWLPFFITHILNMHC 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 257 KSNeiksclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15309  217 DCN---------IPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
20-300 3.30e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 47.88  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLvGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLACllFPLLRTNDDTPGNRTKCFVDLPIR-N 176
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGvWVLSFVIC--FPPLVGWNDGKDGIMDYSGSSSLPcT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIGEVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYhfsfpldFLV 256
Cdd:cd15063  159 CELTNGRGYVIYSALGSFYIPMLVMLFFYFR----------IYRAARMETKAAKTVAIIVGCFIFCWLPF-------FTV 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 257 KSNEIKSclARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15063  222 YLVRAFC--EDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-301 3.38e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 47.56  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15324    8 VVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDtpgnRTKCFvdlpirnvnLAQSVAM 185
Cdd:cd15324   88 IVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHD----EWECL---------LNDETWY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 186 ITIGEVVGFITP--LMIVLYCTWKTALSLQnkypisqhlgeKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsneiKS 263
Cdd:cd15324  155 ILSSCTVSFFAPglIMILVYCKIYRVAKMR-----------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCR----KR 219
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 564399804 264 C-LARRVILIFHSVALClaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15324  220 CgIPDALFNLFFWIGYC----NSSVNPIIYTIFNRDFRK 254
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
21-292 3.99e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 47.53  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQI-LSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15215    1 IRSVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTvLVMPWVIATSVPLFWPLDSHLCTALVVLMH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVG-WLIICLacllfpllrtnDDTPGNRTKCFVDLPIRN-- 176
Cdd:cd15215   81 LFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGtWIVSVL-----------QSTPPLYGWGQAAFDERNal 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 --VNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYpisqhlgeKKKALRMILTCAAVFLICFAPYHFsfpldF 254
Cdd:cd15215  150 csVIWGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARRCY--------HCKAAKVIFIIIFSYVLSMGPYSF-----L 216
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 564399804 255 LVKSNEIKSCLARRVIlifhSVALCLASLNSCLDPVIY 292
Cdd:cd15215  217 SVLAVWVDTQVPQWVI----SIILWLFFLQCCIHPYIY 250
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
58-301 4.40e-06

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 47.47  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  58 MINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI 137
Cdd:cd15349   39 LANIALSDLLTGTSYLVNICLSGERTFRLTPALWFLREGLLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYG 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 138 SIVGWLIICLACLLFPLLRTNddTPGNRTKCFVDLPIrnvnlaQSVAMITIGEVVGFITPL-MIVLYCTWKTALSLQNKY 216
Cdd:cd15349  119 MIVLCWILAFLIGFLPLLGWN--CLCDFRSCSSLLPL------YSKSYILFCLVIFFIILLtIIGLYFAIYCLVRASGQR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 217 PISQHlgEKKKALRM---ILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILifhsvalCLASLNSCLDPVIYY 293
Cdd:cd15349  191 VISAR--SRRRSLRLlktVLMILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGMEWVL-------ALAVLNSAINPLIYS 261

                 ....*...
gi 564399804 294 FTTNEFRR 301
Cdd:cd15349  262 FRSLEVRR 269
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
27-301 6.19e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 47.31  E-value: 6.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNIL--ALWVFYGYMKeTKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGpGLCMFCFYLKYVNMY 103
Cdd:cd15320    9 SVLILSTLLGNTLvcAAVIRFRHLR-SKVTNFFVISLAVSDLLvAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCST 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISI-VGWLIICLACLLFPLLRTNDDTP-----GNRTKcfVDLPIRNV 177
Cdd:cd15320   87 ASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMIsVAWTLSVLISFIPVQLNWHKAKPtsfldLNASL--RDLTMDNC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEVVGFITP--LMIVLY---------------CTWKTALSLQNKYPISQHLG----------------E 224
Cdd:cd15320  165 DSSLNRTYAISSSLISFYIPvaIMIVTYtriyriaqkqirrisALERAAVHAKNCQNSTGNRGsgdcqqpessfkmsfkR 244
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564399804 225 KKKALRMILTCAAVFLICFAPYH-FSFPLDFLVKSNEIKSCLARRVILIFhsvaLCLASLNSCLDPVIYYFTTnEFRR 301
Cdd:cd15320  245 ETKVLKTLSVIMGVFVCCWLPFFiLNCMVPFCKPTSTEPFCISSTTFDVF----VWFGWANSSLNPIIYAFNA-DFRK 317
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
21-300 7.60e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 46.75  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVpGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15080    3 LAAYMFLLILL-GFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFgGFTTTMYTSMHGYFVFGPTGCNLEGFFAT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYP---FRFNDCKQkydlYISIVGWLIICLACLLFPLLRTNDDTP-GNRTKCFVDLPIR 175
Cdd:cd15080   82 LGGEIALWSLVVLAIERYVVVCKPmsnFRFGENHA----IMGVAFTWVMALACAAPPLVGWSRYIPeGMQCSCGIDYYTL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVAMITIGeVVGFITPLMIV------LYCTWKTALSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHFS 249
Cdd:cd15080  158 KPEVNNESFVIYMF-VVHFTIPLIVIffcygrLVCTVKEAAAQQQESATTQK--AEKEVTRMVIIMVIAFLICWVPYASV 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 250 FPLDFLVKSNEIKSclarrvilIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15080  235 AFYIFTHQGSDFGP--------IFMTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
20-301 1.08e-05

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 46.11  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPgLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15297    2 FIVLVAGSLSLVT-IIGNILVMVSIKVNRHLQTVNNYFLFSLACADLiIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRF--NDCKQKYDLYIS---IVGWLIICLACLLFPLLRTNDDTPgnRTKCFVDLp 173
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYpvKRTTKMAGMMIAaawVLSFILWAPAILFWQFIVGGRTVP--EGECYIQF- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 irnvnlaQSVAMITIG-EVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPL 252
Cdd:cd15297  158 -------FSNAAVTFGtAIAAFYLPVIIMTVLYWQ----------ISRASSREKKVTRTILAILLAFIITWTPYNVMVLI 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 253 DFLVksneiKSCLARRVILIfhsvALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15297  221 NTFC-----ASCIPNTVWTI----GYWLCYINSTINPACYALCNATFKK 260
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
23-301 1.25e-05

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 46.02  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15346    4 SVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMFVAL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFwFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNddTPGNRTKCFVDLPirnvnLAQS 182
Cdd:cd15346   84 SASVFSLLAIAIERY-ITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWN--CISALSSCSTVLP-----LYHK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPLMIVLYC-------TWKTALSLQNKYPISQHLGEKKKAL-RMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15346  156 HYILFCTTVFTLLLLSIVILYCriyslvrTRSRRLTFRKNIRKASRSSEKSMALlKTVIIVLSVFIACWAPLFILLLLDV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKsneIKSClarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15346  236 GCK---VKTC----SILFKAEYFLVLAVLNSATNPIIYTLTNKEMRR 275
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-300 1.33e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 45.94  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIF-YYLNHDWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15132    9 ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYrLWKSRPWIFGEFLCRLYHYISEGCTYATI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQKYDL-YISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDL---PIRNVNLAQS 182
Cdd:cd15132   89 LHITALSIERYLAICFPLRAKVLVTRRRVkCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSREckhTPYAVSSGLL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 183 VAMITIGEVVGFITPL-MIVLYCT-----WKTALSLQNKYPISQHLGEkKKALRMILTCAAVFLICFAPYHfsfpldflV 256
Cdd:cd15132  169 GIMIWVTTTYFFLPMLcLSFLYGFigrklWKSKNDLRGPNAAARERSH-RQTVRILAVVVLAFIICWLPFH--------I 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLARRVILI---FHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15132  240 GRILFANTEDYRTMMFsqyFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
21-301 2.00e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 45.32  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLky 99
Cdd:cd14968    2 VYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILvGALAIPLAILISLGLPTNFHGCLFMACLVL-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFND-CKQKYDLYISIVGWLIICLACLLfPLLRTNDDTPGNRTKcfvdlpIRNVN 178
Cdd:cd14968   80 VLTQSSIFSLLAIAIDRYLAIKIPLRYKSlVTGRRAWGAIAVCWVLSFLVGLT-PMFGWNNGAPLESGC------GEGGI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LAQSVAMITIGEVVGFI------TPLMIVL------YCTWKTALSlQNKYPISQ-----HLGEKKKALRMILTCAAVFLI 241
Cdd:cd14968  153 QCLFEEVIPMDYMVYFNffacvlVPLLIMLviylriFRVIRKQLR-QIESLLRSrrsrsTLQKEVKAAKSLAIILFLFAL 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 242 CFAPYHFSFPLDFLvksneiksCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd14968  232 CWLPLHIINCITLF--------CPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
56-301 2.14e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 45.31  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  56 VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYD 134
Cdd:cd15323   37 LFLVSLASADILvATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 135 LYISIVG-WLIIclACLLFPLLRTNDDTPgnrtkcfVDLPIRNVNLAQSVAMITIGEVVGFITPLMIVLyctwktaLSLQ 213
Cdd:cd15323  117 VKAIIVTvWLIS--AVISFPPLISMYRDP-------EGDVYPQCKLNDETWYILSSCIGSFFAPCLIMI-------LVYI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 214 NKYPISQhlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsneiKSC-LARRVILIFHSVALClaslNSCLDPVIY 292
Cdd:cd15323  181 RIYRVAK--AREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICR----EACeVPEPLFKFFFWIGYC----NSSLNPVIY 250

                 ....*....
gi 564399804 293 YFTTNEFRR 301
Cdd:cd15323  251 TIFNQDFRR 259
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
29-301 2.15e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 45.23  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  29 ILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIAD------LLQILSLPLRI---FYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15360   10 INILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADlcmgiyLLLIASVDIRTksqYYNYAIDWQTGAGCAAAGFFTVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYaSIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWlIICLACLLFPLLRTNddtpgNRTKCFVDLPIR-NV 177
Cdd:cd15360   90 ASEL-SVYTLTVITLERWHTITYAMQLDrKVRLRHAAVIMVGGW-IFAFTVALLPIFGIS-----SYMKVSICLPMDiES 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQS-VAMITIGEVVGFItplmIVLYCTWKTALSLQNKYPISQHlGEKKKALRMILTCAAVFLiCFAPYHFsFPLDFLV 256
Cdd:cd15360  163 PLSQAyIIFILVLNVLAFL----IICACYIKIYLTVRNPNFVSSN-SDTKIAKRMAVLIFTDFL-CMAPISF-FAISASL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 257 KSNEIKSCLARRVILIFHSValclaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15360  236 KVPLITVSKSKILLVLFYPI-------NSCANPFLYAIFTKTFRR 273
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
26-303 2.15e-05

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 45.59  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIfYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15171    7 CSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWA-HAAWHGGSLGNPTCKVLVALSSVGLHSE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFNDCKQKYDLYI--SIVGWLIICLACL---LFPLLRTNDDTPgnrtKCFVD----LPIRN 176
Cdd:cd15171   86 ALFNVLLTVQASRVFFHGRLASSARRVAPCGIiaSVLAWLTAFLVTLpefVFYKPQMDSQKS----KCAFSrphfLPAEE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQNKypisqhlGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15171  162 TFWKYFLTLKMN--IVVLVFPLLVFIICCVQLRKTQRFR-------ERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFK 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 257 KSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15171  233 EHFSLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-301 2.48e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 45.32  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgyMKETKRAVV-----FMINLAIADLLQIL-SLPLRI--FYYLNHDWPFGPGLCM 92
Cdd:cd15130    2 LVTAIYLALFVVGTVGNSVTLFTLA--RKKSLQSLQstvryHLGSLALSDLLILLlAMPVELynFIWVHHPWAFGDAGCR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  93 FCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFND--CKQKYDLYISIVgWLIICLACL--LFPLLRTNDDTPGNRTKC 168
Cdd:cd15130   80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKTlmSRSRTKKFISAI-WLASALLAIpmLFTMGLQNESDDGTHPGG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 169 FVDLPIrnVNLAQSVAMITIGEVVGFITPLMIVlyctwktalSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHF 248
Cdd:cd15130  159 LVCTPI--VDTATLKVVIQVNTFMSFLFPMLVT---------SILNTVIANKLVQALRRGVLVLRAVVIAFVVCWLPYHV 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564399804 249 SfPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15130  228 R-RLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
31-303 2.83e-05

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 45.13  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  31 VPGLIGNILALWVFyGYMKETKRAVVFMINLAIADLLQILS----LPLRIFYYLNHdWPFGPGLCMFCFYLKYVnmyASI 106
Cdd:cd15108   12 VCGMAGNGLVVWLL-SCRGRRTPFCVYVLHLAVADLLFLLCmastLSLETSPLVIT-HDLAYEVVRRVKYFAYT---ASL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQKY-DLYISIVGWLIICLACLLFPLLrTNDDTPGNRTKCFVdlpirnvnlaqsVAM 185
Cdd:cd15108   87 SLLTAISTQRCLSVLFPIWYKCHQPRHlSAVVCALLWALSLLMNVLASFF-CSEFWHPDEWQCFK------------VDM 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 186 ITIGEVVGFITPLMIV---LYCTWKTALSLQNKYPISqhlgekkKALRMILTCAAVFLICFAPYHFSFPLDFLVKsneik 262
Cdd:cd15108  154 VFSFLIMGIFTPVMALsslILFVRVRRSSRQWRRRPT-------RLYVVVLASVLVFLACALPLGIYWFLLYWLD----- 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 564399804 263 scLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15108  222 --LPQEVKTLFSCLSRLSSSVSSSANPVIYFLVGSRGSRRL 260
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
23-301 3.15e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 45.17  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGN---ILALWVFY--GYMKetKRAVVFMINLAIADLLQ-ILSLPLRIF--YYLNHDWPFGPGLCMFC 94
Cdd:cd15135    4 TLLYSLILVAGILGNsatIKVTQVLQkkGYLQ--KSVTDHMVSLACSDLLVlLLGMPVELYsaIWDPFATPSGNIACKIY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  95 FYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLiiCLACLLFPLLRT-------NDDTPGNRTK 167
Cdd:cd15135   82 NFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVWL--TSALVALPLLFAmgtedplEAFPSYRGTR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 168 CFVDLPIRNV----NLAQSVAMITIGEVVGFITPLMI---VLYCTWKTALSLQ-------------------NKYPISQH 221
Cdd:cd15135  160 HHCQDQKSNLtictSLSSKWTVFQASIFSAFVLYLLVlasVAFMCRRMMRALMgskkgavavkgpggsvqllRKHESAEG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 222 LGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLV-KSNEIKSCLarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15135  240 KTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKpKDDWTRSYF--RAYIILLPIADTFFYLSSVLNPLLYNLSSQQFR 317

                 .
gi 564399804 301 R 301
Cdd:cd15135  318 S 318
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
34-301 3.60e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 44.55  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCI 112
Cdd:cd15322   15 VFGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 113 SVRRFWFLMYPFRFN--DCKQKYDLYISIVgWLIIclACLLFPLLRTNDDTPGNrtkcfVDLPIRNVNlaQSVAMITIGE 190
Cdd:cd15322   95 SLDRYWSITQAIEYNlkRTPRRIKCIIFIV-WVIS--AVISFPPLITIEKKSGQ-----PEGPICKIN--DEKWYIISSC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 191 VVGFITPLMIVLyctwktaLSLQNKYPISQHlgEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVksneiKSCLARRVI 270
Cdd:cd15322  165 IGSFFAPCLIMV-------LVYIRIYQIAKN--REKRFTFVLAVVIGVFVICWFPFFFTYTLTAVC-----DCSVPETLF 230
                        250       260       270
                 ....*....|....*....|....*....|.
gi 564399804 271 LIFHSVALClaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15322  231 KFFFWFGYC----NSSLNPVIYTIFNHDFRR 257
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-296 3.62e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.81  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILslpLRIFYYLNHDWPF---GPG-LCMFCFYLKYVNMY 103
Cdd:cd15387    9 LILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAV---FQVLPQLIWDITFrfyGPDfLCRLVKYLQVVGMF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRfnDCKQKYDLYISIVGWLIiclaCLLFPLLRTN----DDTPGNRTKCFVDLpirnVNL 179
Cdd:cd15387   86 ASTYMLLLMSIDRCLAICQPLR--SLHRRSDRVYVLFSWLL----SLVFSIPQVHifslREVGNGVYDCWADF----IQP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 180 AQSVAMITIGEVVGFITPLMIVLYC----TWKTALSLQNKYPISQHLGE----------------------KKKALRMIL 233
Cdd:cd15387  156 WGPKAYITWITLSVYIIPVLILSVCygliSFKIWQNVKLKTRRETKTPLssaasggaalarvssvkliskaKIRTVKMTF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 234 TCAAVFLICFAPYhfsfpldFLVKSNEIKSCLARRVILIFhSVALCLASLNSCLDPVIYYFTT 296
Cdd:cd15387  236 VIVLAYIVCWTPF-------FFVQMWSVWDPNAPKEASPF-IIAMLLASLNSCCNPWIYMFFT 290
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
26-300 4.61e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 44.48  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15978    7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQK-YDLYISIVGWLIICLACL-------LFPLLRTNddtpgNRTKCFVDLPIRN 176
Cdd:cd15978   87 STFNLVAISLERYSAICKPLKSRVWQTKsHALKVIAATWCLSFTIMLpypiysnLVPFTRIN-----NSTGNMCRLLWPN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 177 VNLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLqnkYPISQHLGEKKKALRMILTCAAVFLICFAPYhFSFPLDFLV 256
Cdd:cd15978  162 DVTQQSWYIFLL--LILFLIPGIVMMTAYGLISLEL---YRGIKFLMAKKRVIRMLIVIVILFFLCWTPI-FSANAWRAF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 257 KSNEIKSCLARRVILIFHsvalCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15978  236 DTRSADRLLSGAPISFIH----LLSYTSACVNPIIYCFMNKRFR 275
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
57-301 6.04e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 44.04  E-value: 6.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  57 FMINLAIADL-LQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDL 135
Cdd:cd15301   38 FLFSLAVADFaIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 136 YISIVGWLIICLAcLLFPLLRTNDDTPGNRT----KCFVDLPIRNVnlaqsvaMITIG-EVVGFITP--LMIVLYC-TWK 207
Cdd:cd15301  118 AVMIASAWIISLL-LWPPWIYSWPYIEGKRTvpagTCYIQFLETNP-------YVTFGtALAAFYVPvtIMCILYWrIWR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 208 TALSLQNKypisqhlgEKKKALRMILTCAAVFLICFAPYhfsfplDFLVKSNEIKSClARRVILIFHSVALCLASLNSCL 287
Cdd:cd15301  190 ETKKRQKK--------QESKAAKTLSAILLAFIVTWTPY------NVLVLIKAFFPC-SDTIPTELWDFSYYLCYINSTI 254
                        250
                 ....*....|....
gi 564399804 288 DPVIYYFTTNEFRR 301
Cdd:cd15301  255 NPLCYALCNAAFRR 268
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
218-300 6.25e-05

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 44.08  E-value: 6.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 218 ISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKS-NEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTT 296
Cdd:cd15975  214 LSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNeNDPRRCELLSFLLVMDYISINLATMNSCINPIALYFVS 293

                 ....
gi 564399804 297 NEFR 300
Cdd:cd15975  294 KKFK 297
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
61-301 1.02e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 43.38  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  61 LAIADLL-QILSLPLRIFYYLNHDWPFGPGLC--------MFCfylkyvnmYASIYFLVCISVRRF----WFLMYPFRFN 127
Cdd:cd15314   42 LAVADLLvGGLVMPPSMVRSVETCWYFGDLFCkihssfdiTLC--------TASILNLCFISIDRYyavcQPLLYRSKIT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 128 DCKQkydLYISIVGWLIICLACLLFPLLRTNDDTPGNRTK-----CFVDlpirnvnlaQSVAMITIGEVVGFITPLMIVL 202
Cdd:cd15314  114 VRVV---LVMILISWSVSALVGFGIIFLELNIKGIYYNHVaceggCLVF---------FSKVSSVVGSVFSFYIPAVIML 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 203 yCTW--------KTALSLQNKYPISQHLGEKK--KALRMILTCAAVFLICFAPYhfsfpldFLVksNEIKSCLARRVILI 272
Cdd:cd15314  182 -CIYlkiflvaqRQARSIQSARTKSGASSSKMerKATKTLAIVMGVFLLCWTPF-------FLC--NIIDPFINYSIPPV 251
                        250       260
                 ....*....|....*....|....*....
gi 564399804 273 FHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15314  252 LIEVLNWLGYSNSTLNPFIYAFFYSWFRK 280
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
21-301 1.09e-04

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 43.19  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15086    2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCRWYGFANS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWlIICLACLLFPLLRTNDDTP-GNRTKCFVDLPIRNVN 178
Cdd:cd15086   82 LFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSW-LYSLLWTLPPLLGWSSYGPeGPGTTCSVQWTSRSAN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 laqSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPISQHLGEKKK--ALRMILTCAAVFLICFAPYHFSFPLDFLV 256
Cdd:cd15086  161 ---SISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKREqhVLLMVVTMVICYLLCWLPYGVMALLATFG 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 564399804 257 KSNeikscLARRVILIFHSValcLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15086  238 KPG-----LVTPVASIVPSI---LAKSSTVVNPIIYVFMNKQFYR 274
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
27-301 1.19e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 43.25  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYAS 105
Cdd:cd15056    8 SLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLvAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 106 IYFLVCISVRRFWFLMYPFRFndckqkYDLYISIVgWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLAQSVAM 185
Cdd:cd15056   88 IMHLCCIALDRYYAICCQPLV------YKMTPLRV-AVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNCASGSTSCV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 186 I-------TIGEVVGFITPLMIVLYCTWKTAL----------SLQ----NKYPISQHLGEK----KKALRMILTCAAVFL 240
Cdd:cd15056  161 FmvnkpfaIICSTVAFYIPALLMVLAYYRIYVaareqahqirSLQragsSNHEADQHRNSRmrteTKAAKTLGIIMGCFC 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564399804 241 ICFAPyhfsfpldFLVkSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15056  241 VCWAP--------FFV-TNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
20-204 1.27e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 43.08  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLlqILSL----PLRIFYYLNHDWPFGPGLCMFCF 95
Cdd:cd15337    1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDF--GFSAvngfPLKTISSFNKKWIWGKVACELYG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  96 YLKYVNMYASIYFLVCISVRRFWFLMYPFR-FNDCKQKYDLYISIVGWLIICLACLLfPLLRTNDDTP-GNRTKCFVDLP 173
Cdd:cd15337   79 FAGGIFGFMSITTLAAISIDRYLVIAKPLEaMKKMTFKRAFIMIIIIWLWSLLWSIP-PFFGWGRYVPeGFQTSCTFDYL 157
                        170       180       190
                 ....*....|....*....|....*....|..
gi 564399804 174 IRNV-NLAQSVAMItigeVVGFITPLMIVLYC 204
Cdd:cd15337  158 SRDLnNRLFILGLF----IFGFLCPLLIIIFC 185
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
60-292 1.62e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 42.63  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  60 NLAIADLL-QILSLPLRIFYYLN-HDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFW----FLMYPFRFNDCKQKY 133
Cdd:cd15328   41 SMAVSDVLvAALVMPLSLVHELSgRRWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWsitrHLEYTLRTRRRISNV 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 134 DLYISIVGWLIICLACLLFPLLRTNDDtpgNRTKCFVdlpirnvnlAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQ 213
Cdd:cd15328  121 MIALTWALSAVISLAPLLFGWGETYSE---DSEECQV---------SQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAQ 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 214 nkypisqhlgEKKKALRMILTCAAVFLICFAPYhfsfpldFLVK-SNEIKSClarRVILIFHSVALCLASLNSCLDPVIY 292
Cdd:cd15328  189 ----------KEKRAALMVGILIGVFVLCWIPF-------FLTElISPLCSC---DIPPIWKSIFLWLGYSNSFFNPLIY 248
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
24-301 2.59e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 42.14  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFY--GYMKETKRAVVF-MINLAIADLL-QILSLPLRI--FYYLNHDWPFGPGLCMFCFYL 97
Cdd:cd15355    5 AIYLALFVVGTVGNSITLYTLArkKSLQHLQSTVHYhLASLALSDLLiLLLAMPVELynFIWVHHPWAFGDAACRGYYFL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFrfndcKQKYDLYISIVGWLIICL----ACLLFPLLRT------NDDTPGNR-- 165
Cdd:cd15355   85 RDACTYATALNVASLSVERYLAICHPF-----KAKSLMSRSRTKKFISAIwlasALLAIPMLFTmgeqnrSGTHPGGLic 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 166 -----TKCFVDLPIRNVNLAQSVAMITIGEVVGFITPLMIVLY------------CTWKTALSLQNKYPISQHLGEKKKA 228
Cdd:cd15355  160 tpivdTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTVMVnqaeqenqvctiGGQRTVLSVSMEPGRVQSLRHGVLV 239
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 229 LRMILTcaaVFLICFAPYHFSfPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15355  240 LRAVVI---AFVVCWLPYHVR-RLMFCYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQ 308
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
27-126 2.63e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 42.25  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNIL--ALWVFYGYMKeTKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGpGLCMFCFYLKYVNMY 103
Cdd:cd15319    8 SLLILWTLLGNILvcAAVVRFRHLR-SKVTNIFIVSLAVSDLFvALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCST 85
                         90       100
                 ....*....|....*....|...
gi 564399804 104 ASIYFLVCISVRRFWFLMYPFRF 126
Cdd:cd15319   86 ASILNLCVISVDRYWAISSPFRY 108
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
21-300 2.86e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 41.97  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGN-ILALWVfygYMKETKRAVV--FMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFY 96
Cdd:cd15213    2 TLAILMILMIFVGFLGNsIVCLIV---YQKPAMRSAInlLLANLAFSDiMLSLVCMPFAAVTIITGRWIFGDIFCRISAM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  97 LKYVNMYASIYFLVCISVRRFWFLMypfRFNDCKQKYDLYISIVGWLIICLaCLLFPLLRTNDDT--PGNRTKCFVDLPI 174
Cdd:cd15213   79 LYWFFVLEGVAILLIISVDRYLIIV---QRQDKLNPHRAKILIAVSWVLSF-CVSFPPLVGWGKYefPPRAPQCVLGYTE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 RNVNLAQSVAMItigeVVGFITPLMIVLY---CTWKTALSLqnkypisqhlgeKKKALRMILTCAAVFLICFAPYH-FSF 250
Cdd:cd15213  155 SPADRIYVVLLL----VAVFFIPFLIMLYsyfCILNTVRSF------------KTRAFTTILILFIGFSVCWLPYTvYSL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 251 PLDFLVKSNeiksclarrVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15213  219 LSVFSRYSS---------SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
21-300 4.17e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 41.36  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15404    2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADmMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMypfRFNDCKQKYDLYISIVGWLIICLaCLLFPLLRTNDD--TPGNRTKCFVDLPiRNV 177
Cdd:cd15404   82 LFVMEGVAILLIISIDRFLIIV---QKQDKLNPYRAKVLIAVSWAVSF-CVAFPLAVGSPDlqIPSRAPQCVFGYT-TNP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITigeVVGFITPLMIVLYCTWKTALSLQnkypisqhlGEKKKALRMILTCAAVFLICFAPYHF-----SFPL 252
Cdd:cd15404  157 GYQAYVILIM---LIFFFIPFMVMLYSFMGILNTVR---------SFKTRAFTTILILFIVFTVCWAPFTTyslvaTFNS 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 253 DFLVKSN--EIKSCLarrvilifhsvaLCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15404  225 HFYHKHNffEISTWL------------LWLCYLKSALNPLIYYWRIKKFR 262
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
19-300 5.29e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 41.09  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  19 YFIYAVTYTVILVPgLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYL 97
Cdd:cd15299    4 VLIAFLTGILALVT-IIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIiGVISMNLFTTYIIMNRWALGNLACDLWLSI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYP--FRFNDCKQKYDLYIS---IVGWLIICLACLLFPLLRTNDDTPGNrtKCFVDL 172
Cdd:cd15299   83 DYVASNASVMNLLVISFDRYFSITRPltYRAKRTTKRAGVMIGlawVISFVLWAPAILFWQYFVGKRTVPPD--ECFIQF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 173 pirnvnlaQSVAMITIGEVVG-FITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFsfp 251
Cdd:cd15299  161 --------LSEPIITFGTAIAaFYLPVTIMTILYWR----------IYKETIKEKKAAQTLSAILLAFIITWTPYNI--- 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 252 ldFLVKSNEIKSCLARrvilIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15299  220 --MVLVNTFCDSCIPK----TYWNLGYWLCYINSTVNPVCYALCNKTFR 262
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
27-301 5.36e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 41.21  E-value: 5.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  27 TVILVPGLIGNILalwVFYGYMKETKRAVV---FMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM 102
Cdd:cd15066    7 TLIILAAIFGNLL---VIISVMRHRKLRVItnyFVVSLAMADMLvALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 103 YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNR-------TKC-FVdlpi 174
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTEEHLqyrkthpDQCeFV---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 175 rnVNLAQSVamitIGEVVGFITPLMIVLYCTWKtalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDF 254
Cdd:cd15066  160 --VNKIYAL----ISSSVSFWIPCIVMIFTYYR----------IYLEAKREHKAAKTLGIIMGAFILCWLPFFLWYVTTT 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSneikSCLARRVILifhSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15066  224 LCGD----ACPYPPILV---SILFWIGYFNSTLNPLIYAYFNRDFRE 263
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
55-154 7.59e-04

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 40.76  E-value: 7.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  55 VVFMINLAIADLLQILSLPLRIFYYL-NHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQ-K 132
Cdd:cd15169   37 LVYALNLGCSDLLLTVSLPLKAVEALaSGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRpC 116
                         90       100
                 ....*....|....*....|...
gi 564399804 133 YDLYISIVGW-LIICLACLLFPL 154
Cdd:cd15169  117 YSWGVCAAIWaLVLCHLGLVFGL 139
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
23-303 8.23e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 40.43  E-value: 8.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLI-GNILALWVFYGYMKETKRAV-VFMINLAIADLLQILSLPLRIFYYLNHDwPFGPG--LCMFCFYLK 98
Cdd:cd15104    2 AGVILAVLSPLIItGNLLVIVALLKLIRKKDTKSnCFLLNLAIADFLVGLAIPGLATDELLSD-GENTQkvLCLLRMCFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNvn 178
Cdd:cd15104   81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHP-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 laqSVAMITIgeVVGFITPLMIVLYC---TWKTA-----------LSLQNKYPISQHLGEKKkALRMILTCAAVFLICFA 244
Cdd:cd15104  159 ---RVLLVLS--CMVFFPALLLFVFCycdILKIArvhsraiykveHALARQIHPRRTLSDFK-AARTVAVLIGCFLLSWL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564399804 245 PYHFSFPLDFLVKSNEIKSCLarRVILIFhsvalcLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15104  233 PFQITGLVQALCDECKLYDVL--EDYLWL------LGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
26-154 1.03e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 40.14  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  26 YTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYA 104
Cdd:cd15398    7 YTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLfCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMV 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564399804 105 SIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVgWLIICLACLLFPL 154
Cdd:cd15398   87 STLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTV-WTLGFTICSPLPV 135
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
29-301 1.06e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 40.23  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  29 ILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPL--------RIFYYlNH--DWPFGPGLCMFCFYLK 98
Cdd:cd15359   10 INILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLiasvdsqtKSQYY-NHaiDWQTGSGCSTAGFFTV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYaSIYFLVCISVRRFWFLMYPFRFN-DCKQKYDLYISIVGWLIICLACLLfPLLRTNddtpgNRTKCFVDLPIRNV 177
Cdd:cd15359   89 FASEL-SVYTLTVITLERWHTITYAMQLDrKLRLRHAILIMLGGWVFSLLIAVL-PLVGVS-----NYMKVSICLPMDIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIgeVVGFITPLMIVLYCTWKTALSLQNKYPISQHlGEKKKALRMILTCAAVFlICFAPYHFsFPLDFLVK 257
Cdd:cd15359  162 TLLSQAYILLI--LVLNVIAFLVICACYIKIYLAVQNPELVAKN-KDTKIAKRMAILIFTDF-TCMAPISF-FAISAAFK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 564399804 258 SNEIKSCLARRVILIFHSValclaslNSCLDPVIYYFTTNEFRR 301
Cdd:cd15359  237 VPLITVTNSKILLVLFYPI-------NSCANPFLYAIFTKAFRR 273
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
20-301 1.09e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 40.00  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  20 FIYAVTYTVILVPgLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLK 98
Cdd:cd15298    2 FIATVTGSLSLVT-VVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIiGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  99 YVNMYASIYFLVCISVRRFWFLMYPFRF--NDCKQKYDLYIS---IVGWLIICLACLLFPLLRTNDDTPGNrtKCFVDLp 173
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYpaRRTTKMAGLMIAaawVLSFVLWAPAILFWQFVVGKRTVPDN--QCFIQF- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 174 irnvnlaQSVAMITIG-EVVGFITPLMIVlyctwkTALSLQnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFsfpl 252
Cdd:cd15298  158 -------LSNPAVTFGtAIAAFYLPVVIM------TVLYIH----ISLASARERKVTRTIFAILLAFILTWTPYNV---- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 564399804 253 dFLVKSNEIKSCLARRVilifHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15298  217 -MVLVNTFCQSCIPDTV----WSIGYWLCYVNSTINPACYALCNATFKK 260
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
28-204 1.34e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 40.09  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIAD-LLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASI 106
Cdd:cd15336    9 IIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDfLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 107 YFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTP-GNRTKCFVDLpirnVNLAQSVAM 185
Cdd:cd15336   89 ITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPeGLLTSCTWDY----MTFTPSVRA 164
                        170       180
                 ....*....|....*....|.
gi 564399804 186 IT--IGEVVGFItPLMIVLYC 204
Cdd:cd15336  165 YTmlLFCFVFFI-PLGIIIYC 184
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
24-125 1.40e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 39.75  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  24 VTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQIL-SLPLRIfYYLNHDWPF--GPGLCMFCFYLKYV 100
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLlGMPLEL-YEMWSNYPFllGAGGCYFKTLLFET 83
                         90       100
                 ....*....|....*....|....*
gi 564399804 101 NMYASIYFLVCISVRRFWFLMYPFR 125
Cdd:cd15358   84 VCFASILNVTALSVERYIAVVHPLK 108
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
34-301 1.47e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 39.80  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  34 LIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCIS 113
Cdd:cd15345   15 VLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTQWFLREGSMFVALGASTFSLLAIA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 114 VRRFwFLMYPFRFNDCKQKYDLYISI-VGWLIICLACLLfPLLRTNddTPGNRTKCFVDLPIRNVNLAQSVAMITIGEVV 192
Cdd:cd15345   95 IERH-LTMIKMRPYDANKRYRVFLLIgTCWLISVLLGAL-PILGWN--CLDNLPDCSTILPLYSKKYVAFCISIFIAILV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 193 GfitplMIVLYCTWKTALSLQNKYPISQHLGEKKKAL-RMILTCAAVFLICFAPYHFSFPLDFlvkSNEIKSClarrVIL 271
Cdd:cd15345  171 A-----IVILYARIYILVKSSSRRVTNHRNSERSMALlRTVVIVVGVFIACWSPLFILLLIDV---ACEVKQC----PIL 238
                        250       260       270
                 ....*....|....*....|....*....|
gi 564399804 272 IFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15345  239 YKADWFIALAVLNSAMNPIIYTLASKEMRR 268
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
23-128 1.52e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 39.79  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMI--NLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15142    4 PTIPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLgTCLASPVTIATYLKGRWPGGQPLCEYFSFILL 83
                         90       100
                 ....*....|....*....|....*....
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFND 128
Cdd:cd15142   84 FFSLSGLSIICAMSIERYLAINHAYFYNH 112
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
21-301 1.97e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 39.24  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPgLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKY 99
Cdd:cd15300    3 IAAVTAVVSLIT-IVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIiGIFSMNLYTSYILMGYWALGSLACDLWLALDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISI-VGWLIICLacLLFPLLRTNDDTPGNRTkcfvdLPIRNVN 178
Cdd:cd15300   82 VASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIgLAWLISFI--LWAPPILCWQYFVGKRT-----VPERECQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 179 LA-QSVAMITIGEVVG---FITPLMIVLYCTwktalslqnkypISQHLGEKKKALRMILTCAAVFLICFAPYHFsfpldF 254
Cdd:cd15300  155 IQfLSEPTITFGTAIAafyIPVSVMTILYCR------------IYKETIKERKAAQTLSAILLAFIITWTPYNI-----M 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564399804 255 LVKSNEIKSCLArrviLIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15300  218 VLVSTFCSDCIP----LTLWHLGYWLCYVNSTVNPMCYALCNKTFRK 260
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
21-300 2.45e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 39.15  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLky 99
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAvGVLAIPFAITISTGFCAACHGCLFIACFVL-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 100 VNMYASIYFLVCISVRRFWFLMYPFRFND--CKQKYDLYISIVgWLiICLACLLFPLLRTNDDTP--GNRTKCFVDLPIR 175
Cdd:cd15068   80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGlvTGTRAKGIIAIC-WV-LSFAIGLTPMLGWNNCGQpkEGKNHSQGCGEGQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 176 NVNLAQSVA----MITIGEVVGFITPLMIVL--YCTWKTALSLQNKYPISQHLGEKKK---------ALRMILTCAAVFL 240
Cdd:cd15068  158 VACLFEDVVpmnyMVYFNFFACVLVPLLLMLgvYLRIFLAARRQLKQMESQPLPGERArstlqkevhAAKSLAIIVGLFA 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 241 ICFAPYHFSFPLDFLVKSNEiksclarRVILIFHSVALCLASLNSCLDPVIYYFTTNEFR 300
Cdd:cd15068  238 LCWLPLHIINCFTFFCPDCS-------HAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
21-301 3.56e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 38.69  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFY---GYMKETKRAVVFMINLAIADLL-QILSLPLRI--FYYLNHDWPFGPGLCMFC 94
Cdd:cd15356    2 LFTAVYALIWALGAAGNALTIHLVLkkrSLRGLQGTVHYHLVSLALSDLLiLLISVPIELynFVWFHYPWVFGDLVCRGY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  95 FYLKYVNMYASIYFLVCISVRRFWFLMYPFR----FNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFV 170
Cdd:cd15356   82 YFVRDICSYATVLNIASLSAERYLAICQPLRakrlLSKRRTKWLLALIWASSLGFALPMAFIMGQKYELETADGEPEPSS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 171 DLPIRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQnkypiSQHLGEKKKALRMILTcaaVFLICFAPYHfSF 250
Cdd:cd15356  162 RVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLR-----IQSLQHSVQVLRAIVI---AYVICWLPYH-AR 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564399804 251 PLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15356  233 RLMFCYVPDDAWTDSLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRK 283
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
21-246 4.13e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 38.21  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  21 IYAVTYTVILVPGLIGNILALWVFYgYMKETKRAV--VFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYL 97
Cdd:cd15219    1 LLAVLLVVVLVVSLLSNLLVLLCFL-YSAELRKQVpgIFLLNLSFCNLLlTVLNMPFTLLGVVRNRQPFGDGFCQAVGFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  98 KYVNMYASIYFLVCISVRRFWFLMYPFRF-NDCKQKYDLYISIVGWliicLACLLFPLLRTNDDTPGNRT---KCFVDLP 173
Cdd:cd15219   80 ETFLTSNAMLSMAALSIDRWIAVVFPLSYtSKMRYRDAALMVGYSW----LHSLTFSLVALFLSWLGYSSlyaSCTLHLP 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 174 iRNVNLAQSVAMITIGEVVGFITPLmIVLYCTWKTALSLQnkypisqhlgEKKKALRMILTCAAVFLICFAPY 246
Cdd:cd15219  156 -REEERRRFAVFTAFFHAFTFLLSL-LVLCVTYLKVLKVR----------RRQRATKKISIFIGTFVLCFAPY 216
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
28-294 4.19e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  28 VILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADL----LQIL-SLPLRIFYYLNhdwpfGP-GLCMFCFYLKYVN 101
Cdd:cd15385    9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLvvafFQVLpQLCWDITYRFY-----GPdFLCRIVKHLQVLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLAC----LLFPLLRTNDDTpgNRTKCFVDLpIRNV 177
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFILStpqyFIFSLSEIENGS--GVYDCWANF-IVPW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 178 NLAQSVAMITIGEvvgFITPLMIVLYC-------TWKT-------------------ALSLQNKYPISQhlgEKKKALRM 231
Cdd:cd15385  161 GIKAYITWITISI---FVVPVIILLTCygficynIWRNikcktrrglsdnalknillAVCVSSVKTISR---AKIRTVKM 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 232 ILTCAAVFLICFAPYhFSFPLDFLVKSNEIKSCLARRVIlifhSVALCLASLNSCLDPVIYYF 294
Cdd:cd15385  235 TFVIVLAYIVCWAPF-FTIQMWSVWDQNFPWDESENTAV----TITALLASLNSCCNPWIYMF 292
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
56-203 4.46e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 38.20  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  56 VFMINLAIADLLQ-ILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRF----NDCK 130
Cdd:cd15058   37 IFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYqvllTKRR 116
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564399804 131 QKydlYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDlpIRNVNLAQSVAMITIGEVVGFITPLMIVLY 203
Cdd:cd15058  117 AR---VIVCVVWIVSALVSFVPIMNQWWRANDPEANDCYQD--PTCCDFRTNMAYAIASSVVSFYIPLLIMIF 184
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
40-303 7.69e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 37.70  E-value: 7.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  40 ALWVFYGYMKETKRAVVFMI--NLAIADLLQILSLPLR-IFYYLNHDwpfgPGLCMFCFYLKYVNMYASIYFLVCISVRR 116
Cdd:cd15961   19 AIVVLIIFQNPSLRAPMFLLigSLALADLLAGIGLILNfIFAYLLQS----EAAKLVTVGLIVASFSASVCSLLAITVDR 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 117 FWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNddTPGNRTKCFVDLPIRNVNlaqsVAMITIGEVVGFit 196
Cdd:cd15961   95 YLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWN--CLADESTCSVVRPLTKNN----AAILSVSFLLMF-- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 197 PLMIVLYCT-------WKTALSLQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYH-FSFPLDFLVKSneiksclarr 268
Cdd:cd15961  167 ALMLQLYIQickivmrHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTlYSLIADYTYPS---------- 236
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 564399804 269 vilIFHSVALCLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15961  237 ---IYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
37-301 8.72e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 8.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  37 NILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRR 116
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMFVALSASVFSLLAIAIER 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 117 FwFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNddTPGNRTKCFVDLPIRNVNLAQSVAMITIGeVVGFIT 196
Cdd:cd15102   98 H-LTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWN--CLGALDACSTVLPLYSKHYVLFCVTIFAG-ILAAIV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 197 PLMIVLYCTWKTAlslQNKYPISQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKsneIKSClarrVILIFHSV 276
Cdd:cd15102  174 ALYARIYCLVRAS---GRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVACP---VKTC----PILYKADW 243
                        250       260
                 ....*....|....*....|....*
gi 564399804 277 ALCLASLNSCLDPVIYYFTTNEFRR 301
Cdd:cd15102  244 FLALAVLNSALNPIIYTLRSRELRR 268
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
23-303 8.88e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 37.50  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804  23 AVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLL-QILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVN 101
Cdd:cd15078    4 ALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLvSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 102 MYASIYFLVCISVRRFWFLMYPFRFNDCKQKYdlyiSIVGWLIICLACLLFPLLRTNDDT-PGNRTKCFVDLPIRNVNLA 180
Cdd:cd15078   84 GIVSIMTLTVLAYERYIRVVHAKVVNFSWSWR----AITYIWLYSLAWTGAPLLGWNRYTlEVHGLGCSFDWKSKDPNDT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564399804 181 QSVAMITIGevvGFITPLMIVLYC---------TWKTALSLQNKYPISQHLGEKKKAlRMILTCAAVFLICFAPYHFsfp 251
Cdd:cd15078  160 SFVLLFFLG---CLVVPLGIMAYCyghilyeirMLRSVEDLQTFQVIKILKYEKKVA-KMCLLMISTFLICWMPYAV--- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564399804 252 LDFLVKSNeiKSCLARRVILIFHSValcLASLNSCLDPVIYYFTTNEFRRRL 303
Cdd:cd15078  233 VSLLVTSG--YSKLVTPTIAIIPSL---FAKSSTAYNPVIYIFMIRKFRQCL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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