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Conserved domains on  [gi|672048439|ref|XP_008760810|]
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CDK5 and ABL1 enzyme substrate 2 isoform X3 [Rattus norvegicus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 337-412 7.12e-46

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20603:

Pssm-ID: 477360  Cd Length: 121  Bit Score: 157.35  E-value: 7.12e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672048439 337 LTLSKIRSLKREMRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLID 412
Cdd:cd20603    1 LTLSKIRSLKREMRNVAEECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLKKHEVKHLID 76
 
Name Accession Description Interval E-value
CYCLIN_CABLES2 cd20603
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ...
 337-412 7.12e-46

cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410306  Cd Length: 121  Bit Score: 157.35  E-value: 7.12e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672048439 337 LTLSKIRSLKREMRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLID 412
Cdd:cd20603    1 LTLSKIRSLKREMRNVAEECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLKKHEVKHLID 76
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 349-398 4.62e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.42  E-value: 4.62e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 672048439   349 MRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKI 398
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT 52
 
Name Accession Description Interval E-value
CYCLIN_CABLES2 cd20603
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ...
 337-412 7.12e-46

cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410306  Cd Length: 121  Bit Score: 157.35  E-value: 7.12e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672048439 337 LTLSKIRSLKREMRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLID 412
Cdd:cd20603    1 LTLSKIRSLKREMRNVAEECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLKKHEVKHLID 76
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 328-412 7.26e-44

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 152.51  E-value: 7.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672048439 328 FREKFPHIKLTLSKIRSLKREMRNLS-EECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSE 406
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAqEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80


                 ....*.
gi 672048439 407 VKQLID 412
Cdd:cd20602   81 VKHLID 86
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 337-412 5.22e-36

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 130.38  E-value: 5.22e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672048439 337 LTLSKIRSLKREMRNL-SEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLID 412
Cdd:cd20556    1 LTLSKLRSLKREMLKIaLKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDDVKKEDLKSLLE 77
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 344-420 8.55e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 47.02  E-value: 8.55e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672048439 344 SLKREMRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRK-SEVKQLIDVSVRSWRK 420
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTlKEIAKVSGVSEKELRK 78
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 349-414 1.54e-03

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 38.31  E-value: 1.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672048439 349 MRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKseVKQLIDVS 414
Cdd:cd20534    9 IREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRR--LRDIINVS 72
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 349-398 4.62e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.42  E-value: 4.62e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 672048439   349 MRNLSEECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKI 398
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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