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Conserved domains on  [gi|672056341|ref|XP_008762941|]
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leucine-rich repeat protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-293 5.30e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQLESFSVPLCKSTlqkSLQSLDLS 209
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEK-PEVLP 288
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDlPPLAN 270


                 ....*
gi 672056341 289 IINLQ 293
Cdd:COG4886  271 LTNLK 275
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-293 5.30e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQLESFSVPLCKSTlqkSLQSLDLS 209
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEK-PEVLP 288
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDlPPLAN 270


                 ....*
gi 672056341 289 IINLQ 293
Cdd:COG4886  271 LTNLK 275
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-279 4.17e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 131 LEHLQASHCRLARvdMRML-CLKSLTKLDLSHNCIKKLpATIGDLTHLQELNLSDNQL---ESFSV-PLCKSTLQKSLQS 205
Cdd:cd21340   48 LTHLYLQNNQIEK--IENLeNLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLTFdPRSLAALSNSLRV 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672056341 206 LDLSKNKIkalpvqfcqfRELTNLNLndnelihlpfkigrLTNLRFLSAARNKLRNL----PCEFKMLSLEYLDLFGN 279
Cdd:cd21340  125 LNISGNNI----------DSLEPLAP--------------LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
153-330 1.01e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 153 SLTKLDLSHNCIKKLPATIGDLthLQELNLSDNQLesFSVPlckSTLQKSLQSLDLSKNKIKALPvqfcqfreltnlnln 232
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATLPDT--IQEMELSINRI--TELP---ERLPSALQSLDLFHNKISCLP--------------- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 233 DNelihLPfkigrlTNLRFLSAARNKLRNLPCEFKMlSLEYLDLFGNTFEK-PEVLPiINLQVpltlLEACEQAVLSYri 311
Cdd:PRK15370 279 EN----LP------EELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTAlPETLP-PGLKT----LEAGENALTSL-- 340

                        170
                 ....*....|....*....
gi 672056341 312 pygPDIIPYHLcQDLDTAK 330
Cdd:PRK15370 341 ---PASLPPEL-QVLDVSK 355
LRR_8 pfam13855
Leucine rich repeat;
130-187 3.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341  130 SLEHLQASHCRLARVDMRML-CLKSLTKLDLSHNCIKKL-PATIGDLTHLQELNLSDNQL 187
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-293 5.30e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQLESFSVPLCKSTlqkSLQSLDLS 209
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEK-PEVLP 288
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDlPPLAN 270


                 ....*
gi 672056341 289 IINLQ 293
Cdd:COG4886  271 LTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-300 1.11e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQLESFSVPLCKSTlqkSLQSLDLS 209
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT---NLEELDLS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPVQFCQFRELTNLNLNDNELIHLPfKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEKPEVLPI 289
Cdd:COG4886  214 GNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKEL 292

                        170
                 ....*....|.
gi 672056341 290 INLQVPLTLLE 300
Cdd:COG4886  293 ELLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-301 1.09e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQLESFSVPLCKSTlqkSLQSLDLS 209
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT---NLETLDLS 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPvQFCQFRELTNLNLNDNELIHLPfKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEKPEVLPI 289
Cdd:COG4886  237 NNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        170
                 ....*....|..
gi 672056341 290 INLQVPLTLLEA 301
Cdd:COG4886  315 ILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
149-279 1.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 149 LCLKSLTKLDLSHNCIKKLPATIGDLTHLQELNLSDNQ-LESFsvplckstlqKSLQSLDLSKNKIKALPVQFCQFRELT 227
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNL----------TNLESLDLSGNQLTDLPEELANLTNLK 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 672056341 228 NLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKML-SLEYLDLFGN 279
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-279 4.17e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 131 LEHLQASHCRLARvdMRML-CLKSLTKLDLSHNCIKKLpATIGDLTHLQELNLSDNQL---ESFSV-PLCKSTLQKSLQS 205
Cdd:cd21340   48 LTHLYLQNNQIEK--IENLeNLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLTFdPRSLAALSNSLRV 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672056341 206 LDLSKNKIkalpvqfcqfRELTNLNLndnelihlpfkigrLTNLRFLSAARNKLRNL----PCEFKMLSLEYLDLFGN 279
Cdd:cd21340  125 LNISGNNI----------DSLEPLAP--------------LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-299 5.12e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 5.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDMRMLCLKSLTKLDLSHNCIKKLPAtIGDLTHLQELNLSDNQLESFSvplcKSTLQKSLQSLDLS 209
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 210 KNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEKPEVLPI 289
Cdd:COG4886  281 NNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360

                        170
                 ....*....|
gi 672056341 290 INLQVPLTLL 299
Cdd:COG4886  361 LLLTLLLTLG 370
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
153-330 1.01e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 153 SLTKLDLSHNCIKKLPATIGDLthLQELNLSDNQLesFSVPlckSTLQKSLQSLDLSKNKIKALPvqfcqfreltnlnln 232
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATLPDT--IQEMELSINRI--TELP---ERLPSALQSLDLFHNKISCLP--------------- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 233 DNelihLPfkigrlTNLRFLSAARNKLRNLPCEFKMlSLEYLDLFGNTFEK-PEVLPiINLQVpltlLEACEQAVLSYri 311
Cdd:PRK15370 279 EN----LP------EELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTAlPETLP-PGLKT----LEAGENALTSL-- 340

                        170
                 ....*....|....*....
gi 672056341 312 pygPDIIPYHLcQDLDTAK 330
Cdd:PRK15370 341 ---PASLPPEL-QVLDVSK 355
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-279 1.07e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 152 KSLTKLDLSHNCIKK-LPATIGDLTHLQELNLSDNQLeSFSVPLCKSTLQKsLQSLDLSKNKIKA-LPVQFCQFRELTNL 229
Cdd:PLN00113 475 KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKL-SGEIPDELSSCKK-LVSLDLSHNQLSGqIPASFSEMPVLSQL 552

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 672056341 230 NLNDNELI-HLPFKIGRLTNLRFLSAARNKLR-NLPCEFKMLSLEYLDLFGN 279
Cdd:PLN00113 553 DLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGN 604
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
113-263 1.77e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 113 MIITSKKDYPLSKNFPYSLEHLQASHCRLARVDMRMLclKSLTKLDLSHNCIKKLPATIGdlTHLQELNLSDNQLESFSv 192
Cdd:PRK15370 267 LDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLP- 341

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672056341 193 plckSTLQKSLQSLDLSKNKIKALPVQFCQfrELTNLNLNDNELIHLPFKIGrlTNLRFLSAARNKLRNLP 263
Cdd:PRK15370 342 ----ASLPPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLP 404
PLN03150 PLN03150
hypothetical protein; Provisional
 167-236 1.84e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 1.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672056341 167 LPATIGDLTHLQELNLSDNQLESfSVPLCKSTLqKSLQSLDLSKNKIK-ALPVQFCQFRELTNLNLNDNEL 236
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG-NIPPSLGSI-TSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 129-281 2.01e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 129 YSLEHLQASHCRLARVDMRMLC--LKS----LTKLDLSHN-----CIKKLPATIGDLTHLQELNLSDNQLESFSVP-LCK 196
Cdd:cd00116  108 SSLQELKLNNNGLGDRGLRLLAkgLKDlppaLEKLVLGRNrlegaSCEALAKALRANRDLKELNLANNGIGDAGIRaLAE 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 197 S-TLQKSLQSLDLSKNKI-----KALPVQFCQFRELTNLNLNDNEL-------IHLPFKIGrLTNLRFLSAARNKLRNLP 263
Cdd:cd00116  188 GlKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLtdagaaaLASALLSP-NISLLTLSLSCNDITDDG 266

                        170       180
                 ....*....|....*....|....
gi 672056341 264 CE------FKMLSLEYLDLFGNTF 281
Cdd:cd00116  267 AKdlaevlAEKESLLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-293 6.20e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 6.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 122 PLSKNFPYSLEHLQASHCRLA-RVDMRMLCLKSLTKLDLSHNCIK-KLPATIGDLTHLQELNLSDNQLESfSVPLCKSTL 199
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVG-QIPRELGQM 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 200 qKSLQSLDLSKNKIKA-LPVQFCQFRELTNLNLNDNELI-HLPFKIGRLTNLRFLSAARNKLRNL--PCEFKMLSLEYLD 275
Cdd:PLN00113 212 -KSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLD 290

                        170       180
                 ....*....|....*....|
gi 672056341 276 LFGNTF--EKPEVlpIINLQ 293
Cdd:PLN00113 291 LSDNSLsgEIPEL--VIQLQ 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 154-276 2.46e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 154 LTKLDLS-HNCIKKLPATIGDLTHLQELNLSDNQLeSFSVPLCKSTLQKS----------------------LQSLDLSK 210
Cdd:PLN00113  71 VVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSlrylnlsnnnftgsiprgsipnLETLDLSN 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 211 NKIKA-LPVQFCQFRELTNLNLNDNELI-HLPFKIGRLTNLRFLSAARNKLR-NLPCEF-KMLSLEYLDL 276
Cdd:PLN00113 150 NMLSGeIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELgQMKSLKWIYL 219
LRR_8 pfam13855
Leucine rich repeat;
130-187 3.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341  130 SLEHLQASHCRLARVDMRML-CLKSLTKLDLSHNCIKKL-PATIGDLTHLQELNLSDNQL 187
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-280 3.96e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 3.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 130 SLEHLQASHCRLARVDmRMLCLKSLTKLDLSHNCIKKLPaTIGDLTHLQELNLSDNQLESFSVPLCKSTLQ----KSLQS 205
Cdd:COG4886  229 NLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGlnslLLLLL 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672056341 206 LDLSKNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGRLTNLRFLSAARNKLRNLPCEFKMLSLEYLDLFGNT 280
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
LRR_8 pfam13855
Leucine rich repeat;
153-213 4.20e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 4.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672056341  153 SLTKLDLSHNCIKKL-PATIGDLTHLQELNLSDNQLESFSvplcKSTLQ--KSLQSLDLSKNKI 213
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLS----PGAFSglPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
175-236 6.94e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 6.94e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672056341  175 THLQELNLSDNQLESfsvpLCKSTLQ--KSLQSLDLSKNKIKAL-PVQFCQFRELTNLNLNDNEL 236
Cdd:pfam13855   1 PNLRSLDLSNNRLTS----LDDGAFKglSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 153-281 7.30e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 7.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 153 SLTKLDLSHNCIK-KLPATIGDLTHLQELNLSDNQLESF---SVPLCKSTLQKSLQSLDLSKNkikaLPVQFCQFRELTN 228
Cdd:PLN00113 357 NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEipkSLGACRSLRRVRLQDNSFSGE----LPSEFTKLPLVYF 432

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 672056341 229 LNLNDNELI-HLPFKIGRLTNLRFLSAARNK-LRNLPCEFKMLSLEYLDLFGNTF 281
Cdd:PLN00113 433 LDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQF 487
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 152-191 7.23e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 7.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 672056341  152 KSLTKLDLSHNCIKKLPAtIGDLTHLQELNLSDN-QLESFS 191
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNnKITDLS 40
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
127-279 1.18e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 127 FPYSLEHLQASHCRLARVDMrmlCLKSLTKLDLSHNCIKKLPATIgdlTHLQELNLSDNQLESfsVPLCKSTLQK----- 201
Cdd:PRK15387 300 LPPGLQELSVSDNQLASLPA---LPSELCKLWAYNNQLTSLPTLP---SGLQELSVSDNQLAS--LPTLPSELYKlwayn 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 202 -----------SLQSLDLSKNKIKALPVQFCQFRELTnlnLNDNELIHLPFKIGRLTNlrfLSAARNKLRNLPCEFKMLS 270
Cdd:PRK15387 372 nrltslpalpsGLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLS---LSVYRNQLTRLPESLIHLS 445

                        170
                 ....*....|
gi 672056341 271 LE-YLDLFGN 279
Cdd:PRK15387 446 SEtTVNLEGN 455
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 148-279 1.43e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 148 MLC-LKSLTKLDLSHNCIKKlPATIGDLTHLQE------LNLSDNQLESFSVPLCKSTLQ--KSLQSLDLSKNKI----- 213
Cdd:COG5238  231 ALKgNKSLTTLDLSNNQIGD-EGVIALAEALKNnttvetLYLSGNQIGAEGAIALAKALQgnTTLTSLDLSVNRIgdega 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672056341 214 KALPVQFCQFRELTNLNLNDNelihlpfKIGRlTNLRFLSAARNKLRNlpcefkmlsLEYLDLFGN 279
Cdd:COG5238  310 IALAEGLQGNKTLHTLNLAYN-------GIGA-QGAIALAKALQENTT---------LHSLDLSDN 358
PLN03150 PLN03150
hypothetical protein; Provisional
 153-193 5.49e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 5.49e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672056341 153 SLTKLDLSHNCIK-KLPATIGDLTHLQELNLSDNQLeSFSVP 193
Cdd:PLN03150 467 SLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL-SGRVP 507
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
177-288 8.89e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 177 LQELNLSDNQLESF-SVP--LCK-----------STLQKSLQSLDLSKNKIKALPVQFCQFRELTNLNlndNELIHLPfk 242
Cdd:PRK15387 304 LQELSVSDNQLASLpALPseLCKlwaynnqltslPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLP-- 378

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 672056341 243 iGRLTNLRFLSAARNKLRNLPC---EFKMLSLEyldlfGNTFEKPEVLP 288
Cdd:PRK15387 379 -ALPSGLKELIVSGNRLTSLPVlpsELKELMVS-----GNRLTSLPMLP 421
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 152-287 2.62e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 152 KSLTKLDLSHNCIKKLPAtIGDLTHLQELNLSDNQLESFSvPLckSTLqKSLQSLDLSKNKIKALpvqfCQFRELTNL-- 229
Cdd:cd21340   24 KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE-NL--ENL-VNLKKLYLGGNRISVV----EGLENLTNLee 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672056341 230 ------NL-NDNELIHLPFKIGRLTN-LRFLSAARNKLRNLPCEFKMLSLEYLDLFGNTFEKPEVL 287
Cdd:cd21340   95 lhienqRLpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 151-281 2.93e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 151 LKSLTKLDL-SHNCIKKLPATIGDLTHLQELNLSDNQLeSFSVP--LCKstlQKSLQSLDLSKNKIKA-LPVQFCQFREL 226
Cdd:PLN00113 307 LQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPknLGK---HNNLTVLDLSTNNLTGeIPEGLCSSGNL 382

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 672056341 227 TNLNLNDNELI-HLPFKIGRLTNLRFLSAARNKLR-NLPCEFKMLSLEY-LDLFGNTF 281
Cdd:PLN00113 383 FKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYfLDISNNNL 440
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 152-236 4.99e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056341 152 KSLTKLDLSHNCI-----KKLPATIGDLTHLQELNLSDNQLESFSV-PLCKS-TLQKSLQSLDLSKNKIKALPVQFC--- 221
Cdd:COG5238  320 KTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIGDEGAiALAKYlEGNTTLRELNLGKNNIGKQGAEALida 399

                         90
                 ....*....|....*.
gi 672056341 222 -QFRELTNLNLNDNEL 236
Cdd:COG5238  400 lQTNRLHTLILDGNLI 415
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 201-237 9.85e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 9.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 672056341  201 KSLQSLDLSKNKIKALPVqFCQFRELTNLNLNDNELI 237
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKI 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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