|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
56-850 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 777.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 56 KDVEKWWhQQI-------KVqaskisEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRG---------- 118
Cdd:COG0495 8 KEIEKKW-QKYweengtfKA------DEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGynvlhpmgwd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 119 ----------MQ-------------------------------EITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDP 157
Cdd:COG0495 81 afglpaenaaIKngvhpaewtyenianmrrqlkrlglsydwsrEIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 158 VDQTVLANEQVNEyGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEW-YGIKEMQAHWIGDCVGCHLDFTLKvd 236
Cdd:COG0495 161 VDQTVLANEQVID-GRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWpEKVKTMQRNWIGRSEGAEVDFPVE-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 237 gqDTGEKLTAYTATPEAIYGISHVAISPSHGLLhgcSSLKTALQKALVPG--RDCL------------------TPVMAV 296
Cdd:COG0495 238 --GSDEKITVFTTRPDTLFGATFMVLAPEHPLV---KELATPEQNAAVAAfiEEAKkkseiertsetkektgvfTGLYAI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 297 NMLTLQEVPV-------------VIMAKP-----DLEgsldskigipstssedtrLAQALGLPYSEVIETSPDGTERLSG 358
Cdd:COG0495 313 NPLTGEKIPIwiadyvlmdygtgAVMAVPahdqrDFE------------------FAKKYGLPIKQVIAPEDGDDPDILE 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 359 -----------SAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQDLPV 427
Cdd:COG0495 375 eaytgdgvlinSGEFDGLDSEEAKEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPV 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 428 TLPSITSLTGRGGSPLASALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTHSPFSSALADFWMPVDLYIG 507
Cdd:COG0495 455 ELPEDVDFDPTGGSPLARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIG 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 508 GKEHAVMHLFYARFFSHFCHRQKMVKHREPFHKLLAQGLIkgqtfhllsgqclkrEDIDFTGPTpvcaktkerlEVTWEK 587
Cdd:COG0495 535 GIEHAILHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMV---------------LEVGKDGVV----------IGGIEK 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 588 MSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWslttRFIEARTSGTAPQPQLLNN 667
Cdd:COG0495 590 MSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWS--DSGVEGAYRFLNRVW----RLVVDEAEALKLDVADLSE 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 668 KEKAKARSLweykNAVITQVTTHFtEDFALNSVVSQLMGLSGALSQASQRLVLHSPEFEDALCALLVMAAPLAPHITSEL 747
Cdd:COG0495 664 ADKELRRAL----HKTIKKVTEDI-ERLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEEL 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 748 WAGLALVPSklcdryawdagVMLQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPqhVAQDQDKVHEFVLQSELGIKL 827
Cdd:COG0495 739 WERLGHEGS-----------VADAPWPEADEAALVE-DEVTIVVQVNGKVRGKIEVP--ADASKEELEAAALADEKVQKF 804
|
890 900
....*....|....*....|....
gi 672063826 828 LQGRSIRKA-FLSPRtaLINFLVK 850
Cdd:COG0495 805 LEGKTIRKViVVPGK--LVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
58-850 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 725.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 58 VEKWWHQQIKVQASKISEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQ----------------- 120
Cdd:TIGR00396 6 IEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNvlhpigwdafglpaena 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 121 ----------------------------------EITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANE 166
Cdd:TIGR00396 86 aikrgihpakwtyenianmkkqlqalgfsydwdrEIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 167 QVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWY-GIKEMQAHWIGDCVGCHLDFTLKvdgqDTGEKLT 245
Cdd:TIGR00396 166 QVDSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKIA----DHDEKIT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 246 AYTATPEAIYGISHVAISPSHGL--------------LHGCSSLKTAL-QKALVPGRDCLTPVMAVNMLTLQEVPVVImA 310
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLvekaaennpkvaafIKKILNKTVAErTKATKEKKGVDTGIKAIHPLTGEKIPIWV-A 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 311 KPDLEG-SLDSKIGIPSTSSEDTRLAQALGLPYSEVIETSPD---------GTERLSGSAEFTGMTRQDAFVALTRKARG 380
Cdd:TIGR00396 321 NYVLMEyGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 381 MRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQDLPVTLPSITSLTGRGGSPLASALEWVNCSCPRCKGS 460
Cdd:TIGR00396 401 EGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 461 AKRETDTMDTFVDSAWYYFRYTDPHNTHSPFSSALADFWMPVDLYIGGKEHAVMHLFYARFFSHFCHRQKMVKHREPFHK 540
Cdd:TIGR00396 481 ALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 541 LLAQGLIKGqtFHLLSGQCLKREDIDFTGPTPVCAKTKERLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPP 620
Cdd:TIGR00396 561 LINQGMVLG--FYYPPNGKVPADVLTERDEKGKDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPI 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 621 EKDILWDvkTDALPGVLRWQQRLWSLTTRfIEARTSGTAPQPQLLNNKEKAKARSLweykNAVITQVTTHFTEDFALNSV 700
Cdd:TIGR00396 639 AASLEWN--ESGLEGARRFLDRVWNLVYE-ITGELDAASLTVTALEEAQKELRRDV----HKFLKKVTEDLEKRESFNTA 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 701 VSQLMGLSGALSQASQRLVLhspefEDALCALLVMAAPLAPHITSELWAGLALVPSklcdryAWDAgvmlQAWPTVDSQF 780
Cdd:TIGR00396 712 ISAMMELLNKLYKAKKEALM-----LEYLKGFVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETA 776
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 781 LQKpDMVQMAVLINNKACGKIPVPQHVaqDQDKVHEFVLQSELGIKLLQGRSIRKAFLSPrTALINFLVK 850
Cdd:TIGR00396 777 LVE-DKTLIVVQVNGKFRAKITVPKDA--DEEQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
77-840 |
4.85e-159 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 488.95 E-value: 4.85e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 77 DKLKPKFYLLSMFPYPSGK-LHMGHVRVYTLSDTIARFQKMRGM------------------------------------ 119
Cdd:PLN02563 106 DTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYnvlhpmgwdafglpaeqyaietgthpkittlkniar 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 120 ---------------QEITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEyGCSWRSGAKVEKK 184
Cdd:PLN02563 186 frsqlkslgfsydwdREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVD-GLSERGGHPVIRK 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 185 YLRQWFIKTTAYAKAMQDALADLpEW-YGIKEMQAHWIGDCVGCHLDF-TLKVDGQDTGEKLTAYTATPEAIYGISHVAI 262
Cdd:PLN02563 265 PMRQWMLKITAYADRLLEDLDDL-DWpESIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLVV 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 263 SPSHGLLhgcSSLKTALQKALVPG------------RDCL--------TPVMAVNMLTLQEVPV-------------VIM 309
Cdd:PLN02563 344 APEHPLL---SSLTTAEQKEAVEEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIwvadyvlgsygtgAIM 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 310 AkpdlegsldskigIPSTSSEDTRLAQALGLPYSEVIEtSPDGTERLSGSA---------------EFTGMTRQDAFVAL 374
Cdd:PLN02563 421 A-------------VPAHDTRDFEFAQKFDLPIKWVVK-PADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKV 486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 375 TRKARGMRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACG-PVPVPLQDLPVTLPSITSL--TGRGGSPLASALEWVN 451
Cdd:PLN02563 487 IEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFtpTGTGEPPLAKAVSWVN 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 452 CSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTHSPFSSALADFWMPVDLYIGGKEHAVMHLFYARFFSHFCHRQKM 531
Cdd:PLN02563 567 TVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGV 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 532 VKHREPFHKLLAQGLIKGQTFH----------------LLSGQC----LKREDIDFTGPTPVCAKT-KERLEVTWEKMSK 590
Cdd:PLN02563 647 VSTKEPFQCLVNQGMILGEVEYtafkdsdgeyvsadtaDRLGELqqekIPEEKVIKSGDSFVLKDDpSIRLIARAHKMSK 726
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 591 SKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTAPQPQLLNNKE- 669
Cdd:PLN02563 727 SRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEp 802
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 670 -KAKARSLweykNAVITQVTTHfTEDFALNSVVSQLMGLSGALSQASQRlvlhsPefEDALCALLVMAAPLAPHITSELW 748
Cdd:PLN02563 803 sLEQLRLL----HKCIAKVTEE-IESTRFNTAISAMMEFTNAAYKWDKV-----P--REAIEPFVLLLSPYAPHLAEELW 870
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 749 AglalvpsklcdRYAWDAGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHEFVLQSELGIKLL 828
Cdd:PLN02563 871 F-----------RLGHSNSLAYEPWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYL 936
|
890
....*....|..
gi 672063826 829 QGRSIRKAFLSP 840
Cdd:PLN02563 937 DGKEIKKRIYVP 948
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
82-626 |
7.07e-89 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 284.14 E-value: 7.07e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQ----------------------------------------- 120
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNvlfpmgfdafglpaenaaikigrdpedwteynikkmkeqlk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 121 ----------EITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDpvdqtvlaneqvneygcswrsgakvekKYLRQWF 190
Cdd:cd00812 81 rmgfsydwrrEFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC---------------------------KLLDQWF 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 191 IKT--TAYAKAMQDALADLPEWY-GIKEMQAHWIGdcvgchldftlkvdgqdtgekltaytatpeaiygishvaispshg 267
Cdd:cd00812 134 LKYseTEWKEKLLKDLEKLDGWPeEVRAMQENWIG--------------------------------------------- 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 268 llhgcsslktalqkalvpgrdcltpvmavnmltlqevpvvimakpdlegsldskigipstssedtrlaqalglpysevie 347
Cdd:cd00812 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 348 tspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsnklkdwlVSRQRYWGTPIPIvhcpacgpvpvplqdlpv 427
Cdd:cd00812 169 -------------------------------------------------CSRQRYWGTPIPW------------------ 181
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 428 tlpsitsltgrggsplasalewvncscprckgsakreTDTMDTFVDSAWYYFRYTDPHNTHSP------FSSALADFWMP 501
Cdd:cd00812 182 -------------------------------------TDTMESLSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYP 224
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 502 VDLYIGGKEHAVMHLFYARFFSHFCHRQKMVkHREPFHKLLAQGLIKGQTfhllsgqclkredidftgptpvcaktkerl 581
Cdd:cd00812 225 VDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG------------------------------ 273
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 672063826 582 evtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 626
Cdd:cd00812 274 ----EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
45-777 |
1.57e-39 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 157.28 E-value: 1.57e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 45 KWTKEYTLqtrKDVEKWWhqQIKVQASKI--SEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGM--- 119
Cdd:PRK13208 5 ELPKKYDP---EELEEKW--QKIWEEEGTykFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYnvf 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 120 -------------------------------------------------------------QEITTCLPDYYKWTQYLFI 138
Cdd:PRK13208 80 fpqgwddnglpterkvekyygirkddisreefielcreltdedekkfrelwrrlglsvdwsLEYQTISPEYRRISQKSFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 139 KLYEAGLAYQKEALVNWDPVDQTVLANeqvneygcswrsgAKVEKKylrqwfIKTTAYAkamqdaladlpewygikemqa 218
Cdd:PRK13208 160 DLYKKGLIYRAEAPVLWCPRCETAIAQ-------------AEVEYR------EREGKLN--------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 219 hwigdcvgcHLDFTLKvdgqdTGEKLTAYTATPEAIYGISHVAISPS-----HglLHGcsslktalQKALVPgrdcltpv 293
Cdd:PRK13208 200 ---------YIKFPVE-----DGEEIEIATTRPELLPACVAVVVHPDderykH--LVG--------KTAIVP-------- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 294 mavnmLTLQEVPVVI--MAKPDLeGSldskiGIPSTSS----EDTRLAQALGLPYSEVIetSPDGteRLSGSA-EFTGMT 366
Cdd:PRK13208 248 -----LFGVEVPILAdpLVDPDF-GT-----GAVMICTfgdkTDVTWWRELNLPTRIII--DEDG--RMTEAAgKLAGLT 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 367 RQDAfvaltRKA-------RGM---------RVGGH---------VTS------------------NKLK---------- 393
Cdd:PRK13208 313 IEEA-----RKKivedlksGGLlgkqepikhNVKFCercdtpleiLVTrqwfikvldlkeellergKEINwypehmrvrl 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 394 ---------DWLVSRQRYWGTPIPIVHCPACG-PVPVPLQDLPVtlpsitsltgrggSPLASALEWvnCSCPRC-KGSAK 462
Cdd:PRK13208 388 enwieglnwDWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPV-------------DPTKDEPPG--YKCPQCgSPGFE 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 463 RETDTMDTFVDS---AWYYFRYTDPHNTHSPFSsaladfwmPVDLYIGGkehavmH------LFYARFFSHFCHRQKmvk 533
Cdd:PRK13208 453 GETDVMDTWATSsitPLIVTGWERDEDLFEKVF--------PMDLRPQG------HdiirtwLFYTILRAYLLTGKL--- 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 534 hrePFHKLLaqglikgqtfhlLSGQCL--KREdidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIR 611
Cdd:PRK13208 516 ---PWKNIM------------ISGMVLdpDGK-----------------------KMSKSKGNVVTPEELLEKYGADAVR 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 612 LYILfAAPPEKDILWDVKTdaLPGVLRWQQRLWSLtTRFIEARTSGTAPQPQ---------LLN--NKEKAKA-RSLWEY 679
Cdd:PRK13208 558 YWAA-SARLGSDTPFDEKQ--VKIGRRLLTKLWNA-SRFVLHFSADPEPDKAevlepldrwILAklAKVVEKAtEALENY 633
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 680 KNAVITQVTTHFT-EDFA---LNSVVSQLMGLSGALSQASQRLVLHSpefedALCALLVMAAPLAPHITSELWAglalvp 755
Cdd:PRK13208 634 DFAKALEEIESFFwHVFCddyLELVKSRAYGEDEEEEQKSARYTLYT-----VLDTLLRLLAPFLPFITEEVWS------ 702
|
890 900
....*....|....*....|...
gi 672063826 756 sklcdryAWDAG-VMLQAWPTVD 777
Cdd:PRK13208 703 -------WLYGGsVHRASWPEPD 718
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
56-781 |
2.20e-38 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 154.06 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 56 KDVEKWWHQqiKVQASKISE--EDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGM-------------- 119
Cdd:TIGR00422 8 HEVEKKWYK--KWEKSGFFKpdGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYnvlwlpgtdhagia 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 120 -----------------------------------------------------QEITTCLPDYYKWTQYLFIKLYEAGLA 146
Cdd:TIGR00422 86 tqvkvekklgaegktkhdlgreefrekiwewkeesggtiknqikrlgasldwsRERFTMDEGLSKAVKEAFVRLYEKGLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 147 YQKEALVNWDPVDQTVLANEQVnEYgcswrsgakvekkylrqwfikttayakamqdaladlpewygiKEMQAH-Wigdcv 225
Cdd:TIGR00422 166 YRGEYLVNWDPKLNTAISDIEV-EY------------------------------------------KEVKGKlY----- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 226 gcHLDFTLKVDGQDtgeKLTAYTATPEAIYGISHVAISP-----SHglLHGcsslktalQKALVPgrdcltpvmavnmLT 300
Cdd:TIGR00422 198 --YIRYPLANGSKD---YLVVATTRPETMFGDTAVAVHPederyKH--LIG--------KKVILP-------------LT 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 301 LQEVPVVIMAKPDLE-GSLDSKIgIPSTSSEDTRLAQALGLPYSEVIETspDGTERLSGsAEFTGMTRQDA--------- 370
Cdd:TIGR00422 250 GRKIPIIADEYVDMEfGTGAVKV-TPAHDFNDYEWGKRHNLEFINILDE--DGLLNENA-GKYQGLTRFEArkkivedlk 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 371 ---------------------------------FVA---LTRKARGMRVGGHVT-------------SNKLKDWLVSRQR 401
Cdd:TIGR00422 326 eegllvkiephthnvgtcwrsgtvvepllskqwFVKvekLADKALEAAEEGEIKfvpkrmekrylnwLRNIKDWCISRQL 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 402 YWGTPIPIVHCPACGPVPVPLQDLPVTLPSITSltgrggsplaSALEWvncscprckgsaKRETDTMDTFVDSAWYYFRY 481
Cdd:TIGR00422 406 IWGHRIPVWYCKECGEVYVAKEEPLPDDKTNTG----------PSVEL------------EQDTDVLDTWFSSSLWPFST 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 482 TDPHNthspFSSALADFWmPVDLYIGGKEHAVMHLFYARFFSHFCHRQKmvkhrePFHKLLAQGLIKGQTFHllsgqclk 561
Cdd:TIGR00422 464 LGWPD----ETKDLKKFY-PTDLLVTGYDIIFFWVARMIFRSLALTGQV------PFKEVYIHGLVRDEQGR-------- 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 562 redidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTdaLPGVLRWQQ 641
Cdd:TIGR00422 525 -------------------------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKR--VESARNFLN 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 642 RLWSlTTRFIEARTSGTAPQPQLLNNKEKAKaRSLWEYKNAVITQVTTHFtEDFALNSVVSQLM---------------- 705
Cdd:TIGR00422 578 KLWN-ASRFVLMNLSDDLELSGGEEKLSLAD-RWILSKLNRTIKEVRKAL-DKYRFAEAAKALYefiwndfcdwyielvk 654
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 706 -----GLSGALSQASQRLVLhspefedALCALLVMAAPLAPHITSELWAGLalvPSKlcdryawDAGVMLQAWPTVDSQF 780
Cdd:TIGR00422 655 yrlynGNEAEKKAARDTLYY-------VLDKALRLLHPFMPFITEEIWQHF---KEG-------ADSIMLQSYPVVDAEF 717
|
.
gi 672063826 781 L 781
Cdd:TIGR00422 718 V 718
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
90-626 |
5.76e-28 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 116.96 E-value: 5.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 90 PYPSGKLHMGHVRVYTLSDTIARFQKMRG--------------------------------------------------- 118
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGynvlwppgtdhagiatqvvvekklgiegktrhdlgreeflekcwewkeesg 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 119 ------MQEITTCL----------PDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVneygcSWRSGAKVE 182
Cdd:cd00817 90 gkireqLKRLGASVdwsreyftmdPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV-----CSRSGDVIE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 183 KKYLRQWFIKTTAYAKAMQDALAD-LPEWYGiKEMQA---HWIgdcvgchldftlkvdgqdtgekltaytatpeaiygis 258
Cdd:cd00817 165 PLLKPQWFVKVKDLAKKALEAVKEgDIKFVP-ERMEKryeNWL------------------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 259 hvaispshgllhgcsslktalqkalvpgrdcltpvmavnmltlqevpvvimakpdlegsldskigipstssedtrlaqal 338
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 339 glpysevietspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsNKLKDWLVSRQRYWGTPIPIVHCPACGPV 418
Cdd:cd00817 207 ---------------------------------------------------ENIRDWCISRQLWWGHRIPAWYCKDGGHW 235
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 419 PV-PLQDLPVTLPSitsltgrggsplasalewvNCSCPRCKGSA-KRETDTMDTFVDSA-WyyfrytdphnthsPFSS-- 493
Cdd:cd00817 236 VVaREEDEAIDKAA-------------------PEACVPCGGEElKQDEDVLDTWFSSSlW-------------PFSTlg 283
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 494 ------ALADFWmPVDLYIGGKEHAVMHLFYARFFSHFCHRQKmvkhrePFHKLLAQGLIKGqtfhllsgqclkrEDidf 567
Cdd:cd00817 284 wpeetkDLKKFY-PTSLLVTGHDIIFFWVARMIMRGLKLTGKL------PFKEVYLHGLVRD-------------ED--- 340
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 672063826 568 tgptpvcaktkerlevtWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 626
Cdd:cd00817 341 -----------------GRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
626-751 |
1.72e-24 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 98.83 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 626 WDvkTDALPGVLRWQQRLWSLTTRFIEARTSGTAPqpqllnNKEKAKARSLWEYKNAVITQVTTHFtEDFALNSVVSQLM 705
Cdd:cd07958 1 WS--DSGVEGAYRFLNRVWRLVTELAEALAAPAAA------AELSEEDKELRRKLHKTIKKVTEDI-ERLRFNTAIAALM 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 672063826 706 GLSGALSQASQRLVLHSPEFEDALCALLVMAAPLAPHITSELWAGL 751
Cdd:cd07958 72 ELVNALYKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
394-793 |
8.97e-22 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 101.31 E-value: 8.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 394 DWLVSRQRYWGTPIPIVHCPACGPvpvpLQDLPVTLPSITSLTGRGGSPLASALE----WV--NCSCPRCKGSAKRETDT 467
Cdd:COG0060 457 DWCISRQRYWGVPIPIWVCEDCGE----LHRTEEVIGSVAELLEEEGADAWFELDlhrpFLdeTLKCPKCGGTMRRVPDV 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 468 MDTFVDSAwyyfrytdphntHSPFSS--ALADFWMPVDLYI-GGKEHavmhlfyaR--FFS-HF--ChrqkMVKHREPFH 539
Cdd:COG0060 533 LDVWFDSG------------SMHFAVleNREELHFPADFYLeGSDQT--------RgwFYSsLLtsT----ALFGRAPYK 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 540 KLLAQGLI---KGQtfhllsgqclkredidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILF 616
Cdd:COG0060 589 NVLTHGFVldeDGR------------------------------------KMSKSLGNVVDPQEVIDKYGADILRLWVAS 632
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 617 AAPPE-----KDILWDVKTdalpgVLRwqqRLWSlTTRFIEARTSGTAPQPQLLnnkEKAKARSL--W---EYkNAVITQ 686
Cdd:COG0060 633 SDYWGdlrfsDEILKEVRD-----VYR---RLRN-TYRFLLANLDDFDPAEDAV---PYEDLPELdrWilsRL-NELIKE 699
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 687 VTTHFtEDFALNSVVSQLMG-----LS-------------GALSQASQR---LVLHspefeDALCALLVMAAPLAPHITS 745
Cdd:COG0060 700 VTEAY-DNYDFHRAYRALHNfcvedLSnwyldiskdrlytEAADSLDRRaaqTTLY-----EVLETLVRLLAPILPFTAE 773
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 672063826 746 ELWAGLalvpsklcdRYAWDAGVMLQAWPTVDSQFLQKPDMVQMAVLI 793
Cdd:COG0060 774 EIWQNL---------PGEAEESVHLADWPEVDEELIDEELEAKWDLVR 812
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
393-788 |
8.63e-20 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 94.75 E-value: 8.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 393 KDWLVSRQRYWGTPIPIVHCPACGPvpvplqdlPVTLPSI------TSLTGRGGSPLASA---LEWVNCSCPRCkGSAKR 463
Cdd:TIGR00392 461 PDWCISRQRYWGIPIPIWYCEDTGE--------PIVVGSIeelielIELKGIDAWFEDLHrdfLDKITLKSGDG-GEYRR 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 464 ETDTMDTFVDS--AWYYfrytdphNTHSPFSSALADFWMPVDLYIGGKEHaVMHLFYArffSHFChrQKMVKHREPFHKL 541
Cdd:TIGR00392 532 VPDVLDVWFDSgsMPYA-------SIHYPFENEKFKEVFPADFILEGSDQ-TRGWFYS---SLAI--GTALFGQAPYKNV 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 542 LAQGLIkgqtfhllsgqclkredIDFTGptpvcaktkerlevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPpe 621
Cdd:TIGR00392 599 ITHGFT-----------------LDEKG----------------RKMSKSLGNVVDPLKVINKYGADILRLYVASSDP-- 643
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 622 kdilWD---VKTDALPGVLRWQQRLWSLTTRFIeARTSGTAPQPQLLNNKEKAKARSLWEY----KNAVITQVTTHFtED 694
Cdd:TIGR00392 644 ----WEdlrFSDEILKQVVEKYRKIRWNTYRFL-LTYANLDKFDPLFNSVAVEKFPEEDRWilsrLNSLVEEVNEAL-EK 717
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 695 FALNSVVSQLMG-----LSGALSQASQRLVLHSPEFEDALCA----------LLVMAAPLAPHITSELWAGLALVPSKlc 759
Cdd:TIGR00392 718 YNFHKVLRALQDfiveeLSNWYIRIIRDRLYCEAKDNDKRAAqttlyyalltLVRLLAPFLPHTAEEIYQNLPGGEEE-- 795
|
410 420 430
....*....|....*....|....*....|....
gi 672063826 760 dryawdAGVMLQAWPTVDSQFL-----QKPDMVQ 788
Cdd:TIGR00392 796 ------ESVHLNLWPEVDEEFIdealeANMAIVR 823
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
60-627 |
1.39e-19 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 93.63 E-value: 1.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 60 KWWHQQIKVQASKisEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRG----MQEITTC--LPDYYKWT 133
Cdd:pfam00133 4 EFWDEQGYFKPEL--EKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGyyvlWVPGWDHhgLPTEQVVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 134 QYLFIKLYEAGLAYQKEALVN--WdpvdqtvlanEQVNEYGCSWRS-----GAKVEkkYLRQWFIKTTAYAKAMQDALAD 206
Cdd:pfam00133 82 KKLGIKEKKTRHKYGREEFREkcR----------EWKMEYADEIRKqfrrlGRSID--WDREYFTMDPELEAAVWEVFVR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 207 LPE----WYGIKEMqaHWigdCVGCH-----------------LDFTLKVDGQDtGEKLTAYTATPEAIYGISHVAISP- 264
Cdd:pfam00133 150 LHDkgliYRGKKLV--NW---SPALNtalsnleveykdvkgpsIHVAFPLADDE-GASLVIWTTTPWTLPGNTAVAVNPe 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 265 -----SHGLLHGCSSLKTALQKALVPGRDCLTP-------VMAVNMLTLQEVPVVIMAKPDLE-GSLDSKIGiPSTSSED 331
Cdd:pfam00133 224 fdyviTGEGYILAEALLKSLYKKGTDKKILEDFrgkelegKEAIHPFVNREIPIITDDYVDMEfGTGAVHIA-PAHGEND 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 332 TRLAQALGLPYSEVIEtsPDGTERlSGSAEFTGMTRQDAFVALTR--KARGMRVggHVTSNKLK---------------- 393
Cdd:pfam00133 303 YEVGQRHNLEVINPVD--DDGTFT-EEAPDFQGVYRFDARKKIVEllTEKGLLL--KIEPFTHSypfcwrsgtpiiprat 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 394 ----------------------------------------DWLVSRQRYWGTPIPI--------VHCPACGPVPVPLQDL 425
Cdd:pfam00133 378 pqwfvrmdeladqaleavekvqfvpksgekryfnwlaniqDWCISRQRWWGHPIPAwvskdteeVVCRGELFELVAGRFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 426 PVTlpSITSLTGRGGSPLASAlewvncscprcKGSAKRETDTMDTFVDSA-WYYfrytdpHNTHSPFSSA--LADFWmPV 502
Cdd:pfam00133 458 EEG--SIKWLHREAKDKLGYG-----------KGTLEQDEDVLDTWFSSGsWPF------STLGWPFVNTeeFKKFF-PA 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 503 DLYIGGKEhavMHLFYarFFSHFCHRQKMVKhREPFHKLLAQGLI---KGQtfhllsgqclkredidftgptpvcaktke 579
Cdd:pfam00133 518 DMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPFKNVLVHGLVrdeQGR----------------------------- 562
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 672063826 580 rlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 627
Cdd:pfam00133 563 -------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 602
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
94-780 |
1.33e-17 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 87.85 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 94 GKLHMGHVRVYTLSDTIARFQKMRGMQeiTTCLP-------------------------DY---------YKWT-QY--- 135
Cdd:PRK05729 49 GSLHMGHALNNTLQDILIRYKRMQGYN--TLWLPgtdhagiatqmvverqlaaegksrhDLgrekflekvWEWKeESggt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 136 -------------------------------LFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVnEYgcswrsgaKVEKK 184
Cdd:PRK05729 127 itnqlrrlgascdwsrerftmdeglskavreVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-EY--------KEVKG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 185 YLrqWFIKttayakamqdaladlpewYGIKemqahwigdcvgchldftlkvdgqDTGEKLTAYTATPEAIYGISHVAISP 264
Cdd:PRK05729 198 KL--WHIR------------------YPLA------------------------DGSDYLVVATTRPETMLGDTAVAVNP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 265 S-----HglLHGcsslktalQKALVPgrdcltpvmavnmLTLQEVPVVIMAKPDLE---GSLdsKIgipsTSSEDT---R 333
Cdd:PRK05729 234 EderykH--LIG--------KTVILP-------------LVGREIPIIADEYVDPEfgtGAV--KI----TPAHDPndfE 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 334 LAQALGLPYSEVIetSPDGTERLSGsAEFTGMTRqdaFVAltRKA-------------------------RG-------- 380
Cdd:PRK05729 285 VGKRHNLPMINIM--DEDGTINENP-GEYQGLDR---FEA--RKAivadleelgllvkiephthsvghsdRSgvviepyl 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 381 -------M-----RVGGHVTS------------------NKLKDWLVSRQRYWGTPIPIVHCPAcGPVPVPLQDLpvtlp 430
Cdd:PRK05729 357 sdqwfvkMkplakPALEAVENgeikfvperwektyfhwmENIQDWCISRQLWWGHRIPAWYDED-GEVYVGREEP----- 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 431 sitsltgrggsplasalewvncsCPRCKGSAKRETDTMDTfvdsaWyyfrytdphnthspFSSALADF----Wmpvdlyi 506
Cdd:PRK05729 431 -----------------------EAREKALLTQDEDVLDT-----W--------------FSSALWPFstlgW------- 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 507 gGKEHAVMHLFY----------------AR--FFS-HFchrqkmvKHREPFHKLLAQGLI---KGQtfhllsgqclkred 564
Cdd:PRK05729 462 -PEKTEDLKRFYptsvlvtgfdiiffwvARmiMMGlHF-------TGQVPFKDVYIHGLVrdeQGR-------------- 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 565 idftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdalpgvlRWQQ--- 641
Cdd:PRK05729 520 ----------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEE--------RVEGyrn 569
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 642 ---RLWSlTTRFIEARTSGTAPQPQLLNNKEKAKARslW---EYkNAVITQVTTHFtEDFALNSVVSQLMG--------- 706
Cdd:PRK05729 570 fanKLWN-ASRFVLMNLEGADVGELPDPEELSLADR--WilsRL-NRTVAEVTEAL-DKYRFDEAARALYEfiwnefcdw 644
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 707 --------LSGALSQASQRLVLHspefedALCALLVMAAPLAPHITSELWAGLALVPSKlcdryawdAGVMLQAWPTVDS 778
Cdd:PRK05729 645 ylelakpvLQEAAKRATRATLAY------VLEQILRLLHPFMPFITEELWQKLAPLGIE--------ESIMLAPWPEADE 710
|
..
gi 672063826 779 QF 780
Cdd:PRK05729 711 AI 712
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
392-624 |
8.29e-17 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 82.67 E-value: 8.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 392 LKDWLVSRQRYWGTPIPIVHCPACGPVPVplqdlpvtlpsitsltgrggsplasalewvncscprckgsaKRETDTMDTF 471
Cdd:cd00818 189 RRDWCISRQRYWGTPIPVWYCEDCGEVLV-----------------------------------------RRVPDVLDVW 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 472 VDS--AWYYfrytdphNTHSPFSSALADFWMPVDLYIGGKEHaVMHLFYArffSHFChrQKMVKHREPFHKLLAQGLIkg 549
Cdd:cd00818 228 FDSgsMPYA-------QLHYPFENEDFEELFPADFILEGSDQ-TRGWFYS---LLLL--STALFGKAPYKNVIVHGFV-- 292
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672063826 550 qtfhllsgqclkredIDFTGptpvcaktkerlevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 624
Cdd:cd00818 293 ---------------LDEDG----------------RKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
94-794 |
2.98e-16 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 83.56 E-value: 2.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 94 GKLHMGHVRVYTLSDTIARFQKMRG------------------------MQE--------------------------IT 123
Cdd:COG0525 48 GSLHMGHALNNTLQDILIRYKRMQGyntlwqpgtdhagiatqavverqlAEEgksrhdlgrekflervwewkeesggtIT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 124 TCL-----------------PDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVnEYgcswrsgaKVEKKYL 186
Cdd:COG0525 128 NQLrrlgascdwsrerftmdEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV-EH--------EEVKGHL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 187 rqWFIKttayakamqdaladlpewYGIKemqahwigdcvgchldftlkvdgqDTGEKLTAYTATPEAIYGISHVAISPS- 265
Cdd:COG0525 199 --WHIR------------------YPLA------------------------DGSGYIVVATTRPETMLGDTAVAVHPEd 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 266 ----HglLHGcsslktalQKALVP--GRdcltpvmavnmltlqEVPVVIMAKPDLE---GSLdsKIgipsTSSEDT---R 333
Cdd:COG0525 235 erykH--LIG--------KTVILPlvGR---------------EIPIIADEYVDPEfgtGAV--KI----TPAHDPndfE 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 334 LAQALGLPYSEVIetSPDGTERLSGsAEFTGMTRQDAfvaltRK-------ARG---------MRVGgH----------- 386
Cdd:COG0525 284 VGKRHNLPMINIL--DEDGTINENA-GKYRGLDRFEA-----RKaivadleELGllvkvephkHSVG-Hsdrsgtviepy 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 387 -------------------VTSNK------------------LKDWLVSRQRYWGTPIPIVHCPAcGPVPVPLQDLPVtl 429
Cdd:COG0525 355 lsdqwfvkmkplakpaieaVEDGEikfvperwektyfhwmenIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEPEA-- 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 430 psitsltgrggsplasalewvncsCPRCKGSA-KRETDTMDTfvdsaWyyfrytdphnthspFSSALadfW----Mpvdl 504
Cdd:COG0525 432 ------------------------CAKAGSVNlTQDEDVLDT-----W--------------FSSAL---WpfstL---- 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 505 yiGGKEH-AVMHLFY----------------AR--FFS-HFchrqkmvKHREPFHKLLAQGLI---KGQtfhllsgqclk 561
Cdd:COG0525 462 --GWPEKtEDLKYFYptsvlvtgfdiiffwvARmiMMGlHF-------TGEVPFKDVYIHGLVrdeQGR----------- 521
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 562 redidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdalpgvlRWQQ 641
Cdd:COG0525 522 -------------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEE--------RVEG 568
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 642 -R-----LWSlTTRFI----EARTSGTAPQPQLLNNKEKakarslW---EYkNAVITQVTTHFTE---DFALNSVVS--- 702
Cdd:COG0525 569 yRnfankLWN-ASRFVlmnlEGFDPGLDPDPEELSLADR------WilsRL-NKTIAEVTEALEKyrfDEAAQALYDfvw 640
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 703 -------------QLMGLSGALSQASQRLVLHspefedALCALLVMAAPLAPHITSELWAGLALVPSKLCdryawdagVM 769
Cdd:COG0525 641 nefcdwylelakpRLYGGDEAAKRETRATLVY------VLEQILRLLHPFMPFITEEIWQKLPPRKEGES--------IM 706
|
890 900
....*....|....*....|....*
gi 672063826 770 LQAWPTVDSQFLQKPDMVQMAVLIN 794
Cdd:COG0525 707 LAPWPEADEELIDEEAEAEFEWLKE 731
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
392-626 |
4.65e-14 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 73.99 E-value: 4.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 392 LKDWLVSRQRYWGTPIPivhcpacgpvpvplqdlpvtlpsitsltgrggsplasalewvncscprckgsakreTDTMDTF 471
Cdd:cd00668 178 LLDWAISRQRYWGTPLP--------------------------------------------------------EDVFDVW 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 472 VDSAWYYFRYTdphntHSPFSSALADFWMPVDLYIGGKEHAVMHLFyarfFSHFCHrqKMVKHREPFHKLLAQGLIKGQt 551
Cdd:cd00668 202 FDSGIGPLGSL-----GYPEEKEWFKDSYPADWHLIGKDILRGWAN----FWITML--VALFGEIPPKNLLVHGFVLDE- 269
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672063826 552 fhllSGQclkredidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 626
Cdd:cd00668 270 ----GGQ----------------------------KMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
75-778 |
4.17e-12 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 70.02 E-value: 4.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 75 EEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQeiTTCLPDyykwTQYlfiklyeAGLAYQ---KEA 151
Cdd:PRK14900 42 EHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFN--TLWLPG----TDH-------AGIATQmivEKE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 152 LVNWDPVDQTVLANEQVNEYGCSW--RSGAKV--EKKYL-------RQWFIKTTAYAKAMQDALADLPEwYGIKEMQAHW 220
Cdd:PRK14900 109 LKKTEKKSRHDLGREAFLERVWAWkeQYGSRIgeQHKALgasldwqRERFTMDEGLSRAVREVFVRLHE-EGLIYREKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 221 IGDCVGCHLDFT-LKVDGQ---------------DTGEKLTAYTATPEAIYGISHVAISPshgllhgcsslKTALQKALV 284
Cdd:PRK14900 188 INWCPDCRTALSdLEVEHEeahqgelwsfayplaDGSGEIVVATTRPETMLGDTAVAVHP-----------LDPRYMALH 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 285 pGRDCLTPvmavnmLTLQEVPVVimAKPDLegsLDSKIGI------PSTSSEDTRLAQALGLPYSEVIEtsPDG-----T 353
Cdd:PRK14900 257 -GKKVRHP------ITGRTFPIV--ADAIL---VDPKFGTgavkvtPAHDFNDFEVGKRHGLEMITVIG--PDGrmtaeA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 354 ERLSGSAEFTGMTRQDAFVA---LTRKA-----------RGMRVGGHVTSNK---------------------------- 391
Cdd:PRK14900 323 GPLAGLDRFEARKEVKRLLAeqgLDRGAkphvlplgrcqRSATILEPLLSDQwyvrieplarpaieaveqgrtrfipeqw 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 392 ----------LKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQdlpvtlPSitsltgrggsplasalewvncSCPRCKGSA 461
Cdd:PRK14900 403 tntymawmrnIHDWCISRQLWWGHQIPAWYCPDGHVTVARET------PE---------------------ACSTCGKAE 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 462 KRE-TDTMDTFVDSA-WYYFRYTDPHNTHSpfssaLADFWmPVDLYIGGkeHAVMHLFYARFFSHFCHRQKMVkhrePFH 539
Cdd:PRK14900 456 LRQdEDVLDTWFSSGlWPFSTMGWPEQTDT-----LRTFY-PTSVMETG--HDIIFFWVARMMMMGLHFMGEV----PFR 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 540 KLLAQGLIKgqtfhllsgqclkrediDFTGptpvcaktkerlevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 619
Cdd:PRK14900 524 TVYLHPMVR-----------------DEKG----------------QKMSKTKGNVIDPLVITEQYGADALRFTLAALTA 570
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 620 PEKDIlwDVKTDALPGVLRWQQRLWSlTTRFIEARTSGTAPQPQLLNNKEKAKARS--LWEYKNAVITQVTThfTEDFAL 697
Cdd:PRK14900 571 QGRDI--KLAKERIEGYRAFANKLWN-ASRFALMNLSGYQERGEDPARLARTPADRwiLARLQRAVNETVEA--LEAFRF 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 698 NSVVSQLMGLSGA------LSQASQRLVLHSPEFEDALCALLVMAA--------PLAPHITSELWAGLALVPSKlcdrYA 763
Cdd:PRK14900 646 NDAANAVYAFVWHelcdwyIELAKEALASEDPEARRSVQAVLVHCLqtsyrllhPFMPFITEELWHVLRAQVGA----SA 721
|
810
....*....|....*
gi 672063826 764 WDAGVMLQAWPTVDS 778
Cdd:PRK14900 722 WADSVLAAEYPRKGE 736
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
586-767 |
6.17e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 68.76 E-value: 6.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD------ILWDVKTDALPGVL-RWQQRLWSLTTRFIEartsGT 658
Cdd:PRK11893 298 EKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDgdfsreAFINRINADLANDLgNLAQRTLSMIAKNFD----GK 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 659 APQPQLLNNKEKAkarsLWEYKNAVITQVTTHFtEDFALNSVVSQLMGLSGALSQ--ASQRLVLH----SPEFEDALCAL 732
Cdd:PRK11893 374 VPEPGALTEADEA----LLEAAAALLERVRAAM-DNLAFDKALEAILALVRAANKyiDEQAPWSLaktdPERLATVLYTL 448
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 672063826 733 L-------VMAAPLAPHITSELWAGLALVPSKLCDRYAWDAG 767
Cdd:PRK11893 449 LevlrgiaVLLQPVMPELAAKILDQLGVEEDENRDFAALSWG 490
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
81-210 |
1.08e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 65.13 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 81 PKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRG----------------MQE----------------------- 121
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGhdvlfvtgtdehgtkiELAaekegitpqelvdrihaefkelf 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 122 ----------ITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQV----------NEYG--C------ 173
Cdd:COG0143 81 eklgisfdnfIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYVegtcpkcgaeDAYGdqCencgat 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 672063826 174 ----------SWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEW 210
Cdd:COG0143 161 leptelinprSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDI 207
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
219-378 |
1.96e-10 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 60.64 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 219 HWIGDCVGCHLDFTLKvdgqDTGEKLTAYTATPEAIYGISHVAISPSHGL--------------LHGCSSLKTALQ-KAL 283
Cdd:pfam13603 2 NWIGRSEGAEITFPVE----GTDEKIEVFTTRPDTLMGVTFVALAPEHPLveklaeknpevaafIEECKNTSEIERtSET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 284 VPGRDCLTPVMAVNMLTLQEVPV-------------VIMAkpdlegsldskigIPSTSSEDTRLAQALGLPYSEVIEtSP 350
Cdd:pfam13603 78 KEKEGVFTGLYAIHPITGEKIPIwianfvlmeygtgAVMA-------------VPAHDQRDFEFAKKYNLPIKPVIQ-PE 143
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 672063826 351 DGTE-------------RLSGSAEFTGMTRQDAFVALTRKA 378
Cdd:pfam13603 144 DGDLdldimteayteegILVNSGEFDGLDSEEAKEAIIKKL 184
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
586-785 |
9.56e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 58.97 E-value: 9.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDIlwDVKTDALpgvlrwQQR-----------LWSLTTRFIEAR 654
Cdd:COG0143 326 EKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDG--DFSWEDF------VARvnsdlandlgnLASRTLSMIHKY 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 655 TSGTAPQPQLLNNKEKAkarsLWEYKNAVITQVTTHFtEDFALNSVVSQLMGLSGAL--------------SQASQRL-- 718
Cdd:COG0143 398 FDGKVPEPGELTEADEE----LLAEAEAALEEVAEAM-EAFEFRKALEEIMALARAAnkyidetapwklakDEDPERLat 472
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672063826 719 VLHSpEFEdALCALLVMAAPLAPHITSELWAGLALVPSKLcdryAWDAgvmlQAWPTVDSQFLQKPD 785
Cdd:COG0143 473 VLYT-LLE-ALRILAILLKPFLPETAEKILEQLGLEGDEL----TWED----AGWPLPAGHKIGKPE 529
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
586-623 |
3.69e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.00 E-value: 3.69e-08
10 20 30
....*....|....*....|....*....|....*...
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD 623
Cdd:cd00814 279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
82-210 |
5.66e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 55.62 E-value: 5.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGM--------------------------QEIT------------ 123
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYdvlfvtgtdehgtkieqkaeeegvtpQELCdkyheifkdlfk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 124 -----------TCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLAneqvneygcswrsgakvEKKYLRQWFIK 192
Cdd:cd00814 81 wlnisfdyfirTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP-----------------EWREEEHYFFR 143
|
170
....*....|....*...
gi 672063826 193 TTAYAKAMQDALADLPEW 210
Cdd:cd00814 144 LSKFQDRLLEWLEKNPDF 161
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
681-797 |
6.12e-08 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 52.41 E-value: 6.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 681 NAVITQVTTHFtEDFALNSVVSQLM-GLSGALSQ-----ASQRLVLHSPEFE------DALCALLVMAAPLAPHITSELW 748
Cdd:pfam08264 9 NKLIKEVTEAY-ENYRFNTAAQALYeFFWNDLSDwylelIKDRLYGEEPDSRaqttlyEVLETLLRLLAPFMPFITEELW 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 672063826 749 AGLAlvpsklcdryawdagVMLQAWPTV----DSQFLQKPDMVQMAVLINNKA 797
Cdd:pfam08264 88 QKES---------------IHLAPWPEDaeleEAELEEAFELRQEIVQAIRKL 125
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
586-748 |
5.02e-07 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 53.72 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdALPGVLRWQQRLWSLTTRFIEA--RTSGTAPQPQ 663
Cdd:PRK12300 576 KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREK--EVESVRRQLERFYELAKELIEIggEEELRFIDKW 653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 664 LLNN-----KEKAKARSLWEYKNAVITQVtthftedFALNSVVSQLMGLSGALSQASQRLVLHspefedalcALLVMAAP 738
Cdd:PRK12300 654 LLSRlnriiKETTEAMESFQTRDAVQEAF-------YELLNDLRWYLRRVGEANNKVLREVLE---------IWIRLLAP 717
|
170
....*....|
gi 672063826 739 LAPHITSELW 748
Cdd:PRK12300 718 FTPHLAEELW 727
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
563-624 |
7.92e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 52.29 E-value: 7.92e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672063826 563 EDIDFTGPTPVCAKtkERLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 624
Cdd:pfam09334 302 LGAGYRLPTTVFAH--GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDT 361
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
586-619 |
1.14e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.11 E-value: 1.14e-06
10 20 30
....*....|....*....|....*....|....
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 619
Cdd:PRK12267 298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVP 331
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
83-223 |
1.34e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 51.52 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 83 FYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRG----------------MQE------------------------- 121
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGydvlfvcgtdehgtpiELKaekegitpeelvdryheihredfkk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 122 --------ITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQV----------NEYG-----C----- 173
Cdd:pfam09334 81 fnisfddyGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVegtcphcgseDARGdqcenCgrhle 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 174 --------SWRSGAKVEKKYLRQWFIKTTAYAKAMQDALA-DLPEW-YGIKEMQAHWIGD 223
Cdd:pfam09334 161 ptelinpkCVICGTTPEVKETEHYFFDLSKFQDKLREWIEeNNPEWpENVKNMVLEWLKE 220
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
393-615 |
1.37e-06 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 52.28 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 393 KDWLVSRQRYWGTPIPIVHCPACGPVpvplqdlpVTLPSITSLTGRGGSPLASAL-----EWVNCSCPRCKG--SAKRET 465
Cdd:PTZ00427 569 KDWCISRNRYWGTPIPIWADEKMETV--------ICVESIKHLEELSGVKNINDLhrhfiDHIEIKNPKGKTypKLKRIP 640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 466 DTMDTFVDSAwyyfryTDPH-NTHSPFSSALADFW--MPVDLYIGGKEHAVMHLFYARFFShfchrqKMVKHREPFHKLL 542
Cdd:PTZ00427 641 EVFDCWFESG------SMPYaKVHYPFSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVIS------TLLFDKAPFKNLI 708
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672063826 543 AQGLIkgqtfhllsgqclkredidftgptpvcaktkerLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 615
Cdd:PTZ00427 709 CNGLV---------------------------------LASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
56-780 |
3.11e-06 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 51.16 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 56 KDVE----KWWHQQIKVQASKISEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGmqEITTCLP---- 127
Cdd:PTZ00419 31 KEVEsgwyEWWEKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKG--DETLWVPgtdh 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 128 ----------------------DY-----------YK-------------------WTQYL--------------FIKLY 141
Cdd:PTZ00419 109 agiatqvvvekklmkeenktrhDLgreeflkkvweWKdkhgnnicnqlrrlgssldWSREVftmdeqrskavkeaFVRLY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 142 EAGLAYQKEALVNWDPVDQTVLANEQVNEygcswrsgAKVEKKYlrqwFIKTTAYAKAMqdaladlpewygikEMQAHWi 221
Cdd:PTZ00419 189 EDGLIYRDTRLVNWCCYLKTAISDIEVEF--------EEIEKPT----KITIPGYDKKV--------------EVGVLW- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 222 gdcvgcHLDFTLKVDGQdtgEKLTAYTATPEAIYGISHVAISP-----SHglLHGCSslktaLQKALVPGRdcltpvmav 296
Cdd:PTZ00419 242 ------HFAYPLEDSGQ---EEIVVATTRIETMLGDVAVAVHPkderyKK--LHGKE-----LIHPFIPDR--------- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 297 nmltlqEVPVVimAKPDLegsLDSKIG------IPSTSSEDTRLAQALGLPYSeVIETSpDGTERLSGsAEFTGMTRQDA 370
Cdd:PTZ00419 297 ------KIPII--ADDEL---VDMEFGtgavkiTPAHDPNDYEIAKRHNLPFI-NIFTL-DGKINENG-GEFAGMHRFDC 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 371 FVALTRK-----------ARGMRVG-----------------------------GHVTSNKLK----------------- 393
Cdd:PTZ00419 363 RRKIEEElkemgllrdkvPNPMRLPrcsrsgdivepmlipqwyvnckdmakravEAVRNGELKiipsshenvwyhwleni 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 394 -DWLVSRQRYWGTPIPIVHCPACGPVPVPL-QDLPVTLPSITsltgrggSPLASALEWVNCSCPRCkgSAKRETDTMDTF 471
Cdd:PTZ00419 443 qDWCISRQLWWGHRIPAYRVISKGPETDPSdEEPWVVARSEE-------EALEKAKKKFGLSEEDF--ELEQDEDVLDTW 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 472 VDSAWYyfrytdphnthsPFSS-----ALADF--WMPVDLYIGGkeHAVMHLFYARFFSHFCHRQKMVkhrePFHKLLAQ 544
Cdd:PTZ00419 514 FSSGLF------------PFSTlgwpdQTDDLqrFFPTSLLETG--SDILFFWVARMVMMSLHLTDKL----PFKTVFLH 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 545 GLIKgqtfhllsgqclkrediDFTGptpvcaktkerlevtwEKMSKSKHNGVDPEEIVAqyGI------DTIRLYILfaa 618
Cdd:PTZ00419 576 AMVR-----------------DSQG----------------EKMSKSKGNVIDPLEVIE--GIslqdlnQKLYEGNL--- 617
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 619 pPEKDILWDVK--------------TDALP-GVLRWQQ--------------------RLWSlTTRFIEARTSGTAPQPQ 663
Cdd:PTZ00419 618 -PEKEIKRAIElqkkefpngipecgTDALRfGLLAYTQqgrninldinrvvgyrhfcnKLWN-AVKFALMKLLKDFNLPN 695
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 664 LLNNKEKAKARSLWEYK------NAVITQVTTHFTE-DFAL--NSVVS----QLMGLSGALSQAsqRLVLHSPeFEDALC 730
Cdd:PTZ00419 696 STLFKPNNVESLPWEDKwilhrlNVAIKEVTEGFKEyDFSEatQATYNfwlyELCDVYLELIKP--RLSKQSD-GERKQH 772
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 731 ALLVMAA----------PLAPHITSELWAGLALVPSKLcdryawdAGVMLQAWPTVDSQF 780
Cdd:PTZ00419 773 AQDVLHTvldiglrllhPMMPFITEELYQRLPNYLRKS-------ESISIAKYPQPNPGW 825
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
90-164 |
3.14e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 47.45 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 90 PYPSGKLHMGHVRVYTLSDTIARFQKMRG--------------------MQEITTclP---------------------- 127
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGhevlfvcaddahgtpimlkaEKEGIT--Peeliaryhaehkrdfagfgisf 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 672063826 128 DYY---------KWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLA 164
Cdd:PRK00133 89 DNYgsthseenrELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLP 134
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
393-785 |
4.66e-05 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 47.07 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 393 KDWLVSRQRYWGTPIPIVHCPACGPvpvPLQDlPVTLPSITSLTGRGGSPLASALEWVNCSCPRCKGSA---KRETDTMD 469
Cdd:PLN02843 467 SDWCISRQRTWGVPIPVFYHVETKE---PLMN-EETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAsdyEKGTDTMD 542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 470 TFVDSAwyyfrytdphnthSPFSSAL---ADFWMPVDLYIGGKEHavmhlfyarffshfcHR---QKMV------KHREP 537
Cdd:PLN02843 543 VWFDSG-------------SSWAGVLgsrEGLSYPADLYLEGSDQ---------------HRgwfQSSLltsvatKGKAP 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 538 FHKLLAQGLI---KGQtfhllsgqclkredidftgptpvcaktkerlevtweKMSKSKHNGVDPEEIV---------AQY 605
Cdd:PLN02843 595 YKSVLTHGFVldeKGF------------------------------------KMSKSLGNVVDPRLVIeggknqkqePAY 638
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 606 GIDTIRLYILFAappekdilwDVKTDALPGVLRWQQ-----RLWSLTTRFIEARTSGTAPQ--------PQL-------L 665
Cdd:PLN02843 639 GADVLRLWVASV---------DYTGDVLIGPQILKQmsdiyRKLRGTLRYLLGNLHDWKPDnavpyedlPSIdkyalfqL 709
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 666 NNKEKAKARSLWEYKNAVITQVTTHFT----EDFALNSVVSQLM--GLSGALSQASQRlVLHSpefedALCALLVMAAPL 739
Cdd:PLN02843 710 ENVVNEIEESYDNYQFFKIFQILQRFTivdlSNFYLDVAKDRLYvgGTTSFTRRSCQT-VLAA-----HLLSLLRAIAPI 783
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 672063826 740 APHITSELWAGLALVPSKLCDRYAWDAGvmlqaWPTVDSQFLQKPD 785
Cdd:PLN02843 784 LPHLAEDAWQNLPFQEDGSAAESVFEAG-----WPTPNEEWLSFPA 824
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
80-118 |
4.76e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 47.10 E-value: 4.76e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 672063826 80 KPKFYLLSMFPYPSGKLHMGHvrVYT--LSDTIARFQKMRG 118
Cdd:PRK12267 3 KKTFYITTPIYYPNGKPHIGH--AYTtiAADALARYKRLQG 41
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
96-118 |
2.52e-04 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 44.86 E-value: 2.52e-04
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
48-409 |
4.07e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 44.16 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 48 KEYTLQTRKDVEKWWHQQikvqaskiseeDKLKPKF------YLLSMfPYP--SGKLHMGHVRVYTLSDTIARFQKMRGM 119
Cdd:PLN02943 59 KSFDFTSEERIYNWWESQ-----------GYFKPNFdrggdpFVIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 120 QeiTTCLPDyykwTQYlfiklyeAGLAYQ--KEALVNWDPVDQTVLANEQVNE--------YG-------------CSWR 176
Cdd:PLN02943 127 P--TLWIPG----TDH-------AGIATQlvVEKMLASEGIKRTDLGRDEFTKrvwewkekYGgtitnqikrlgasCDWS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 177 ----------SGAKVEK-------------KYLRQWfikttayAKAMQDALADLPEWYGIKEMQAHWIgdcvgchldfTL 233
Cdd:PLN02943 194 rerftldeqlSRAVVEAfvrlhekgliyqgSYMVNW-------SPNLQTAVSDLEVEYSEEPGTLYYI----------KY 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 234 KVDGQdTGEKLTAYTATPEAIYGISHVAISPSHGLLHgcsslKTALQKALVPgrdcltpvmavnMLTLQEVPVVIMAKPD 313
Cdd:PLN02943 257 RVAGG-SEDFLTIATTRPETLFGDVAIAVNPEDDRYS-----KYIGKMAIVP------------MTYGRHVPIIADRYVD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063826 314 LE-GSLDSKIgIPSTSSEDTRLAQALGLPYSEVIetSPDGT-------------ERLSGSAEFTGMT------------- 366
Cdd:PLN02943 319 KDfGTGVLKI-SPGHDHNDYLLARKLGLPILNVM--NKDGTlnevaglywfearEKLWSDLEETGLAvkkephtlrvprs 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672063826 367 -----------RQDAFVA---LTRKA--------------RGMRVGGHVTSNkLKDWLVSRQRYWGTPIPI 409
Cdd:PLN02943 396 qrggevieplvSKQWFVTmepLAEKAlkavengeltiipeRFEKIYNHWLSN-IKDWCISRQLWWGHRIPV 465
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
52-118 |
6.15e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 43.52 E-value: 6.15e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672063826 52 LQTRKDVEKWWHQQIKVQASKISEEDKLKPKFYllSMFPYP--SGKLHMGHvrVYTLSDTI--ARFQKMRG 118
Cdd:PLN02959 16 LEIEVAVQKWWEEEKVFEAEAGDEPPKPGEKFF--GNFPYPymNGLLHLGH--AFSLSKLEfaAAYHRLRG 82
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
393-409 |
9.81e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 42.79 E-value: 9.81e-04
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
587-615 |
2.33e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 41.63 E-value: 2.33e-03
10 20
....*....|....*....|....*....
gi 672063826 587 KMSKSKHNGVDPEEIVAQYGIDTIRLYIL 615
Cdd:PLN02882 614 KMSKSLKNYPDPNEVIDKYGADALRLYLI 642
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
586-615 |
3.50e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.86 E-value: 3.50e-03
10 20 30
....*....|....*....|....*....|
gi 672063826 586 EKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 615
Cdd:COG0215 264 EKMSKSLGNFFTVRDLLKKYDPEVLRFFLL 293
|
|
| |
