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Conserved domains on  [gi|672039925|ref|XP_008758512|]
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nicotinamide riboside kinase 1 isoform X1 [Rattus norvegicus]

Protein Classification

nicotinamide riboside kinase( domain architecture ID 10113996)

nicotinamide riboside kinase catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-158 2.17e-90

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


:

Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 263.42  E-value: 2.17e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925   5 VIGIGGVTNGGKTTLAKNLQKRLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENP------- 77
Cdd:cd02024    1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfpkflr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925  78 ----------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEP----- 136
Cdd:cd02024   81 shgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                        170       180
                 ....*....|....*....|...
gi 672039925 137 -PDPPGYFDGHVWPMYLKHRQEM 158
Cdd:cd02024  161 wPDPPGYFDGHVWPMYLKHHAEM 183
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-158 2.17e-90

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 263.42  E-value: 2.17e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925   5 VIGIGGVTNGGKTTLAKNLQKRLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENP------- 77
Cdd:cd02024    1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfpkflr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925  78 ----------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEP----- 136
Cdd:cd02024   81 shgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                        170       180
                 ....*....|....*....|...
gi 672039925 137 -PDPPGYFDGHVWPMYLKHRQEM 158
Cdd:cd02024  161 wPDPPGYFDGHVWPMYLKHHAEM 183
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-154 2.72e-22

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 89.90  E-value: 2.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925   1 MKTFVIGIGGVTNGGKTTLAKNLQKRLP--NCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWME--- 75
Cdd:COG0572    5 GKPRIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAges 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925  76 ---------NPGSSAGPAALESAqgvPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRR-----STRVYEPPDPPG 141
Cdd:COG0572   85 velpvydfaTGTRSGETVKVEPA---DVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIE 161

                        170
                 ....*....|...
gi 672039925 142 YFDGHVWPMYLKH 154
Cdd:COG0572  162 QYWATVRPGHEQY 174
AAA_18 pfam13238
AAA domain;
6-148 2.88e-19

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 79.78  E-value: 2.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925    6 IGIGGVTNGGKTTLAKNLQKRLpNCSVISQDDFFKPESEIDIDENgflqYDVLEALNMEKMMSAVSCWMENPGSSAGpaa 85
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENAALEEG--- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672039925   86 lesaqgvPILIIEGFLLFNYKPLDTIWNRsYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVW 148
Cdd:pfam13238  73 -------GNLIIDGHLAELEPERAKDLVG-IVLRASPEELLERLEKRGYEEAKIKENEEAEIL 127
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-56 1.45e-07

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 49.77  E-value: 1.45e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 672039925   1 MKTFVIGIGGVTNGGKTTLAKNLQKRLPN--CSVISQDDFFKPESEIDIDENGFLQYD 56
Cdd:PRK05480   4 KKPIIIGIAGGSGSGKTTVASTIYEELGDesIAVIPQDSYYKDQSHLSFEERVKTNYD 61
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-158 2.17e-90

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 263.42  E-value: 2.17e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925   5 VIGIGGVTNGGKTTLAKNLQKRLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENP------- 77
Cdd:cd02024    1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfpkflr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925  78 ----------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEP----- 136
Cdd:cd02024   81 shgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                        170       180
                 ....*....|....*....|...
gi 672039925 137 -PDPPGYFDGHVWPMYLKHRQEM 158
Cdd:cd02024  161 wPDPPGYFDGHVWPMYLKHHAEM 183
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-154 2.72e-22

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 89.90  E-value: 2.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925   1 MKTFVIGIGGVTNGGKTTLAKNLQKRLP--NCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWME--- 75
Cdd:COG0572    5 GKPRIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAges 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925  76 ---------NPGSSAGPAALESAqgvPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRR-----STRVYEPPDPPG 141
Cdd:COG0572   85 velpvydfaTGTRSGETVKVEPA---DVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIE 161

                        170
                 ....*....|...
gi 672039925 142 YFDGHVWPMYLKH 154
Cdd:COG0572  162 QYWATVRPGHEQY 174
AAA_18 pfam13238
AAA domain;
6-148 2.88e-19

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 79.78  E-value: 2.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925    6 IGIGGVTNGGKTTLAKNLQKRLpNCSVISQDDFFKPESEIDIDENgflqYDVLEALNMEKMMSAVSCWMENPGSSAGpaa 85
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENAALEEG--- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672039925   86 lesaqgvPILIIEGFLLFNYKPLDTIWNRsYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVW 148
Cdd:pfam13238  73 -------GNLIIDGHLAELEPERAKDLVG-IVLRASPEELLERLEKRGYEEAKIKENEEAEIL 127
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 5-56 1.25e-07

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 49.86  E-value: 1.25e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672039925   5 VIGIGGVTNGGKTTLAKNLQKRLPN--CSVISQDDFFKPESEIDIDENGFLQYD 56
Cdd:cd02023    1 IIGIAGGSGSGKTTVAEEIIEQLGNpkVVIISQDSYYKDLSHEELEERKNNNYD 54
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-56 1.45e-07

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 49.77  E-value: 1.45e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 672039925   1 MKTFVIGIGGVTNGGKTTLAKNLQKRLPN--CSVISQDDFFKPESEIDIDENGFLQYD 56
Cdd:PRK05480   4 KKPIIIGIAGGSGSGKTTVASTIYEELGDesIAVIPQDSYYKDQSHLSFEERVKTNYD 61
PRK08233 PRK08233
hypothetical protein; Provisional
 1-49 5.68e-07

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 47.82  E-value: 5.68e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 672039925   1 MKTFVIGIGGVTNGGKTTLAKNLQKRLPNcSVISQDDFFKPESE-IDIDE 49
Cdd:PRK08233   1 KKTKIITIAAVSGGGKTTLTERLTHKLKN-SKALYFDRYDFDNCpEDICK 49
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 5-62 9.43e-06

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 44.22  E-value: 9.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672039925   5 VIGIGGVTNGGKTTLAK----NLQKRLPNCSVISQDDFFKPEsEIDIDENGFlqYDV-----LEALN 62
Cdd:cd02028    1 VVGIAGPSGSGKTTFAKklsnQLRVNGIGPVVISLDDYYVPR-KTPRDEDGN--YDFesildLDLLN 64
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-139 2.08e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672039925    3 TFVIGIGGVtngGKTTLAKNLQKRLPnCSVISQDDFFK---PESEIDID---ENGFLQYDVLEALNMEKMMSAVSCWMEN 76
Cdd:pfam13671   2 ILLVGLPGS---GKSTLARRLLEELG-AVRLSSDDERKrlfGEGRPSISyytDATDRTYERLHELARIALRAGRPVILDA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672039925   77 PGSS----AGPAALESAQGVPILIIegfllfnykpldtiwnrsYFLTvPYEECKRRRSTRVYEPPDP 139
Cdd:pfam13671  78 TNLRrderARLLALAREYGVPVRIV------------------VFEA-PEEVLRERLAARARAGGDP 125
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 5-71 5.33e-04

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 39.60  E-value: 5.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672039925   5 VIGIGGVTNGGKTTLAKNLQKRL------PNCSVISQDDFFKPESEID----IDENGFlqydvLEALNMEKMMSAVS 71
Cdd:cd02025    1 IIGIAGSVAVGKSTTARVLQALLsrwpdhPNVELITTDGFLYPNKELIerglMDRKGF-----PESYDMEALLKFLK 72
PRK06762 PRK06762
hypothetical protein; Provisional
 1-36 7.18e-03

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 35.72  E-value: 7.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 672039925   1 MKTFVIgIGGVTNGGKTTLAKNLQKRL-PNCSVISQD 36
Cdd:PRK06762   1 MTTLII-IRGNSGSGKTTIAKQLQERLgRGTLLVSQD 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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