|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1915-2241 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
:
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 674.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1915 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYKAVGKIFSG 1994
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1995 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2074
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2075 PVVVIVPDLQQICEIMLFSEGFLGAKTLAKKMTVLYKLAREQLSKQHHYDFGLRALKSVLVMAGELKRGSADLQEDVVLM 2154
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2155 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVG 2234
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 1958670707 2235 PTGGGKS 2241
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
309-879 |
4.19e-178 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
:
Pssm-ID: 462457 Cd Length: 560 Bit Score: 560.66 E-value: 4.19e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 309 VETLEQCVINWLGQISYAvdsqLKKKPQGN--GPLAEIEFWRERNATLSALYEQTKLPFVRKVLEVIKEAESMLTANVQP 386
Cdd:pfam08385 1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 387 VLTELFKLHMEASDNVRFLSTVERHFKNITHGSNFHVVLDTIPSMMSALRMVWIISRHYNRDERMIPLMERIAWEIAERV 466
Cdd:pfam08385 77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 467 CRVINLRTLFKENRANAQFKTQEAKNTLKLWKKSYFDIRAKIEASGREARWEFDRKRLFERTDYMANICQDLSDILRVLE 546
Cdd:pfam08385 157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 547 EF------YNIFGPELKAVtgdpkrIDDVLCRVDSLVAPMETLNFDPFNIRsAPYWKYVMEDFKLEVLVIEKEAKNFIDE 620
Cdd:pfam08385 237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVS-NEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 621 SFKTLRSAEAAFDMLLKFKHIRSREAINRQMMMKFNDILAQYYKEIDIVNKIFEQNLDNP-PLYKNHPPVAGAICWERSL 699
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 700 FYRIKHTILRFMEVEELLDSERGQEVKQRYLEVGRKMKEYEDVKYEHWKETTEQSLPNLMKKSLLTKNTITSEdsavidr 779
Cdd:pfam08385 390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPETGK------- 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 780 gtMFVINFSPVLREIINETKYLEQLGFTVPELARNVALQEDKFLRYTEGIQRMLDHYHLLVNTLNEAESVLLDDHSQELL 859
Cdd:pfam08385 463 --LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
|
570 580
....*....|....*....|
gi 1958670707 860 RVFRSGYKRLNWNSLGIADY 879
Cdd:pfam08385 541 EKLEPGLTTLTWNSLGIDEY 560
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1375-1780 |
1.12e-160 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
:
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 503.72 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1375 LMKVQKEMAGLRMIYDLYDSLKIAKEEWSQTLWINLNVQYLQEGIEGFLKNLRKLPRHVRSLSVAFHLETKMKAFKDSIP 1454
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1455 LLLDLKHEALRERHWKELMEKTGVFFEM-TETFTLDNMFAMELHKHTEVLNEIVTAAVKEVAIEKAVKEILDTWENMKFT 1533
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1534 VVKYYKGTqerGYILGSVDDIIQCLDDNTVNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1613
Cdd:pfam08393 161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1614 GGDIRSQLPEEAKKFDVIDRIFKRIMGDTLKDPVIKRCCEAPNRLHDLQTVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1693
Cdd:pfam08393 238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1694 DDELLSILGNS-DPLCVQEHMIKMYDNIAMLRFHDgdsgEKLVSAMISAEGEVMVFRK-IVRAEGRVEDWMTTVLNEMRR 1771
Cdd:pfam08393 318 NDELLEILSQTkDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393
|
....*....
gi 1958670707 1772 TNRLITKEA 1780
Cdd:pfam08393 394 TLRDLLKEA 402
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2894-3153 |
3.43e-118 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
:
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 375.41 E-value: 3.43e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2894 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLE 2973
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2974 NKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALFTEEEKDNILSQIGQEALKHGMGPAKESVWQFFVNKSANNLHIVLG 3053
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3054 MSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQALHAVAKSFLGNNSmIPSEKLEDLVEHVVLVHQSVGEFSKQFQQKLR 3133
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIE-IPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 1958670707 3134 RSNYVTPKNYLDFINTYSKL 3153
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4291-4589 |
3.02e-114 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
:
Pssm-ID: 465677 Cd Length: 301 Bit Score: 365.79 E-value: 3.02e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4291 TQAARDMWGHLLELQPQT--GESSSGVSRDDYIGQVAKDIENKMPKIFDLDQV-RKHLGLNISPTSVVLLQELGRFNKLV 4367
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAeEKYPVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4368 IRMTRSLAELQRALAGEVGMSNELDDVARSLFLGHIPHIWRKLAPDTLKTLGNWMVYFLRRFNQYTLWV-TESEPSVMWL 4446
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4447 SGLHIPESYLTALVQATCRRNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIERGCLVKSKPKVLVV 4526
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670707 4527 DLPILKIIPIEGHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTAKHISHWVLQGVCLTL 4589
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
1616-4234 |
3.55e-110 |
|
Dynein, heavy chain [Cytoskeleton];
The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 397.44 E-value: 3.55e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1616 DIRSQLPEEAKKFDVIDRIFKRIMGDTLKdpvikrCCEAPNRLH-----DLQTVSEGLEKCQKSLNDYLDSKRNAFPRFf 1690
Cdd:COG5245 639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVS------GCEAINTILedvgdDLDLFYKEMDQVFMSIEKVLGLRWREVERA- 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1691 fISDDELLSILGN-SDPLCVQEHMIKMYDNIAMLR-FHDGDSGEKLVSAMISAEGEVMVFRKIVRAEGRVEDWMTTVLNE 1768
Cdd:COG5245 712 -SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINRSMGRVLSQ 790
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1769 MRRTNRLITKEAIFRYCEDRSRVDWMMMYQGMvvlaasqvwWTWEVEDVFNKvkqgdkqAMKNYGKKMHRQIDDLVTRit 1848
Cdd:COG5245 791 YLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCFDP-------PLSEYFRILEKIFPSEEGY-- 852
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1849 mqLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFEWESQLRFYwDREPDELNIRQCTGTFGYGYEYMGLNGRLVI 1928
Cdd:COG5245 853 --FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFE 929
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1929 TPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYKAvgKIFSGLAQCGAWGcFDEFN 2008
Cdd:COG5245 930 HSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESA 996
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2009 RIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPESVKALFRPVVVIVPdLQQI 2086
Cdd:COG5245 997 LLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAI 1068
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2087 CEIMlfsegflgaKTLAKKMTVLYKLAREQLSKQHHYDFglRALKSVLVMAGELKRGSADLQEDVVLMRALrdmnlpkfv 2166
Cdd:COG5245 1069 KSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLEEKTEYLNKILSITGL--------- 1128
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2167 fedvPLFLGLISDLFPGLDCprvRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVGPTGGGKSVVINT 2246
Cdd:COG5245 1129 ----PLISDTLRERIDTLDA---EWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTD 1201
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2247 LCQaqtklgiltklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKERKYILFDGdvdalWVENMNSVM 2326
Cdd:COG5245 1202 ACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSKMEYEVER-----YVEKTKAEV 1261
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2327 DDNKLLTLANGERirlqshcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYQPYWKKWLQQIQNKVEQKylNDLFE--K 2404
Cdd:COG5245 1262 SSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLDEC--LDFFScfE 1329
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2405 YVPILIDLIIEGILDG--RQGEKLKMVVPQTDLNMVTQLTKMMDSLLEGEIEDPDLLE------------CFFLeaLYCS 2470
Cdd:COG5245 1330 EVQKEIDELSMVFCADalRFSADLYHIVKERRFSGVLAGSDASESLGGKSIELAAILEhkdlivemkrgiNDVL--KLRI 1407
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2471 LGSSLLEEGR----IKFDECIKNLSSMPTAETEgnwarpgelpghLPTLYEFHFDSKRNYWIPWNKLVPEYVhnhqKRFV 2546
Cdd:COG5245 1408 FGDKCRESTPrfylISDGDLIKDLNERSDYEEM------------LIMMFNISAVITNNGSIAGFELRGERV----MLRK 1471
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2547 DILVHTVDTTRTTWILEQMVKIKHPVLFVGESGTSKTATTQNFLKNlnEETNIVLMVNFSSRTTSLDIQRNLEANVEKRT 2626
Cdd:COG5245 1472 EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPSKLSVLERETEYYP 1549
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2627 KD----TYGPPMGKRLLVFMDDMNMPKVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKSIRDLGFIAAMGKAGG-GRN 2700
Cdd:COG5245 1550 NTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VTICGIILYGACNPGTDeGRV 1627
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2701 EVDPRFLSLFSVFNVPFPSEESLHLIYYSILKGHTSTFAEsISGVSRKLTFCTLTLYkNIVQDLPPTPSKFHYIFNLRDL 2780
Cdd:COG5245 1628 KYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDE-FNRLSEETMSASVELY-LSSKDKTKFFLQMNYGYKPREL 1705
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2781 SRV---FNGLVLTNPDrfQTVSQMVRVWRNECLRVFHDRLINEVDK----QLVQD----YIGNLVKEHFNDdyEMVMRDP 2849
Cdd:COG5245 1706 TRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESstsrQDLYDfglrAIREMIAGHIGE--AEITFSM 1781
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2850 ILFGDFRTALQeeepriyediqdyeAAKALF-EEILEEYNEVNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGS 2928
Cdd:COG5245 1782 ILFFGMACLLK--------------KDLAVFvEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIR 1847
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2929 GKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLENKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALF 3008
Cdd:COG5245 1848 GACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLF 1927
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3009 TEEEKDNILSQIGQEALKHGMG-PAKESVWQFFVNKSANNLHIVLGMSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQA 3087
Cdd:COG5245 1928 SGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEE 2007
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3088 LHAVAksflgnNSMIPSEKLEDLVEHV--------------VLVHQSVGEFSKQFQQKLRR-SNYVTPKNYLDFINTYSK 3152
Cdd:COG5245 2008 MSQYA------NSVETLSRDGGRVFFIngelgvgkgaliseVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDA 2081
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3153 LLDEKTQYNIAQCKRLEGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACETLLEEIATNTAIAEEKKKLAEEKAIEIE 3232
Cdd:COG5245 2082 RCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLF 2161
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3233 EQNKIIAVEKAEAETALAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGMMSD- 3311
Cdd:COG5245 2162 LLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFEAKIWFGEQQSLRRd 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3312 ---PNFLRSLMELDFDsiTQGQVKNIKGLLKTLNTTIEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKRDKVARLERN 3388
Cdd:COG5245 2242 dfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGE 2319
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3389 FFLTKrelERIQNELAAIQK---ELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENVRWLNDLDELMHR 3465
Cdd:COG5245 2320 AFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKL 2396
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3466 RVKLLGDCLLCAAFLSYEGAFTWEFRDAMVNQEWRndILDRDIPLSQPFR---LENLLTDDVEiSRWGSQglpPDELSVQ 3542
Cdd:COG5245 2397 MVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMSFI--RISKEFRDKEIRRrqfITEGVQKIED-FKEEAC---STDYGLE 2470
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3543 N-GILTTRASRFPLCIDPQQQALNWIKRKEERNNLRVASFNDPDFLKQLEMSIKYGTPFLFHDVdEYIDPVIDNVLEKNI 3621
Cdd:COG5245 2471 NsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDA-EALDEEIGRLIKEEF 2549
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3622 KISQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQ 3701
Cdd:COG5245 2550 KSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNA 2629
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3702 ETSENKNLLKDLEDSLLRELATSTGNMLDNVELVQTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFF 3781
Cdd:COG5245 2630 LKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRV 2709
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3782 VLSEMALVNSMYQYSLIAFLEVFGLSLKKSlpdSILLKRLKNIMDTLTFNiynygctgLFEKHKLLFSFNMTIKieqaeg 3861
Cdd:COG5245 2710 EIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWI--------LDHEDRSGFIHRLDVS------ 2772
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3862 rvpqdeldFFLKGNISLEKSkwkkpctwLSDQGWEDIilLSEKFSDIFGNLpfdiehnlptwqewydKDSLEQFPFplry 3941
Cdd:COG5245 2773 --------FLLRTKRFVSTL--------LEDKNYRQV--LSSCSLYGNDVI----------------SHSCDRFDR---- 2814
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3942 dDHITAFQKLLILRCFRVDRVYRAVTDYVTLtmgEKYVQPPMISFEAifEQSTPNSPIVFILSPGSDPASDLMKLAERSg 4021
Cdd:COG5245 2815 -DVYRALKHQMDNRTHSTILTSNSKTNPYKE---YTYNDSWAEAFEV--EDSGDLYKFEEGLLELIVGHAPLIYAHKKS- 2887
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4022 fgGTRLKFLAMGQGQEKVALQLLETAVAR--GQWLMLQNCHLLVKWLKD-LEKSLERI--TKPHPDF-RLWLTTDPTKGF 4095
Cdd:COG5245 2888 --LENERNVDRLGSKENEVYAVLNSLFSRkeKSWFEVYNISLSFGWFKRyVEDVVYPIkaSRVCGKVkNMWTSMVDADML 2965
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4096 PIGILQKSLKVVTEPPNGLKLNMrATYFKISHDMLEQCPHTAFKpLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQ 4175
Cdd:COG5245 2966 PIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFE 3043
|
2650 2660 2670 2680 2690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958670707 4176 VCMEILNTYLtkaFQQHDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTTYMDEYLGDF 4234
Cdd:COG5245 3044 FKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGAHE 3099
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1915-2241 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 674.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1915 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYKAVGKIFSG 1994
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1995 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2074
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2075 PVVVIVPDLQQICEIMLFSEGFLGAKTLAKKMTVLYKLAREQLSKQHHYDFGLRALKSVLVMAGELKRGSADLQEDVVLM 2154
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2155 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVG 2234
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 1958670707 2235 PTGGGKS 2241
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
309-879 |
4.19e-178 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 560.66 E-value: 4.19e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 309 VETLEQCVINWLGQISYAvdsqLKKKPQGN--GPLAEIEFWRERNATLSALYEQTKLPFVRKVLEVIKEAESMLTANVQP 386
Cdd:pfam08385 1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 387 VLTELFKLHMEASDNVRFLSTVERHFKNITHGSNFHVVLDTIPSMMSALRMVWIISRHYNRDERMIPLMERIAWEIAERV 466
Cdd:pfam08385 77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 467 CRVINLRTLFKENRANAQFKTQEAKNTLKLWKKSYFDIRAKIEASGREARWEFDRKRLFERTDYMANICQDLSDILRVLE 546
Cdd:pfam08385 157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 547 EF------YNIFGPELKAVtgdpkrIDDVLCRVDSLVAPMETLNFDPFNIRsAPYWKYVMEDFKLEVLVIEKEAKNFIDE 620
Cdd:pfam08385 237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVS-NEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 621 SFKTLRSAEAAFDMLLKFKHIRSREAINRQMMMKFNDILAQYYKEIDIVNKIFEQNLDNP-PLYKNHPPVAGAICWERSL 699
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 700 FYRIKHTILRFMEVEELLDSERGQEVKQRYLEVGRKMKEYEDVKYEHWKETTEQSLPNLMKKSLLTKNTITSEdsavidr 779
Cdd:pfam08385 390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPETGK------- 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 780 gtMFVINFSPVLREIINETKYLEQLGFTVPELARNVALQEDKFLRYTEGIQRMLDHYHLLVNTLNEAESVLLDDHSQELL 859
Cdd:pfam08385 463 --LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
|
570 580
....*....|....*....|
gi 1958670707 860 RVFRSGYKRLNWNSLGIADY 879
Cdd:pfam08385 541 EKLEPGLTTLTWNSLGIDEY 560
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1375-1780 |
1.12e-160 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 503.72 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1375 LMKVQKEMAGLRMIYDLYDSLKIAKEEWSQTLWINLNVQYLQEGIEGFLKNLRKLPRHVRSLSVAFHLETKMKAFKDSIP 1454
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1455 LLLDLKHEALRERHWKELMEKTGVFFEM-TETFTLDNMFAMELHKHTEVLNEIVTAAVKEVAIEKAVKEILDTWENMKFT 1533
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1534 VVKYYKGTqerGYILGSVDDIIQCLDDNTVNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1613
Cdd:pfam08393 161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1614 GGDIRSQLPEEAKKFDVIDRIFKRIMGDTLKDPVIKRCCEAPNRLHDLQTVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1693
Cdd:pfam08393 238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1694 DDELLSILGNS-DPLCVQEHMIKMYDNIAMLRFHDgdsgEKLVSAMISAEGEVMVFRK-IVRAEGRVEDWMTTVLNEMRR 1771
Cdd:pfam08393 318 NDELLEILSQTkDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393
|
....*....
gi 1958670707 1772 TNRLITKEA 1780
Cdd:pfam08393 394 TLRDLLKEA 402
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2894-3153 |
3.43e-118 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 375.41 E-value: 3.43e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2894 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLE 2973
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2974 NKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALFTEEEKDNILSQIGQEALKHGMGPAKESVWQFFVNKSANNLHIVLG 3053
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3054 MSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQALHAVAKSFLGNNSmIPSEKLEDLVEHVVLVHQSVGEFSKQFQQKLR 3133
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIE-IPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 1958670707 3134 RSNYVTPKNYLDFINTYSKL 3153
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4291-4589 |
3.02e-114 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 365.79 E-value: 3.02e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4291 TQAARDMWGHLLELQPQT--GESSSGVSRDDYIGQVAKDIENKMPKIFDLDQV-RKHLGLNISPTSVVLLQELGRFNKLV 4367
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAeEKYPVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4368 IRMTRSLAELQRALAGEVGMSNELDDVARSLFLGHIPHIWRKLAPDTLKTLGNWMVYFLRRFNQYTLWV-TESEPSVMWL 4446
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4447 SGLHIPESYLTALVQATCRRNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIERGCLVKSKPKVLVV 4526
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670707 4527 DLPILKIIPIEGHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTAKHISHWVLQGVCLTL 4589
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1616-4234 |
3.55e-110 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 397.44 E-value: 3.55e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1616 DIRSQLPEEAKKFDVIDRIFKRIMGDTLKdpvikrCCEAPNRLH-----DLQTVSEGLEKCQKSLNDYLDSKRNAFPRFf 1690
Cdd:COG5245 639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVS------GCEAINTILedvgdDLDLFYKEMDQVFMSIEKVLGLRWREVERA- 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1691 fISDDELLSILGN-SDPLCVQEHMIKMYDNIAMLR-FHDGDSGEKLVSAMISAEGEVMVFRKIVRAEGRVEDWMTTVLNE 1768
Cdd:COG5245 712 -SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINRSMGRVLSQ 790
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1769 MRRTNRLITKEAIFRYCEDRSRVDWMMMYQGMvvlaasqvwWTWEVEDVFNKvkqgdkqAMKNYGKKMHRQIDDLVTRit 1848
Cdd:COG5245 791 YLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCFDP-------PLSEYFRILEKIFPSEEGY-- 852
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1849 mqLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFEWESQLRFYwDREPDELNIRQCTGTFGYGYEYMGLNGRLVI 1928
Cdd:COG5245 853 --FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFE 929
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1929 TPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYKAvgKIFSGLAQCGAWGcFDEFN 2008
Cdd:COG5245 930 HSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESA 996
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2009 RIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPESVKALFRPVVVIVPdLQQI 2086
Cdd:COG5245 997 LLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAI 1068
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2087 CEIMlfsegflgaKTLAKKMTVLYKLAREQLSKQHHYDFglRALKSVLVMAGELKRGSADLQEDVVLMRALrdmnlpkfv 2166
Cdd:COG5245 1069 KSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLEEKTEYLNKILSITGL--------- 1128
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2167 fedvPLFLGLISDLFPGLDCprvRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVGPTGGGKSVVINT 2246
Cdd:COG5245 1129 ----PLISDTLRERIDTLDA---EWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTD 1201
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2247 LCQaqtklgiltklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKERKYILFDGdvdalWVENMNSVM 2326
Cdd:COG5245 1202 ACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSKMEYEVER-----YVEKTKAEV 1261
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2327 DDNKLLTLANGERirlqshcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYQPYWKKWLQQIQNKVEQKylNDLFE--K 2404
Cdd:COG5245 1262 SSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLDEC--LDFFScfE 1329
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2405 YVPILIDLIIEGILDG--RQGEKLKMVVPQTDLNMVTQLTKMMDSLLEGEIEDPDLLE------------CFFLeaLYCS 2470
Cdd:COG5245 1330 EVQKEIDELSMVFCADalRFSADLYHIVKERRFSGVLAGSDASESLGGKSIELAAILEhkdlivemkrgiNDVL--KLRI 1407
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2471 LGSSLLEEGR----IKFDECIKNLSSMPTAETEgnwarpgelpghLPTLYEFHFDSKRNYWIPWNKLVPEYVhnhqKRFV 2546
Cdd:COG5245 1408 FGDKCRESTPrfylISDGDLIKDLNERSDYEEM------------LIMMFNISAVITNNGSIAGFELRGERV----MLRK 1471
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2547 DILVHTVDTTRTTWILEQMVKIKHPVLFVGESGTSKTATTQNFLKNlnEETNIVLMVNFSSRTTSLDIQRNLEANVEKRT 2626
Cdd:COG5245 1472 EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPSKLSVLERETEYYP 1549
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2627 KD----TYGPPMGKRLLVFMDDMNMPKVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKSIRDLGFIAAMGKAGG-GRN 2700
Cdd:COG5245 1550 NTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VTICGIILYGACNPGTDeGRV 1627
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2701 EVDPRFLSLFSVFNVPFPSEESLHLIYYSILKGHTSTFAEsISGVSRKLTFCTLTLYkNIVQDLPPTPSKFHYIFNLRDL 2780
Cdd:COG5245 1628 KYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDE-FNRLSEETMSASVELY-LSSKDKTKFFLQMNYGYKPREL 1705
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2781 SRV---FNGLVLTNPDrfQTVSQMVRVWRNECLRVFHDRLINEVDK----QLVQD----YIGNLVKEHFNDdyEMVMRDP 2849
Cdd:COG5245 1706 TRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESstsrQDLYDfglrAIREMIAGHIGE--AEITFSM 1781
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2850 ILFGDFRTALQeeepriyediqdyeAAKALF-EEILEEYNEVNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGS 2928
Cdd:COG5245 1782 ILFFGMACLLK--------------KDLAVFvEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIR 1847
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2929 GKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLENKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALF 3008
Cdd:COG5245 1848 GACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLF 1927
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3009 TEEEKDNILSQIGQEALKHGMG-PAKESVWQFFVNKSANNLHIVLGMSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQA 3087
Cdd:COG5245 1928 SGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEE 2007
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3088 LHAVAksflgnNSMIPSEKLEDLVEHV--------------VLVHQSVGEFSKQFQQKLRR-SNYVTPKNYLDFINTYSK 3152
Cdd:COG5245 2008 MSQYA------NSVETLSRDGGRVFFIngelgvgkgaliseVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDA 2081
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3153 LLDEKTQYNIAQCKRLEGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACETLLEEIATNTAIAEEKKKLAEEKAIEIE 3232
Cdd:COG5245 2082 RCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLF 2161
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3233 EQNKIIAVEKAEAETALAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGMMSD- 3311
Cdd:COG5245 2162 LLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFEAKIWFGEQQSLRRd 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3312 ---PNFLRSLMELDFDsiTQGQVKNIKGLLKTLNTTIEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKRDKVARLERN 3388
Cdd:COG5245 2242 dfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGE 2319
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3389 FFLTKrelERIQNELAAIQK---ELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENVRWLNDLDELMHR 3465
Cdd:COG5245 2320 AFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKL 2396
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3466 RVKLLGDCLLCAAFLSYEGAFTWEFRDAMVNQEWRndILDRDIPLSQPFR---LENLLTDDVEiSRWGSQglpPDELSVQ 3542
Cdd:COG5245 2397 MVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMSFI--RISKEFRDKEIRRrqfITEGVQKIED-FKEEAC---STDYGLE 2470
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3543 N-GILTTRASRFPLCIDPQQQALNWIKRKEERNNLRVASFNDPDFLKQLEMSIKYGTPFLFHDVdEYIDPVIDNVLEKNI 3621
Cdd:COG5245 2471 NsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDA-EALDEEIGRLIKEEF 2549
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3622 KISQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQ 3701
Cdd:COG5245 2550 KSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNA 2629
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3702 ETSENKNLLKDLEDSLLRELATSTGNMLDNVELVQTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFF 3781
Cdd:COG5245 2630 LKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRV 2709
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3782 VLSEMALVNSMYQYSLIAFLEVFGLSLKKSlpdSILLKRLKNIMDTLTFNiynygctgLFEKHKLLFSFNMTIKieqaeg 3861
Cdd:COG5245 2710 EIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWI--------LDHEDRSGFIHRLDVS------ 2772
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3862 rvpqdeldFFLKGNISLEKSkwkkpctwLSDQGWEDIilLSEKFSDIFGNLpfdiehnlptwqewydKDSLEQFPFplry 3941
Cdd:COG5245 2773 --------FLLRTKRFVSTL--------LEDKNYRQV--LSSCSLYGNDVI----------------SHSCDRFDR---- 2814
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3942 dDHITAFQKLLILRCFRVDRVYRAVTDYVTLtmgEKYVQPPMISFEAifEQSTPNSPIVFILSPGSDPASDLMKLAERSg 4021
Cdd:COG5245 2815 -DVYRALKHQMDNRTHSTILTSNSKTNPYKE---YTYNDSWAEAFEV--EDSGDLYKFEEGLLELIVGHAPLIYAHKKS- 2887
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4022 fgGTRLKFLAMGQGQEKVALQLLETAVAR--GQWLMLQNCHLLVKWLKD-LEKSLERI--TKPHPDF-RLWLTTDPTKGF 4095
Cdd:COG5245 2888 --LENERNVDRLGSKENEVYAVLNSLFSRkeKSWFEVYNISLSFGWFKRyVEDVVYPIkaSRVCGKVkNMWTSMVDADML 2965
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4096 PIGILQKSLKVVTEPPNGLKLNMrATYFKISHDMLEQCPHTAFKpLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQ 4175
Cdd:COG5245 2966 PIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFE 3043
|
2650 2660 2670 2680 2690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958670707 4176 VCMEILNTYLtkaFQQHDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTTYMDEYLGDF 4234
Cdd:COG5245 3044 FKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGAHE 3099
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3527-3748 |
6.57e-102 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 327.09 E-value: 6.57e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3527 SRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEERNNLRVASFNDPDFLKQLEMSIKYGTPFLFHDVD 3606
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3607 EYIDPVIDNVLEKNIKISQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVA 3686
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958670707 3687 YERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVELVQTLEETKSKATEV 3748
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1915-2241 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 674.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1915 YGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYKAVGKIFSG 1994
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1995 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFR 2074
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2075 PVVVIVPDLQQICEIMLFSEGFLGAKTLAKKMTVLYKLAREQLSKQHHYDFGLRALKSVLVMAGELKRGSADLQEDVVLM 2154
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2155 RALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVG 2234
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 1958670707 2235 PTGGGKS 2241
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
309-879 |
4.19e-178 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 560.66 E-value: 4.19e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 309 VETLEQCVINWLGQISYAvdsqLKKKPQGN--GPLAEIEFWRERNATLSALYEQTKLPFVRKVLEVIKEAESMLTANVQP 386
Cdd:pfam08385 1 LHALESVVIKWTKQIQDV----LKEDSQGRnpGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 387 VLTELFKLHMEASDNVRFLSTVERHFKNITHGSNFHVVLDTIPSMMSALRMVWIISRHYNRDERMIPLMERIAWEIAERV 466
Cdd:pfam08385 77 LDTELTDALNEAKDNVKYLKTLERPFEDLEELTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 467 CRVINLRTLFKENRANAQFKTQEAKNTLKLWKKSYFDIRAKIEASGREARWEFDRKRLFERTDYMANICQDLSDILRVLE 546
Cdd:pfam08385 157 KKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERPWDFSERYIFGRFDAFLERLEKILELFETIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 547 EF------YNIFGPELKAVtgdpkrIDDVLCRVDSLVAPMETLNFDPFNIRsAPYWKYVMEDFKLEVLVIEKEAKNFIDE 620
Cdd:pfam08385 237 QFsklekiGGTKGPELEGV------IEEILEEFQEAYKVFKSKTYDILDVS-NEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 621 SFKTLRSAEAAFDMLLKFKHIRSREAINRQMMMKFNDILAQYYKEIDIVNKIFEQNLDNP-PLYKNHPPVAGAICWERSL 699
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNPsPIAKNMPPVAGAIIWARQL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 700 FYRIKHTILRFMEVEELLDSERGQEVKQRYLEVGRKMKEYEDVKYEHWKETTEQSLPNLMKKSLLTKNTITSEdsavidr 779
Cdd:pfam08385 390 FRRIQEPMKRFKEELGLLKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPETGK------- 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 780 gtMFVINFSPVLREIINETKYLEQLGFTVPELARNVALQEDKFLRYTEGIQRMLDHYHLLVNTLNEAESVLLDDHSQELL 859
Cdd:pfam08385 463 --LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDID 540
|
570 580
....*....|....*....|
gi 1958670707 860 RVFRSGYKRLNWNSLGIADY 879
Cdd:pfam08385 541 EKLEPGLTTLTWNSLGIDEY 560
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1375-1780 |
1.12e-160 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 503.72 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1375 LMKVQKEMAGLRMIYDLYDSLKIAKEEWSQTLWINLNVQYLQEGIEGFLKNLRKLPRHVRSLSVAFHLETKMKAFKDSIP 1454
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1455 LLLDLKHEALRERHWKELMEKTGVFFEM-TETFTLDNMFAMELHKHTEVLNEIVTAAVKEVAIEKAVKEILDTWENMKFT 1533
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1534 VVKYYKGTqerGYILGSVDDIIQCLDDNTVNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFI 1613
Cdd:pfam08393 161 LVPYKDTG---TFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1614 GGDIRSQLPEEAKKFDVIDRIFKRIMGDTLKDPVIKRCCEAPNRLHDLQTVSEGLEKCQKSLNDYLDSKRNAFPRFFFIS 1693
Cdd:pfam08393 238 SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1694 DDELLSILGNS-DPLCVQEHMIKMYDNIAMLRFHDgdsgEKLVSAMISAEGEVMVFRK-IVRAEGRVEDWMTTVLNEMRR 1771
Cdd:pfam08393 318 NDELLEILSQTkDPTRVQPHLKKCFEGIASLEFDE----NKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393
|
....*....
gi 1958670707 1772 TNRLITKEA 1780
Cdd:pfam08393 394 TLRDLLKEA 402
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2894-3153 |
3.43e-118 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 375.41 E-value: 3.43e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2894 MNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLE 2973
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2974 NKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALFTEEEKDNILSQIGQEALKHGMGPAKESVWQFFVNKSANNLHIVLG 3053
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3054 MSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQALHAVAKSFLGNNSmIPSEKLEDLVEHVVLVHQSVGEFSKQFQQKLR 3133
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIE-IPEELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 1958670707 3134 RSNYVTPKNYLDFINTYSKL 3153
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4291-4589 |
3.02e-114 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 365.79 E-value: 3.02e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4291 TQAARDMWGHLLELQPQT--GESSSGVSRDDYIGQVAKDIENKMPKIFDLDQV-RKHLGLNISPTSVVLLQELGRFNKLV 4367
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAeEKYPVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4368 IRMTRSLAELQRALAGEVGMSNELDDVARSLFLGHIPHIWRKLAPDTLKTLGNWMVYFLRRFNQYTLWV-TESEPSVMWL 4446
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4447 SGLHIPESYLTALVQATCRRNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIERGCLVKSKPKVLVV 4526
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670707 4527 DLPILKIIPIEGHRLKLQ-NTFRTPVYTTSMRRNAmgvGLVFEADLFTAKHISHWVLQGVCLTL 4589
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHST---NFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1616-4234 |
3.55e-110 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 397.44 E-value: 3.55e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1616 DIRSQLPEEAKKFDVIDRIFKRIMGDTLKdpvikrCCEAPNRLH-----DLQTVSEGLEKCQKSLNDYLDSKRNAFPRFf 1690
Cdd:COG5245 639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVS------GCEAINTILedvgdDLDLFYKEMDQVFMSIEKVLGLRWREVERA- 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1691 fISDDELLSILGN-SDPLCVQEHMIKMYDNIAMLR-FHDGDSGEKLVSAMISAEGEVMVFRKIVRAEGRVEDWMTTVLNE 1768
Cdd:COG5245 712 -SEVEELMDRVRElENRVYSYRFFVKKIAKEEMKTvFSSRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINRSMGRVLSQ 790
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1769 MRRTNRLITKEAIFRYCEDRSRVDWMMMYQGMvvlaasqvwWTWEVEDVFNKvkqgdkqAMKNYGKKMHRQIDDLVTRit 1848
Cdd:COG5245 791 YLESVQEALEIEDGSFFVSRHRVRDGGLEKGR---------GCDAWENCFDP-------PLSEYFRILEKIFPSEEGY-- 852
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1849 mqLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFEWESQLRFYwDREPDELNIRQCTGTFGYGYEYMGLNGRLVI 1928
Cdd:COG5245 853 --FFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFE 929
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 1929 TPLTDRIYLTLTQALSMYLggapAGPAGTGKTETTKDLAKALGLLCvvtncgEGMDYKAvgKIFSGLAQCGAWGcFDEFN 2008
Cdd:COG5245 930 HSMDTSQHQKLFEAVCDEV----CRFVDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESA 996
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2009 RIDASVLSvISSQIQTIRNAL--IHQLTTFQFEgqEISLDSRMGIFITMNPgyagRTELPESVKALFRPVVVIVPdLQQI 2086
Cdd:COG5245 997 LLDEISRT-ILVDEYLNSDEFrmLEELNSAVVE--HGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAI 1068
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2087 CEIMlfsegflgaKTLAKKMTVLYKLAREQLSKQHHYDFglRALKSVLVMAGELKRGSADLQEDVVLMRALrdmnlpkfv 2166
Cdd:COG5245 1069 KSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLEEKTEYLNKILSITGL--------- 1128
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2167 fedvPLFLGLISDLFPGLDCprvRYPDFNDAVEDVLEENGYVLLPVQVDKVVQMFETMLTRHTTMVVGPTGGGKSVVINT 2246
Cdd:COG5245 1129 ----PLISDTLRERIDTLDA---EWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTD 1201
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2247 LCQaqtklgiltklYILNPKAVSVIELYgiLDPTTrDWTdGVLSNIFREINKPTDKKERKYILFDGdvdalWVENMNSVM 2326
Cdd:COG5245 1202 ACD-----------YLWHVKSPYVKKKY--FDADM-ELR-QFFLMFNREDMEARLADSKMEYEVER-----YVEKTKAEV 1261
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2327 DDNKLLTLANGERirlqshcALLFEVGDlqyASPATVSRCGMVYVDPKNLKYQPYWKKWLQQIQNKVEQKylNDLFE--K 2404
Cdd:COG5245 1262 SSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLDEC--LDFFScfE 1329
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2405 YVPILIDLIIEGILDG--RQGEKLKMVVPQTDLNMVTQLTKMMDSLLEGEIEDPDLLE------------CFFLeaLYCS 2470
Cdd:COG5245 1330 EVQKEIDELSMVFCADalRFSADLYHIVKERRFSGVLAGSDASESLGGKSIELAAILEhkdlivemkrgiNDVL--KLRI 1407
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2471 LGSSLLEEGR----IKFDECIKNLSSMPTAETEgnwarpgelpghLPTLYEFHFDSKRNYWIPWNKLVPEYVhnhqKRFV 2546
Cdd:COG5245 1408 FGDKCRESTPrfylISDGDLIKDLNERSDYEEM------------LIMMFNISAVITNNGSIAGFELRGERV----MLRK 1471
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2547 DILVHTVDTTRTTWILEQMVKIKHPVLFVGESGTSKTATTQNFLKNlnEETNIVLMVNFSSRTTSLDIQRNLEANVEKRT 2626
Cdd:COG5245 1472 EVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPSKLSVLERETEYYP 1549
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2627 KD----TYGPPMGKRLLVFMDDMNMPKVDEYGTQQPIALLKLLLEK-GYLYDRGKELncKSIRDLGFIAAMGKAGG-GRN 2700
Cdd:COG5245 1550 NTgvvrLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAVSW--VTICGIILYGACNPGTDeGRV 1627
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2701 EVDPRFLSLFSVFNVPFPSEESLHLIYYSILKGHTSTFAEsISGVSRKLTFCTLTLYkNIVQDLPPTPSKFHYIFNLRDL 2780
Cdd:COG5245 1628 KYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDE-FNRLSEETMSASVELY-LSSKDKTKFFLQMNYGYKPREL 1705
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2781 SRV---FNGLVLTNPDrfQTVSQMVRVWRNECLRVFHDRLINEVDK----QLVQD----YIGNLVKEHFNDdyEMVMRDP 2849
Cdd:COG5245 1706 TRSlraIFGYAETRID--TPDVSLIIDWYCEAIREKIDRLVQQKESstsrQDLYDfglrAIREMIAGHIGE--AEITFSM 1781
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2850 ILFGDFRTALQeeepriyediqdyeAAKALF-EEILEEYNEVNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGS 2928
Cdd:COG5245 1782 ILFFGMACLLK--------------KDLAVFvEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIR 1847
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2929 GKQSLARLAAFTAGYEVFEILLSRGYSENNFRDDLKNLYMKLGLENKLMIFLFTDAHVAEEGFLELINNMLTSGMVPALF 3008
Cdd:COG5245 1848 GACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLF 1927
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3009 TEEEKDNILSQIGQEALKHGMG-PAKESVWQFFVNKSANNLHIVLGMSPVGDTLRTRCRNFPGLVNNTGIDWFMPWPPQA 3087
Cdd:COG5245 1928 SGNERIRIPENLRFVFESTSLEkDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEE 2007
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3088 LHAVAksflgnNSMIPSEKLEDLVEHV--------------VLVHQSVGEFSKQFQQKLRR-SNYVTPKNYLDFINTYSK 3152
Cdd:COG5245 2008 MSQYA------NSVETLSRDGGRVFFIngelgvgkgaliseVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDA 2081
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3153 LLDEKTQYNIAQCKRLEGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACETLLEEIATNTAIAEEKKKLAEEKAIEIE 3232
Cdd:COG5245 2082 RCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLF 2161
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3233 EQNKIIAVEKAEAETALAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGMMSD- 3311
Cdd:COG5245 2162 LLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFEAKIWFGEQQSLRRd 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3312 ---PNFLRSLMELDFDsiTQGQVKNIKGLLKTLNTTIEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKRDKVARLERN 3388
Cdd:COG5245 2242 dfiRIIGKYPDEIEFD--LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGE 2319
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3389 FFLTKrelERIQNELAAIQK---ELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENVRWLNDLDELMHR 3465
Cdd:COG5245 2320 AFLVE---DRLTLGKGLSSDlmtFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKL 2396
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3466 RVKLLGDCLLCAAFLSYEGAFTWEFRDAMVNQEWRndILDRDIPLSQPFR---LENLLTDDVEiSRWGSQglpPDELSVQ 3542
Cdd:COG5245 2397 MVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMSFI--RISKEFRDKEIRRrqfITEGVQKIED-FKEEAC---STDYGLE 2470
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3543 N-GILTTRASRFPLCIDPQQQALNWIKRKEERNNLRVASFNDPDFLKQLEMSIKYGTPFLFHDVdEYIDPVIDNVLEKNI 3621
Cdd:COG5245 2471 NsRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDA-EALDEEIGRLIKEEF 2549
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3622 KISQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQ 3701
Cdd:COG5245 2550 KSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNA 2629
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3702 ETSENKNLLKDLEDSLLRELATSTGNMLDNVELVQTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFF 3781
Cdd:COG5245 2630 LKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRV 2709
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3782 VLSEMALVNSMYQYSLIAFLEVFGLSLKKSlpdSILLKRLKNIMDTLTFNiynygctgLFEKHKLLFSFNMTIKieqaeg 3861
Cdd:COG5245 2710 EIAMFDEKALMYNKSICELSSEFEKWRRMK---SKYLCAIRYMLMSSEWI--------LDHEDRSGFIHRLDVS------ 2772
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3862 rvpqdeldFFLKGNISLEKSkwkkpctwLSDQGWEDIilLSEKFSDIFGNLpfdiehnlptwqewydKDSLEQFPFplry 3941
Cdd:COG5245 2773 --------FLLRTKRFVSTL--------LEDKNYRQV--LSSCSLYGNDVI----------------SHSCDRFDR---- 2814
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3942 dDHITAFQKLLILRCFRVDRVYRAVTDYVTLtmgEKYVQPPMISFEAifEQSTPNSPIVFILSPGSDPASDLMKLAERSg 4021
Cdd:COG5245 2815 -DVYRALKHQMDNRTHSTILTSNSKTNPYKE---YTYNDSWAEAFEV--EDSGDLYKFEEGLLELIVGHAPLIYAHKKS- 2887
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4022 fgGTRLKFLAMGQGQEKVALQLLETAVAR--GQWLMLQNCHLLVKWLKD-LEKSLERI--TKPHPDF-RLWLTTDPTKGF 4095
Cdd:COG5245 2888 --LENERNVDRLGSKENEVYAVLNSLFSRkeKSWFEVYNISLSFGWFKRyVEDVVYPIkaSRVCGKVkNMWTSMVDADML 2965
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4096 PIGILQKSLKVVTEPPNGLKLNMrATYFKISHDMLEQCPHTAFKpLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQ 4175
Cdd:COG5245 2966 PIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRYPFDYTLVIACD-DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFE 3043
|
2650 2660 2670 2680 2690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958670707 4176 VCMEILNTYLtkaFQQHDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTTYMDEYLGDF 4234
Cdd:COG5245 3044 FKTHLLKNIL---FLNHLNARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGAHE 3099
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3527-3748 |
6.57e-102 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 327.09 E-value: 6.57e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3527 SRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEERNNLRVASFNDPDFLKQLEMSIKYGTPFLFHDVD 3606
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3607 EYIDPVIDNVLEKNIKISQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVA 3686
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958670707 3687 YERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVELVQTLEETKSKATEV 3748
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
2539-2718 |
2.40e-88 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 286.21 E-value: 2.40e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2539 HNHQKRFVDILVHTVDTTRTTWILEQMVKIKHPVLFVGESGTSKTATTQNFLKNLNEETNIVLMVNFSSRTTSLDIQRNL 2618
Cdd:pfam12775 1 IPPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2619 EANVEKRTKDTYGPPMGKRLLVFMDDMNMPKVDEYGTQQPIALLKLLLEKGYLYDRgKELNCKSIRDLGFIAAMGKAGGG 2698
Cdd:pfam12775 81 ESKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDR-KKLTFKEIVDVQFVAAMGPPGGG 159
|
170 180
....*....|....*....|
gi 1958670707 2699 RNEVDPRFLSLFSVFNVPFP 2718
Cdd:pfam12775 160 RNDITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
4138-4285 |
7.48e-66 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 220.40 E-value: 7.48e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 4138 FKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAfqqhDPRIPWGSLKYLIGEVMYGGRAIDS 4217
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEY----DEKIPWDALRYLIGEINYGGRVTDD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670707 4218 FDRRILTTYMDEYLGDFIFDtfQPFHFFRNkdvDYKIPVGDVKDKFVEAIEALPLANTPEVFGLHSNA 4285
Cdd:pfam18198 77 WDRRLLNTYLEEFFNPEVLE--EDFKFSPS---LYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
3994-4107 |
4.93e-56 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 191.12 E-value: 4.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3994 TPNSPIVFILSPGSDPASDLMKLAERSGFGGtRLKFLAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVKWLKDLEKSL 4073
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFGG-KLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEKIL 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 1958670707 4074 ERI--TKPHPDFRLWLTTDPTKGFPIGILQKSLKVV 4107
Cdd:pfam03028 80 EELpeETLHPDFRLWLTSEPSPKFPISILQNSIKIT 115
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3166-3500 |
9.08e-53 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 191.05 E-value: 9.08e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3166 KRLEGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACETLLEEIATNTAIAEEKKKLAEEKAIEIEEQNKIIAVEKAEA 3245
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3246 ETALAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIM-----KGYKELNWKTAKGMMSDPN-FLRSLM 3319
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILmapggKIPKDKSWKAAKIMMAKVDgFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3320 ELDFDSITQGQVKNIKGLLKTLNTTIEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKRDKVARLERNFFLTKRELERI 3399
Cdd:pfam12777 161 KFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAAI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3400 QNELAAIQKELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENVRWLNDLDELMHRRVKLLGDCLLCAAF 3479
Cdd:pfam12777 241 KAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISAF 320
|
330 340
....*....|....*....|.
gi 1958670707 3480 LSYEGAFTWEFRDAMVNQEWR 3500
Cdd:pfam12777 321 ISYLGFFTKKYRNELLDKFWI 341
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
2398-2531 |
2.26e-20 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 89.65 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2398 LNDLFEKYVPILIDLIIEgildgrqgeKLKMVVPQTDLNMVTQLTKMMDSLLEGEIED-----------PDLLECFFLEA 2466
Cdd:pfam17852 1 LEPLFEWLVPPALEFVRK---------NCKEIVPTSDLNLVQSLCRLLESLLDEVLEYngvhplspdklKEYLEKLFLFA 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670707 2467 LYCSLGSSLLEEGRIKFDECIKNLSS---MPTAETEgnwarpgelpghlpTLYEFHFDSKRNYWIPWN 2531
Cdd:pfam17852 72 LVWSIGGTLDEDSRKKFDEFLRELFSgldLPPPEKG--------------TVYDYFVDLEKGEWVPWS 125
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
2754-2852 |
2.32e-14 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 71.89 E-value: 2.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2754 LTLYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPDRFQTVSQMVRVWRNECLRVFHDRLINEVDKQLVQDYIGNL 2833
Cdd:pfam17857 6 LAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDKIQMAS 85
|
90
....*....|....*....
gi 1958670707 2834 VKEHFNDdyemvMRDPILF 2852
Cdd:pfam17857 86 LKKFFDD-----IEDELEF 99
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2231-2366 |
6.04e-09 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 57.30 E-value: 6.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2231 MVVGPTGGGKSVVINTLCQAqtkLGILTKLYILNPKAVSVIELYGILDPTTRD--WTDGVLSNIFREinkptdkkerKYI 2308
Cdd:pfam07728 3 LLVGPPGTGKTELAERLAAA---LSNRPVFYVQLTRDTTEEDLFGRRNIDPGGasWVDGPLVRAARE----------GEI 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670707 2309 LFDGDVDAL---WVENMNSVMDDNKLLTLANGERIRLQSHCALLFEVG-----DLQYASPATVSRC 2366
Cdd:pfam07728 70 AVLDEINRAnpdVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMnpldrGLNELSPALRSRF 135
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2571-2710 |
1.05e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 50.75 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 2571 PVLFVGESGTSKTATTQNFLKNLneETNIVLMVNFSSRTTSLDI--QRNLEANVEKRTKDTYGPPMGKRLLVFMDDMNMP 2648
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAAL--SNRPVFYVQLTRDTTEEDLfgRRNIDPGGASWVDGPLVRAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670707 2649 KVDEYGTQQPiallklLLEKGYLY--DRGKELNCKSiRDLGFIAAMGKAGGGRNEVDPRFLSLF 2710
Cdd:pfam07728 79 NPDVLNSLLS------LLDERRLLlpDGGELVKAAP-DGFRLIATMNPLDRGLNELSPALRSRF 135
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
3374-3445 |
7.48e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.21 E-value: 7.48e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958670707 3374 EIKPKRDKVARLERnffltkrELERIQNELAAIQKELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLI 3445
Cdd:COG3883 17 QIQAKQKELSELQA-------ELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI 81
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2919-2960 |
3.48e-03 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 40.74 E-value: 3.48e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1958670707 2919 HALLVGVGGSGKQSLA-RLAAFTAGYEVFEILLSRGYSENNFR 2960
Cdd:pfam07728 1 GVLLVGPPGTGKTELAeRLAAALSNRPVFYVQLTRDTTEEDLF 43
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3373-3438 |
4.07e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.97 E-value: 4.07e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670707 3373 REIKPKRDKVARLERNFFLTKRELERIQNELAAIQKELEALGAKYEAAILEKQKLQEEAEIMERRL 3438
Cdd:COG4372 52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEEL 117
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3373-3462 |
5.94e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.00 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670707 3373 REIKPKRDKVARLERNFFLTKRELERIQNELAAIQKELEALGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSEN 3452
Cdd:COG1196 246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325
|
90
....*....|
gi 1958670707 3453 VRWLNDLDEL 3462
Cdd:COG1196 326 AELEEELEEL 335
|
|
| |
