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Conserved domains on  [gi|672070193|ref|XP_008766699|]
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NAD-dependent protein deacetylase sirtuin-7 isoform X1 [Rattus norvegicus]

Protein Classification

SIR2 family NAD-dependent protein deacylase( domain architecture ID 10105444)

SIR2 family NAD-dependent protein deacylase such as NAD-dependent deacetylase, which catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

CATH:  3.40.50.1220|3.30.1600.10
EC:  2.3.1.-
Gene Ontology:  GO:0070403|GO:0017136|GO:0046872|GO:0008270
PubMed:  7498786|15128440|10873683
SCOP:  4003387

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 102-339 8.25e-106

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


:

Pssm-ID: 238701  Cd Length: 206  Bit Score: 311.54  E-value: 8.25e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 102 HLVVYTGAGISTAASIPDYRGPNGVWTLLQ--KGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGL 179
Cdd:cd01410    2 HLVVFTGAGISTSAGIPDFRGPNGVWTLLPedKGRRRFSWRFRRAEPTLTHMALVELERAGLLKFVISQNVDGLHLRSGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 180 PRTAISELHGNMYIEvssaqrtqglgdkqmsltvpslpqVCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRD 259
Cdd:cd01410   82 PREKLSELHGNMFIE------------------------VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKD 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 260 TIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 339
Cdd:cd01410  133 TIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 11-91 5.45e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193   11 ERKAAERVRRLREEQQRE--RLRQV--SRILRKAAAERSA----EEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDD 82
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREveRRRKLeeAEKARQAEMDRQAaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAME 373


                  ....*....
gi 672070193   83 PEELRRKVR 91
Cdd:pfam17380 374 ISRMRELER 382
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 102-339 8.25e-106

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 311.54  E-value: 8.25e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 102 HLVVYTGAGISTAASIPDYRGPNGVWTLLQ--KGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGL 179
Cdd:cd01410    2 HLVVFTGAGISTSAGIPDFRGPNGVWTLLPedKGRRRFSWRFRRAEPTLTHMALVELERAGLLKFVISQNVDGLHLRSGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 180 PRTAISELHGNMYIEvssaqrtqglgdkqmsltvpslpqVCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRD 259
Cdd:cd01410   82 PREKLSELHGNMFIE------------------------VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKD 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 260 TIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 339
Cdd:cd01410  133 TIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 89-351 3.16e-36

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 133.00  E-value: 3.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  89 KVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTllqKGRPVSAAD---------------------LSEAEPT 147
Cdd:PRK00481   2 RIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWE---EHRPEDVASpegfardpelvwkfynerrrqLLDAKPN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 148 LTHMSITQLHKHKLVQHVVSQNCDGLHLRSGlpRTAISELHGNMYievssaqrtqglgdkqmslTVpslpqVCTSCipNR 227
Cdd:PRK00481  79 AAHRALAELEKLGKLVTVITQNIDGLHERAG--SKNVIELHGSLL-------------------RA-----RCTKC--GQ 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 228 EYVRVFDVTERtalhrhltGRTCHKCGTQLRDTIVHFGErgtlgqPLN---WEAATEAASKADTILCLGSSLKVlkkYPR 304
Cdd:PRK00481 131 TYDLDEYLKPE--------PPRCPKCGGILRPDVVLFGE------MLPelaIDEAYEALEEADLFIVIGTSLVV---YPA 193

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 672070193 305 LWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDEL 351
Cdd:PRK00481 194 AGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 89-349 6.19e-36

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 132.21  E-value: 6.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  89 KVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTllqKGRPVSAAD---------------------LSEAEPT 147
Cdd:COG0846    3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWE---KYDPEEVASpeafrrdpelvwafynerrrlLRDAEPN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 148 LTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRtaISELHGNMYievssaqRTQglgdkqmsltvpslpqvCTSC---I 224
Cdd:COG0846   80 AAHRALAELEKAGKLVFVITQNVDGLHQRAGSKN--VIELHGSLH-------RLR-----------------CTKCgkrY 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 225 PNREYVRVFDVTErtalhrhltGRTCHKCGTQLRDTIVHFGERGtlgQPLNWEAATEAASKADTILCLGSSLKVlkkYP- 303
Cdd:COG0846  134 DLEDVLEDLEGEL---------PPRCPKCGGLLRPDVVWFGEML---PEEALERALEALAEADLFLVIGTSLVV---YPa 198

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 672070193 304 -RLWCMTKppSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 349
Cdd:COG0846  199 aGLPEYAK--RAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 108-299 5.02e-22

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 92.70  E-value: 5.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  108 GAGISTAASIPDYRGPNGVWTLLQKgRPVSAAD-----------------------LSEAEPTLTHMSITQLHKHKLVQH 164
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAP-EELASPEaffsnpelvwdpepfyniarellPGEAQPNPAHYFIAKLEDKGKLLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  165 VVSQNCDGLHLRSGLPRtaISELHGNMyievssaqrtqglgdkqmsLTVPslpqvCTSCIPNREYVRVFDVTERTALHRh 244
Cdd:pfam02146  80 LITQNIDGLHERAGSKK--VVELHGSF-------------------AKAR-----CVSCHQKYTGETLYERIRPEKVPH- 132

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672070193  245 ltgrtCHKCGTQLRDTIVHFGErgtlGQPLNWEAATEAASKADTILCLGSSLKVL 299
Cdd:pfam02146 133 -----CPQCGGLLKPDIVFFGE----NLPDKFHRAYEDLEEADLLIVIGTSLKVY 178
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 11-91 5.45e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193   11 ERKAAERVRRLREEQQRE--RLRQV--SRILRKAAAERSA----EEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDD 82
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREveRRRKLeeAEKARQAEMDRQAaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAME 373


                  ....*....
gi 672070193   83 PEELRRKVR 91
Cdd:pfam17380 374 ISRMRELER 382
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-101 6.33e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193     7 LSRSERKAAERVRRLREEQ-----QRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCD 81
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLeeleaQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                           90       100
                   ....*....|....*....|
gi 672070193    82 DPEELRRKVRELAGAVRSAR 101
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLN 399
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
12-93 2.65e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.89  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  12 RKAAERVRRLREE--QQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVcddpEELRRK 89
Cdd:COG4372   41 DKLQEELEQLREEleQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA----EELQEE 116


                 ....
gi 672070193  90 VREL 93
Cdd:COG4372  117 LEEL 120
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 102-339 8.25e-106

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 311.54  E-value: 8.25e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 102 HLVVYTGAGISTAASIPDYRGPNGVWTLLQ--KGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGL 179
Cdd:cd01410    2 HLVVFTGAGISTSAGIPDFRGPNGVWTLLPedKGRRRFSWRFRRAEPTLTHMALVELERAGLLKFVISQNVDGLHLRSGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 180 PRTAISELHGNMYIEvssaqrtqglgdkqmsltvpslpqVCTSCIPNREYVRVFDvtertALHRHLTGRTCHKCGTQLRD 259
Cdd:cd01410   82 PREKLSELHGNMFIE------------------------VCKSCGPEYVRDDVVE-----TRGDKETGRRCHACGGILKD 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 260 TIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGK 339
Cdd:cd01410  133 TIVDFGERLPPE---NWMGAAAAACRADLFLCLGTSLQV---TPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
 101-339 1.40e-71

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 224.37  E-value: 1.40e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 101 RHLVVYTGAGISTAASIPDYRGPNGVWTLLQ-----------KGRPVSAADLS-------EAEPTLTHMSITQLHKHKLV 162
Cdd:cd01407    1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDpeelafspeafRRDPELFWGFYrerryplNAQPNPAHRALAELERKGKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 163 QHVVSQNCDGLHLRSGLPRtaISELHGNMYIEvssaqrtqglgdkqmsltvpslpqVCTSCipNREYVRVFDVtertALH 242
Cdd:cd01407   81 KRVITQNVDGLHQRAGSPK--VIELHGSLFRV------------------------RCTKC--GKEYPRDELQ----ADI 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 243 RHLTGRTCHKCGTQLRDTIVHFGERGtlgqPLNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYIVN 322
Cdd:cd01407  129 DREEVPRCPKCGGLLRPDVVFFGESL----PEELDEAAEALAKADLLLVIGTSLQV---YPAAGLPLYAPERGAPVVIIN 201

                        250
                 ....*....|....*..
gi 672070193 323 LQWTPKDDWAALKLHGK 339
Cdd:cd01407  202 LEPTPADRKADLVILGD 218
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 101-339 2.35e-56

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 185.24  E-value: 2.35e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 101 RHLVVYTGAGISTAASIPDYRGPN-GVWTLLQ-----------KGRPVSAADLS--------EAEPTLTHMSITQLHKHK 160
Cdd:cd00296    1 KRVVVFTGAGISTESGIPDFRGLGtGLWTRLDpeelafspeafRRDPELFWLFYkerrytplDAKPNPAHRALAELERKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 161 LVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEvssaqrtqglgdkqmsltvpslpqVCTSCIPNREYVRVFDVTERta 240
Cdd:cd00296   81 KLKRIITQNVDGLHERAGSRRNRVIELHGSLDRV------------------------RCTSCGKEYPRDEVLEREKP-- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 241 lhrhltgRTCHKCGTQLRDTIVHFGERGTLGqplNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKLYI 320
Cdd:cd00296  135 -------PRCPKCGGLLRPDVVDFGEALPKE---WFDRALEALLEADLVLVIGTSLTV---YPAARLLLRAPERGAPVVI 201

                        250       260
                 ....*....|....*....|.
gi 672070193 321 VNLQWTPKDDW--AALKLHGK 339
Cdd:cd00296  202 INREPTPADALkkADLVILGD 222
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 89-351 3.16e-36

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 133.00  E-value: 3.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  89 KVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTllqKGRPVSAAD---------------------LSEAEPT 147
Cdd:PRK00481   2 RIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWE---EHRPEDVASpegfardpelvwkfynerrrqLLDAKPN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 148 LTHMSITQLHKHKLVQHVVSQNCDGLHLRSGlpRTAISELHGNMYievssaqrtqglgdkqmslTVpslpqVCTSCipNR 227
Cdd:PRK00481  79 AAHRALAELEKLGKLVTVITQNIDGLHERAG--SKNVIELHGSLL-------------------RA-----RCTKC--GQ 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 228 EYVRVFDVTERtalhrhltGRTCHKCGTQLRDTIVHFGErgtlgqPLN---WEAATEAASKADTILCLGSSLKVlkkYPR 304
Cdd:PRK00481 131 TYDLDEYLKPE--------PPRCPKCGGILRPDVVLFGE------MLPelaIDEAYEALEEADLFIVIGTSLVV---YPA 193

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 672070193 305 LWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDEL 351
Cdd:PRK00481 194 AGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 89-349 6.19e-36

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 132.21  E-value: 6.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  89 KVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTllqKGRPVSAAD---------------------LSEAEPT 147
Cdd:COG0846    3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWE---KYDPEEVASpeafrrdpelvwafynerrrlLRDAEPN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 148 LTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRtaISELHGNMYievssaqRTQglgdkqmsltvpslpqvCTSC---I 224
Cdd:COG0846   80 AAHRALAELEKAGKLVFVITQNVDGLHQRAGSKN--VIELHGSLH-------RLR-----------------CTKCgkrY 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 225 PNREYVRVFDVTErtalhrhltGRTCHKCGTQLRDTIVHFGERGtlgQPLNWEAATEAASKADTILCLGSSLKVlkkYP- 303
Cdd:COG0846  134 DLEDVLEDLEGEL---------PPRCPKCGGLLRPDVVWFGEML---PEEALERALEALAEADLFLVIGTSLVV---YPa 198

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 672070193 304 -RLWCMTKppSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMD 349
Cdd:COG0846  199 aGLPEYAK--RAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
 97-339 2.06e-32

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 122.09  E-value: 2.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  97 VRSARHLVVYTGAGISTAASIPDYRGPNGVWtllQKGRPVSAADLS---------------------EAEPTLTHMSITQ 155
Cdd:cd01413    1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLW---KKYDPEEVASIDyfyrnpeefwrfykeiilgllEAQPNKAHYFLAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 156 LHKHKLVQHVVSQNCDGLHLRSGLPRtaISELHGNMyiEVSSaqrtqglgdkqmsltvpslpqvCTSCipNREYvrvfDV 235
Cdd:cd01413   78 LEKQGIIKAIITQNIDGLHQRAGSKN--VIELHGTL--QTAY----------------------CVNC--GSKY----DL 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 236 TERTALHRHLTGRtCHKCGTQLRDTIVHFGErgTLGQPLnWEAATEAASKADTILCLGSSLKVlkkYP--RLWCMTKppS 313
Cdd:cd01413  126 EEVKYAKKHEVPR-CPKCGGIIRPDVVLFGE--PLPQAL-LREAIEAAKEADLFIVLGSSLVV---YPanLLPLIAK--E 196

                        250       260
                 ....*....|....*....|....*.
gi 672070193 314 RRPKLYIVNLQWTPKDDWAALKLHGK 339
Cdd:cd01413  197 NGAKLVIVNADETPFDYIADLVIQDK 222
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
 93-344 3.94e-27

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 108.92  E-value: 3.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  93 LAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTllQKGRPVSAAD---------------------LSEAEPTLTHM 151
Cdd:cd01409    1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYS--RTFRPMTHQEfmrspaarqrywarsfvgwprFSAAQPNAAHR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 152 SITQLHKHKLVQHVVSQNCDGLHLRSGlpRTAISELHGNMYievssaqrtqglgdkqmslTVpslpqVCTSC---IPNRE 228
Cdd:cd01409   79 ALAALEAAGRLHGLITQNVDGLHTKAG--SRNVVELHGSLH-------------------RV-----VCLSCgfrTPRAE 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 229 YVRVF------------------DVTERTALHRHLTGRTCHKCGTQLRDTIVHFGE---RGTLgqplnwEAATEAASKAD 287
Cdd:cd01409  133 LQDRLealnpgfaeqaagqapdgDVDLEDEQVAGFRVPECERCGGVLKPDVVFFGEnvpRDRV------VTAAARLAEAD 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 672070193 288 TILCLGSSLKVLKKYpRLwCMTKPPSRRPkLYIVNLQWTPKDDWAALKLHGKCDDVM 344
Cdd:cd01409  207 ALLVLGSSLMVYSGY-RF-VLAAAEAGLP-IAIVNIGPTRADHLATLKVDARCGEVL 260
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
 90-353 1.27e-24

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 101.44  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  90 VRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQK---------GRPVS----AAD----LSEAEPTLTHMS 152
Cdd:PRK14138   1 MKEFLELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYPQnvfdidffySHPEEfyrfAKEgifpMLEAKPNLAHVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 153 ITQLHKHKLVQHVVSQNCDGLHLRSGLPRtaISELHGNMYievssaqrtqglgdkqmsltvpslPQVCTSCIPNREYVRV 232
Cdd:PRK14138  81 LAKLEEKGLIEAVITQNIDRLHQKAGSKK--VIELHGNVE------------------------EYYCVRCGKRYTVEDV 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 233 FDVTERTALHRhltgrtCHKCGTQLRDTIVHFGERgtlgqpLNWEAATEA---ASKADTILCLGSSLKVlkkYPRLWCMT 309
Cdd:PRK14138 135 IEKLEKSDVPR------CDDCSGLIRPNIVFFGEA------LPQDALREAirlSSKASLMIVMGSSLVV---YPAAELPL 199

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 672070193 310 KPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGL 353
Cdd:PRK14138 200 ITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSEGGI 243
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 101-348 3.16e-23

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 97.28  E-value: 3.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 101 RHLVVYTGAGISTAASIPDYRGPNGVWTllqKGRPVSAA---------------------DLSEAEPTLTHMSITQLHKH 159
Cdd:cd01412    1 RRVVVLTGAGISAESGIPTFRDADGLWA---RFDPEELAtpeafardpelvwefynwrrrKALRAQPNPAHLALAELERR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 160 KLVQHVVSQNCDGLHLRSGlpRTAISELHGNMYievssaqRTQglgdkqmsltvpslpqvCTSCipnrEYVRVFDVTE-R 238
Cdd:cd01412   78 LPNVLLITQNVDGLHERAG--SRNVIELHGSLF-------RVR-----------------CSSC----GYVGENNEEIpE 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 239 TALHRhltgrtCHKCGTQLRDTIVHFGERgtlgQPLNWEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSRRPKL 318
Cdd:cd01412  128 EELPR------CPKCGGLLRPGVVWFGES----LPLALLEAVEALAKADLFLVIGTSGVV---YPAAGLPEEAKERGARV 194

                        250       260       270
                 ....*....|....*....|....*....|
gi 672070193 319 YIVNLQWTPKDDWAALKLHGKCDDVMRLLM 348
Cdd:cd01412  195 IEINPEPTPLSPIADFAFRGKAGEVLPALL 224
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 108-299 5.02e-22

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 92.70  E-value: 5.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  108 GAGISTAASIPDYRGPNGVWTLLQKgRPVSAAD-----------------------LSEAEPTLTHMSITQLHKHKLVQH 164
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAP-EELASPEaffsnpelvwdpepfyniarellPGEAQPNPAHYFIAKLEDKGKLLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  165 VVSQNCDGLHLRSGLPRtaISELHGNMyievssaqrtqglgdkqmsLTVPslpqvCTSCIPNREYVRVFDVTERTALHRh 244
Cdd:pfam02146  80 LITQNIDGLHERAGSKK--VVELHGSF-------------------AKAR-----CVSCHQKYTGETLYERIRPEKVPH- 132

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672070193  245 ltgrtCHKCGTQLRDTIVHFGErgtlGQPLNWEAATEAASKADTILCLGSSLKVL 299
Cdd:pfam02146 133 -----CPQCGGLLKPDIVFFGE----NLPDKFHRAYEDLEEADLLIVIGTSLKVY 178
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
 96-303 1.21e-21

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 92.81  E-value: 1.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  96 AVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRP---VSAADLSE-----------------AEPTLTHMSITQ 155
Cdd:cd01411    4 ILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYKYSPeylLSHDFLERepekfyqfvkenlyfpdAKPNIIHQKMAE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 156 LHKHKLVQhVVSQNCDGLHLRSGlPRTAIsELHGNMYievssaqrtqglgdkqmsltvpslpQV-CTSC---IPNREYVR 231
Cdd:cd01411   84 LEKMGLKA-VITQNIDGLHQKAG-SKNVV-EFHGSLY-------------------------RIyCTVCgktVDWEEYLK 135

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672070193 232 VFdvtertalhrhltgrTCHKCGTQLRDTIVHFGErgtlgqPLNWEA---ATEAASKADTILCLGSSLKVlkkYP 303
Cdd:cd01411  136 SP---------------YHAKCGGVIRPDIVLYEE------MLNESVieeAIQAIEKADLLVIVGTSFVV---YP 186
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
 101-347 9.11e-19

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 84.99  E-value: 9.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 101 RHLVVYTGAGISTAASIPDYRGPN-GVWTLLQK---GRPVSAADLS-------------------EAEPTLTHMSITQLH 157
Cdd:cd01408    1 KKIVVLVGAGISTSAGIPDFRSPGtGLYANLARynlPYPEAMFDISyfrknprpfyalakelypgQFKPSVAHYFIKLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 158 KHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYievssaqrtqglgdkqmsltvpslPQVCTSC---IPNrEYVRVFD 234
Cdd:cd01408   81 DKGLLLRNYTQNIDTLERVAGVPDDRIIEAHGSFA------------------------TAHCIKCkhkYPG-DWMREDI 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 235 VTERTALhrhltgrtCHKCGTQLRDTIVHFGErgTLGQPLNwEAATEAASKADTILCLGSSLKVlkkYPRLWCMTKPPSR 314
Cdd:cd01408  136 FNQEVPK--------CPRCGGLVKPDIVFFGE--SLPSRFF-SHMEEDKEEADLLIVIGTSLKV---APFASLPSRVPSE 201

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 672070193 315 RPKLYI-----VNLQWTPKDdwaaLKLHGKCDDVMRLL 347
Cdd:cd01408  202 VPRVLInrepvGHLGKRPFD----VALLGDCDDGVREL 235
PRK05333 PRK05333
NAD-dependent protein deacetylase;
97-353 1.15e-16

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 79.72  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  97 VRSARHLVVYTGAGISTAASIPDYRGPNGVWtllQKGRPVSAAD---------------------LSEAEPTLTHMSITQ 155
Cdd:PRK05333  16 VERHPRLFVLTGAGISTDSGIPDYRDRNGQW---KRSPPITYQAfmgsdaarrrywarsmvgwpvFGRAQPNAAHHALAR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 156 LHKHKLVQHVVSQNCDGLHLRSGlpRTAISELHG--NMYIEVSSAQRTQGLGDKQMSLTV-PSLPQVCTSCIPNReyvrv 232
Cdd:PRK05333  93 LGAAGRIERLVTQNVDGLHQRAG--SRDVIELHGrlDGVRCMGCGARHPRAEIQHVLEAAnPEWLALEAAPAPDG----- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 233 fDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGE-----RGtlgqplnwEAATEAASKADTILCLGSSLKVLKKYPrlWC 307
Cdd:PRK05333 166 -DADLEWAAFDHFRVPACPACGGILKPDVVFFGEnvpreRV--------AAARAALDAADAVLVVGSSLMVYSGYR--FC 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 672070193 308 MTKPPSRRPkLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGL 353
Cdd:PRK05333 235 VWAAQQGKP-IAALNLGRTRADPLLTLKVEASCAQALAALVARLGL 279
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
 97-303 1.47e-12

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 67.16  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  97 VRSARHLVVYTGAGISTAASIPDYRGPNGVW------------------TLLQK--GRPVSAADLSEAEPTLTHMSITQL 156
Cdd:PTZ00408   1 MKACRCITILTGAGISAESGISTFRDGNGLWenhrvedvatpdaflrnpALVQRfyNERRRALLSSSVKPNKAHFALAKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 157 HKH----KLVqhVVSQNCDGLHLRSGlpRTAISELHGnmyievssaqrtqglgdkqmsltvpSLPQVCtsCIPNReyvRV 232
Cdd:PTZ00408  81 EREyrggKVV--VVTQNVDNLHERAG--STHVLHMHG-------------------------ELLKVR--CTATG---HV 126

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672070193 233 FDVTERTAlhrHLTGRtCHKCG--TQLRDTIVHFGErgtlgQPLNWEAATEAASKADTILCLGSSLKVlkkYP 303
Cdd:PTZ00408 127 FDWTEDVV---HGSSR-CKCCGcvGTLRPHIVWFGE-----MPLYMDEIESVMSKTDLFVAVGTSGNV---YP 187
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
 92-298 1.20e-11

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 64.94  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  92 ELAGAVRSARHLVVYTGAGISTAASIPDYRGPN----------------GVWTLLQKGRPVSAADLSEAEPTLT--HMSI 153
Cdd:PTZ00409  20 DLADMIRKCKYVVALTGSGTSAESNIPSFRGPSssiwskydpkiygtiwGFWKYPEKIWEVIRDISSDYEIELNpgHVAL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 154 TQLHKHKLVQHVVSQNCDGLHLRSGlpRTAISELHGNMyievssaqrtqglgdkqmsltvpsLPQVCTSCipnREYVRVF 233
Cdd:PTZ00409 100 STLESLGYLKFVVTQNVDGLHEESG--NTKVIPLHGSV------------------------FEARCCTC---RKTIQLN 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672070193 234 DVT-ERTALHRHLTGRTChKCGTQLRDTIVHFGErgtlGQPLNW-EAATEAASKADTILCLGSSLKV 298
Cdd:PTZ00409 151 KIMlQKTSHFMHQLPPEC-PCGGIFKPNVILFGE----VIPKSLlKQAEKEIDKCDLLLVVGTSSSV 212
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
 76-311 5.07e-08

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 54.49  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  76 QEEVCDDP--EELRRKVRElagavRSARHLVVYTGAGISTAASIPDYRGPN-GVWTLLQK---GRPVSAADLS------- 142
Cdd:PTZ00410   8 QEHVVGEPtfEGLARYIER-----NNVTKILVMVGAGISVAAGIPDFRSPHtGIYAKLGKynlNSPTDAFSLTllrekpe 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 143 --------------EAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMyievSSAqrtqglgdkq 208
Cdd:PTZ00410  83 vfysiaremdlwpgHFQPTAVHHFIRLLADEGRLLRCCTQNIDGLERAAGVPPSLLVEAHGSF----SAA---------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193 209 msltvpslpqvctSCIPNREyvrVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGErgtlGQPLNWEAATEAASKADT 288
Cdd:PTZ00410 149 -------------SCIECHT---PYDIEQAYLEARSGKVPHCSTCGGIVKPDVVFFGE----NLPDAFFNVHHDIPEAEL 208

                        250       260
                 ....*....|....*....|...
gi 672070193 289 ILCLGSSLKVlKKYPRLWCMTKP 311
Cdd:PTZ00410 209 LLIIGTSLQV-HPFALLACVVPK 230
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 11-91 5.45e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193   11 ERKAAERVRRLREEQQRE--RLRQV--SRILRKAAAERSA----EEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDD 82
Cdd:pfam17380 294 EKMEQERLRQEKEEKAREveRRRKLeeAEKARQAEMDRQAaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAME 373


                  ....*....
gi 672070193   83 PEELRRKVR 91
Cdd:pfam17380 374 ISRMRELER 382
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-101 6.33e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193     7 LSRSERKAAERVRRLREEQ-----QRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCD 81
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLeeleaQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                           90       100
                   ....*....|....*....|
gi 672070193    82 DPEELRRKVRELAGAVRSAR 101
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLN 399
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 7-101 6.40e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 40.02  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193    7 LSRSERKAAERVRRLREEQQRERLRQvsrILRKAAAERS--AEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDP- 83
Cdd:pfam05672  22 QAREQREREEQERLEKEEEERLRKEE---LRRRAEEERArrEEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQEr 98

                          90       100
                  ....*....|....*....|...
gi 672070193   84 -----EELRRKVRELAGAVRSAR 101
Cdd:pfam05672  99 lqkqkEEAEAKAREEAERQRQER 121
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
12-93 2.65e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.89  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  12 RKAAERVRRLREE--QQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVcddpEELRRK 89
Cdd:COG4372   41 DKLQEELEQLREEleQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA----EELQEE 116


                 ....
gi 672070193  90 VREL 93
Cdd:COG4372  117 LEEL 120
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 7-78 4.57e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 4.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672070193   7 LSRSERKAAERVRRLRE-EQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEE 78
Cdd:COG1196  248 LEELEAELEELEAELAElEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 11-101 5.20e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  11 ERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKV 90
Cdd:COG1196  309 ERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL 388

                         90
                 ....*....|.
gi 672070193  91 RELAGAVRSAR 101
Cdd:COG1196  389 LEALRAAAELA 399
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
16-98 6.99e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 38.69  E-value: 6.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  16 ERVRRLREeqQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVcddpEELRRKVRELAG 95
Cdd:COG2433  413 EEIRRLEE--QVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREISRLDREI----ERLERELEEERE 486


                 ...
gi 672070193  96 AVR 98
Cdd:COG2433  487 RIE 489
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 5-93 7.24e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.90  E-value: 7.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193     5 GGlSRSERKAAERVRRLREE--QQRERLRQVSRILRKAAAERSAEEGR---LLAESEDLVTELQGRSRRREGLKRRQEEV 79
Cdd:TIGR02169  657 GG-SRAPRGGILFSRSEPAElqRLRERLEGLKRELSSLQSELRRIENRldeLSQELSDASRKIGEIEKEIEQLEQEEEKL 735

                           90
                   ....*....|....
gi 672070193    80 CDDPEELRRKVREL 93
Cdd:TIGR02169  736 KERLEELEEDLSSL 749
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 11-102 8.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193  11 ERKAAERVRRLREE-QQRERLRQVSRI--LRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELR 87
Cdd:COG1196  208 QAEKAERYRELKEElKELEAELLLLKLreLEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQ 287

                         90
                 ....*....|....*
gi 672070193  88 RKVRELAGAVRSARH 102
Cdd:COG1196  288 AEEYELLAELARLEQ 302
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-104 9.39e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.36  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193   12 RKAAERVRRL--REEQQRERLRQVSRILRKAAAERsaeEGRLLAESEDLVTELQGRSRRREGLKRR----QEEVCDDPE- 84
Cdd:COG4913   305 ARLEAELERLeaRLDALREELDELEAQIRGNGGDR---LEQLEREIERLERELEERERRRARLEALlaalGLPLPASAEe 381

                          90       100
                  ....*....|....*....|..
gi 672070193   85 --ELRRKVRELAGAVRSARHLV 104
Cdd:COG4913   382 faALRAEAAALLEALEEELEAL 403
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 16-101 9.78e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672070193    16 ERVRRLREEQQRErLRQVSRILRKAAAERsaeeGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAG 95
Cdd:TIGR02169  304 ASLERSIAEKERE-LEDAEERLAKLEAEI----DKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDK 378


                   ....*.
gi 672070193    96 AVRSAR 101
Cdd:TIGR02169  379 EFAETR 384
DUF5788 pfam19101
Family of unknown function (DUF5788); This is a family of proteins of unknown function ...
 16-55 9.99e-03

Family of unknown function (DUF5788); This is a family of proteins of unknown function predominantly found in Halobacteria.


Pssm-ID: 436967  Cd Length: 132  Bit Score: 35.99  E-value: 9.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 672070193   16 ERVRRLREEQQRERLRQVSRIlrKAAAERSAEEGRLLAES 55
Cdd:pfam19101  56 ERVERAKRNLRRERLERVERI--ESEGEISREEGEELAES 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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